Andrew J. Connolly

Pathologist

Autopsy pathologist

Professional Education

Fellowship: Univ of California San Francisco (1992) CA

Residency: Univ of California San Francisco (1991) CA

Internship: Univ of California San Francisco (1989) CA

AB, Princeton University, Chemistry (1984)

MD, Harvard University, Medicine (1989)

PhD, UCSF, Biomedical Sciences (1997)

Medical Education: Harvard Medical School (1989) MA

Board Certification: Anatomic Pathology, American Board of Pathology (1992)

Honors & Awards

The Henry J. Kaiser Family Foundation Award for Excellence in Preclinical Teaching, Stanford University School of Medicine (2013)

The Henry J. Kaiser Family Foundation Award for Innovation in Teaching, Stanford University School of Medicine (2010)

The Lawrence H. Mathers, Jr. Award for Exceptional Commitment to Teaching and M.D. Student Education, Stanford University School of Medicine (2009)

The Henry J. Kaiser Family Foundation Award for Excellence in Preclinical Teaching,, Stanford University School of Medicine (2006)

Administrative Appointments

Residency Program Director, Department of Pathology, 2010

Associate Director, Autopsy Service, Stanford University, 2004

Clonal analysis reveals nerve-dependent and independent roles on mammalian hind limb tissue maintenance and regeneration
Rinkevich, Y., Montoro, D. T., Muhonen, E., Walmsley, G. G., Lo, D., & Longaker, M. T. (2014). Clonal analysis reveals nerve-dependent and independent roles on mammalian hind limb tissue maintenance and regeneration. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 111(27), 9846-9851.

Assessment of elastin deficit in a marfan mouse aneurysm model using an elastin-specific magnetic resonance imaging contrast agent.
Okamura, H., Pisani, L. J., Dalal, A. R., Emrich, F., Dake, B. A., & Fischbein, M. P. (2014). Assessment of elastin deficit in a marfan mouse aneurysm model using an elastin-specific magnetic resonance imaging contrast agent. Circulation. Cardiovascular imaging, 7(4), 690-696.

Obligate Progression Precedes Lung Adenocarcinoma Dissemination
Caswell, D. R., Chuang, C.-H., Yang, D., Chiou, S.-H., Cheemalavagu, S., & Winslow, M. M. (2014). Obligate Progression Precedes Lung Adenocarcinoma Dissemination. CANCER DISCOVERY, 4(7), 781-789.

Histological characteristics of myocardial bridge with an ultrasonic echolucent band. Comparison between intravascular ultrasound and histology.
Yamada, R., Turcott, R. G., Connolly, A. J., Ikeno, F., McConnell, M. V., & Honda, Y. (2014). Histological characteristics of myocardial bridge with an ultrasonic echolucent band. Comparison between intravascular ultrasound and histology. Circulation journal , 78(2), 502-504.

Atherosclerosis Causing Recurrent Catastrophic Aortopulmonary Shunt Dehiscence in a Patient with Alagille Syndrome
May, L., Hanley, F. L., Connolly, A. J., & Reddy, S. (2013). Atherosclerosis Causing Recurrent Catastrophic Aortopulmonary Shunt Dehiscence in a Patient with Alagille Syndrome. PEDIATRIC CARDIOLOGY, 34(8), 1945-1948.

In vivo directed differentiation of pluripotent stem cells for skeletal regeneration
Levi, B., Hyun, J. S., Montoro, D. T., Lo, D. D., Chan, C. Kf., & Longaker, M. T. (2012). In vivo directed differentiation of pluripotent stem cells for skeletal regeneration. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 109(50), 20379-20384.

Femtosecond plasma mediated laser ablation has advantages over mechanical osteotomy of cranial bone
Lo, D. D., Mackanos, M. A., Chung, M. T., Hyun, J. S., Montoro, D. T., & Wan, D. C. (2012). Femtosecond plasma mediated laser ablation has advantages over mechanical osteotomy of cranial bone. LASERS IN SURGERY AND MEDICINE, 44(10), 805-814.

Microfluidic Single-Cell Analysis Shows That Porcine Induced Pluripotent Stem Cell-Derived Endothelial Cells Improve Myocardial Function by Paracrine Activation
Gu, M., Nguyen, P. K., Lee, A. S., Xu, D., Hu, S., & Wu, J. C. (2012). Microfluidic Single-Cell Analysis Shows That Porcine Induced Pluripotent Stem Cell-Derived Endothelial Cells Improve Myocardial Function by Paracrine Activation. CIRCULATION RESEARCH, 111(7), 882-893.

