Biography
He developed the Stanford Endocrine Genetics Clinic in 2012 which is part of the interdisciplinary Stanford Hypertension Center and Stanford Neuroendocrine Tumor Program.
He has medical practice has focused on hereditary endocrine disease since 2008.
Professional Summary
Education & Certifications
- Medical Education: NYU Grossman School of Medicine (2004) NY
- Residency: Childrens Hospital Harvard Medical School Medical Genetics Residency (2009) MA
- Residency: Brigham and Women's Hospital Internal Medicine Residency (2009) MA
- Internship: Brigham and Women's Hospital Internal Medicine Residency (2005) MA
- Board Certification: American Board of Internal Medicine, Internal Medicine (2008)
- Fellowship, Brigham and Women's Hospital / Harvard Medical School, Clinical Genetics (2009)
- Residency, Brigham and Women's Hospital, Internal Medicine (2009)
- M.D., Ph.D., NYU School of Medicine, Cell Biology (2004)
- BS, Haverford College, Molecular Biology (1996)
Honors & Awards
- AOA, Delta Chapter, NYU Medical School (2004)
- Cellome Award for "Best High-Content Screening Publication in 2012", Thermo Fisher Scientific (2013)
- Hoopes Mentorship Award, Harvard University (2012)
- Medical Scientist Training Award, NIH (1996-2002)
- Mentored Clinical Scientist Research Career Development Award, NIH (2009-2014)
- R01: The Role of Adenosine Kinase in Controlling Beta-Cell Regeneration, NIH NIDDK (2015-20)
- Stanford Cancer Center Innovation Award, Stanford University (2018)
- Stanford Diabetes Research Center, Training Outreach Program (PI), Stanford University (2017-)
- The Best of Basic Research, Endocrine Society (2014)
- Translation Research Innovation Award, The Friedenrich BII Diabetes Fund (2016-2017)
Memberships
- Medical Advisory Board Member, Pheo Para Alliance (2018 - Present)
- Admissions Committee, Stanford MSTP (2013 - Present)
Publications
-
PKC-theta is required for TCR-induced NF-kappa B activation in mature but not immature T lymphocytes
Sun, Z. M., Arendt, C. W., Ellmeier, W., Schaeffer, E. M., Sunshine, M. J., Gandhi, L., … Littman, D. R. (2000). PKC-theta is required for TCR-induced NF-kappa B activation in mature but not immature T lymphocytes. NATURE, 404(6776), 402–407. -
The latent transforming growth factor-beta-binding protein-1 promotes in vitro differentiation of embryonic stem cells into endothelium
Gualandris, A., Annes, J. P., Arese, M., Noguera, I., Jurukovski, V., & Rifkin, D. B. (2000). The latent transforming growth factor-beta-binding protein-1 promotes in vitro differentiation of embryonic stem cells into endothelium. MOLECULAR BIOLOGY OF THE CELL, 11(12), 4295–4308. -
The integrin alpha(V)beta(6) binds and activates latent TGF beta 3
Annes, J. P., RIFKIN, D. B., & Munger, J. S. (2002). The integrin alpha(V)beta(6) binds and activates latent TGF beta 3. FEBS LETTERS, 511(1-3), 65–68. -
Latent TGF-beta binding protein-3 (LTBP-3) requires binding to TGF-beta for secretion
Chen, Y., Dabovic, B., Annes, J. P., & Rifkin, D. B. (2002). Latent TGF-beta binding protein-3 (LTBP-3) requires binding to TGF-beta for secretion. FEBS LETTERS, 517(1-3), 277–280. -
Making sense of latent TGF beta activation
Annes, J. P., Munger, J. S., & RIFKIN, D. B. (2003). Making sense of latent TGF beta activation. JOURNAL OF CELL SCIENCE, 116(2), 217–224. -
Annexin II-mediated plasmin generation activates TGF-beta 3 during epithelial-mesenchymal transformation in the developing avian heart
Krishnan, S., Deora, A. B., Annes, J. P., Osoria, J., RIFKIN, D. B., & Hajar, K. A. (2004). Annexin II-mediated plasmin generation activates TGF-beta 3 during epithelial-mesenchymal transformation in the developing avian heart. DEVELOPMENTAL BIOLOGY, 265(1), 140–154. -
A genetic screen to identify latent transforming growth factor beta activators
Annes, J., Vassallo, M., Munger, J. S., & Rifkin, D. B. (2004). A genetic screen to identify latent transforming growth factor beta activators. ANALYTICAL BIOCHEMISTRY, 327(1), 45–54. -
Integrin alpha(v)beta(6)-mediated activation of latent TGF-beta requires the latent TGF-beta binding protein-1
Annes, J. P., Chen, Y., Munger, J. S., & Rifkin, D. B. (2004). Integrin alpha(v)beta(6)-mediated activation of latent TGF-beta requires the latent TGF-beta binding protein-1. JOURNAL OF CELL BIOLOGY, 165(5), 723–734. -
Risks of Presymptomatic Direct-to-Consumer Genetic Testing.
