Themistocles (Tim) Assimes

Cardiologist

Stanford South Asian Translational Heart Initiative

  • 300 Pasteur Drive
  • Stanford, CA 94305
  • Phone: 650-723-6459
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Professional Education

Fellowship: Stanford University (2005) CA

Medical Education: Mcgill University (1994) Canada

Board Certification: Cardiovascular Disease, American Board of Internal Medicine (2004)

Residency: McGill University Health Center (2000) Canada

PhD, McGill University, Epidemiology & Biostatistics (2008)

Board Certified, ABIM (training at Stanford University), Cardiovascular Medicine (2004)

MS, McGill University, Epidemiology & Biostatistics (2001)

Board Certified, ABIM (training at McGill University), Internal Medicine (1999)

MD, CM, McGill University, Medicine (1994)

Clinical Trials

Clinical trials are research studies that evaluate a new medical approach, device, drug, or other treatment. As a Stanford Hospital & Clinics patient, you have access to the latest, advanced clinical trials.

Open trials refer to studies currently accepting participants. Closed trials are not currently enrolling, but may open in the future.

Loss-of-Function Mutations in APOC3, Triglycerides, and Coronary Disease.
Loss-of-Function Mutations in APOC3, Triglycerides, and Coronary Disease. (2014). Loss-of-Function Mutations in APOC3, Triglycerides, and Coronary Disease. The New England journal of medicine.

Disease-Related Growth Factor and Embryonic Signaling Pathways Modulate an Enhancer of TCF21 Expression at the 6q23.2 Coronary Heart Disease Locus
Miller, C. L., Anderson, D. R., Kundu, R. K., Raiesdana, A., Nuernberg, S. T., & Quertermous, T. (2013). Disease-Related Growth Factor and Embryonic Signaling Pathways Modulate an Enhancer of TCF21 Expression at the 6q23.2 Coronary Heart Disease Locus. PLOS GENETICS, 9(7).

Genetics and Genomics for the Prevention and Treatment of Cardiovascular Disease: Update: A Scientific Statement From the American Heart Association.
Ganesh, S. K., Arnett, D. K., Assimes, T. L., Basson, C. T., & Chakravarti, A. (2013). Genetics and Genomics for the Prevention and Treatment of Cardiovascular Disease: Update: A Scientific Statement From the American Heart Association. Circulation.

Large-scale association analysis identifies new risk loci for coronary artery disease
Deloukas, P., Kanoni, S., Willenborg, C., Farrall, M., Assimes, T. L., & Samani, N. J. (2013). Large-scale association analysis identifies new risk loci for coronary artery disease. NATURE GENETICS, 45(1), 25-U52.

Randomized Trial of Personal Genomics for Preventive Cardiology Design and Challenges
Knowles, J. W., Assimes, T. L., Kiernan, M., Pavlovic, A., Goldstein, B. A., & Ioannidis, J. Pa. (2012). Randomized Trial of Personal Genomics for Preventive Cardiology Design and Challenges. CIRCULATION-CARDIOVASCULAR GENETICS, 5(3), 368-376.

Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease
Schunkert, H., Koenig, I. R., Kathiresan, S., Reilly, M. P., Assimes, T. L., & Samani, N. J. (2011). Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease. NATURE GENETICS, 43(4), 333-U153.

Identification of ADAMTS7 as a novel locus for coronary atherosclerosis and association of ABO with myocardial infarction in the presence of coronary atherosclerosis: two genome-wide association studies
Reilly, M. P., Li, M., He, J., Ferguson, J. F., Stylianou, I. M., & Rader, D. J. (2011). Identification of ADAMTS7 as a novel locus for coronary atherosclerosis and association of ABO with myocardial infarction in the presence of coronary atherosclerosis: two genome-wide association studies. LANCET, 377(9763), 383-392.

