Gilbert Chu

Medical oncologist, GI specialist

Professor of Medicine (Oncology) and of Biochemistry

Gastrointestinal (GI) Cancer Program

  • 875 Blake Wilbur Drive
  • Palo Alto, CA 94304
  • Phone: 650-498-6000
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Professional Education

Fellowship: Stanford University School of Medicine (1986) CA

Residency: Massachusetts General Hospital (1982) MA

M.D., Harvard, Medicine (1980)

Ph.D., M.I.T., Physics (1973)

A.B., Princeton, Physics (1967)

Board Certification: Internal Medicine, American Board of Internal Medicine (1983)

Medical Education: Harvard Medical School (1980) MA

Honors & Awards

Phi Beta Kappa, Princeton University (1967)

Giulio Racah Prize, International School of Subnuclear Physics, Erice, Italy (1973)

Henry Asbury Christian Award for Notable Scholarship, Harvard Medical School (1980)

Rita Allen Award, Rita Allen Foundation (1988-1993)

Clinical Scientist Award for Translational Research, Burroughs-Wellcome Fund (1997-2002)

Kaiser Award for Preclinical Teaching, Stanford University (2003, 2007)

Lawrence H. Mathers Teaching Award, Stanford University (2014)

Cooperative Assembly of a Protein-DNA Filament for Nonhomologous End Joining
Tsai, C. J., & Chu, G. (2013). Cooperative Assembly of a Protein-DNA Filament for Nonhomologous End Joining. JOURNAL OF BIOLOGICAL CHEMISTRY, 288(25), 18110-18120.

Local false discovery rate facilitates comparison of different microarray experiments
Hong, W.-J., Tibshirani, R., & Chu, G. (2009). Local false discovery rate facilitates comparison of different microarray experiments. NUCLEIC ACIDS RESEARCH, 37(22), 7483-7497.

Here Comes the Sun: Recognition of UV-Damaged DNA
Chu, G., & Yang, W. (2008). Here Comes the Sun: Recognition of UV-Damaged DNA. CELL, 135(7), 1172-1174.

Cernunnos/XLF promotes the ligation of mismatched and noncohesive DNA ends
Tsai, C. J., Kim, S. A., & Chu, G. (2007). Cernunnos/XLF promotes the ligation of mismatched and noncohesive DNA ends. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 104(19), 7851-7856.

Processing of DNA for nonhomologous end-joining is controlled by kinase activity and XRCC4/Ligase IV
Budman, J., Kim, S. A., & Chu, G. (2007). Processing of DNA for nonhomologous end-joining is controlled by kinase activity and XRCC4/Ligase IV. JOURNAL OF BIOLOGICAL CHEMISTRY, 282(16), 11950-11959.

Processing of DNA for nonhomologous end-joining by cell-free extract
Budman, J., & Chu, G. (2005). Processing of DNA for nonhomologous end-joining by cell-free extract. EMBO JOURNAL, 24(4), 849-860.

Toxicity from radiation therapy associated with abnormal transcriptional responses to DNA damage
Rieger, K. E., Hong, W. J., Tusher, V. G., Tang, J., Tibshirani, R., & Chu, G. (2004). Toxicity from radiation therapy associated with abnormal transcriptional responses to DNA damage. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 101(17), 6635-6640.

Significance analysis of microarrays applied to the ionizing radiation response
Tusher, V. G., Tibshirani, R., & Chu, G. (2001). Significance analysis of microarrays applied to the ionizing radiation response. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 98(9), 5116-5121.

Electrophoretic mobility shift assays for protein-DNA complexes involved in DNA repair.
Tsai, C., Smider, V., Hwang, B. J., & Chu, G. (2012). Electrophoretic mobility shift assays for protein-DNA complexes involved in DNA repair. Methods in molecular biology (Clifton, N.J.), 920, 53-78.

An Information Theoretic, Microfluidic-Based Single Cell Analysis Permits Identification of Subpopulations among Putatively Homogeneous Stem Cells
Glotzbach, J. P., Januszyk, M., Vial, I. N., Wong, V. W., Gelbard, A., & Gurtner, G. C. (2011). An Information Theoretic, Microfluidic-Based Single Cell Analysis Permits Identification of Subpopulations among Putatively Homogeneous Stem Cells. PLOS ONE, 6(6).

Crystal structure of human XLF: A twist in nonhomologous DNA end-joining
Andres, S. N., Modesti, M., Tsai, C. J., Chu, G., & Junop, M. S. (2007). Crystal structure of human XLF: A twist in nonhomologous DNA end-joining. MOLECULAR CELL, 28(6), 1093-1101.