A novel epidermal growth factor receptor variant lacking multiple domains directly activates transcription and is overexpressed in tumors
Piccione, E. C., LIEU, T. J., Gentile, C. F., Williams, T. R., Connolly, A. J., & Wong, A. J. (2012). A novel epidermal growth factor receptor variant lacking multiple domains directly activates transcription and is overexpressed in tumors. ONCOGENE, 31(24), 2953-2967.

Cardiac pressure overload hypertrophy is differentially regulated by beta-adrenergic receptor subtypes
Zhao, M., Fajardo, G., Urashima, T., Spin, J. M., Poorfarahani, S., & Bernstein, D. (2011). Cardiac pressure overload hypertrophy is differentially regulated by beta-adrenergic receptor subtypes. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 301(4), H1461-H1470.

Pretreatment with angiotensin-converting enzyme inhibitor improves doxorubicin-induced cardiomyopathy via preservation of mitochondrial function
Hiona, A., Lee, A. S., Nagendran, J., Xie, X., Connolly, A. J., & Wu, J. C. (2011). Pretreatment with angiotensin-converting enzyme inhibitor improves doxorubicin-induced cardiomyopathy via preservation of mitochondrial function. JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY, 142(2), 396-U529.

Influences of Aortic Motion and Curvature on Vessel Expansion in Murine Experimental Aneurysms
Goergen, C. J., Azuma, J., Barr, K. N., Magdefessel, L., Kallop, D. Y., & Greve, J. M. (2011). Influences of Aortic Motion and Curvature on Vessel Expansion in Murine Experimental Aneurysms. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 31(2), 270-U102.

In Vivo Quantification of Murine Aortic Cyclic Strain, Motion, and Curvature: Implications for Abdominal Aortic Aneurysm Growth
Goergen, C. J., Barr, K. N., Huynh, D. T., Eastham-Anderson, J. R., Choi, G., & Greve, J. M. (2010). In Vivo Quantification of Murine Aortic Cyclic Strain, Motion, and Curvature: Implications for Abdominal Aortic Aneurysm Growth. JOURNAL OF MAGNETIC RESONANCE IMAGING, 32(4), 847-858.

The role of recipient mast cells in acute and chronic cardiac allograft rejection in C57BL/6-KitW-sh/W-sh mice
Itoh, S., Nakae, S., Velotta, J. B., Kosuge, H., Connolly, A., & Fischbein, M. P. (2010). The role of recipient mast cells in acute and chronic cardiac allograft rejection in C57BL/6-KitW-sh/W-sh mice. JOURNAL OF HEART AND LUNG TRANSPLANTATION, 29(4), 401-409.

Effects of cell number on teratoma formation by human embryonic stem cells
Lee, A. S., Tang, C., Cao, F., Xie, X., van der Bogt, K., & Wu, J. C. (2009). Effects of cell number on teratoma formation by human embryonic stem cells. CELL CYCLE, 8(16), 2608-2612.

Imaging Gene Expression in Human Mesenchymal Stem Cells: From Small to Large Animals
Willmann, J. K., Paulmurugan, R., Rodriguez-Porcel, M., Stein, W., Brinton, T. J., & Gambhir, S. S. (2009). Imaging Gene Expression in Human Mesenchymal Stem Cells: From Small to Large Animals. RADIOLOGY, 252(1), 117-127.

Insulin resistance is associated with a modest increase in inflammation in subcutaneous adipose tissue of moderately obese women
McLaughlin, T., Deng, A., Gonzales, O., AILLAUD, M., Yee, G., & Tsao, P. S. (2008). Insulin resistance is associated with a modest increase in inflammation in subcutaneous adipose tissue of moderately obese women. DIABETOLOGIA, 51(12), 2303-2308.

In Vivo Imaging of Embryonic Stem Cells Reveals Patterns of Survival and Immune Rejection Following Transplantation
Swijnenburg, R.-J., Schrepfer, S., Cao, F., Pearl, J. I., Xie, X., & Wu, J. C. (2008). In Vivo Imaging of Embryonic Stem Cells Reveals Patterns of Survival and Immune Rejection Following Transplantation. STEM CELLS AND DEVELOPMENT, 17(6), 1023-1029.

Integrin alpha(v)beta(3)-Targeted Radioimmunotherapy of Glioblastoma Multiforme
Veeravagu, A., Liu, Z., Niu, G., Chen, K., Jia, B., & Chen, X. (2008). Integrin alpha(v)beta(3)-Targeted Radioimmunotherapy of Glioblastoma Multiforme. CLINICAL CANCER RESEARCH, 14(22), 7330-7339.

