TYPE-SPECIFIC ANTIBODIES TO HERPES-SIMPLEX VIRUS TYPE-2 (HSV-2) GLYCOPROTEIN-G IN PREGNANT-WOMEN, INFANTS EXPOSED TO MATERNAL HSV-2 INFECTION AT DELIVERY, AND INFANTS WITH NEONATAL HERPES JOURNAL OF INFECTIOUS DISEASES Sullender, W. M., Yasukawa, L. L., Schwartz, M., Pereira, L., Hensleigh, P. A., Prober, C. G., Arvin, A. M. 1988; 157 (1): 164-171

Abstract

We used a murine monoclonal antibody to herpes simplex virus (HSV) type 2 (HSV-2) glycoprotein G (gG) to develop an enzyme immunoassay that detected HSV-2 type-specific antibodies in human sera. Antibodies to HSV-2 gG were detected in 98 (96%) of 102 sera from pregnant women with culture-proved HSV-2 infection. Sixty-five percent of the women had serological evidence of past HSV-2 infection by the Rawls index, based on titers of neutralizing antibody to HSV type 1 and HSV-2. Thirty (88%) of 34 infants exposed to maternal HSV infection at delivery had antibodies to HSV-2 gG and remained well. One infant exposed to primary maternal HSV-2 infection lacked antibodies to HSV-2 gG and developed neonatal HSV-2 infection. The mean +/- SD optical density by HSV-2 gG enzyme-linked immunosorbent assay for sera obtained from 17 infants within one week after onset of neonatal HSV-2 infection was 0.25 +/- 0.12, compared with 1.15 +/- 0.34 in cord blood sera from exposed infants who did not develop symptoms (P less than .0001 by t test).

View details for Web of Science ID A1988L370400023

View details for PubMedID 2826604