Steven Artandi

Hematologist, Medical oncologist, Leukemia specialist

Professor of Medicine (Hematology) and of Biochemistry

Hematology Program

  • 875 Blake Wilbur Drive
  • Palo Alto, CA 94304
  • Phone: 650-498-6000
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Professional Education

Medical Education: Columbia University (1995) NY

Residency: Massachusetts General Hospital (1997) MA

Fellowship: Dana-Farber Cancer Institute (2000) MA

Ph.D., Columbia University, Microbiology (1995)

M.D., Columbia University (1995)

A.B., Princeton University, Chemistry (1986)

Honors & Awards

Elected Member, American Society for Clinical Investigation (2008)

Fellow, American Association for the Advancement of Science (AAAS) (2008)

Understanding telomere diseases through analysis of patient-derived iPS cells.
Batista, L. Fz., & Artandi, S. E. (2013). Understanding telomere diseases through analysis of patient-derived iPS cells. Current opinion in genetics & development, 23(5), 526-533.

TPP1 OB-Fold Domain Controls Telomere Maintenance by Recruiting Telomerase to Chromosome Ends
Zhong, F. L., Batista, L. Fz., Freund, A., Pech, M. F., Venteicher, A. S., & Artandi, S. E. (2012). TPP1 OB-Fold Domain Controls Telomere Maintenance by Recruiting Telomerase to Chromosome Ends. CELL, 150(3), 481-494.

Reversible cell-cycle entry in adult kidney podocytes through regulated control of telomerase and Wnt signaling
Shkreli, M., Sarin, K. Y., Pech, M. F., Papeta, N., Chang, W., & Artandi, S. E. (2012). Reversible cell-cycle entry in adult kidney podocytes through regulated control of telomerase and Wnt signaling. NATURE MEDICINE, 18(1), 111-119.

Genomic Maps of Long Noncoding RNA Occupancy Reveal Principles of RNA-Chromatin Interactions
Chu, C., Qu, K., Zhong, F. L., Artandi, S. E., & Chang, H. Y. (2011). Genomic Maps of Long Noncoding RNA Occupancy Reveal Principles of RNA-Chromatin Interactions. MOLECULAR CELL, 44(4), 667-678.

In Situ Genetic Correction of the Sickle Cell Anemia Mutation in Human Induced Pluripotent Stem Cells Using Engineered Zinc Finger Nucleases
Sebastiano, V., Maeder, M. L., Angstman, J. F., Haddad, B., Khayter, C., & Joung, J. K. (2011). In Situ Genetic Correction of the Sickle Cell Anemia Mutation in Human Induced Pluripotent Stem Cells Using Engineered Zinc Finger Nucleases. STEM CELLS, 29(11), 1717-1726.

Telomere shortening and loss of self-renewal in dyskeratosis congenita induced pluripotent stem cells
Batista, L. Fz., Pech, Mf., Zhong, F. L., Nguyen, H. N., Xie, K. T., & Artandi, S. E. (2011). Telomere shortening and loss of self-renewal in dyskeratosis congenita induced pluripotent stem cells. NATURE, 474(7351), 399-?.

TRAPping telomerase within the intestinal stem cell niche
Pech, M. F., & Artandi, S. E. (2011). TRAPping telomerase within the intestinal stem cell niche. EMBO JOURNAL, 30(6), 986-987.

Disruption of telomerase trafficking by TCAB1 mutation causes dyskeratosis congenita
Zhong, F., Savage, S. A., Shkreli, M., Giri, N., Jessop, L., & Artandi, S. E. (2011). Disruption of telomerase trafficking by TCAB1 mutation causes dyskeratosis congenita. GENES & DEVELOPMENT, 25(1), 11-16.

