Identification of a Hydrophobic Domain in Varicella-Zoster Virus ORF61 Necessary for ORF61 Self-Interaction, Viral Replication, and Skin Pathogenesis JOURNAL OF VIROLOGY Wang, L., Rajamani, J., Sommer, M., Zerboni, L., Arvin, A. M. 2013; 87 (7): 4075-4079

Abstract

The varicella-zoster virus (VZV) ORF61 protein is necessary for normal replication in vitro and virulence in human skin xenografts in the severe combined immunodeficiency mouse model in vivo. These experiments identify a hydrophobic domain that mediates ORF61 self-interaction. While not needed to inhibit host cell defenses, disruption of this domain (residues 250 to 320) severely impairs VZV growth, transactivation of the immediate early 63 and glycoprotein E genes, and the pathogenesis of VZV skin infection in vivo.

View details for DOI 10.1128/JVI.02963-12

View details for Web of Science ID 000315957100042

View details for PubMedID 23345513