Construction of varicella-zoster virus recombinants from parent Oka cosmids and demonstration that ORF65 protein is dispensable for infection of human skin and T cells in the SCID-hu mouse model JOURNAL OF VIROLOGY Niizuma, T., Zerboni, L., Sommer, M. H., Ito, H., Hinchliffe, S., Arvin, A. M. 2003; 77 (10): 6062-6065


We generated an ORF65 deletion mutant by using a cosmid system constructed from the genome of a low-passage clinical isolate (P-Oka). Using the SCID-hu mouse model, we demonstrated that the ORF65 protein is dispensable for viral replication in skin and T cells, which are critical host cell targets during primary varicella-zoster virus infection.

View details for DOI 10.1128/JVI.77.10.6062-6065.2003

View details for Web of Science ID 000182631100052

View details for PubMedID 12719598