Howard Y. Chang

Dermatologist, General dermatologist, Cutaneous oncology specialist, Medical oncologist

Professor of Dermatology

Skin Cancer Program

  • 900 Blake Wilbur Drive
  • Palo Alto, CA 94304
  • Phone: 650-498-6000
Learn More About the Clinic Getting Here Make An Appointment

General Dermatology Clinic

  • 450 Broadway Street
  • Redwood City, CA 94063
  • Phone: 650-723-6316
Learn More About the Clinic Getting Here Make An Appointment

General Dermatology Clinic in Redwood City

  • 450 Broadway Street
  • Redwood City, CA 94063
  • Phone: 650-723-6316
Learn More About the Clinic Getting Here Make An Appointment

Professional Education

Internship: Santa Clara Valley Medical Center (2001) CA

Fellowship: Stanford University School of Medicine (2004) CA

Residency: Stanford University School of Medicine (2003) CA

Medical Education: Harvard Medical School (2000) MA

Board Certification: Dermatology, American Board of Dermatology (2004)

Ph.D., MIT, Biology (1998)

A.B., Harvard, Biochemistry (1994)

Honors & Awards

Salvador E. Luria Lecture, Massachusetts Institute of Technology (2012)

Montagna Lecture, Society for Investigative Dermatology (2012)

Alfred Marchionini Research Prize, Alfred Marchionini Foundation (2011)

CE.R.I.E.S. Award, Chanel Research and Technology (2010)

Early Career Scientist, Howard Hughes Medical Institute (2009-2015)

Senior Scholar Award in Aging, Ellison Medical Foundation (2009)

Elected Member, American Society for Clinical Investigation (2009)

Vilcek Prize for Creative Promise, Vilcek Foundation (2009)

New Faculty Award, California Institute for Regenerative Medicine (2008-2013)

Research Scholar Award, American Cancer Society (2007-2010)

Scholar Award, Damon Runyon Cancer Research Foundation (2006-2008)

Clinical Scientist Career Development Award (K08), NIH (2004-2009)

Physician-Scientist Career Development Award, Dermatology Foundation (2004)

Young Investigator Award, American Academy of Dermatology (2003)

Administrative Appointments

Program Committee, Cancer Biology (2005 - 2012)

Clinical Trials

Clinical trials are research studies that evaluate a new medical approach, device, drug, or other treatment. As a Stanford Health Care patient, you have access to the latest, advanced clinical trials.

Open trials refer to studies currently accepting participants. Closed trials are not currently enrolling, but may open in the future.

Landscape and variation of RNA secondary structure across the human transcriptome.
Wan, Y., Qu, K., Zhang, Q. C., Flynn, R. A., Manor, O., & Chang, H. Y. (2014). Landscape and variation of RNA secondary structure across the human transcriptome. Nature, 505(7485), 706-709.

Transposition of native chromatin for fast and sensitive epigenomic profiling of open chromatin, DNA-binding proteins and nucleosome position.
Buenrostro, J. D., Giresi, P. G., Zaba, L. C., Chang, H. Y., & Greenleaf, W. J. (2013). Transposition of native chromatin for fast and sensitive epigenomic profiling of open chromatin, DNA-binding proteins and nucleosome position. Nature methods, 10(12), 1213-1218.

Transposition of native chromatin for fast and sensitive epigenomic profiling of open chromatin, DNA-binding proteins and nucleosome position
Buenrostro, J. D., Giresi, P. G., Zaba, L. C., Chang, H. Y., & Greenleaf, W. J. (2013). Transposition of native chromatin for fast and sensitive epigenomic profiling of open chromatin, DNA-binding proteins and nucleosome position. NATURE METHODS, 10(12), 1213-?.

Hierarchical Mechanisms for Direct Reprogramming of Fibroblasts to Neurons
Wapinski, O. L., Vierbuchen, T., Qu, K., Lee, Q. Y., Chanda, S., & Wernig, M. (2013). Hierarchical Mechanisms for Direct Reprogramming of Fibroblasts to Neurons. CELL, 155(3), 621-635.

Long Noncoding RNAs: Cellular Address Codes in Development and Disease
Batista, P. J., & Chang, H. Y. (2013). Long Noncoding RNAs: Cellular Address Codes in Development and Disease. CELL, 152(6), 1298-1307.

Control of somatic tissue differentiation by the long non-coding RNA TINCR.
Kretz, M., Siprashvili, Z., Chu, C., Webster, D. E., Zehnder, A., & Khavari, P. A. (2013). Control of somatic tissue differentiation by the long non-coding RNA TINCR. Nature, 493(7431), 231-235.