Multimodal evaluation of in vivo magnetic resonance imaging of myocardial restoration by mouse embryonic stem cells
Hendry, S. L., van der Bogt, K. Ea., Sheikh, A. Y., Arai, T., Dylla, S. J., & Yang, P. C. (2008). Multimodal evaluation of in vivo magnetic resonance imaging of myocardial restoration by mouse embryonic stem cells. JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY, 136(4), 1028-U14.

Immunosuppressive therapy mitigates immunological rejection of human embryonic stem cell xenografts
Swijnenburg, R.-J., Schrepfer, S., Govaert, J. A., Cao, F., Ransohoff, K., & Wu, J. C. (2008). Immunosuppressive therapy mitigates immunological rejection of human embryonic stem cell xenografts. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 105(35), 12991-12996.

Introducing the first polymer-free leflunomide eluting stent
Deuse, T., Erben, R. G., Ikeno, F., Behnisch, B., Boeger, R., & Schrepfer, S. (2008). Introducing the first polymer-free leflunomide eluting stent. ATHEROSCLEROSIS, 200(1), 126-134.

Comparison of reporter gene and iron particle labeling for tracking fate of human embryonic stem cells and differentiated endothelial cells in living subjects
Li, Z., Suzuki, Y., Huang, M., Cao, F., Xie, X., & Wu, J. C. (2008). Comparison of reporter gene and iron particle labeling for tracking fate of human embryonic stem cells and differentiated endothelial cells in living subjects. STEM CELLS, 26(4), 864-873.

In vivo genetic profiling and cellular localization of apelin reveals a hypoxia-sensitive, endothelial-centered pathway activated in ischemic heart failure
Sheikh, A. Y., Chun, H. J., Glassford, A. J., Kundu, R. K., Kutschka, I., & Quertermous, T. (2008). In vivo genetic profiling and cellular localization of apelin reveals a hypoxia-sensitive, endothelial-centered pathway activated in ischemic heart failure. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 294(1), H88-H98.

Spatial and temporal kinetics, of teratoma formation from murine embryonic stem cell transplantation
Cao, F., van der Bogt, K. Ea., Sadrzadeh, A., Xie, X., Sheikh, A. Y., & Wu, J. C. (2007). Spatial and temporal kinetics, of teratoma formation from murine embryonic stem cell transplantation. STEM CELLS AND DEVELOPMENT, 16(6), 883-891.

Molecular imaging of embryonic stem cell misbehavior and suicide gene ablation
Cao, F., Drukker, M., Lin, S., Sheikh, A. Y., Xie, X., & Wu, J. C. (2007). Molecular imaging of embryonic stem cell misbehavior and suicide gene ablation. CLONING AND STEM CELLS, 9(1), 107-117.

Genetic modification of embryonic stem cells with VEGF enhances cell survival and improves cardiac function
Xie, X., Cao, F., Sheikh, A. Y., Li, Z., Connolly, A. J., & Wui, J. C. (2007). Genetic modification of embryonic stem cells with VEGF enhances cell survival and improves cardiac function. CLONING AND STEM CELLS, 9(4), 549-563.

Network analysis of human in-stent restenosis
Ashley, E. A., Ferrara, R., King, J. Y., Vailaya, A., Kuchinsky, A., & Quertermous, T. (2006). Network analysis of human in-stent restenosis. CIRCULATION, 114(24), 2644-2654.

Proteomic analysis of reporter genes for molecular imaging of transplanted embryonic stem cells
Wu, J. C., Cao, F., Dutta, S., Xie, X., Kim, E., & Wang, E. W. (2006). Proteomic analysis of reporter genes for molecular imaging of transplanted embryonic stem cells. PROTEOMICS, 6(23), 6234-6249.

Adenoviral human BCL-2 transgene expression attenuates early donor cell death after cardiomyoblast transplantation into ischemic rat hearts
Kutschka, I., Kofidis, T., Chen, I. Y., von Degenfeld, G., Zwierzchoniewska, M., & Robbins, R. C. (2006). Adenoviral human BCL-2 transgene expression attenuates early donor cell death after cardiomyoblast transplantation into ischemic rat hearts. CIRCULATION, 114, I174-I180.

In vivo visualization of embryonic stem cell survival, proliferation, and migration after cardiac delivery
Cao, F., Lin, S., Xie, X. Y., Ray, P., Patel, M., & Wu, J. C. (2006). In vivo visualization of embryonic stem cell survival, proliferation, and migration after cardiac delivery. CIRCULATION, 113(7), 1005-1014.

