Granulysin blocks replication of varicella-zoster virus and triggers apoptosis of infected cells VIRAL IMMUNOLOGY Hata, A., Zerboni, L., Sommer, M., Kaspar, A. A., CLAYBERGER, C., KRENSKY, A. M., Arvin, A. M. 2001; 14 (2): 125-133


Granulysin, a lytic protein present in cytolytic granules of human natural killer and cytotoxic T cells, entered cells infected with varicella-zoster virus (VZV). Exposure to granulysin accelerated death of infected cells as assessed by apoptosis markers. The functional domain of granulysin that mediated its antiviral effects was amino acid 23-51; this domain also mediates the additional antitumor cell effects of granulysin. Because granulysin is a product of natural killer cells and T lymphocytes, it is possible that its antiviral activity may act as a mediator of innate and adaptive immune mechanisms.

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View details for PubMedID 11398808