Electrophoretic mobility shift assays to study protein binding to damaged DNA.
Smider, V., Hwang, B. J., & Chu, G. (2006). Electrophoretic mobility shift assays to study protein binding to damaged DNA. Methods in molecular biology (Clifton, N.J.), 314, 323-344.

Assays for nonhomologous end joining in extracts
Budman, J., & Chu, G. (2006). Assays for nonhomologous end joining in extracts. DNA REPAIR, PT A, 408, 430-444.

Toxicity from radiation therapy associated with abnormal transcriptional responses to DNA damage
Rieger, K. E., Hong, W. J., Tusher, V. G., Tang, J., Tibshirani, R., & Chu, G. (2004). Toxicity from radiation therapy associated with abnormal transcriptional responses to DNA damage. RADIOTHERAPY AND ONCOLOGY, 72, S29-S29.

Portrait of transcriptional responses to ultraviolet and ionizing radiation in human cells
Rieger, K. E., & Chu, G. (2004). Portrait of transcriptional responses to ultraviolet and ionizing radiation in human cells. NUCLEIC ACIDS RESEARCH, 32(16), 4786-4803.

Class prediction by nearest shrunken centroids, with applications to DNA microarrays
Tibshirani, R., Hastie, T., Narasimhan, B., & Chu, G. (2003). Class prediction by nearest shrunken centroids, with applications to DNA microarrays. STATISTICAL SCIENCE, 18(1), 104-117.

Interaction between UV-damaged DNA binding activity proteins and the c-Abl tyrosine kinase
Cong, F., Tang, J., Hwang, B. J., Vuong, B. Q., Chu, G., & Goff, S. P. (2002). Interaction between UV-damaged DNA binding activity proteins and the c-Abl tyrosine kinase. JOURNAL OF BIOLOGICAL CHEMISTRY, 277(38), 34870-34878.

Xeroderma pigmentosum complementation group E and UV-damaged DNA-binding protein
Tang, J., & Chu, G. (2002). Xeroderma pigmentosum complementation group E and UV-damaged DNA-binding protein. DNA REPAIR, 1(8), 601-616.

Synapsis of DNA ends by DNA-dependent protein kinase
DeFazio, L. G., Stansel, R. M., Griffith, J. D., & Chu, G. (2002). Synapsis of DNA ends by DNA-dependent protein kinase. EMBO JOURNAL, 21(12), 3192-3200.

Diagnosis of multiple cancer types by shrunken centroids of gene expression
Tibshirani, R., Hastie, T., Narasimhan, B., & Chu, G. (2002). Diagnosis of multiple cancer types by shrunken centroids of gene expression. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 99(10), 6567-6572.

p53 binds and activates the xeroderma pigmentosum DDB2 gene in humans but not mice
Tan, T., & Chu, G. (2002). p53 binds and activates the xeroderma pigmentosum DDB2 gene in humans but not mice. MOLECULAR AND CELLULAR BIOLOGY, 22(10), 3247-3254.

Supervised learning from microarray data
Hastie, T., Tibshirani, R., Narasimhan, B., & Chu, G. (2002). Supervised learning from microarray data. COMPSTAT 2002: PROCEEDINGS IN COMPUTATIONAL STATISTICS, 67-77.

Xeroderma pigmentosum p48 gene enhances global genomic repair and suppresses UV-induced mutagenesis
Tang, J. Y., Hwang, B. J., Ford, J. M., Hanawalt, P. C., & Chu, G. (2000). Xeroderma pigmentosum p48 gene enhances global genomic repair and suppresses UV-induced mutagenesis. MOLECULAR CELL, 5(4), 737-744.

Activation of DNA-dependent protein kinase by single-stranded DNA ends
Hammarsten, O., DeFazio, L. G., & Chu, G. (2000). Activation of DNA-dependent protein kinase by single-stranded DNA ends. JOURNAL OF BIOLOGICAL CHEMISTRY, 275(3), 1541-1550.

Structure of DNA-dependent protein kinase: implications for its regulation by DNA
Leuther, K. K., Hammarsten, O., Kornberg, R. D., & Chu, G. (1999). Structure of DNA-dependent protein kinase: implications for its regulation by DNA. EMBO JOURNAL, 18(5), 1114-1123.

Expression of the p48 xeroderma pigmentosum gene is p53-dependent and is involved in global genomic repair
Hwang, B. J., Ford, J. M., Hanawalt, P. C., & Chu, G. (1999). Expression of the p48 xeroderma pigmentosum gene is p53-dependent and is involved in global genomic repair. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 96(2), 424-428.