A mammalian pseudogene lncRNA at the interface of inflammation and anti-inflammatory therapeutics.
Rapicavoli, N. A., Qu, K., Zhang, J., Mikhail, M., Laberge, R.-M., & Chang, H. Y. (2013). A mammalian pseudogene lncRNA at the interface of inflammation and anti-inflammatory therapeutics. eLife, 2.

Aging, Rejuvenation, and Epigenetic Reprogramming: Resetting the Aging Clock
Rando, T. A., & Chang, H. Y. (2012). Aging, Rejuvenation, and Epigenetic Reprogramming: Resetting the Aging Clock. CELL, 148(1-2), 46-57.

A long noncoding RNA maintains active chromatin to coordinate homeotic gene expression
Wang, K. C., Yang, Y. W., Liu, B., Sanyal, A., Corces-Zimmerman, R., & Chang, H. Y. (2011). A long noncoding RNA maintains active chromatin to coordinate homeotic gene expression. NATURE, 472(7341), 120-U158.

Targeted Disruption of Hotair Leads to Homeotic Transformation and Gene Derepression
Li, L., Liu, B., Wapinski, O. L., Tsai, M.-C., Qu, K., & Chang, H. Y. (2013). Targeted Disruption of Hotair Leads to Homeotic Transformation and Gene Derepression. CELL REPORTS, 5(1), 3-12.

Genome-wide mapping of RNA structure using nuclease digestion and high-throughput sequencing.
Wan, Y., Qu, K., Ouyang, Z., & Chang, H. Y. (2013). Genome-wide mapping of RNA structure using nuclease digestion and high-throughput sequencing. Nature protocols, 8(5), 849-869.

Cytotopic localization by long noncoding RNAs
Batista, P. J., & Chang, H. Y. (2013). Cytotopic localization by long noncoding RNAs. CURRENT OPINION IN CELL BIOLOGY, 25(2), 195-199.

The NeST long ncRNA controls microbial susceptibility and epigenetic activation of the interferon-? locus.
Gomez, J. A., Wapinski, O. L., Yang, Y. W., Bureau, J.-F., Gopinath, S., & Kirkegaard, K. (2013). The NeST long ncRNA controls microbial susceptibility and epigenetic activation of the interferon-? locus. Cell, 152(4), 743-754.

Rejuvenation of gene expression pattern of aged human skin by broadband light treatment: a pilot study.
Chang, A. Ls., Bitter, P. H., Qu, K., Lin, M., Rapicavoli, N. A., & Chang, H. Y. (2013). Rejuvenation of gene expression pattern of aged human skin by broadband light treatment: a pilot study. journal of investigative dermatology, 133(2), 394-402.

SeqFold: Genome-scale reconstruction of RNA secondary structure integrating high-throughput sequencing data
Ouyang, Z., Snyder, M. P., & Chang, H. Y. (2013). SeqFold: Genome-scale reconstruction of RNA secondary structure integrating high-throughput sequencing data. GENOME RESEARCH, 23(2), 377-387.

RNA SHAPE analysis in living cells.
Spitale, R. C., Crisalli, P., Flynn, R. A., Torre, E. A., Kool, E. T., & Chang, H. Y. (2013). RNA SHAPE analysis in living cells. Nature chemical biology, 9(1), 18-20.

Systematic reconstruction of RNA functional motifs with high-throughput microfluidics
Martin, L., Meier, M., Lyons, S. M., Sit, R. V., Marzluff, W. F., & Chang, H. Y. (2012). Systematic reconstruction of RNA functional motifs with high-throughput microfluidics. NATURE METHODS, 9(12), 1192-U85.

Identification of proteins binding coding and non-coding human RNAs using protein microarrays
Siprashvili, Z., Webster, D. E., Kretz, M., Johnston, D., Rinn, J. L., & Khavari, P. A. (2012). Identification of proteins binding coding and non-coding human RNAs using protein microarrays. BMC GENOMICS, 13.

Genome-wide Measurement of RNA Folding Energies
Wan, Y., Qu, K., Ouyang, Z., Kertesz, M., Li, J., & Chang, H. Y. (2012). Genome-wide Measurement of RNA Folding Energies. MOLECULAR CELL, 48(2), 169-181.

Detection of Long Non-Coding RNA in Archival Tissue: Correlation with Polycomb Protein Expression in Primary and Metastatic Breast Carcinoma
Chisholm, K. M., Wan, Y., Li, R., Montgomery, K. D., Chang, H. Y., & West, R. B. (2012). Detection of Long Non-Coding RNA in Archival Tissue: Correlation with Polycomb Protein Expression in Primary and Metastatic Breast Carcinoma. PLOS ONE, 7(10).