Lack of Association Between the Trp719Arg Polymorphism in Kinesin-Like Protein-6 and Coronary Artery Disease in 19 Case-Control Studies
Assimes, T. L., Holm, H., Kathiresan, S., Reilly, M. P., Thorleifsson, G., & Quertermous, T. (2010). Lack of Association Between the Trp719Arg Polymorphism in Kinesin-Like Protein-6 and Coronary Artery Disease in 19 Case-Control Studies. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 56(19), 1552-1563.

Call to Action: Cardiovascular Disease in Asian Americans A Science Advisory From the American Heart Association
Palaniappan, L. P., Araneta, M. R. G., Assimes, T. L., Barrett-Connor, E. L., Carnethon, M. R., & Wong, N. D. (2010). Call to Action: Cardiovascular Disease in Asian Americans A Science Advisory From the American Heart Association. CIRCULATION, 122(12), 1242-1252.

Biological, clinical and population relevance of 95 loci for blood lipids
Teslovich, T. M., Musunuru, K., Smith, A. V., Edmondson, A. C., Stylianou, I. M., & Kathiresan, S. (2010). Biological, clinical and population relevance of 95 loci for blood lipids. NATURE, 466(7307), 707-713.

Use of venlafaxine compared with other antidepressants and the risk of sudden cardiac death or near death: a nested case-control study
Martinez, C., Assimes, T. L., Mines, D., Dell'Aniello, S., & Suissa, S. (2010). Use of venlafaxine compared with other antidepressants and the risk of sudden cardiac death or near death: a nested case-control study. BRITISH MEDICAL JOURNAL, 340.

Impact of type 2 diabetes susceptibility variants on quantitative glycemic traits reveals mechanistic heterogeneity.
Dimas, A. S., Lagou, V., Barker, A., Knowles, J. W., Mägi, R., & Prokopenko, I. (2014). Impact of type 2 diabetes susceptibility variants on quantitative glycemic traits reveals mechanistic heterogeneity. Diabetes, 63(6), 2158-2171.

Dissecting the causal genetic mechanisms of coronary heart disease.
Miller, C. L., Assimes, T. L., Montgomery, S. B., & Quertermous, T. (2014). Dissecting the causal genetic mechanisms of coronary heart disease. Current atherosclerosis reports, 16(5), 406-?.

Clinical interpretation and implications of whole-genome sequencing.
Dewey, F. E., Grove, M. E., Pan, C., Goldstein, B. A., Bernstein, J. A., & Quertermous, T. (2014). Clinical interpretation and implications of whole-genome sequencing. JAMA : the journal of the American Medical Association, 311(10), 1035-1045.

Whole-Exome Sequencing Identifies Rare and Low-Frequency Coding Variants Associated with LDL Cholesterol.
Lange, L. A., Hu, Y., Zhang, H., Xue, Cy., Schmidt, E. M., & Willer, C. J. (2014). Whole-Exome Sequencing Identifies Rare and Low-Frequency Coding Variants Associated with LDL Cholesterol. American journal of human genetics, 94(2), 233-245.

The combination of 9p21.3 genotype and biomarker profile improves a peripheral artery disease risk prediction model.
Downing, K. P., Nead, K. T., Kojima, Y., Assimes, T., Maegdefessel, L., & Leeper, N. J. (2014). The combination of 9p21.3 genotype and biomarker profile improves a peripheral artery disease risk prediction model. Vascular medicine , 19(1), 3-8.

Near-Term Prediction of Sudden Cardiac Death in Older Hemodialysis Patients Using Electronic Health Records
Goldstein, B. A., Chang, T. I., Mitani, A. A., Assimes, T. L., & Winkelmayer, W. C. (2014). Near-Term Prediction of Sudden Cardiac Death in Older Hemodialysis Patients Using Electronic Health Records. CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 9(1), 82-91.

Shared Genetic Susceptibility to Ischemic Stroke and Coronary Artery Disease A Genome-Wide Analysis of Common Variants
Dichgans, M., Malik, R., Koenig, I. R., Rosand, J., Clarke, R., & Schunkert, H. (2014). Shared Genetic Susceptibility to Ischemic Stroke and Coronary Artery Disease A Genome-Wide Analysis of Common Variants. STROKE, 45(1), 24-36.