The use of electrophoretic mobility shift assays to study DNA repair.
Hwang, B. J., Smider, V., & Chu, G. (1999). The use of electrophoretic mobility shift assays to study DNA repair. Methods in molecular biology (Clifton, N.J.), 113, 103-120.

Failure of hairpin-ended and nicked DNA to activate DNA-dependent protein kinase: Implications for V(D)J recombination
Smider, V., Rathmell, W. K., Brown, G., Lewis, S., & Chu, G. (1998). Failure of hairpin-ended and nicked DNA to activate DNA-dependent protein kinase: Implications for V(D)J recombination. MOLECULAR AND CELLULAR BIOLOGY, 18(11), 6853-6858.

p48 activates a UV-damaged-DNA binding factor and is defective in xeroderma pigmentosum group E cells that lack binding activity
Hwang, B. J., Toering, S., FRANCKE, U., & Chu, G. (1998). p48 activates a UV-damaged-DNA binding factor and is defective in xeroderma pigmentosum group E cells that lack binding activity. MOLECULAR AND CELLULAR BIOLOGY, 18(7), 4391-4399.

DNA-dependent protein kinase: DNA binding and activation in the absence of Ku
Hammarsten, O., & Chu, G. (1998). DNA-dependent protein kinase: DNA binding and activation in the absence of Ku. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 95(2), 525-530.

Double strand break repair
Chu, G. (1997). Double strand break repair. JOURNAL OF BIOLOGICAL CHEMISTRY, 272(39), 24097-24100.

The end-joining reaction in V(D)J recombination.
Smider, V., & Chu, G. (1997). The end-joining reaction in V(D)J recombination. Seminars in immunology, 9(3), 189-197.

DNA-dependent protein kinase is not required for accumulation of p53 or cell cycle arrest after DNA damage
Rathmell, W. K., Kaufmann, W. K., Hurt, J. C., Byrd, L. L., & Chu, G. (1997). DNA-dependent protein kinase is not required for accumulation of p53 or cell cycle arrest after DNA damage. CANCER RESEARCH, 57(1), 68-74.

Xeroderma pigmentosum, Cockayne syndrome and trichothiodystrophy: Do the genes explain the diseases?
Chu, G., & Mayne, L. (1996). Xeroderma pigmentosum, Cockayne syndrome and trichothiodystrophy: Do the genes explain the diseases?. TRENDS IN GENETICS, 12(5), 187-192.

Ku86 defines the genetic defect and restores X-ray resistance and V(D)J recombination to complementation group 5 hamster cell mutants
Errami, A., Smider, V., Rathmell, W. K., He, D. M., Hendrickson, E. A., & Chu, G. (1996). Ku86 defines the genetic defect and restores X-ray resistance and V(D)J recombination to complementation group 5 hamster cell mutants. MOLECULAR AND CELLULAR BIOLOGY, 16(4), 1519-1526.

Isolation of a cDNA encoding a UV-damaged DNA binding factor defective in xeroderma pigmentosum group E cells
Hwang, B. J., Liao, J. C., & Chu, G. (1996). Isolation of a cDNA encoding a UV-damaged DNA binding factor defective in xeroderma pigmentosum group E cells. MUTATION RESEARCH-DNA REPAIR, 362(1), 105-117.

Role of the Ku autoantigen in V(D)J recombination and double-strand break repair
Chu, G. (1996). Role of the Ku autoantigen in V(D)J recombination and double-strand break repair. MOLECULAR ANALYSIS OF DNA REARRANGEMENTS IN THE IMMUNE SYSTEM, 217, 113-132.

A NOVEL ROLE FOR DNA PHOTOLYASE - BINDING TO DNA DAMAGED BY DRUGS IS ASSOCIATED WITH ENHANCED CYTOTOXICITY IN SACCHAROMYCES-CEREVISIAE
Fox, M. E., Feldman, B. J., & Chu, G. (1994). A NOVEL ROLE FOR DNA PHOTOLYASE - BINDING TO DNA DAMAGED BY DRUGS IS ASSOCIATED WITH ENHANCED CYTOTOXICITY IN SACCHAROMYCES-CEREVISIAE. MOLECULAR AND CELLULAR BIOLOGY, 14(12), 8071-8077.

RESTORATION OF X-RAY RESISTANCE AND V(D)J RECOMBINATION IN MUTANT-CELLS BY KU CDNA
Smider, V., Rathmell, W. K., Lieber, M. R., & Chu, G. (1994). RESTORATION OF X-RAY RESISTANCE AND V(D)J RECOMBINATION IN MUTANT-CELLS BY KU CDNA. SCIENCE, 266(5183), 288-291.