Transcriptome sequencing in Sezary syndrome identifies Sezary cell and mycosis fungoides-associated lncRNAs and novel transcripts
Lee, C. S., Ungewickell, A., Bhaduri, A., Qu, K., Webster, D. E., & Khavari, P. A. (2012). Transcriptome sequencing in Sezary syndrome identifies Sezary cell and mycosis fungoides-associated lncRNAs and novel transcripts. BLOOD, 120(16), 3288-3297.

A Molecular Signature for Purified Definitive Endoderm Guides Differentiation and Isolation of Endoderm from Mouse and Human Embryonic Stem Cells
Wang, P., McKnight, K. D., Wong, D. J., Rodriguez, R. T., Sugiyama, T., & Kim, S. K. (2012). A Molecular Signature for Purified Definitive Endoderm Guides Differentiation and Isolation of Endoderm from Mouse and Human Embryonic Stem Cells. STEM CELLS AND DEVELOPMENT, 21(12), 2273-2287.

The Transcription Factor ZNF217 Is a Prognostic Biomarker and Therapeutic Target during Breast Cancer Progression
Littlepage, L. E., Adler, A. S., Kouros-Mehr, H., Huang, G., Chou, J., & Werb, Z. (2012). The Transcription Factor ZNF217 Is a Prognostic Biomarker and Therapeutic Target during Breast Cancer Progression. CANCER DISCOVERY, 2(7), 638-651.

Active chromatin and noncoding RNAs: an intimate relationship
Flynn, R. A., & Chang, H. Y. (2012). Active chromatin and noncoding RNAs: an intimate relationship. CURRENT OPINION IN GENETICS & DEVELOPMENT, 22(2), 172-178.

Suppression of progenitor differentiation requires the long noncoding RNA ANCR
Kretz, M., Webster, D. E., Flockhart, R. J., Lee, C. S., Zehnder, A., & Khavari, P. A. (2012). Suppression of progenitor differentiation requires the long noncoding RNA ANCR. GENES & DEVELOPMENT, 26(4), 338-343.

Transcriptional profiling of long non-coding RNAs and novel transcribed regions across a diverse panel of archived human cancers
Brunner, A. L., Beck, A. H., Edris, B., Sweeney, R. T., Zhu, S. X., & West, R. B. (2012). Transcriptional profiling of long non-coding RNAs and novel transcribed regions across a diverse panel of archived human cancers. GENOME BIOLOGY, 13(8).

Genome Regulation by Long Noncoding RNAs
Rinn, J. L., & Chang, H. Y. (2012). Genome Regulation by Long Noncoding RNAs. ANNUAL REVIEW OF BIOCHEMISTRY, VOL 81, 81, 145-166.

Chromatin isolation by RNA purification (ChIRP).
Chu, C., Quinn, J., & Chang, H. Y. (2012). Chromatin isolation by RNA purification (ChIRP). Journal of visualized experiments : JoVE, (61).

High throughput automated chromatin immunoprecipitation as a platform for drug screening and antibody validation
Wu, A. R., Kawahara, T. La., Rapicavoli, N. A., van Riggelen, J., Shroff, E. H., & Quake, S. R. (2012). High throughput automated chromatin immunoprecipitation as a platform for drug screening and antibody validation. LAB ON A CHIP, 12(12), 2190-2198.

Genomic Maps of Long Noncoding RNA Occupancy Reveal Principles of RNA-Chromatin Interactions
Chu, C., Qu, K., Zhong, F. L., Artandi, S. E., & Chang, H. Y. (2011). Genomic Maps of Long Noncoding RNA Occupancy Reveal Principles of RNA-Chromatin Interactions. MOLECULAR CELL, 44(4), 667-678.

Direct Lineage Conversion of Terminally Differentiated Hepatocytes to Functional Neurons
Marro, S., Pang, Z. P., Yang, N., Tsai, M.-C., Qu, K., & Wernig, M. (2011). Direct Lineage Conversion of Terminally Differentiated Hepatocytes to Functional Neurons. CELL STEM CELL, 9(4), 374-382.

Molecular Mechanisms of Long Noncoding RNAs
Wang, K. C., & Chang, H. Y. (2011). Molecular Mechanisms of Long Noncoding RNAs. MOLECULAR CELL, 43(6), 904-914.

Disruption of PPAR gamma/beta-catenin-mediated regulation of apelin impairs BMP-induced mouse and human pulmonary arterial EC survival
Alastalo, T.-P., Li, M., Perez, V. D. J., Pham, D., Sawada, H., & Rabinovitch, M. (2011). Disruption of PPAR gamma/beta-catenin-mediated regulation of apelin impairs BMP-induced mouse and human pulmonary arterial EC survival. JOURNAL OF CLINICAL INVESTIGATION, 121(9), 3735-3746.