Meta-analysis of genome-wide association studies in East Asian-ancestry populations identifies four new loci for body mass index.
Wen, W., Zheng, W., Okada, Y., Takeuchi, F., Tabara, Y., & Tanaka, T. (2014). Meta-analysis of genome-wide association studies in East Asian-ancestry populations identifies four new loci for body mass index. Human molecular genetics.

Multiple Non-glycemic Genomic Loci Are Newly Associated with Blood Level of Glycated Hemoglobin in East Asians.
Chen, P., Takeuchi, F., Lee, J. Y., Li, H., Wu, J. Y., & Tai, E. S. (2014). Multiple Non-glycemic Genomic Loci Are Newly Associated with Blood Level of Glycated Hemoglobin in East Asians. Diabetes.

Insulin resistance: regression and clustering.
Yoon, S., Assimes, T. L., Quertermous, T., Hsiao, C.-F., Chuang, L.-M., & Olshen, R. A. (2014). Insulin resistance: regression and clustering. PloS one, 9(6).

Use of Medicare Data to Identify Coronary Heart Disease Outcomes in the Women's Health Initiative.
Hlatky, M. A., Ray, R. M., Burwen, D. R., Margolis, K. L., Johnson, K. C., & Stefanick, M. L. (2014). Use of Medicare Data to Identify Coronary Heart Disease Outcomes in the Women's Health Initiative. Circulation. Cardiovascular quality and outcomes, 7(1), 157-162.

Discovery and refinement of loci associated with lipid levels.
Willer, C. J., Schmidt, E. M., Sengupta, S., Peloso, G. M., Gustafsson, S., & Abecasis, G. R. (2013). Discovery and refinement of loci associated with lipid levels. Nature genetics, 45(11), 1274-1283.

Imputation of coding variants in African Americans: better performance using data from the exome sequencing project
Duan, Q., Liu, E. Y., Auer, P. L., Zhang, G., Lange, E. M., & Li, Y. (2013). Imputation of coding variants in African Americans: better performance using data from the exome sequencing project. BIOINFORMATICS, 29(21), 2744-2749.

Common variants associated with plasma triglycerides and risk for coronary artery disease.
Do, R., Willer, C. J., Schmidt, E. M., Sengupta, S., Gao, C., & Kathiresan, S. (2013). Common variants associated with plasma triglycerides and risk for coronary artery disease. Nature genetics, 45(11), 1345-1352.

Mendelian randomization studies do not support a causal role for reduced circulating adiponectin levels in insulin resistance and type 2 diabetes.
Yaghootkar, H., Lamina, C., Scott, R. A., Dastani, Z., Hivert, M.-F., & Frayling, T. M. (2013). Mendelian randomization studies do not support a causal role for reduced circulating adiponectin levels in insulin resistance and type 2 diabetes. Diabetes, 62(10), 3589-3598.

A systems biology framework identifies molecular underpinnings of coronary heart disease.
Huan, T., Zhang, B., Wang, Z., Joehanes, R., Zhu, J., & Levy, D. (2013). A systems biology framework identifies molecular underpinnings of coronary heart disease. Arteriosclerosis, thrombosis, and vascular biology, 33(6), 1427-1434.

Sex-stratified genome-wide association studies including 270,000 individuals show sexual dimorphism in genetic loci for anthropometric traits.
Randall, J. C., Winkler, T. W., Kutalik, Z., Berndt, S. I., Jackson, A. U., & Heid, I. M. (2013). Sex-stratified genome-wide association studies including 270,000 individuals show sexual dimorphism in genetic loci for anthropometric traits. PLoS genetics, 9(6).

Genetic variants associated with glycine metabolism and their role in insulin sensitivity and type 2 diabetes.
Xie, W., Wood, A. R., Lyssenko, V., Weedon, M. N., Knowles, J. W., & Walker, M. (2013). Genetic variants associated with glycine metabolism and their role in insulin sensitivity and type 2 diabetes. Diabetes, 62(6), 2141-2150.

