Manish J. Butte, MD PhD

Assistant Professor of Pediatrics (Immunology)

Professional Education

Board Certification: Pediatrics, American Board of Pediatrics (2004)

Fellowship: Children's Hospital Boston (06/2006) MA

Board Certification: Allergy and Immunology, American Board of Allergy and Immunology (2005)

Residency: Children's Hospital of Philadelphia (06/2003) PA

Ph.D., UCSF, Biophysics (2000)

Medical Education: Brown University - School of Medicine (06/1996) RI

M.D., Brown Univ. School of Medicine, Medicine (1996)

Sc.B., Brown University, Physics (1993)

Honors & Awards

Award, Bio-X Interdisciplinary Award (2010)

Scholar, SPARK (2010-11,11-13,14-15)

Fellow, American Academy of Pediatrics (2008-)

Administrative Appointments

Assistant Professor, Pediatrics Immunology & Allergy (2009 - Present)

Use of bio-mimetic three-dimensional technology in therapeutics for heart disease.
Serpooshan, V., Zhao, M., Metzler, S. A., Wei, K., Shah, P. B., & Ruiz-Lozano, P. (2014). Use of bio-mimetic three-dimensional technology in therapeutics for heart disease. Bioengineered, 5(3), 193-197.

Spatiotemporally and mechanically controlled triggering of mast cells using atomic force microscopy
Hu, K. K., Bruce, M. A., & Butte, M. J. (2014). Spatiotemporally and mechanically controlled triggering of mast cells using atomic force microscopy. IMMUNOLOGIC RESEARCH, 58(2-3), 211-217.

Real-time GPU-based 3D Deconvolution
Bruce, M. A., & Butte, M. J. (2013). Real-time GPU-based 3D Deconvolution. OPTICS EXPRESS, 21(4), 4766-4773.

CD28 Costimulation Regulates Genome-Wide Effects on Alternative Splicing
Butte, M. J., Lee, S. J., Jesneck, J., Keir, M. E., Haining, W. N., & Sharpe, A. H. (2012). CD28 Costimulation Regulates Genome-Wide Effects on Alternative Splicing. PLOS ONE, 7(6).

Atomic Force Mechanobiology of Pluripotent Stem Cell-Derived Cardiomyocytes
Liu, Jw., Sun, N., Bruce, M. A., Wu, J. C., & Butte, M. J. (2012). Atomic Force Mechanobiology of Pluripotent Stem Cell-Derived Cardiomyocytes. PLOS ONE, 7(5).

Counting cells with a low-cost integrated microfluidics-waveguide sensor
Garcia, D., Ghansah, I., Leblanc, J., & Butte, M. J. (2012). Counting cells with a low-cost integrated microfluidics-waveguide sensor. BIOMICROFLUIDICS, 6(1).

Optical planar waveguide for cell counting.
Leblanc, J., Mueller, A. J., Prinz, A., & Butte, M. J. (2012). Optical planar waveguide for cell counting. Applied physics letters, 100(4), 43701-437015.

Single molecule labeling of an atomic force microscope cantilever tip.
Liu, J., & Butte, M. J. (2012). Single molecule labeling of an atomic force microscope cantilever tip. Applied physics letters, 101(16), 163705.

The effect of bioengineered acellular collagen patch on cardiac remodeling and ventricular function post myocardial infarction.
Serpooshan, V., Zhao, M., Metzler, S. A., Wei, K., Shah, P. B., & Ruiz-Lozano, P. (2013). The effect of bioengineered acellular collagen patch on cardiac remodeling and ventricular function post myocardial infarction. Biomaterials, 34(36), 9048-9055.

Polyvinylpyrrolidone microneedles enable delivery of intact proteins for diagnostic and therapeutic applications
Sun, W., Araci, Z., Inayathullah, M., Manickam, S., Zhang, X., & Butte, M. J. (2013). Polyvinylpyrrolidone microneedles enable delivery of intact proteins for diagnostic and therapeutic applications. ACTA BIOMATERIALIA, 9(8), 7767-7774.

