Timothy Angelotti MD, PhD

Anesthesiologist

Professional Education

Internship: St Joseph's Mercy Hospital (1995) MI

Residency: Duke University Medical Center (1999) NC

Fellowship: Stanford University School of Medicine (2000) CA

Board Certification: Anesthesia, American Board of Anesthesiology (2000)

Board Certification: Critical Care Medicine, American Board of Anesthesiology (2001)

Medical Education: University of Michigan School of Medicine (1994) MI

MD, University of Michigan (1994)

PhD, University of Michigan, Pharmacology (1994)

Honors & Awards

Best of Meeting Award (82nd Annual IARS Congress), IARS (2008)

Alexander von Humboldt Foundation Post-Doctoral Fellowship, Alexander von Humboldt Foundation (1995-1996)

Dean's Award for Research Excellence, University of Michigan (1994)

Administrative Appointments

Medical Director - Critical Care Transport, Stanford Life Flight, 2000

Associate Medical Director, MICU, Stanford University Medical Center, 2005

Common a2A and a2C adrenergic receptor polymorphisms do not affect plasma membrane trafficking.
Hurt, C. M., Sorensen, M. W., & Angelotti, T. (2014). Common a2A and a2C adrenergic receptor polymorphisms do not affect plasma membrane trafficking. Naunyn-Schmiedeberg's archives of pharmacology, 387(6), 569-579.

REEP1 and REEP2 proteins are preferentially expressed in neuronal and neuronal-like exocytotic tissues.
Hurt, C. M., Björk, S., Ho, V. K., Gilsbach, R., Hein, L., & Angelotti, T. (2014). REEP1 and REEP2 proteins are preferentially expressed in neuronal and neuronal-like exocytotic tissues. Brain research, 1545, 12-22.

REEPs Are Membrane Shaping Adapter Proteins That Modulate Specific G Protein-Coupled Receptor Trafficking by Affecting ER Cargo Capacity
Bjork, S., Hurt, C. M., Ho, V. K., & Angelotti, T. (2013). REEPs Are Membrane Shaping Adapter Proteins That Modulate Specific G Protein-Coupled Receptor Trafficking by Affecting ER Cargo Capacity. PLOS ONE, 8(10).

Systematic and Quantitative Analysis of G Protein-Coupled Receptor Trafficking Motifs
Hurt, C. M., Ho, V. K., & Angelotti, T. (2013). Systematic and Quantitative Analysis of G Protein-Coupled Receptor Trafficking Motifs. G PROTEIN COUPLED RECEPTORS: TRAFFICKING AND OLIGOMERIZATION, 521, 171-187.

Regulation of G-Protein Coupled Receptor Traffic by an Evolutionary Conserved Hydrophobic Signal
Angelotti, T., Daunt, D., Shcherbakova, O. G., Kobilka, B., & Hurt, C. M. (2010). Regulation of G-Protein Coupled Receptor Traffic by an Evolutionary Conserved Hydrophobic Signal. TRAFFIC, 11(4), 560-578.

Epitope-tagged Receptor Knock-in Mice Reveal That Differential Desensitization of alpha(2)-Adrenergic Responses Is because of Ligand-selective Internalization
Lu, R., Li, Y., Zhang, Y., Chen, Y., Shields, A. D., & Wang, Q. (2009). Epitope-tagged Receptor Knock-in Mice Reveal That Differential Desensitization of alpha(2)-Adrenergic Responses Is because of Ligand-selective Internalization. JOURNAL OF BIOLOGICAL CHEMISTRY, 284(19), 13233-13243.

Sex-specific modulation of spinal nociception by alpha(2)-adrenoceptors: Differential regulation by estrogen and testosterone
Thompson, A. D., Angelotti, T., Nag, S., & Mokha, S. S. (2008). Sex-specific modulation of spinal nociception by alpha(2)-adrenoceptors: Differential regulation by estrogen and testosterone. NEUROSCIENCE, 153(4), 1268-1277.