Genetic predisposition to higher blood pressure increases coronary artery disease risk.
Lieb, W., Jansen, H., Loley, C., Pencina, M. J., Nelson, C. P., & Stewart, A. Fr. (2013). Genetic predisposition to higher blood pressure increases coronary artery disease risk. Hypertension, 61(5), 995-1001.

Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture.
Berndt, S. I., Gustafsson, S., Mägi, R., Ganna, A., Wheeler, E., & Ingelsson, E. (2013). Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture. Nature genetics, 45(5), 501-512.

Identification of heart rate-associated loci and their effects on cardiac conduction and rhythm disorders.
Den Hoed, M., Eijgelsheim, M., Esko, T., Brundel, B. Jjm., Peal, D. S., & Loos, R. Jf. (2013). Identification of heart rate-associated loci and their effects on cardiac conduction and rhythm disorders. Nature genetics, 45(6), 621-631.

Measurement of insulin-mediated glucose uptake: direct comparison of the modified insulin suppression test and the euglycemic, hyperinsulinemic clamp.
Knowles, J. W., Assimes, T. L., Tsao, P. S., Natali, A., Mari, A., & Abbasi, F. (2013). Measurement of insulin-mediated glucose uptake: direct comparison of the modified insulin suppression test and the euglycemic, hyperinsulinemic clamp. Metabolism, 62(4), 548-553.

Association Between the Chromosome 9p21 Locus and Angiographic Coronary Artery Disease Burden A Collaborative Meta-Analysis
Chan, K., Patel, R. S., Newcombe, P., Nelson, C. P., Qasim, A., & Ye, S. (2013). Association Between the Chromosome 9p21 Locus and Angiographic Coronary Artery Disease Burden A Collaborative Meta-Analysis. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 61(9), 957-970.

Trans-Ethnic Fine-Mapping of Lipid Loci Identifies Population-Specific Signals and Allelic Heterogeneity That Increases the Trait Variance Explained
Wu, Y., Waite, L. L., Jackson, A. U., Sheu, W. Hh., Buyske, S., & Mohlke, K. L. (2013). Trans-Ethnic Fine-Mapping of Lipid Loci Identifies Population-Specific Signals and Allelic Heterogeneity That Increases the Trait Variance Explained. PLOS GENETICS, 9(3).

Quantifying rare, deleterious variation in 12 human cytochrome P450 drug-metabolism genes in a large-scale exome dataset.
Gordon, A. S., Tabor, H. K., Johnson, A. D., Snively, B. M., & Assimes, T. L. (2013). Quantifying rare, deleterious variation in 12 human cytochrome P450 drug-metabolism genes in a large-scale exome dataset. Human molecular genetics.

The shared allelic architecture of adiponectin levels and coronary artery disease.
Dastani, Z., Johnson, T., Kronenberg, F., Nelson, C. P., Assimes, T. L., & Brent Richards, J. (2013). The shared allelic architecture of adiponectin levels and coronary artery disease. Atherosclerosis.

Long-Term Use of Angiotensin Receptor Blockers and the Risk of Cancer
Azoulay, L., Assimes, T. L., Yin, H., Bartels, D. B., Schiffrin, E. L., & Suissa, S. (2012). Long-Term Use of Angiotensin Receptor Blockers and the Risk of Cancer. PLOS ONE, 7(12).

FTO genotype is associated with phenotypic variability of body mass index
Yang, J., Loos, R. Jf., Powell, J. E., Medland, S. E., Speliotes, E. K., & Visscher, P. M. (2012). FTO genotype is associated with phenotypic variability of body mass index. NATURE, 490(7419), 267-?.

Genetic determinants of the ankle-brachial index: A meta-analysis of a cardiovascular candidate gene 50K SNP panel in the candidate gene association resource (CARe) consortium
Wassel, C. L., Lamina, C., Nambi, V., Coassin, S., Mukamal, K. J., & Murabito, J. M. (2012). Genetic determinants of the ankle-brachial index: A meta-analysis of a cardiovascular candidate gene 50K SNP panel in the candidate gene association resource (CARe) consortium. ATHEROSCLEROSIS, 222(1), 138-147.