Annes, J. P., Giovanni, M. A., & Murray, M. F. (2010). Risks of Presymptomatic Direct-to-Consumer Genetic Testing. NEW ENGLAND JOURNAL OF MEDICINE, 363(12), 1100–1101. -
Erdheim-Chester disease presenting with cutaneous involvement: a case report and literature review
Volpicelli, E. R., Doyle, L., Annes, J. P., Murray, M. F., Jacobsen, E., Murphy, G. F., & Saavedra, A. P. (2011). Erdheim-Chester disease presenting with cutaneous involvement: a case report and literature review. JOURNAL OF CUTANEOUS PATHOLOGY, 38(3), 280–285. -
Adenosine kinase inhibition selectively promotes rodent and porcine islet beta-cell replication
Annes, J. P., Ryu, J. H., Lam, K., Carolan, P. J., Utz, K., Hollister-Lock, J., … Melton, D. A. (2012). Adenosine kinase inhibition selectively promotes rodent and porcine islet beta-cell replication. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 109(10), 3915–3920. -
Genetics of adrenocortical disease: an update
Bar-Lev, A., & Annes, J. P. (2012). Genetics of adrenocortical disease: an update. CURRENT OPINION IN ENDOCRINOLOGY DIABETES AND OBESITY, 19(3), 159–167. -
In Vivo Screening for Secreted Proteins That Modulate Glucose Handling Identifies Interleukin-6 Family Members as Potent Hypoglycemic Agents
Chen, C. A., Carolan, P. C., & Annes, J. P. (2012). In Vivo Screening for Secreted Proteins That Modulate Glucose Handling Identifies Interleukin-6 Family Members as Potent Hypoglycemic Agents. PLOS ONE, 7(9). -
The influence of sodium- and calcium-regulatory hormone interventions on adipocytokines in obesity and diabetes.
Vaidya, A., Underwood, P. C., Annes, J. P., Sun, B., Williams, G. H., Forman, J. P., & Williams, J. S. (2013). The influence of sodium- and calcium-regulatory hormone interventions on adipocytokines in obesity and diabetes. Metabolism, 62(4), 539–47. -
A liver Hif-2a-Irs2 pathway sensitizes hepatic insulin signaling and is modulated by Vegf inhibition.
Wei, K., Piecewicz, S. M., McGinnis, L. M., Taniguchi, C. M., Wiegand, S. J., Anderson, K., … Kuo, C. J. (2013). A liver Hif-2a-Irs2 pathway sensitizes hepatic insulin signaling and is modulated by Vegf inhibition. Nature Medicine, 19(10), 1331–37. -
Adult tissue sources for new beta cells
Nichols, R. J., New, C., & Annes, J. P. (2014). Adult tissue sources for new beta cells. TRANSLATIONAL RESEARCH, 163(4), 418–31. -
A liver Hif-2 alpha-Irs2 pathway sensitizes hepatic insulin signaling and is modulated by Vegf inhibition
Wei, K., Piecewicz, S. M., McGinnis, L. M., Taniguchi, C. M., Wiegand, S. J., Anderson, K., … Kuo, C. J. (2013). A liver Hif-2 alpha-Irs2 pathway sensitizes hepatic insulin signaling and is modulated by Vegf inhibition. NATURE MEDICINE, 19(10), 1331-? -
Repurposing cAMP-Modulating Medications to Promote beta-Cell Replication
Zhao, Z., Low, Y. S., Armstrong, N. A., Ryu, J. H., Sun, S. A., Arvanites, A. C., … Annes, J. P. (2014). Repurposing cAMP-Modulating Medications to Promote beta-Cell Replication. MOLECULAR ENDOCRINOLOGY, 28(10), 1682–97. -
A High-content In Vitro Pancreatic Islet ß-cell Replication Discovery Platform.