Understanding the transcriptome through RNA structure
Wan, Y., Kertesz, M., Spitale, R. C., Segal, E., & Chang, H. Y. (2011). Understanding the transcriptome through RNA structure. NATURE REVIEWS GENETICS, 12(9), 641-655.

Crystal structure of the N-terminal region of human Ash2L shows a winged-helix motif involved in DNA binding
Chen, Y., Wan, B., Wang, K. C., Cao, F., Yang, Y., & Lei, M. (2011). Crystal structure of the N-terminal region of human Ash2L shows a winged-helix motif involved in DNA binding. EMBO REPORTS, 12(8), 797-803.

Extensive and coordinated transcription of noncoding RNAs within cell-cycle promoters
Hung, T., Wang, Y., Lin, M. F., Koegel, A. K., Kotake, Y., & Chang, H. Y. (2011). Extensive and coordinated transcription of noncoding RNAs within cell-cycle promoters. NATURE GENETICS, 43(7), 621-U196.

Long noncoding RNAs and human disease
Wapinski, O., & Chang, H. Y. (2011). Long noncoding RNAs and human disease. TRENDS IN CELL BIOLOGY, 21(6), 354-361.

Dynamic Chromatin Localization of Sirt6 Shapes Stress- and Aging-Related Transcriptional Networks
Kawahara, T. La., Rapicavoli, N. A., Wu, A. R., Qu, K., Quake, S. R., & Chang, H. Y. (2011). Dynamic Chromatin Localization of Sirt6 Shapes Stress- and Aging-Related Transcriptional Networks. PLOS GENETICS, 7(6).

RNA templating the epigenome Long noncoding RNAs as molecular scaffolds
Spitale, R. C., Tsai, M.-C., & Chang, H. Y. (2011). RNA templating the epigenome Long noncoding RNAs as molecular scaffolds. EPIGENETICS, 6(5), 539-543.

Long Intergenic Noncoding RNAs: New Links in Cancer Progression
Tsai, M.-C., Spitale, R. C., & Chang, H. Y. (2011). Long Intergenic Noncoding RNAs: New Links in Cancer Progression. CANCER RESEARCH, 71(1), 3-7.

Noncoding RNA Landmarks of Pluripotency and Reprogramming
Ouyang, Z., Zheng, G. Xy., & Chang, H. Y. (2010). Noncoding RNA Landmarks of Pluripotency and Reprogramming. CELL STEM CELL, 7(6), 649-650.

G1 arrest and differentiation can occur independently of Rb family function
Wirt, S. E., Adler, A. S., Gebala, V., Weimann, J. M., Schaffer, B. E., & Sage, J. (2010). G1 arrest and differentiation can occur independently of Rb family function. JOURNAL OF CELL BIOLOGY, 191(4), 809-825.

Genome-wide measurement of RNA secondary structure in yeast
Kertesz, M., Wan, Y., Mazor, E., Rinn, J. L., Nutter, R. C., & Segal, E. (2010). Genome-wide measurement of RNA secondary structure in yeast. NATURE, 467(7311), 103-107.

Long noncoding RNA in genome regulation Prospects and mechanisms
Hung, T., & Chang, H. Y. (2010). Long noncoding RNA in genome regulation Prospects and mechanisms. RNA BIOLOGY, 7(5), 582-585.

HOTAIR Flight of noncoding RNAs in cancer metastasis
Wan, Y., & Chang, H. Y. (2010). HOTAIR Flight of noncoding RNAs in cancer metastasis. CELL CYCLE, 9(17), 3391-3392.

Long Noncoding RNA as Modular Scaffold of Histone Modification Complexes
Tsai, M.-C., Manor, O., Wan, Y., Mosammaparast, N., Wang, J. K., & Chang, H. Y. (2010). Long Noncoding RNA as Modular Scaffold of Histone Modification Complexes. SCIENCE, 329(5992), 689-693.

Tumor suppression by the histone demethylase UTX
Tsai, M.-C., Wang, J. K., & Chang, H. Y. (2010). Tumor suppression by the histone demethylase UTX. CELL CYCLE, 9(11), 2043-2044.

Long non-coding RNA HOTAIR reprograms chromatin state to promote cancer metastasis
Gupta, R. A., Shah, N., Wang, K. C., Kim, J., Horlings, H. M., & Chang, H. Y. (2010). Long non-coding RNA HOTAIR reprograms chromatin state to promote cancer metastasis. NATURE, 464(7291), 1071-U148.

A TGF beta-Responsive Gene Signature Is Associated with a Subset of Diffuse Scleroderma with Increased Disease Severity
Sargent, J. L., Milano, A., Bhattacharyya, S., Varga, J., Connolly, M. K., & Whitfield, M. L. (2010). A TGF beta-Responsive Gene Signature Is Associated with a Subset of Diffuse Scleroderma with Increased Disease Severity. JOURNAL OF INVESTIGATIVE DERMATOLOGY, 130(3), 694-705.