Myocardial restoration with embryonic stem cell transplantation in a murine myocardial infarction model
Hendry, S. L., Arai, T., Dylla, S. J., Drukker, M., Sheikh, A. Y., & Robbins, R. C. (2005). Myocardial restoration with embryonic stem cell transplantation in a murine myocardial infarction model. CIRCULATION, 112(17), U432-U432.

Myocardial restoration with embryonic stem cell transplantation in a murine myocardial infarction model
Hendry, S. L., Arai, T., Dylla, S. J., Drukker, M., Sheikh, A. Y., & Robbins, R. C. (2005). Myocardial restoration with embryonic stem cell transplantation in a murine myocardial infarction model. CIRCULATION, 112(17), U37-U38.

Pathway analysis of coronary atherosclerosis
King, J. Y., Ferrara, R., Tabibiazar, R., Spin, J. M., Chen, M. M., & Ashley, E. A. (2005). Pathway analysis of coronary atherosclerosis. PHYSIOLOGICAL GENOMICS, 23(1), 103-118.

Heterogeneity of endothelial cells from different organ sites in T-cell subset recruitment
Lim, Y. C., Garcia-Cardena, G., Allport, J. R., Zervoglos, M., Connolly, A. J., & Luscinskas, F. W. (2003). Heterogeneity of endothelial cells from different organ sites in T-cell subset recruitment. AMERICAN JOURNAL OF PATHOLOGY, 162(5), 1591-1601.

Antibodies to protease-activated receptor 3 inhibit activation of mouse platelets by thrombin
Ishihara, H., Zeng, D. Z., Connolly, A. J., Tam, C., & Coughlin, S. R. (1998). Antibodies to protease-activated receptor 3 inhibit activation of mouse platelets by thrombin. BLOOD, 91(11), 4152-4157.

Mice lacking the thrombin receptor, PAR1, have normal skin wound healing
Connolly, A. J., Suh, D. Y., Hunt, T. K., & Coughlin, S. R. (1997). Mice lacking the thrombin receptor, PAR1, have normal skin wound healing. AMERICAN JOURNAL OF PATHOLOGY, 151(5), 1199-1204.

Protease-activated receptor 3 is a second thrombin receptor in humans
Ishihara, H., Connolly, A. J., Zeng, D. W., Kahn, M. L., Zheng, Y. W., & Coughlin, S. R. (1997). Protease-activated receptor 3 is a second thrombin receptor in humans. NATURE, 386(6624), 502-506.

The cloned thrombin receptor is necessary and sufficient for activation of mitogen-activated protein kinase and mitogenesis in mouse lung fibroblasts - Loss of responses in fibroblasts from receptor knockout mice
Trejo, J., Connolly, A. J., & Coughlin, S. R. (1996). The cloned thrombin receptor is necessary and sufficient for activation of mitogen-activated protein kinase and mitogenesis in mouse lung fibroblasts - Loss of responses in fibroblasts from receptor knockout mice. JOURNAL OF BIOLOGICAL CHEMISTRY, 271(35), 21536-21541.

Role of the thrombin receptor In development and evidence for a second receptor
Connolly, A. J., Ishihara, H., Kahn, M. L., Farese, R. V., & Coughlin, S. R. (1996). Role of the thrombin receptor In development and evidence for a second receptor. NATURE, 381(6582), 516-519.

Transgenic mice that overexpress mouse apolipoprotein B - Evidence that the DNA sequences controlling intestinal expression of the apolipoprotein B gene are distant from the structural gene
McCormick, S. Pa., Ng, J. K., Veniant, M., Boren, J., Pierotti, V., & Young, S. G. (1996). Transgenic mice that overexpress mouse apolipoprotein B - Evidence that the DNA sequences controlling intestinal expression of the apolipoprotein B gene are distant from the structural gene. JOURNAL OF BIOLOGICAL CHEMISTRY, 271(20), 11963-11970.

Conserved structure and adjacent location of the thrombin receptor and protease-activated receptor 2 genes define a protease-activated receptor gene cluster
Kahn, M., Ishii, K., Kuo, W. L., Riper, M., Connolly, A., & Coughlin, S. R. (1996). Conserved structure and adjacent location of the thrombin receptor and protease-activated receptor 2 genes define a protease-activated receptor gene cluster. MOLECULAR MEDICINE, 2(3), 349-357.