Zhao, Z., Abdolazimi, Y., Armstrong, N. A., & Annes, J. P. (2016). A High-content In Vitro Pancreatic Islet ß-cell Replication Discovery Platform. Journal of Visualized Experiments : JoVE, (113). -
Electrically controlled release of insulin using polypyrrole nanoparticles
Hosseini-Nassab, N., Samanta, D., Abdolazimi, Y., Annes, J. P., & Zare, R. N. (2017). Electrically controlled release of insulin using polypyrrole nanoparticles. NANOSCALE, 9(1), 143–49. -
Genetic Disruption of Adenosine Kinase in Mouse Pancreatic ß-Cells Protects Against High Fat Diet-Induced Glucose Intolerance.
Navarro, G., Abdolazami, Y., Zhao, Z., Xu, H., Lee, S., Armstrong, N. A., & Annes, J. P. (2017). Genetic Disruption of Adenosine Kinase in Mouse Pancreatic ß-Cells Protects Against High Fat Diet-Induced Glucose Intolerance. Diabetes. -
Hyaluronan content governs tissue stiffness in pancreatic islet inflammation.
Nagy, N., de la Zerda, A., Kaber, G., Johnson, P. Y., Hu, K. H., Kratochvil, M. J., … Butte, M. J. (2017). Hyaluronan content governs tissue stiffness in pancreatic islet inflammation. The Journal of Biological Chemistry. -
CC-401 Promotes ß-Cell Replication via Pleiotropic Consequences of DYRK1A/B Inhibition.
Abdolazimi, Y., Lee, S., Xu, H., Allegretti, P., Horton, T. M., Yeh, B., … Annes, J. P. (2018). CC-401 Promotes ß-Cell Replication via Pleiotropic Consequences of DYRK1A/B Inhibition. Endocrinology. -
Zinc-Chelating Small Molecules Preferentially Accumulate and Function within Pancreatic ß Cells.
Horton, T. M., Allegretti, P. A., Lee, S., Moeller, H. P., Smith, M., & Annes, J. P. (2018). Zinc-Chelating Small Molecules Preferentially Accumulate and Function within Pancreatic ß Cells. Cell Chemical Biology. -
Generation of highly potent DYRK1A-dependent inducers of human beta-Cell replication via Multi-Dimensional compound optimization.
Allegretti, P. A., Horton, T. M., Abdolazimi, Y., Moeller, H. P., Yeh, B., Caffet, M., … Annes, J. P. (2019). Generation of highly potent DYRK1A-dependent inducers of human beta-Cell replication via Multi-Dimensional compound optimization. Bioorganic & Medicinal Chemistry, 115193. -
Zinc-Chelating Small Molecules Preferentially Accumulate and Function within Pancreatic beta Cells
Horton, T. M., Allegretti, P. A., Lee, S., Moeller, H. P., Smith, M., & Annes, J. P. (2019). Zinc-Chelating Small Molecules Preferentially Accumulate and Function within Pancreatic beta Cells. CELL CHEMICAL BIOLOGY, 26(2), 213-+. -
CC-401 Promotes beta-Cell Replication via Pleiotropic Consequences of DYRK1A/B Inhibition
Abdolazimi, Y., Zhao, Z., Lee, S., Xu, H., Allegretti, P., Horton, T. M., … Annes, J. P. (2018). CC-401 Promotes beta-Cell Replication via Pleiotropic Consequences of DYRK1A/B Inhibition. ENDOCRINOLOGY, 159(9), 3143–57. -
On-demand drug release from polypyrrole nanoparticulate films
Chamberlayne, C., Baltsavias, S., Xu, H., Arbabian, A., Annes, J., & Zare, R. (2019). On-demand drug release from polypyrrole nanoparticulate films. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY. AMER CHEMICAL SOC. -
Genetic testing in endocrine surgery: Opportunities for precision surgery.