New methods for direct verification of correct endotracheal tube placement
Angelotti, T., & Brock-Utne, J. (2007). New methods for direct verification of correct endotracheal tube placement. ANESTHESIA AND ANALGESIA, 105(4), 1168-1168.

Pharmacology and mechanism of action of pregabalin: The calcium channel alpha(2)-delta (alpha(2)-delta) subunit as a target for antiepileptic drug discovery
Taylor, C. P., Angelotti, T., & Fauman, E. (2007). Pharmacology and mechanism of action of pregabalin: The calcium channel alpha(2)-delta (alpha(2)-delta) subunit as a target for antiepileptic drug discovery. EPILEPSY RESEARCH, 73(2), 137-150.

Anesthetic implications of a near-lethal sodium azide exposure
Angelotti, T., Mireles, S., & McMahon, D. (2007). Anesthetic implications of a near-lethal sodium azide exposure. ANESTHESIA AND ANALGESIA, 104(1), 229-230.

Molecular insights into alpha2 adrenergic receptor function: Clinical implications
Hurt CM, & Angelotti T. (2007). Molecular insights into alpha2 adrenergic receptor function: Clinical implications. Seminars in Anesthesia, Perioperative Medicine and Pain, 26(1).

Differential targeting and function of alpha(2A) and alpha(2C) adrenergic receptor subtypes in cultured sympathetic neurons
Brum, P. C., Hurt, C. M., Shcherbakova, O. G., Kobilka, B., & Angelotti, T. (2006). Differential targeting and function of alpha(2A) and alpha(2C) adrenergic receptor subtypes in cultured sympathetic neurons. NEUROPHARMACOLOGY, 51(3), 397-413.

Verification of endotracheal tube placement by prehospital providers: is a portable fiberoptic bronchoscope of value?
Angelotti, T., Weiss, E. L., Lemmens, H. Jm., & Brock-Utne, J. (2006). Verification of endotracheal tube placement by prehospital providers: is a portable fiberoptic bronchoscope of value?. Air medical journal, 25(2), 74-78.

Anesthesia for older patients with hypertrophic cardiomyopathy: is there cause for concern?
Angelotti, T., Fuller, A., Rivera, L., & Schmiesing, C. (2005). Anesthesia for older patients with hypertrophic cardiomyopathy: is there cause for concern?. JOURNAL OF CLINICAL ANESTHESIA, 17(6), 478-481.

Diagnosis of an unsuspected maternal hemorrhage via fetal heart rate tracing
Doyle, C., & Angelotti, T. (2004). Diagnosis of an unsuspected maternal hemorrhage via fetal heart rate tracing. JOURNAL OF CLINICAL ANESTHESIA, 16(6), 465-468.

Alpha2A and alpha2C adrenoceptors undergo agonist stimulated internalization when expressed in neurons: Role of cell type in signaling and trafficking of G-protein coupled receptors.
Angelotti T, Hurt CM, Brum PC, Lee TW, Feng FY, & Kobilka B. (2004). Alpha2A and alpha2C adrenoceptors undergo agonist stimulated internalization when expressed in neurons: Role of cell type in signaling and trafficking of G-protein coupled receptors. Mol Pharm (in preparation)..

Right subclavian artery injury
Angelotti, T., & Amador, E. R. (2003). Right subclavian artery injury. ANESTHESIA AND ANALGESIA, 96(4), 1237-1237.

Nodular invasive tracheobronchitis due to Aspergillus in a patient with systemic lupus erythematosus
Angelotti, T., Krishna, G., Scott, J., Berry, G., & Weinacker, A. (2002). Nodular invasive tracheobronchitis due to Aspergillus in a patient with systemic lupus erythematosus. LUPUS, 11(5), 325-328.

Activation of phosphatidylinositol 3-kinase is necessary for differentiation of FDC-P1 cells following stimulation of type III receptor tyrosine kinases
Kubota, Y., Angelotti, T., Niederfellner, G., Herbst, R., & Ullrich, A. (1998). Activation of phosphatidylinositol 3-kinase is necessary for differentiation of FDC-P1 cells following stimulation of type III receptor tyrosine kinases. CELL GROWTH & DIFFERENTIATION, 9(3), 247-256.

