We generated an ORF65 deletion mutant by using a cosmid system constructed from the genome of a low-passage clinical isolate (P-Oka). Using the SCID-hu mouse model, we demonstrated that the ORF65 protein is dispensable for viral replication in skin and T cells, which are critical host cell targets during primary varicella-zoster virus infection.
View details for DOI 10.1128/JVI.77.10.6062-6065.2003
View details for Web of Science ID 000182631100052
View details for PubMedID 12719598