The histone demethylase UTX enables RB-dependent cell fate control
Wang, J. K., Tsai, M.-C., Poulin, G., Adler, A. S., Chen, S., & Chang, H. Y. (2010). The histone demethylase UTX enables RB-dependent cell fate control. GENES & DEVELOPMENT, 24(4), 327-332.

Anatomic Demarcation of Cells: Genes to Patterns
Chang, H. Y. (2009). Anatomic Demarcation of Cells: Genes to Patterns. SCIENCE, 326(5957), 1206-1207.

Identification, molecular characterization, clinical prognosis, and therapeutic targeting of human bladder tumor-initiating cells
Chan, K. S., Espinosa, I., Chao, M., Wong, D., Ailles, L., & Weissman, I. L. (2009). Identification, molecular characterization, clinical prognosis, and therapeutic targeting of human bladder tumor-initiating cells. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 106(33), 14016-14021.

Gene dates, parties and galas Symposium on Chromatin Dynamics and Higher Order Organization
Chang, H. Y., Cuvier, O., & Dekker, J. (2009). Gene dates, parties and galas Symposium on Chromatin Dynamics and Higher Order Organization. EMBO REPORTS, 10(7), 689-693.

Tumor Vasculature Is Regulated by PHD2-Mediated Angiogenesis and Bone Marrow-Derived Cell Recruitment
Chan, D. A., Kawahara, T. La., Sutphin, P. D., Chang, H. Y., Chi, J.-T., & Giaccia, A. J. (2009). Tumor Vasculature Is Regulated by PHD2-Mediated Angiogenesis and Bone Marrow-Derived Cell Recruitment. CANCER CELL, 15(6), 527-538.

Modeling Inducible Human Tissue Neoplasia Identifies an Extracellular Matrix Interaction Network Involved in Cancer Progression
Reuter, J. A., Ortiz-Urda, S., Kretz, M., Garcia, J., Scholl, F. A., & Khavari, P. A. (2009). Modeling Inducible Human Tissue Neoplasia Identifies an Extracellular Matrix Interaction Network Involved in Cancer Progression. CANCER CELL, 15(6), 477-488.

Regeneration, repair and remembering identity: the three Rs of Hox gene expression
Wang, K. C., Helms, J. A., & Chang, H. Y. (2009). Regeneration, repair and remembering identity: the three Rs of Hox gene expression. TRENDS IN CELL BIOLOGY, 19(6), 268-275.

Hierarchical Maintenance of MLL Myeloid Leukemia Stem Cells Employs a Transcriptional Program Shared with Embryonic Rather Than Adult Stem Cells
Somervaille, T. Cp., Matheny, C. J., Spencer, G. J., Iwasaki, M., Rinn, J. L., & Cleary, M. L. (2009). Hierarchical Maintenance of MLL Myeloid Leukemia Stem Cells Employs a Transcriptional Program Shared with Embryonic Rather Than Adult Stem Cells. CELL STEM CELL, 4(2), 129-140.

Molecular Framework for Response to Imatinib Mesylate in Systemic Sclerosis
Chung, L., Fiorentino, D. F., Benbarak, M. J., Adler, A. S., Mariano, M. M., & Robinson, W. H. (2009). Molecular Framework for Response to Imatinib Mesylate in Systemic Sclerosis. ARTHRITIS AND RHEUMATISM, 60(2), 584-591.

ING4 Mediates Crosstalk between Histone H3 K4 Trimethylation and H3 Acetylation to Attenuate Cellular Transformation
Hung, T., Binda, O., Champagne, K. S., Kuo, A. J., Johnson, K., & Gozani, O. (2009). ING4 Mediates Crosstalk between Histone H3 K4 Trimethylation and H3 Acetylation to Attenuate Cellular Transformation. MOLECULAR CELL, 33(2), 248-256.

SIRT6 Links Histone H3 Lysine 9 Deacetylation to NF-kappa B-Dependent Gene Expression and Organismal Life Span
Kawahara, T. La., Michishita, E., Adler, A. S., Damian, M., Berber, E., & Chua, K. F. (2009). SIRT6 Links Histone H3 Lysine 9 Deacetylation to NF-kappa B-Dependent Gene Expression and Organismal Life Span. CELL, 136(1), 62-74.

Genome-Wide Views of Chromatin Structure
Rando, O. J., & Chang, H. Y. (2009). Genome-Wide Views of Chromatin Structure. ANNUAL REVIEW OF BIOCHEMISTRY, 78, 245-271.