Central obesity is important but not essential component of the metabolic syndrome for predicting diabetes mellitus in a hypertensive family-based cohort. Results from the Stanford Asia-pacific program for hypertension and insulin resistance (SAPPHIRe) Taiwan follow-up study
Lee, I.-T., Chiu, Y.-F., Hwu, C.-M., He, C.-T., Chiang, F.-T., & Sheu, W. Hh. (2012). Central obesity is important but not essential component of the metabolic syndrome for predicting diabetes mellitus in a hypertensive family-based cohort. Results from the Stanford Asia-pacific program for hypertension and insulin resistance (SAPPHIRe) Taiwan follow-up study. CARDIOVASCULAR DIABETOLOGY, 11.

Evaluation of the Metabochip Genotyping Array in African Americans and Implications for Fine Mapping of GWAS-Identified Loci: The PAGE Study
Buyske, S., Wu, Y., Carty, C. L., Cheng, I., Assimes, T. L., & North, K. E. (2012). Evaluation of the Metabochip Genotyping Array in African Americans and Implications for Fine Mapping of GWAS-Identified Loci: The PAGE Study. PLOS ONE, 7(4).

Interleukin-6 receptor pathways in coronary heart disease: a collaborative meta-analysis of 82 studies
Sarwar, N., Butterworth, A. S., Freitag, D. F., Gregson, J., Willeit, P., & Danesh, J. (2012). Interleukin-6 receptor pathways in coronary heart disease: a collaborative meta-analysis of 82 studies. LANCET, 379(9822), 1205-1213.

Age-Related Somatic Structural Changes in the Nuclear Genome of Human Blood Cells
Forsberg, L. A., Rasi, C., Razzaghian, H. R., Pakalapati, G., Waite, L., & Dumanski, J. P. (2012). Age-Related Somatic Structural Changes in the Nuclear Genome of Human Blood Cells. AMERICAN JOURNAL OF HUMAN GENETICS, 90(2), 217-228.

Homocysteine and Coronary Heart Disease: Meta-analysis of MTHFR Case-Control Studies, Avoiding Publication Bias
Clarke, R., Bennett, D. A., Parish, S., Verhoef, P., Dotsch-Klerk, M., & Peto, R. (2012). Homocysteine and Coronary Heart Disease: Meta-analysis of MTHFR Case-Control Studies, Avoiding Publication Bias. PLOS MEDICINE, 9(2).

Association Between Chromosome 9p21 Variants and the Ankle-Brachial Index Identified by a Meta-Analysis of 21 Genome-Wide Association Studies
Murabito, J. M., White, C. C., Kavousi, M., Sun, Y. V., Feitosa, M. F., & Kronenberg, F. (2012). Association Between Chromosome 9p21 Variants and the Ankle-Brachial Index Identified by a Meta-Analysis of 21 Genome-Wide Association Studies. CIRCULATION-CARDIOVASCULAR GENETICS, 5(1), 100-112.

Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals.
Dastani, Z., Hivert, M.-F., Timpson, N., Perry, J. Rb., Yuan, X., & Kathiresan, S. (2012). Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals. PLoS genetics, 8(3).

Abdominal Aortic Aneurysm Is Associated with a Variant in Low-Density Lipoprotein Receptor-Related Protein 1
Bown, M. J., Jones, G. T., Harrison, S. C., Wright, B. J., Bumpstead, S., & Samani, N. J. (2011). Abdominal Aortic Aneurysm Is Associated with a Variant in Low-Density Lipoprotein Receptor-Related Protein 1. AMERICAN JOURNAL OF HUMAN GENETICS, 89(5), 619-627.

Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk
Ehret, G. B., Munroe, P. B., Rice, K. M., Bochud, M., Johnson, A. D., & Johnson, T. (2011). Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk. NATURE, 478(7367), 103-109.

