Glycoprotein I of Varicella-zoster virus is required for viral replication in skin and T cells JOURNAL OF VIROLOGY Moffat, J., Ito, H., Sommer, M., Taylor, S., Arvin, A. M. 2002; 76 (16): 8468-8471

Abstract

Varicella-zoster virus (VZV) glycoprotein I (gI) is dispensable in cell culture; the SCIDhu model of VZV pathogenesis was used to determine whether gI is necessary in vivo. The parental and repaired viruses grew in human skin and thymus/liver implants, but the gI deletion mutant was not infectious. Thus, gI is essential for VZV infectivity in skin and T cells.

View details for DOI 10.1128/JVI.16.8468-8471.2002

View details for Web of Science ID 000177049500055

View details for PubMedID 12134050