XERODERMA-PIGMENTOSUM GROUP-E BINDING-FACTOR RECOGNIZES A BROAD-SPECTRUM OF DNA-DAMAGE
Payne, A., & Chu, G. (1994). XERODERMA-PIGMENTOSUM GROUP-E BINDING-FACTOR RECOGNIZES A BROAD-SPECTRUM OF DNA-DAMAGE. MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS, 310(1), 89-102.

INVOLVEMENT OF THE KU AUTOANTIGEN IN THE CELLULAR-RESPONSE TO DNA DOUBLE-STRAND BREAKS
Rathmell, W. K., & Chu, G. (1994). INVOLVEMENT OF THE KU AUTOANTIGEN IN THE CELLULAR-RESPONSE TO DNA DOUBLE-STRAND BREAKS. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 91(16), 7623-7627.

A DNA END-BINDING FACTOR INVOLVED IN DOUBLE-STRAND BREAK REPAIR AND V(D)J RECOMBINATION
Rathmell, W. K., & Chu, G. (1994). A DNA END-BINDING FACTOR INVOLVED IN DOUBLE-STRAND BREAK REPAIR AND V(D)J RECOMBINATION. MOLECULAR AND CELLULAR BIOLOGY, 14(7), 4741-4748.

CELLULAR-RESPONSES TO CISPLATIN - THE ROLES OF DNA-BINDING PROTEINS AND DNA-REPAIR
Chu, G. (1994). CELLULAR-RESPONSES TO CISPLATIN - THE ROLES OF DNA-BINDING PROTEINS AND DNA-REPAIR. JOURNAL OF BIOLOGICAL CHEMISTRY, 269(2), 787-790.

MASSIVE CISPLATIN OVERDOSE BY ACCIDENTAL SUBSTITUTION FOR CARBOPLATIN - TOXICITY AND MANAGEMENT
Chu, G., MANTIN, R., Shen, Y. M., BASKETT, G., & Sussman, H. (1993). MASSIVE CISPLATIN OVERDOSE BY ACCIDENTAL SUBSTITUTION FOR CARBOPLATIN - TOXICITY AND MANAGEMENT. CANCER, 72(12), 3707-3714.

PURIFICATION AND CHARACTERIZATION OF A HUMAN PROTEIN THAT BINDS TO DAMAGED DNA
Hwang, B. J., & Chu, G. (1993). PURIFICATION AND CHARACTERIZATION OF A HUMAN PROTEIN THAT BINDS TO DAMAGED DNA. BIOCHEMISTRY, 32(6), 1657-1666.

BAG MODEL FOR DNA MIGRATION DURING PULSED-FIELD ELECTROPHORESIS
Chu, G. (1991). BAG MODEL FOR DNA MIGRATION DURING PULSED-FIELD ELECTROPHORESIS. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 88(24), 11071-11075.

PULSED-FIELD ELECTROPHORESIS OF MEGABASE-SIZED DNA
Gunderson, K., & Chu, G. (1991). PULSED-FIELD ELECTROPHORESIS OF MEGABASE-SIZED DNA. MOLECULAR AND CELLULAR BIOLOGY, 11(6), 3348-3354.

SEPARATION OF LARGE DNA BY A VARIABLE-ANGLE CONTOUR-CLAMPED HOMOGENEOUS ELECTRIC-FIELD APPARATUS
Chu, G., & Gunderson, K. (1991). SEPARATION OF LARGE DNA BY A VARIABLE-ANGLE CONTOUR-CLAMPED HOMOGENEOUS ELECTRIC-FIELD APPARATUS. ANALYTICAL BIOCHEMISTRY, 194(2), 439-446.

CISPLATIN-RESISTANT CELLS EXPRESS INCREASED LEVELS OF A FACTOR THAT RECOGNIZES DAMAGED DNA
Chu, G., & Chang, E. (1990). CISPLATIN-RESISTANT CELLS EXPRESS INCREASED LEVELS OF A FACTOR THAT RECOGNIZES DAMAGED DNA. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 87(9), 3324-3327.

XERODERMA PIGMENTOSUM GROUP-E CELLS LACK A NUCLEAR FACTOR THAT BINDS TO DAMAGED DNA
Chu, G., & Chang, E. (1988). XERODERMA PIGMENTOSUM GROUP-E CELLS LACK A NUCLEAR FACTOR THAT BINDS TO DAMAGED DNA. SCIENCE, 242(4878), 564-567.