Short Telomeres and Stem Cell Exhaustion Model Duchenne Muscular Dystrophy in mdx/mTR Mice
Sacco, A., Mourkioti, F., Tran, R., Choi, J., Llewellyn, M., & Blau, H. M. (2010). Short Telomeres and Stem Cell Exhaustion Model Duchenne Muscular Dystrophy in mdx/mTR Mice. CELL, 143(7), 1059-1071.

Shared molecular mechanisms regulate multiple catenin proteins: canonical Wnt signals and components modulate p120-catenin isoform-1 and additional p120 subfamily members
Hong, J. Y., Park, J.- il, Cho, K., Gu, D., Ji, H., & McCrea, P. D. (2010). Shared molecular mechanisms regulate multiple catenin proteins: canonical Wnt signals and components modulate p120-catenin isoform-1 and additional p120 subfamily members. JOURNAL OF CELL SCIENCE, 123(24), 4351-4365.

Telomeres and telomerase in cancer
Artandi, S. E., & DePinho, R. A. (2010). Telomeres and telomerase in cancer. CARCINOGENESIS, 31(1), 9-18.

Reverse Transcribing the Code for Chromosome Stability
Artandi, S. E., & Cooper, J. P. (2009). Reverse Transcribing the Code for Chromosome Stability. MOLECULAR CELL, 36(5), 715-719.

Telomerase modulates Wnt signalling by association with target gene chromatin
Park, J.- il, Venteicher, A. S., Hong, J. Y., Choi, J., Jun, S., & Artandi, S. E. (2009). Telomerase modulates Wnt signalling by association with target gene chromatin. NATURE, 460(7251), 66-U77.

Stem Cell Aging and Aberrant Differentiation within the Niche
Choi, J., & Artandi, S. (2009). Stem Cell Aging and Aberrant Differentiation within the Niche. CELL STEM CELL, 5(1), 6-8.

Telomere Uncapping, Chromosomes, and Carcinomas
Batista, L. Fz., & Artandi, S. E. (2009). Telomere Uncapping, Chromosomes, and Carcinomas. CANCER CELL, 15(6), 455-457.

TCAB1 Driving telomerase to Cajal bodies
Venteicher, A. S., & Artandi, S. E. (2009). TCAB1 Driving telomerase to Cajal bodies. CELL CYCLE, 8(9), 1329-1331.

A Human Telomerase Holoenzyme Protein Required for Cajal Body Localization and Telomere Synthesis
Venteicher, A. S., Abreu, E. B., Meng, Z., McCann, K. E., Terns, R. M., & Artandi, S. E. (2009). A Human Telomerase Holoenzyme Protein Required for Cajal Body Localization and Telomere Synthesis. SCIENCE, 323(5914), 644-648.

Telomerase-dependent and -independent chromosome healing in mouse embryonic stem cells
Gao, Q., Reynolds, G. E., Wilcox, A., Miller, D., Cheung, P., & Murnane, J. P. (2008). Telomerase-dependent and -independent chromosome healing in mouse embryonic stem cells. DNA REPAIR, 7(8), 1233-1249.

Identification of ATPases pontin and reptin as telomerase components essential for holoenzyme assembly
Venteicher, A. S., Meng, Z., Mason, P. J., Veenstra, T. D., & Artandi, S. E. (2008). Identification of ATPases pontin and reptin as telomerase components essential for holoenzyme assembly. CELL, 132(6), 945-957.

Telomere uncapping in progenitor cells with critical telomere shortening is coupled to S-phase progression in vivo
Rajaraman, S., Choi, J., Cheung, P., Beaudry, V., Moore, H., & Artandi, S. E. (2007). Telomere uncapping in progenitor cells with critical telomere shortening is coupled to S-phase progression in vivo. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 104(45), 17747-17752.

DNA-dependent protein kinase catalytic subunit is not required for dysfunctional telomere fusion and checkpoint response in the telomerase-deficient mouse
Maser, R. S., Wong, K.-K., Sahin, E., Xia, H., Naylor, M., & DePinho, R. A. (2007). DNA-dependent protein kinase catalytic subunit is not required for dysfunctional telomere fusion and checkpoint response in the telomerase-deficient mouse. MOLECULAR AND CELLULAR BIOLOGY, 27(6), 2253-2265.