Molecular cloning, expression and potential functions of the human proteinase-activated receptor-2
Bohm, S. K., Kong, W. Y., Bromme, D., Smeekens, S. P., Anderson, D. C., & Bunnett, N. W. (1996). Molecular cloning, expression and potential functions of the human proteinase-activated receptor-2. BIOCHEMICAL JOURNAL, 314, 1009-1016.

A genetic model for absent chylomicron formation: Mice producing apolipoprotein B in the liver, but not in the intestine
Young, S. G., Cham, C. M., Pitas, R. E., Burri, B. J., Connolly, A., & Farese, R. V. (1995). A genetic model for absent chylomicron formation: Mice producing apolipoprotein B in the liver, but not in the intestine. JOURNAL OF CLINICAL INVESTIGATION, 96(6), 2932-2946.

DESIGN AND INITIAL TESTING OF AN ULTRASOUND-GUIDED DIRECTIONAL ATHERECTOMY DEVICE
Fitzgerald, P. J., Belef, M., Connolly, A. J., Sudhir, K., & Yock, P. G. (1995). DESIGN AND INITIAL TESTING OF AN ULTRASOUND-GUIDED DIRECTIONAL ATHERECTOMY DEVICE. AMERICAN HEART JOURNAL, 129(3), 593-598.

MOLECULAR-CLONING AND FUNCTIONAL EXPRESSION OF 2 MONOCYTE CHEMOATTRACTANT PROTEIN-1 RECEPTORS REVEALS ALTERNATIVE SPLICING OF THE CARBOXYL-TERMINAL TAILS
Charo, I. F., Myers, S. J., Herman, A., Franci, C., Connolly, A. J., & Coughlin, S. R. (1994). MOLECULAR-CLONING AND FUNCTIONAL EXPRESSION OF 2 MONOCYTE CHEMOATTRACTANT PROTEIN-1 RECEPTORS REVEALS ALTERNATIVE SPLICING OF THE CARBOXYL-TERMINAL TAILS. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 91(7), 2752-2756.

POTASSIUM PRESERVES ENDOTHELIAL FUNCTION AND ENHANCES AORTIC COMPLIANCE IN DAHL RATS
Sudhir, K., Kurtz, T. W., Yock, P. G., Connolly, A. J., & Morris, R. C. (1993). POTASSIUM PRESERVES ENDOTHELIAL FUNCTION AND ENHANCES AORTIC COMPLIANCE IN DAHL RATS. HYPERTENSION, 22(3), 315-322.

INTRAVASCULAR ULTRASOUND IMAGING OF CORONARY-ARTERIES - IS 3 LAYERS THE NORM
Fitzgerald, P. J., STGOAR, F. G., Connolly, A. J., Pinto, F. J., Billingham, M. E., & Yock, P. G. (1992). INTRAVASCULAR ULTRASOUND IMAGING OF CORONARY-ARTERIES - IS 3 LAYERS THE NORM. CIRCULATION, 86(1), 154-158.

FLUID SHEAR-STRESS MODULATES CYTOSOLIC FREE CALCIUM IN VASCULAR ENDOTHELIAL-CELLS
Shen, J., Luscinskas, F. W., Connolly, A., Dewey, C. F., & Gimbrone, M. A. (1992). FLUID SHEAR-STRESS MODULATES CYTOSOLIC FREE CALCIUM IN VASCULAR ENDOTHELIAL-CELLS. AMERICAN JOURNAL OF PHYSIOLOGY, 262(2), C384-C390.

MYOCARDIAL-INFARCTION - ASSESSMENT WITH AN INTRAVASCULAR MR CONTRAST-MEDIUM - WORK IN PROGRESS
Saeed, M., Wendland, M. F., Masui, T., Connolly, A. J., Derugin, N., & Higgins, C. B. (1991). MYOCARDIAL-INFARCTION - ASSESSMENT WITH AN INTRAVASCULAR MR CONTRAST-MEDIUM - WORK IN PROGRESS. RADIOLOGY, 180(1), 153-160.

THE EFFECTS OF DIMETHYL-SULFOXIDE ON THE OSMOTIC PROPERTIES OF A RAT MEGAKARYOCYTOPOIETIC CELL-LINE
Connolly, A., & HEMPLING, H. G. (1985). THE EFFECTS OF DIMETHYL-SULFOXIDE ON THE OSMOTIC PROPERTIES OF A RAT MEGAKARYOCYTOPOIETIC CELL-LINE. CRYOBIOLOGY, 22(4), 351-358.