Alobuia, W., Annes, J., & Kebebew, E. (2020). Genetic testing in endocrine surgery: Opportunities for precision surgery. Surgery. -
PAM staining intensity of primary neuroendocrine neoplasms is a potential prognostic biomarker.
Horton, T. M., Sundaram, V., Lee, C. H.-J., Hornbacker, K., Van Vleck, A., Benjamin, K. N., … Annes, J. P. (2020). PAM staining intensity of primary neuroendocrine neoplasms is a potential prognostic biomarker. Scientific Reports, 10(1), 10943. -
Probability of positive genetic testing in patients diagnosed with pheochromocytoma and paraganglioma: Criteria beyond a family history.
Alobuia, W. M., Ammar, S., Tyagi, M., Ghosh, C., Gunda, V., Annes, J. P., & Kebebew, E. (2020). Probability of positive genetic testing in patients diagnosed with pheochromocytoma and paraganglioma: Criteria beyond a family history. Surgery. -
Intracardiac paragangliomas: surgical approach and perioperative management.
Guenthart, B. A., Trope, W., Keeyapaj, W., Weiel, J. J., Edmonson, A., MacArthur, J. W., … Lui, N. S. (2020). Intracardiac paragangliomas: surgical approach and perioperative management. General Thoracic and Cardiovascular Surgery. -
Protocol for determining zinc-dependent beta cell-selective small-molecule delivery in mouse pancreas.
Horton, T. M., Kraemer, B. R., & Annes, J. P. (2021). Protocol for determining zinc-dependent beta cell-selective small-molecule delivery in mouse pancreas. STAR Protocols, 2(1), 100263. -
Metastatic Paraganglioma of the Spine With SDHB Mutation: Case Report and Review of the Literature
Jabarkheel, R., Pendharkar, A., Lavezo, J. L., Annes, J., Desai, K., Vogel, H., & Desai, A. M. (2021). Metastatic Paraganglioma of the Spine With SDHB Mutation: Case Report and Review of the Literature. INTERNATIONAL JOURNAL OF SPINE SURGERY, 14, S37–S45. -
Metastatic Paraganglioma of the Spine With SDHB Mutation: Case Report and Review of the Literature.
Jabarkheel, R., Pendharkar, A. V., Lavezo, J. L., Annes, J., Desai, K., Vogel, H., & Desai, A. M. (2021). Metastatic Paraganglioma of the Spine With SDHB Mutation: Case Report and Review of the Literature. International Journal of Spine Surgery, 14(s4), S37–S45. -
Novel Pathogenic de novo INS p.T97P Variant Presenting with Severe Neonatal DKA.
Lal, R. A., Moeller, H. P., Thomson, E. A., Horton, T. M., Lee, S., Freeman, R., … Annes, J. P. (2021). Novel Pathogenic de novo INS p.T97P Variant Presenting with Severe Neonatal DKA. Endocrinology. -
A Wireless Implantable Potentiostat for Programmable Electrochemical Drug Delivery
Wang, M. L., Yeon, P., Chamberlayne, C. F., Mofidfar, M., Xu, H., Annes, J. P., … Arbabian, A. (2021). A Wireless Implantable Potentiostat for Programmable Electrochemical Drug Delivery. IEEE Biomedical Circuits and Systems (BIOCAS). -
SDHB knockout and succinate accumulation are insufficient for tumorigenesis but dual SDHB/NF1 loss yields SDHx-like pheochromocytomas.
Armstrong, N., Storey, C. M., Noll, S. E., Margulis, K., Soe, M. H., Xu, H., … Annes, J. P. (2022). SDHB knockout and succinate accumulation are insufficient for tumorigenesis but dual SDHB/NF1 loss yields SDHx-like pheochromocytomas. Cell Reports, 38(9), 110453. -
beta-Cell Succinate Dehydrogenase Deficiency Triggers Metabolic Dysfunction and Insulinopenic Diabetes.