Global Expression Profiling in Atopic Eczema Reveals Reciprocal Expression of Inflammatory and Lipid Genes
Saaf, A. M., Tengvall-Linder, M., Chang, H. Y., Adler, A. S., Wahlgren, C.-F., & Bradley, M. (2008). Global Expression Profiling in Atopic Eczema Reveals Reciprocal Expression of Inflammatory and Lipid Genes. PLOS ONE, 3(12).

Stemness, cancer and cancer stem cells
Wong, D. J., Segal, E., & Chang, H. Y. (2008). Stemness, cancer and cancer stem cells. CELL CYCLE, 7(23), 3622-3624.

Combining biological gene expression signatures in predicting outcome in breast cancer: An alternative to supervised classification
Nuyten, D. Sa., Hastie, T., Chi, J.-T. A., Chang, H. Y., & van de Vijver, M. J. (2008). Combining biological gene expression signatures in predicting outcome in breast cancer: An alternative to supervised classification. EUROPEAN JOURNAL OF CANCER, 44(15), 2319-2329.

Deletional tolerance mediated by extrathymic Aire-expressing cells
Gardner, J. M., DeVoss, J. J., Friedman, R. S., Wong, D. J., Tan, Y. X., & Anderson, M. S. (2008). Deletional tolerance mediated by extrathymic Aire-expressing cells. SCIENCE, 321(5890), 843-847.

Control of differentiation in a self-renewing mammalian tissue by the histone demethylase JMJD3
Sen, G. L., Webster, D. E., Barragan, D. I., Chang, H. Y., & Khavari, P. A. (2008). Control of differentiation in a self-renewing mammalian tissue by the histone demethylase JMJD3. GENES & DEVELOPMENT, 22(14), 1865-1870.

Mechanisms of an autoimmunity syndrome in mice caused by a dominant mutation in Aire
Su, M. A., Giang, K., Zumer, K., Jiang, H., Oven, I., & Anderson, M. S. (2008). Mechanisms of an autoimmunity syndrome in mice caused by a dominant mutation in Aire. JOURNAL OF CLINICAL INVESTIGATION, 118(5), 1712-1726.

Module map of stem cell genes guides creation of epithelial cancer stem cells
Wong, D. J., Liu, H., Ridky, T. W., Cassarino, D., Segal, E., & Chang, H. Y. (2008). Module map of stem cell genes guides creation of epithelial cancer stem cells. CELL STEM CELL, 2(4), 333-344.

A systems biology approach to anatomic diversity of skin
Rinn, J. L., Wang, J. K., Liu, H., Montgomery, K., van de Rijn, M., & Chang, H. Y. (2008). A systems biology approach to anatomic diversity of skin. JOURNAL OF INVESTIGATIVE DERMATOLOGY, 128(4), 776-782.

SIRT6 is a histone H3 lysine 9 deacetylase that modulates telomeric chromatin
Michishita, E., McCord, R. A., Berber, E., Kioi, M., Padilla-Nash, H., & Chua, K. F. (2008). SIRT6 is a histone H3 lysine 9 deacetylase that modulates telomeric chromatin. NATURE, 452(7186), 492-U16.

Reversal of aging by NF kappa B blockade
Adler, A. S., Kawahara, T. La., Segal, E., & Chang, H. Y. (2008). Reversal of aging by NF kappa B blockade. CELL CYCLE, 7(5), 556-559.

Systematic functional characterization of cis-regulatory motifs in human core promoters
Sinha, S., Adler, A. S., Field, Y., Chang, H. Y., & Segal, E. (2008). Systematic functional characterization of cis-regulatory motifs in human core promoters. GENOME RESEARCH, 18(3), 477-488.

A dermal HOX transcriptional program regulates site-specific epidermal fate
Rinn, J. L., Wang, J. K., Allen, N., Brugmann, S. A., Mikels, A. J., & Chang, H. Y. (2008). A dermal HOX transcriptional program regulates site-specific epidermal fate. GENES & DEVELOPMENT, 22(3), 303-307.

CSN5 isopeptidase activity links COP9 signalosome activation to breast cancer progression
Adler, A. S., Littlepage, L. E., Lin, M., Kawahara, T. La., Wong, D. J., & Chang, H. Y. (2008). CSN5 isopeptidase activity links COP9 signalosome activation to breast cancer progression. CANCER RESEARCH, 68(2), 506-515.

Revealing targeted therapy for human cancer by gene module maps
Wong, D. J., Nuyten, D. Sa., Regev, A., Lin, M., Adler, A. S., & Chang, H. Y. (2008). Revealing targeted therapy for human cancer by gene module maps. CANCER RESEARCH, 68(2), 369-378.

Motif module map reveals enforcement of aging by continual NF-kappa B activity
Adler, A. S., Sinha, S., Kawahara, T. La., Zhang, J. Y., Segal, E., & Chang, H. Y. (2007). Motif module map reveals enforcement of aging by continual NF-kappa B activity. GENES & DEVELOPMENT, 21(24), 3244-3257.

