IMMUNIZATION WITH THE IMMEDIATE-EARLY TEGUMENT PROTEIN (OPEN READING FRAME-62) OF VARICELLA-ZOSTER VIRUS PROTECTS GUINEA-PIGS AGAINST VIRUS CHALLENGE JOURNAL OF VIROLOGY Sabella, C., Lowry, P. W., ABBRUZZI, G. M., Koropchak, C. M., Kinchington, P. R., Sadeghzadeh, M., Hay, J., Ruyechan, W. T., Arvin, A. M. 1993; 67 (12): 7673-7676

Abstract

The IE62 protein, the primary regulatory protein of varicella-zoster virus (VZV) and the major component of the virion tegument, was an effective immunogen in the guinea pig model of VZV infection, whereas the ORF 29 gene product, a nonstructural DNA replication protein, did not elicit protection. All animals immunized with the ORF 29 protein had cell-associated viremia compared with 2 of 11 guinea pigs given the IE62 protein (P = 0.005). VZV was detected in ganglia from 38% of the animals given the ORF 29 protein and 44% of the control animals compared with 9% of the animals immunized with the IE62 protein (P = 0.04). In contrast to the IE62 protein, immunization with the ORF 29 protein did not prime the animals for an enhanced T-cell response upon challenge with infectious virus. The VZV IE62 protein has potential value as a vaccine component.

View details for Web of Science ID A1993MG30700092

View details for PubMedID 8230489