Immortal Person Time Bias in Pharmacoepidemiological Studies of Antihypertensive Drugs
Assimes, T. L., & Suissa, S. (2011). Immortal Person Time Bias in Pharmacoepidemiological Studies of Antihypertensive Drugs. AMERICAN JOURNAL OF CARDIOLOGY, 108(6), 902-903.

Large-Scale Gene-Centric Analysis Identifies Novel Variants for Coronary Artery Disease
Butterworth, A. S., Braund, P. S., Farrall, M., Hardwick, R. J., Saleheen, D., & Samani, N. J. (2011). Large-Scale Gene-Centric Analysis Identifies Novel Variants for Coronary Artery Disease. PLOS GENETICS, 7(9).

Human metabolic individuality in biomedical and pharmaceutical research
Suhre, K., Shin, S.-Y., Petersen, A.-K., Mohney, R. P., Meredith, D., & Gieger, C. (2011). Human metabolic individuality in biomedical and pharmaceutical research. NATURE, 477(7362), 54-U60.

Low lifetime recreational activity is a risk factor for peripheral arterial disease
Wilson, A. M., Sadrzadeh-Rafie, A. H., Myers, J., Assimes, T., Nead, K. T., & Cooke, J. P. (2011). Low lifetime recreational activity is a risk factor for peripheral arterial disease. JOURNAL OF VASCULAR SURGERY, 54(2), 427-432.

A Bivariate Genome-Wide Approach to Metabolic Syndrome STAMPEED Consortium
Kraja, A. T., Vaidya, D., Pankow, J. S., Goodarzi, M. O., Assimes, T. L., & Borecki, I. B. (2011). A Bivariate Genome-Wide Approach to Metabolic Syndrome STAMPEED Consortium. DIABETES, 60(4), 1329-1339.

Genome-Wide Association Analysis Identifies Variants Associated with Nonalcoholic Fatty Liver Disease That Have Distinct Effects on Metabolic Traits
Speliotes, E. K., Yerges-Armstrong, L. M., Wu, J., Hernaez, R., Kim, L. J., & Borecki, I. B. (2011). Genome-Wide Association Analysis Identifies Variants Associated with Nonalcoholic Fatty Liver Disease That Have Distinct Effects on Metabolic Traits. PLOS GENETICS, 7(3).

Family History of Heart Disease The Re-Emergence of a Traditional Risk Factor
Assimes, T. L. (2011). Family History of Heart Disease The Re-Emergence of a Traditional Risk Factor. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 57(5), 628-629.

Sex differences in the prevalence of peripheral artery disease in patients undergoing coronary catheterization
Rafie, A. Hs., Stefanick, M. L., Sims, S. T., Phan, T., Higgins, M., & Cooke, J. P. (2010). Sex differences in the prevalence of peripheral artery disease in patients undergoing coronary catheterization. VASCULAR MEDICINE, 15(6), 443-450.

Genetics of Coronary Atherosclerotic Plaque Rupture and Myocardial Infarction
Ferguson, J. F., Li, M., He, J., Qasim, A. N., Burnett, M. S., & Reilly, M. P. (2010). Genetics of Coronary Atherosclerotic Plaque Rupture and Myocardial Infarction. CIRCULATION, 122(21).

Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution
Heid, I. M., Jackson, A. U., Randall, J. C., Winkler, T. W., Qi, L., & Lindgren, C. M. (2010). Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution. NATURE GENETICS, 42(11), 949-U160.

Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index
Speliotes, E. K., Willer, C. J., Berndt, S. I., Monda, K. L., Thorleifsson, G., & Loos, R. Jf. (2010). Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. NATURE GENETICS, 42(11), 937-U53.

Hundreds of variants clustered in genomic loci and biological pathways affect human height
Allen, H. L., Estrada, K., Lettre, G., Berndt, S. I., Weedon, M. N., & Hirschhorn, J. N. (2010). Hundreds of variants clustered in genomic loci and biological pathways affect human height. NATURE, 467(7317), 832-838.