A histone H3 lysine 27 demethylase regulates animal posterior development
Lan, F., Bayliss, P. E., Rinn, J. L., Whetstine, J. R., Wang, J. K., & Shi, Y. (2007). A histone H3 lysine 27 demethylase regulates animal posterior development. NATURE, 449(7163), 689-U3.

Turning skin into embryonic stem cells
Chang, H. Y., & Cotsarelis, G. (2007). Turning skin into embryonic stem cells. NATURE MEDICINE, 13(7), 783-784.

Functional demarcation of active and silent chromatin domains in human HOX loci by Noncoding RNAs
Rinn, J. L., Kertesz, M., Wang, J. K., Squazzo, S. L., Xu, X., & Chang, H. Y. (2007). Functional demarcation of active and silent chromatin domains in human HOX loci by Noncoding RNAs. CELL, 129(7), 1311-1323.

Decoding global gene expression programs in liver cancer by noninvasive imaging
Segal, E., Sirlin, C. B., Ooi, C., Adler, A. S., Gollub, J., & Kuo, M. D. (2007). Decoding global gene expression programs in liver cancer by noninvasive imaging. NATURE BIOTECHNOLOGY, 25(6), 675-680.

A transcriptional program mediating entry into cellular quiescence
Liu, H., Adler, A. S., Segal, E., & Chang, H. Y. (2007). A transcriptional program mediating entry into cellular quiescence. PLOS GENETICS, 3(6), 996-1008.

Genome-wide analysis of KAP1 binding suggests autoregulation of KRAB-ZNFs
O'Geen, H., Squazzo, S. L., Iyengar, S., Blahnik, K., Rinn, J. L., & Farnham, P. J. (2007). Genome-wide analysis of KAP1 binding suggests autoregulation of KRAB-ZNFs. PLOS GENETICS, 3(6), 916-926.

Patterning skin pigmentation via dickkopf
Chang, H. Y. (2007). Patterning skin pigmentation via dickkopf. JOURNAL OF INVESTIGATIVE DERMATOLOGY, 127(5), 994-995.

GSK3 beta mediates suppression of cyclin D2 expression by tumor suppressor PTEN
Huang, W., Chang, H. Y., Fei, T., Wu, H., & Chen, Y.-G. (2007). GSK3 beta mediates suppression of cyclin D2 expression by tumor suppressor PTEN. ONCOGENE, 26(17), 2471-2482.

Spontaneous autoimmunity prevented by thymic expression of a single self-antigen
DeVoss, J., Hou, Y., Johannes, K., Lu, W., Liou, G. I., & Anderson, M. S. (2006). Spontaneous autoimmunity prevented by thymic expression of a single self-antigen. JOURNAL OF EXPERIMENTAL MEDICINE, 203(12), 2727-2735.

Bone morphogenetic protein antagonist gremlin 1 is widely expressed by cancer-associated stromal cells and can promote tumor cell proliferation
Sneddon, J. B., Zhen, H. H., Montgomery, K., van de Rijn, M., Tward, A. D., & Brown, P. O. (2006). Bone morphogenetic protein antagonist gremlin 1 is widely expressed by cancer-associated stromal cells and can promote tumor cell proliferation. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 103(40), 14842-14847.

Anatomic demarcation by positional variation in fibroblast gene expression programs
Rinn, J. L., Bondre, C., Gladstone, H. B., Brown, P. O., & Chang, H. Y. (2006). Anatomic demarcation by positional variation in fibroblast gene expression programs. PLOS GENETICS, 2(7), 1084-1096.

MYC can induce DNA breaks in vivo and in vitro independent of reactive oxygen species
Ray, S., Atkuri, K. R., Deb-Basu, D., Adler, A. S., Chang, H. Y., & Felsher, D. W. (2006). MYC can induce DNA breaks in vivo and in vitro independent of reactive oxygen species. CANCER RESEARCH, 66(13), 6598-6605.

From description to causality - Mechanisms of gene expression signatures in cancer
Adler, A. S., & Chang, H. Y. (2006). From description to causality - Mechanisms of gene expression signatures in cancer. CELL CYCLE, 5(11), 1148-1151.

Genetic regulators of large-scale transcriptional signatures in cancer
Adler, A. S., Lin, M. H., Horlings, H., Nuyten, D. Sa., Van de Vijver, M. J., & Chang, H. Y. (2006). Genetic regulators of large-scale transcriptional signatures in cancer. NATURE GENETICS, 38(4), 421-430.

Microarray analysis of stem cells and differentiation
Chang, H. Y., Thomson, J. A., & Chen, X. (2006). Microarray analysis of stem cells and differentiation. STEM CELL TOOLS AND OTHER EXPERIMENTAL PROTOCOLS, 420, 225-254.