Lee, S., Xu, H., Van Vleck, A., Mawla, A. M., Li, A. M., Ye, J., … Annes, J. P. (2022). beta-Cell Succinate Dehydrogenase Deficiency Triggers Metabolic Dysfunction and Insulinopenic Diabetes. Diabetes. -
On-demand electrochemically controlled compound release from an ultrasonically powered implant
Wang, M. L., Chamberlayne, C. F., Xu, H., Mofidfar, M., Baltsavias, S., Annes, J. P., … Arbabian, A. (2022). On-demand electrochemically controlled compound release from an ultrasonically powered implant. RSC ADVANCES, 12(36), 23337–23345. -
On-demand electrochemically controlled compound release from an ultrasonically powered implant.
Wang, M. L., Chamberlayne, C. F., Xu, H., Mofidfar, M., Baltsavias, S., Annes, J. P., … Arbabian, A. (2022). On-demand electrochemically controlled compound release from an ultrasonically powered implant. RSC Advances, 12(36), 23337–23345. -
Rare Presentation of Paroxysmal High B-Pee.
Bradshaw, C., Abounasr, A., Brunsing, R. L., Kao, C.-S. S., Reejhsinghani, R., Annes, J. P., … Bhalla, V. (2023). Rare Presentation of Paroxysmal High B-Pee. Hypertension (Dallas, Tex. : 1979). -
Caution on the Use of 68Ga-DOTATATE for the Diagnosis of Pheochromocytoma: A Report of 2 Cases.
Needleman, L., Enamandram, S., & Annes, J. P. (2023). Caution on the Use of 68Ga-DOTATATE for the Diagnosis of Pheochromocytoma: A Report of 2 Cases. JCEM Case Reports, 1(6), luad149.
Practice Locations
Hypertension Center Stanford, CA
Stanford, CAHypertension Center
300 Pasteur Drive, 1st Floor, Suite A11
Stanford , CA 94305
Make An Appointment More Clinic Information » Getting Here »Diabetes Care Program Palo Alto, CA
Palo Alto, CADiabetes Care Program
211 Quarry Road
Palo Alto , CA 94304
Make An Appointment More Clinic Information » Getting Here »Endocrinology Clinic at Boswell Building Stanford, CA
Stanford, CAEndocrinology Clinic at Boswell Building
300 Pasteur Drive , 1st Floor, Suite A175
Stanford , CA 94305
Make An Appointment More Clinic Information » Getting Here »Neurogenetic Cancer Palo Alto, CA
Palo Alto, CANeurogenetic Cancer
213 Quarry Road
Palo Alto , CA 94304
Make An Appointment More Clinic Information » Getting Here »Important Information about Our Organizations and Physician Affiliation
Stanford Health Care, Stanford Health Care Tri-Valley, and Stanford Medicine Partners are each independent nonprofit organizations that are affiliated with but separate from each other and from Stanford University. The physicians who provide care at facilities operated by Stanford Health Care, Stanford Health Care Tri-Valley, and Stanford Medicine Partners are faculty, foundation, or community physicians who are not employees, representatives, or agents of Stanford Health Care, Stanford Health Care Tri- Valley, or Stanford Medicine Partners. Stanford Health Care, Stanford Health Care Tri-Valley, and Stanford Medicine Partners do not exercise control over the care provided by such faculty, foundation, and community physicians and are not responsible for their actions.
Patient Reviews
(30 reviews)
View More »
Referring Physicians
PHYSICIAN HELPLINE
Fax: 650-320-9443
Monday–Friday, 8 a.m.–5 p.m.
Stanford Health Care provides comprehensive services to refer and track patients, as well as the latest information and news for physicians and office staff. For help with all referral needs and questions, visit Referral Information.
You may also submit a web referral or complete a referral form and fax it to 650-320-9443 or email the Referral Center at ReferralCenter@stanfordhealthcare.org.
- Send referrals online
- Place radiology and lab orders
- View referral status
- Access medical records