Design of the Coronary ARtery DIsease Genome-Wide Replication And Meta-Analysis (CARDIoGRAM) Study A Genome-Wide Association Meta-analysis Involving More Than 22 000 Cases and 60 000 Controls
Preuss, M., Koenig, I. R., Thompson, J. R., Erdmann, J., Absher, D., & Schunkert, H. (2010). Design of the Coronary ARtery DIsease Genome-Wide Replication And Meta-Analysis (CARDIoGRAM) Study A Genome-Wide Association Meta-analysis Involving More Than 22 000 Cases and 60 000 Controls. CIRCULATION-CARDIOVASCULAR GENETICS, 3(5), 475-U186.

An "Almost Exhaustive" Search-Based Sequential Permutation Method for Detecting Epistasis in Disease Association Studies
Ma, L., Assimes, T. L., Asadi, N. B., Iribarren, C., Quertermous, T., & Wong, W. H. (2010). An "Almost Exhaustive" Search-Based Sequential Permutation Method for Detecting Epistasis in Disease Association Studies. GENETIC EPIDEMIOLOGY, 34(5), 434-443.

Detailed Physiologic Characterization Reveals Diverse Mechanisms for Novel Genetic Loci Regulating Glucose and Insulin Metabolism in Humans
Ingelsson, E., Langenberg, C., Hivert, M.-F., Prokopenko, I., Lyssenko, V., & Florez, J. C. (2010). Detailed Physiologic Characterization Reveals Diverse Mechanisms for Novel Genetic Loci Regulating Glucose and Insulin Metabolism in Humans. DIABETES, 59(5), 1266-1275.

Genome-wide meta-analyses identify multiple loci associated with smoking behavior
Furberg, H., Kim, Y., Dackor, J., Boerwinkle, E., Franceschini, N., & Sullivan, P. F. (2010). Genome-wide meta-analyses identify multiple loci associated with smoking behavior. NATURE GENETICS, 42(5), 441-U134.

Age at incident treatment of hypertension and risk of cancer: a population study
Assimes, T. L., & Suissa, S. (2009). Age at incident treatment of hypertension and risk of cancer: a population study. CANCER CAUSES & CONTROL, 20(10), 1811-1820.

Characterizing the admixed African ancestry of African Americans
Zakharia, F., Basu, A., Absher, D., Assimes, T. L., Go, A. S., & Tang, H. (2009). Characterizing the admixed African ancestry of African Americans. GENOME BIOLOGY, 10(12).

Digital ischemia
Kapoor, J. R., Kapoor, R., & Assimes, T. L. (2008). Digital ischemia. JOURNAL OF CARDIOVASCULAR MEDICINE, 9(12), 1285-1286.

Long-term use of antihypertensive drugs and risk of cancer
Assimes, T. L., Elstein, E., Langleben, A., & Suissa, S. (2008). Long-term use of antihypertensive drugs and risk of cancer. PHARMACOEPIDEMIOLOGY AND DRUG SAFETY, 17(11), 1039-1049.

Susceptibility locus for clinical and subclinical coronary artery disease at chromosome 9p21 in the multi-ethnic ADVANCE study
Assimes, T. L., Knowles, J. W., Basu, A., Iribarren, C., Southwick, A., & Quertermous, T. (2008). Susceptibility locus for clinical and subclinical coronary artery disease at chromosome 9p21 in the multi-ethnic ADVANCE study. HUMAN MOLECULAR GENETICS, 17(15), 2320-2328.

A near null variant of 12/15-LOX encoded by a novel SNP in ALOX15 and the risk of coronary artery disease
Assimes, T. L., Knowles, J. W., Priest, J. R., Basu, A., Borchert, A., & Quertermous, T. (2008). A near null variant of 12/15-LOX encoded by a novel SNP in ALOX15 and the risk of coronary artery disease. ATHEROSCLEROSIS, 198(1), 136-144.