The "VH1-like" dual-specificity protein tyrosine phosphatases
Martell, K. J., Angelotti, T., & Ullrich, A. (1998). The "VH1-like" dual-specificity protein tyrosine phosphatases. MOLECULES AND CELLS, 8(1), 2-11.

Tissue-specific expression of splice variants of the mouse voltage-gated calcium channel alpha 2/delta subunit
Angelotti, T., & Hofmann, F. (1996). Tissue-specific expression of splice variants of the mouse voltage-gated calcium channel alpha 2/delta subunit. FEBS LETTERS, 397(2-3), 331-337.

Enhancement of recombinant alpha 1 beta 1 gamma 2L gamma-aminobutyric acid(A) receptor whole-cell currents by protein kinase C is mediated through phosphorylation of both beta 1 and gamma 2L subunits
Lin, Y. F., ANGELOTTI, T. P., Dudek, E. M., Browning, M. D., & Macdonald, R. L. (1996). Enhancement of recombinant alpha 1 beta 1 gamma 2L gamma-aminobutyric acid(A) receptor whole-cell currents by protein kinase C is mediated through phosphorylation of both beta 1 and gamma 2L subunits. MOLECULAR PHARMACOLOGY, 50(1), 185-195.

Functional expression of recombinant GABAA receptor channels in L929 fibroblasts.
Macdonald, R. L., Saxena, N. C., & ANGELOTTI, T. P. (1996). Functional expression of recombinant GABAA receptor channels in L929 fibroblasts. Epilepsy research. Supplement, 12, 177-185.

THE TYPE-II ISOFORM OF CGMP-DEPENDENT PROTEIN-KINASE IS DIMERIC AND POSSESSES REGULATORY AND CATALYTIC PROPERTIES DISTINCT FROM THE TYPE-I ISOFORMS
Gamm, D. M., Francis, S. H., ANGELOTTI, T. P., Corbin, J. D., & Uhler, M. D. (1995). THE TYPE-II ISOFORM OF CGMP-DEPENDENT PROTEIN-KINASE IS DIMERIC AND POSSESSES REGULATORY AND CATALYTIC PROPERTIES DISTINCT FROM THE TYPE-I ISOFORMS. JOURNAL OF BIOLOGICAL CHEMISTRY, 270(45), 27380-27388.

Fluorescent b-galactosidase staining of transfected cells prior to patch clamp recording.
Angelotti, Tp., & Macdonald RL. (1994). Fluorescent b-galactosidase staining of transfected cells prior to patch clamp recording. AxoBits, 15(15).

ENHANCEMENT OF RECOMBINANT GAMMA-AMINOBUTYRIC-ACID TYPE-A RECEPTOR CURRENTS BY CHRONIC ACTIVATION OF CAMP-DEPENDENT PROTEIN-KINASE
ANGELOTTI, T. P., Uhler, M. D., & Macdonald, R. L. (1993). ENHANCEMENT OF RECOMBINANT GAMMA-AMINOBUTYRIC-ACID TYPE-A RECEPTOR CURRENTS BY CHRONIC ACTIVATION OF CAMP-DEPENDENT PROTEIN-KINASE. MOLECULAR PHARMACOLOGY, 44(6), 1202-1210.

NATIVE AND RECOMBINANT GABA(A) RECEPTOR CHANNELS
Macdonald, R. L., & ANGELOTTI, T. P. (1993). NATIVE AND RECOMBINANT GABA(A) RECEPTOR CHANNELS. CELLULAR PHYSIOLOGY AND BIOCHEMISTRY, 3(5-6), 352-373.