High-Bandwidth AFM Probes for Imaging in Air and Fluid
Vijayraghavan, K., Gellineau, A. A., Wang, A., Butte, M. J., Melosh, N. A., & Solgaard, O. (2013). High-Bandwidth AFM Probes for Imaging in Air and Fluid. JOURNAL OF MICROELECTROMECHANICAL SYSTEMS, 22(3), 603-612.

Measurement of elastic properties in fluid using high bandwidth atomic force microscope probes
Vijayraghavan, K., Wang, A., Solgaard, O., Butte, M. J., & Melosh, N. A. (2013). Measurement of elastic properties in fluid using high bandwidth atomic force microscope probes. APPLIED PHYSICS LETTERS, 102(10).

Single molecule labeling of an atomic force microscope cantilever tip
Liu, Jw., & Butte, M. J. (2012). Single molecule labeling of an atomic force microscope cantilever tip. APPLIED PHYSICS LETTERS, 101(16).

Human amniotic mesenchymal stem cell-derived induced pluripotent stem cells may generate a universal source of cardiac cells.
Ge, X., Wang, I.-N. E., Toma, I., Sebastiano, V., Liu, Jw., & Yang, P. C. (2012). Human amniotic mesenchymal stem cell-derived induced pluripotent stem cells may generate a universal source of cardiac cells. Stem cells and development, 21(15), 2798-2808.

Apelin Enhances Directed Cardiac Differentiation of Mouse and Human Embryonic Stem Cells
Wang, I.-N. E., Wang, X., Ge, X., Anderson, J., Ho, M., & Yang, P. C. (2012). Apelin Enhances Directed Cardiac Differentiation of Mouse and Human Embryonic Stem Cells. PLOS ONE, 7(6).

Patient-Specific Induced Pluripotent Stem Cells as a Model for Familial Dilated Cardiomyopathy
Sun, N., Yazawa, M., Liu, Jw., Han, L., Sanchez-Freire, V., & Wu, J. C. (2012). Patient-Specific Induced Pluripotent Stem Cells as a Model for Familial Dilated Cardiomyopathy. SCIENCE TRANSLATIONAL MEDICINE, 4(130).

Optical planar waveguide for cell counting
Leblanc, J., Mueller, A. J., Prinz, A., & Butte, M. J. (2012). Optical planar waveguide for cell counting. APPLIED PHYSICS LETTERS, 100(4).

Dependence of Avidity on Linker Length for a Bivalent Ligand-Bivalent Receptor Model System
Mack, E. T., Snyder, P. W., Perez-Castillejos, R., Bilgicer, B., Moustakas, D. T., & Whitesides, G. M. (2012). Dependence of Avidity on Linker Length for a Bivalent Ligand-Bivalent Receptor Model System. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 134(1), 333-345.

Thread as a Matrix for Biomedical Assays
Reches, M., Mirica, K. A., Dasgupta, R., Dickey, M. D., Butte, M. J., & Whitesides, G. M. (2010). Thread as a Matrix for Biomedical Assays. ACS APPLIED MATERIALS & INTERFACES, 2(6), 1722-1728.

Interaction of human PD-L1 and B7-1
Butte, M. J., Pena-Cruz, V., Kim, M.-J., Freeman, G. J., & Sharpe, A. H. (2008). Interaction of human PD-L1 and B7-1. MOLECULAR IMMUNOLOGY, 45(13), 3567-3572.

Cell Encapsulation in Sub-mm Sized Gel Modules Using Replica Molding
McGuigan, A. P., Bruzewicz, D. A., Glavan, A., Butte, M., & Whitesides, G. M. (2008). Cell Encapsulation in Sub-mm Sized Gel Modules Using Replica Molding. PLOS ONE, 3(5).

PD-1 and its ligands in tolerance and immunity
Keir, M. E., Butte, M. J., Freeman, G. J., & Sharpel, A. H. (2008). PD-1 and its ligands in tolerance and immunity. ANNUAL REVIEW OF IMMUNOLOGY, 26, 677-704.