Common polymorphisms of ALOX5 and ALOX5AP and risk of coronary artery disease
Assimes, T. L., Knowles, J. W., Priest, J. R., Basu, A., Volcik, K. A., & Quertermous, T. (2008). Common polymorphisms of ALOX5 and ALOX5AP and risk of coronary artery disease. HUMAN GENETICS, 123(4), 399-408.

Failure to replicate an association of SNPs in the oxidized LDL receptor gene (OLRI) with CAD
Knowles, J. W., Assimes, T. L., Boerwinkle, E., Fortmann, S. P., Go, A., & Quertermous, T. (2008). Failure to replicate an association of SNPs in the oxidized LDL receptor gene (OLRI) with CAD. BMC MEDICAL GENETICS, 9.

Associations Among Multiple Markers and Complex Disease: Models, Algorithms, and Applications
Assimes, T. L., Olshen, A. B., Narasimhan, B., & Olshen, R. A. (2008). Associations Among Multiple Markers and Complex Disease: Models, Algorithms, and Applications. GENETIC DISSECTION OF COMPLEX TRAITS, 2ND EDITION, 60, 437-464.

Polymorphisms in hypoxia inducible factor 1 and the initial clinical presentation of coronary disease
Hlatky, M. A., Quertermous, T., Boothroyd, D. B., Priest, J. R., Glassford, A. J., & Go, A. S. (2007). Polymorphisms in hypoxia inducible factor 1 and the initial clinical presentation of coronary disease. AMERICAN HEART JOURNAL, 154(6), 1035-1042.

Circulating chemokines accurately identify individuals with clinically significant atherosclerotic heart disease
Ardigo, D., Assimes, T. L., Fortmann, S. P., Go, A. S., Hlatky, M., & Quertermous, T. (2007). Circulating chemokines accurately identify individuals with clinically significant atherosclerotic heart disease. PHYSIOLOGICAL GENOMICS, 31(3), 402-409.

Genetic susceptibility to peripheral arterial disease: A dark corner in vascular biology
Knowles, J. W., Assimes, T. L., Li, J., Quertermous, T., & Cooke, J. P. (2007). Genetic susceptibility to peripheral arterial disease: A dark corner in vascular biology. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 27(10), 2068-2078.

Heritability of left ventricular mass in Japanese families living in Hawaii: the SAPPHIRe Study
Assimes, T. L., Narasimhan, B., Seto, T. B., Yoon, S., Curb, J. D., & Quertermous, T. (2007). Heritability of left ventricular mass in Japanese families living in Hawaii: the SAPPHIRe Study. JOURNAL OF HYPERTENSION, 25(5), 985-992.

Cardiac outcomes occurred more frequently with PCI than CABG or medical therapy in coronary artery disease.
Assimes, T., & Hlatky, M. A. (2004). Cardiac outcomes occurred more frequently with PCI than CABG or medical therapy in coronary artery disease. ACP journal club, 141(3), 57-?.

Inhaled corticosteroid use in asthma and the prevention of myocardial infarction
Suissa, S., Assimes, T., Brassard, P., & Ernst, P. (2003). Inhaled corticosteroid use in asthma and the prevention of myocardial infarction. AMERICAN JOURNAL OF MEDICINE, 115(5), 377-381.

Inhaled short acting beta agonist use in COPD and the risk of acute myocardial infarction
Suissa, S., Assimes, T., & Ernst, P. (2003). Inhaled short acting beta agonist use in COPD and the risk of acute myocardial infarction. THORAX, 58(1), 43-46.

The use of perioperative corticosteroids in craniomaxillofacial surgery
Assimes, T. L., & Lessard, M. L. (1999). The use of perioperative corticosteroids in craniomaxillofacial surgery. PLASTIC AND RECONSTRUCTIVE SURGERY, 103(1), 313-321.

Torsade de pointes with sotalol overdose treated successfully with lidocaine
Assimes, T. L., & Malcolm, I. (1998). Torsade de pointes with sotalol overdose treated successfully with lidocaine. CANADIAN JOURNAL OF CARDIOLOGY, 14(5), 753-756.