Justin P. Annes M.D., Ph.D.

Assistant Professor of Medicine (Endocrinology)

Professional Education

Residency: Brigham and Women's Hospital Harvard Medical School (2009) MA

Internship: Brigham and Women's Hospital Harvard Medical School (2005) MA

Medical Education: New York University - School Of Medicine (2004) NY

Residency: Children's Hospital Harvard Medical School Program (2009) MA

Board Certification: Internal Medicine, American Board of Internal Medicine (2008)

Fellowship, Brigham and Women's Hospital / Harvard Medical School, Clinical Genetics (2009)

Residency, Brigham and Women's Hospital, Internal Medicine (2009)

M.D., Ph.D., NYU School of Medicine, Cell Biology (2004)

BS, Haverford College, Molecular Biology (1996)

Honors & Awards

Cellome Award for "Best High-Content Screening Publication in 2012", Thermo Fisher Scientific (2013)

Hoopes Mentorship Award, Harvard University (2012)

Mentored Clinical Scientist Research Career Development Award, NIH (2009-2014)

AOA, Delta Chapter, NYU Medical School (2004)

Medical Scientist Training Award, NIH (1996-2002)

Adult tissue sources for new beta cells
Nichols, R. J., New, C., & Annes, J. P. (2014). Adult tissue sources for new beta cells. TRANSLATIONAL RESEARCH, 163(4), 418-431.

Repurposing cAMP-Modulating Medications to Promote β-Cell Replication.
Zhao, Z., Low, Y. S., Armstrong, N. A., Hyoje Ryu, J., Sun, S., & Annes, J. P. (2014). Repurposing cAMP-Modulating Medications to Promote β-Cell Replication. Molecular endocrinology (Baltimore, Md.), me20141120.

A liver Hif-2a-Irs2 pathway sensitizes hepatic insulin signaling and is modulated by Vegf inhibition.
Wei, K., Piecewicz, S. M., McGinnis, L. M., Taniguchi, C. M., Wiegand, S. J., & Kuo, C. J. (2013). A liver Hif-2a-Irs2 pathway sensitizes hepatic insulin signaling and is modulated by Vegf inhibition. Nature medicine, 19(10), 1331-1337.

A liver Hif-2 alpha-Irs2 pathway sensitizes hepatic insulin signaling and is modulated by Vegf inhibition
Wei, K., Piecewicz, S. M., McGinnis, L. M., Taniguchi, C. M., Wiegand, S. J., & Kuo, C. J. (2013). A liver Hif-2 alpha-Irs2 pathway sensitizes hepatic insulin signaling and is modulated by Vegf inhibition. NATURE MEDICINE, 19(10), 1331-?.

The influence of sodium- and calcium-regulatory hormone interventions on adipocytokines in obesity and diabetes.
Vaidya, A., Underwood, P. C., Annes, J. P., Sun, B., Williams, G. H., & Williams, J. S. (2013). The influence of sodium- and calcium-regulatory hormone interventions on adipocytokines in obesity and diabetes. Metabolism, 62(4), 539-547.

In Vivo Screening for Secreted Proteins That Modulate Glucose Handling Identifies Interleukin-6 Family Members as Potent Hypoglycemic Agents
Chen, C. A., Carolan, P. C., & Annes, J. P. (2012). In Vivo Screening for Secreted Proteins That Modulate Glucose Handling Identifies Interleukin-6 Family Members as Potent Hypoglycemic Agents. PLOS ONE, 7(9).

Genetics of adrenocortical disease: an update
Bar-Lev, A., & Annes, J. P. (2012). Genetics of adrenocortical disease: an update. CURRENT OPINION IN ENDOCRINOLOGY DIABETES AND OBESITY, 19(3), 159-167.

Adenosine kinase inhibition selectively promotes rodent and porcine islet beta-cell replication
Annes, J. P., Ryu, J. H., Lam, K., Carolan, P. J., Utz, K., & Melton, D. A. (2012). Adenosine kinase inhibition selectively promotes rodent and porcine islet beta-cell replication. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 109(10), 3915-3920.

Erdheim-Chester disease presenting with cutaneous involvement: a case report and literature review
Volpicelli, E. R., Doyle, L., Annes, J. P., Murray, M. F., Jacobsen, E., & Saavedra, A. P. (2011). Erdheim-Chester disease presenting with cutaneous involvement: a case report and literature review. JOURNAL OF CUTANEOUS PATHOLOGY, 38(3), 280-285.

Risks of Presymptomatic Direct-to-Consumer Genetic Testing.
Annes, J. P., Giovanni, M. A., & Murray, M. F. (2010). Risks of Presymptomatic Direct-to-Consumer Genetic Testing. NEW ENGLAND JOURNAL OF MEDICINE, 363(12), 1100-1101.

Integrin alpha(v)beta(6)-mediated activation of latent TGF-beta requires the latent TGF-beta binding protein-1
Annes, J. P., Chen, Y., Munger, J. S., & Rifkin, D. B. (2004). Integrin alpha(v)beta(6)-mediated activation of latent TGF-beta requires the latent TGF-beta binding protein-1. JOURNAL OF CELL BIOLOGY, 165(5), 723-734.

A genetic screen to identify latent transforming growth factor beta activators
Annes, J., Vassallo, M., Munger, J. S., & Rifkin, D. B. (2004). A genetic screen to identify latent transforming growth factor beta activators. ANALYTICAL BIOCHEMISTRY, 327(1), 45-54.

Annexin II-mediated plasmin generation activates TGF-beta 3 during epithelial-mesenchymal transformation in the developing avian heart
Krishnan, S., Deora, A. B., Annes, J. P., Osoria, J., RIFKIN, D. B., & Hajar, K. A. (2004). Annexin II-mediated plasmin generation activates TGF-beta 3 during epithelial-mesenchymal transformation in the developing avian heart. DEVELOPMENTAL BIOLOGY, 265(1), 140-154.

Making sense of latent TGF beta activation
Annes, J. P., Munger, J. S., & RIFKIN, D. B. (2003). Making sense of latent TGF beta activation. JOURNAL OF CELL SCIENCE, 116(2), 217-224.

Latent TGF-beta binding protein-3 (LTBP-3) requires binding to TGF-beta for secretion
Chen, Y., Dabovic, B., Annes, J. P., & Rifkin, D. B. (2002). Latent TGF-beta binding protein-3 (LTBP-3) requires binding to TGF-beta for secretion. FEBS LETTERS, 517(1-3), 277-280.

The integrin alpha(V)beta(6) binds and activates latent TGF beta 3
Annes, J. P., RIFKIN, D. B., & Munger, J. S. (2002). The integrin alpha(V)beta(6) binds and activates latent TGF beta 3. FEBS LETTERS, 511(1-3), 65-68.

The latent transforming growth factor-beta-binding protein-1 promotes in vitro differentiation of embryonic stem cells into endothelium
Gualandris, A., Annes, J. P., Arese, M., Noguera, I., Jurukovski, V., & Rifkin, D. B. (2000). The latent transforming growth factor-beta-binding protein-1 promotes in vitro differentiation of embryonic stem cells into endothelium. MOLECULAR BIOLOGY OF THE CELL, 11(12), 4295-4308.

PKC-theta is required for TCR-induced NF-kappa B activation in mature but not immature T lymphocytes
Sun, Z. M., Arendt, C. W., Ellmeier, W., Schaeffer, E. M., Sunshine, M. J., & Littman, D. R. (2000). PKC-theta is required for TCR-induced NF-kappa B activation in mature but not immature T lymphocytes. NATURE, 404(6776), 402-407.