ASSEMBLY OF GABA(A) RECEPTOR SUBUNITS - ANALYSIS OF TRANSIENT SINGLE-CELL EXPRESSION UTILIZING A FLUORESCENT SUBSTRATE MARKER GENE TECHNIQUE
ANGELOTTI, T. P., Uhler, M. D., & Macdonald, R. L. (1993). ASSEMBLY OF GABA(A) RECEPTOR SUBUNITS - ANALYSIS OF TRANSIENT SINGLE-CELL EXPRESSION UTILIZING A FLUORESCENT SUBSTRATE MARKER GENE TECHNIQUE. JOURNAL OF NEUROSCIENCE, 13(4), 1418-1428.

ASSEMBLY OF GABA(A) RECEPTOR SUBUNITS - ALPHA-1-BETA-1-SUBUNIT AND ALPHA-1-BETA-1-GAMMA-2S-SUBUNIT PRODUCE UNIQUE ION CHANNELS WITH DISSIMILAR SINGLE-CHANNEL PROPERTIES
ANGELOTTI, T. P., & Macdonald, R. L. (1993). ASSEMBLY OF GABA(A) RECEPTOR SUBUNITS - ALPHA-1-BETA-1-SUBUNIT AND ALPHA-1-BETA-1-GAMMA-2S-SUBUNIT PRODUCE UNIQUE ION CHANNELS WITH DISSIMILAR SINGLE-CHANNEL PROPERTIES. JOURNAL OF NEUROSCIENCE, 13(4), 1429-1440.

MOLECULAR AND ELECTROPHYSIOLOGICAL CHARACTERIZATION OF A ALLELIC VARIANT OF THE RAT ALPHA-6 GABA-A RECEPTOR SUBUNIT
ANGELOTTI, T. P., Tan, F., Chahine, K. G., & Macdonald, R. L. (1992). MOLECULAR AND ELECTROPHYSIOLOGICAL CHARACTERIZATION OF A ALLELIC VARIANT OF THE RAT ALPHA-6 GABA-A RECEPTOR SUBUNIT. MOLECULAR BRAIN RESEARCH, 16(1-2), 173-178.

KINETIC-PROPERTIES OF ALPHA-1-BETA-1-GAMMA-AMINOBUTYRIC ACID(A) RECEPTOR CHANNELS EXPRESSED IN CHINESE-HAMSTER OVARY CELLS - REGULATION BY PENTOBARBITAL AND PICROTOXIN
Porter, N. M., ANGELOTTI, T. P., Twyman, R. E., & Macdonald, R. L. (1992). KINETIC-PROPERTIES OF ALPHA-1-BETA-1-GAMMA-AMINOBUTYRIC ACID(A) RECEPTOR CHANNELS EXPRESSED IN CHINESE-HAMSTER OVARY CELLS - REGULATION BY PENTOBARBITAL AND PICROTOXIN. MOLECULAR PHARMACOLOGY, 42(5), 872-881.

REGULATION OF GABA-A-RECEPTOR CHANNELS BY ANTICONVULSANT AND CONVULSANT DRUGS AND BY PHOSPHORYLATION
Macdonald, R. L., Twyman, R. E., RYANJASTROW, T., ANGELOTTI, T. P., Wilson, W. A., & Ticku, M. K. (1992). REGULATION OF GABA-A-RECEPTOR CHANNELS BY ANTICONVULSANT AND CONVULSANT DRUGS AND BY PHOSPHORYLATION. EPILEPSY RESEARCH, 265-277.

BIOTINYLATED GRANULOCYTE MACROPHAGE COLONY-STIMULATING FACTOR ANALOGS - EFFECT OF LINKAGE CHEMISTRY ON ACTIVITY AND BINDING
ANGELOTTI, T. P., Clarke, M. F., Longino, M. A., & Emerson, S. G. (1991). BIOTINYLATED GRANULOCYTE MACROPHAGE COLONY-STIMULATING FACTOR ANALOGS - EFFECT OF LINKAGE CHEMISTRY ON ACTIVITY AND BINDING. BIOCONJUGATE CHEMISTRY, 2(6), 466-474.