Aging, graying and loss of melanocyte stem cells
Sarin, K. Y., & Artandi, S. E. (2007). Aging, graying and loss of melanocyte stem cells. STEM CELL REVIEWS, 3(3), 212-217.

Telomeres, telomerase, and human disease.
Artandi, S. E. (2006). Telomeres, telomerase, and human disease. New England journal of medicine, 355(12), 1195-1197.

Telomerase flies the coop: the telomerase RNA component as a viral-encoded oncogene
Artandi, S. E. (2006). Telomerase flies the coop: the telomerase RNA component as a viral-encoded oncogene. JOURNAL OF EXPERIMENTAL MEDICINE, 203(5), 1143-1145.

Regulation of cellular immortalization and steady-state levels of the telomerase reverse transcriptase through its carboxy-terminal domain
Middleman, E. J., Choi, J. K., Venteicher, A. S., Cheung, P., & Artandi, S. E. (2006). Regulation of cellular immortalization and steady-state levels of the telomerase reverse transcriptase through its carboxy-terminal domain. MOLECULAR AND CELLULAR BIOLOGY, 26(6), 2146-2159.

Conditional telomerase induction causes proliferation of hair follicle stem cells
Sarin, K. Y., Cheung, P., Gilison, D., Lee, E., Tennen, R. I., & Artandi, S. E. (2005). Conditional telomerase induction causes proliferation of hair follicle stem cells. NATURE, 436(7053), 1048-1052.

Pathways connecting telomeres and p53 in senescence, apoptosis, and cancer
Artandi, S. E., & Attardi, L. D. (2005). Pathways connecting telomeres and p53 in senescence, apoptosis, and cancer. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 331(3), 881-890.

Complex roles for telomeres and telomerase in breast carcinogenesis
Artandi, S. E. (2003). Complex roles for telomeres and telomerase in breast carcinogenesis. BREAST CANCER RESEARCH, 5(1), 37-41.

Constitutive telomerase expression promotes mammary carcinomas in aging mice
Artandi, S. E., Alson, S., Tietze, M. K., Sharpless, N. E., Ye, S., & DePinho, R. A. (2002). Constitutive telomerase expression promotes mammary carcinomas in aging mice. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 99(12), 8191-8196.

Telomere shortening and cell fates in mouse models of neoplasia
Artandi, S. E. (2002). Telomere shortening and cell fates in mouse models of neoplasia. TRENDS IN MOLECULAR MEDICINE, 8(1), 44-47.

Telomere dysfunction promotes non-reciprocal translocations and epithelial cancers in mice
Artandi, S. E., Chang, S., Lee, S. L., Alson, S., Gottlieb, G. J., & DePinho, R. A. (2000). Telomere dysfunction promotes non-reciprocal translocations and epithelial cancers in mice. NATURE, 406(6796), 641-645.

Mice without telomerase: what can they teach us about human cancer?
Artandi, S. E., & DePinho, R. A. (2000). Mice without telomerase: what can they teach us about human cancer?. NATURE MEDICINE, 6(8), 852-855.

A critical role for telomeres in suppressing and facilitating carcinogenesis
Artandi, S. E., & DePinho, R. A. (2000). A critical role for telomeres in suppressing and facilitating carcinogenesis. CURRENT OPINION IN GENETICS & DEVELOPMENT, 10(1), 39-46.

p53 deficiency rescues the adverse effects of telomere loss and cooperates with telomere dysfunction to accelerate carcinogenesis
Chin, L., Artandi, S. E., Shen, Q., Tam, A., Lee, S. L., & DePinho, R. A. (1999). p53 deficiency rescues the adverse effects of telomere loss and cooperates with telomere dysfunction to accelerate carcinogenesis. CELL, 97(4), 527-538.