TIM-1 and TIM-4 glycoproteins bind phosphatidylserine and mediate uptake of apoptotic cells
Kobayashi, N., Karisola, P., Pena-Cruz, V., Dorfman, D. M., Jinushi, M., & Freeman, G. J. (2007). TIM-1 and TIM-4 glycoproteins bind phosphatidylserine and mediate uptake of apoptotic cells. IMMUNITY, 27(6), 927-940.

IL-7 receptor deficient SCID with a unique intronic mutation and post-transplant autoimmunity due to chronic GVHD
Butte, M. J., Haines, C., Bonilla, F. A., & Puck, J. (2007). IL-7 receptor deficient SCID with a unique intronic mutation and post-transplant autoimmunity due to chronic GVHD. CLINICAL IMMUNOLOGY, 125(2), 159-164.

Endothelial programmed death-1 ligand 1 (PD-L1) regulates CD8(+) T-cell-mediated injury in the heart
Grabie, N., Gotsman, I., DaCosta, R., Pang, H., Stavrakis, G., & Lichtman, A. H. (2007). Endothelial programmed death-1 ligand 1 (PD-L1) regulates CD8(+) T-cell-mediated injury in the heart. CIRCULATION, 116(18), 2062-2071.

Programmed death-1 ligand 1 interacts specifically with the B7-1 costimulatory molecule to inhibit T cell responses
Butte, M. J., Keir, M. E., Phamduy, T. B., Sharpe, A. H., & Freeman, G. J. (2007). Programmed death-1 ligand 1 interacts specifically with the B7-1 costimulatory molecule to inhibit T cell responses. IMMUNITY, 27(1), 111-122.

Patterned paper as a platform for inexpensive, low-volume, portable bioassays
Martinez, A. W., Phillips, S. T., Butte, M. J., & Whitesides, G. M. (2007). Patterned paper as a platform for inexpensive, low-volume, portable bioassays. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 46(8), 1318-1320.

Pentobarbital desensitization in a 3-month-old child
Butte, M. J., Dodson, B., & Dioun, A. (2004). Pentobarbital desensitization in a 3-month-old child. ALLERGY AND ASTHMA PROCEEDINGS, 25(4), 225-227.

Neurotrophic factor structures reveal clues to evolution, binding, specificity, and receptor activation
Butte, M. J. (2001). Neurotrophic factor structures reveal clues to evolution, binding, specificity, and receptor activation. CELLULAR AND MOLECULAR LIFE SCIENCES, 58(8), 1003-1013.

Functional studies of the BTB domain in the Drosophila GAGA and Mod(mdg4) proteins
Read, D., Butte, M. J., Dernburg, A. F., Frasch, M., & Kornberg, T. B. (2000). Functional studies of the BTB domain in the Drosophila GAGA and Mod(mdg4) proteins. NUCLEIC ACIDS RESEARCH, 28(20), 3864-3870.

Pediatric myocardial infarction after racemic epinephrine administration
Butte, M. J., Nguyen, B. X., Hutchison, T. J., Wiggins, J. W., & Ziegler, J. W. (1999). Pediatric myocardial infarction after racemic epinephrine administration. PEDIATRICS, 104(1).

Crystal structure of neurotrophin-3 homodimer shows distinct regions are used to bind its receptors
Butte, M. J., Hwang, P. K., Mobley, W. C., & Fletterick, R. J. (1998). Crystal structure of neurotrophin-3 homodimer shows distinct regions are used to bind its receptors. BIOCHEMISTRY, 37(48), 16846-16852.

TOPOLOGICAL AND PHENOMENOLOGICAL CLASSIFICATION OF BURSTING OSCILLATIONS
Bertram, R., Butte, M. J., Kiemel, T., & Sherman, A. (1995). TOPOLOGICAL AND PHENOMENOLOGICAL CLASSIFICATION OF BURSTING OSCILLATIONS. BULLETIN OF MATHEMATICAL BIOLOGY, 57(3), 413-439.