Predicting a local recurrence after breast-conserving therapy by gene expression profiling
Nuyten, D. Sa., Kreike, B., Hart, A. Am., Chi, J.-T. A., Sneddon, J. B., & van de Vijver, M. J. (2006). Predicting a local recurrence after breast-conserving therapy by gene expression profiling. BREAST CANCER RESEARCH, 8(5).

Learning more from microarrays: Insights from modules and networks
Wong, D. J., & Chang, H. Y. (2005). Learning more from microarrays: Insights from modules and networks. JOURNAL OF INVESTIGATIVE DERMATOLOGY, 125(2), 175-182.

Robustness, scalability, and integration of a wound-response gene expression signature in predicting breast cancer survival
Chang, H. Y., Nuyten, D. Sa., Sneddon, J. B., Hastie, T., Tibshirani, R., & van de Vijver, M. J. (2005). Robustness, scalability, and integration of a wound-response gene expression signature in predicting breast cancer survival. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 102(10), 3738-3743.

Gene expression signature of fibroblast serum response predicts human cancer progression: Similarities between tumors and wounds
Chang, H. Y., Sneddon, J. B., Alizadeh, A. A., Sood, R., West, R. B., & Brown, P. O. (2004). Gene expression signature of fibroblast serum response predicts human cancer progression: Similarities between tumors and wounds. PLOS BIOLOGY, 2(2), 206-214.

Gene expression signature of fibroblast serum response predicts human cancer progression: similarities between tumors and wounds.
Chang, H. Y., Sneddon, J. B., Alizadeh, A. A., Sood, R., West, R. B., & Brown, P. O. (2004). Gene expression signature of fibroblast serum response predicts human cancer progression: similarities between tumors and wounds. PLoS biology, 2(2), E7-?.

Kinetics and specificity of Fas ligand induction in toxic epidermal necrolysis
Chang, H. Y., Cooper, Z. A., Swetter, S. A., & Marinkovich, M. P. (2004). Kinetics and specificity of Fas ligand induction in toxic epidermal necrolysis. ARCHIVES OF DERMATOLOGY, 140(2), 242-244.

Endothelial cell diversity revealed by global expression profiling
Chi, J. T., Chang, H. Y., Haraldsen, G., Jahnsen, F. L., Troyanskaya, O. G., & Brown, P. O. (2003). Endothelial cell diversity revealed by global expression profiling. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 100(19), 10623-10628.

Eruptive xanthomas associated with olanzapine use
Chang, H. Y., Ridky, T. W., Kimball, A. B., Hughes, E., & Oro, A. E. (2003). Eruptive xanthomas associated with olanzapine use. ARCHIVES OF DERMATOLOGY, 139(8), 1045-1048.

Myelogenous leukemia cutis resembling stasis dermatitis
Chang, H. Y., Wong, K. M., Bosenberg, M., McKee, P. H., & Haynes, H. A. (2003). Myelogenous leukemia cutis resembling stasis dermatitis. JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, 49(1), 128-129.

Genomewide view of gene silencing by small interfering RNAs
Chi, J. T., Chang, H. Y., Wang, N. N., Chang, D. S., Dunphy, N., & Brown, P. O. (2003). Genomewide view of gene silencing by small interfering RNAs. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 100(11), 6343-6346.

Diversity, topographic differentiation, and positional memory in human fibroblasts
Chang, H. Y., Chi, J. T., Dudoit, S., Bondre, C., van de Rijn, M., & Brown, P. O. (2002). Diversity, topographic differentiation, and positional memory in human fibroblasts. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 99(20), 12877-12882.

Proteases for cell suicide: Functions and regulation of caspases
Chang, H. Y., & Yang, X. L. (2000). Proteases for cell suicide: Functions and regulation of caspases. MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS, 64(4), 821-?.

Dissecting Fas signaling with an altered-specificity death-domain mutant: Requirement of FADD binding for apoptosis but not Jun N-terminal kinase activation
Chang, H. Y., Yang, X. L., & Baltimore, D. (1999). Dissecting Fas signaling with an altered-specificity death-domain mutant: Requirement of FADD binding for apoptosis but not Jun N-terminal kinase activation. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 96(4), 1252-1256.

Activation of apoptosis signal regulating kinase 1 (ASK1) by the adapter protein Daxx
Chang, H. Y., Nishitoh, H., Yang, X. L., ICHIJO, H., & Baltimore, D. (1998). Activation of apoptosis signal regulating kinase 1 (ASK1) by the adapter protein Daxx. SCIENCE, 281(5384), 1860-1863.

Essential role of CED-4 oligomerization in CED-3 activation and apoptosis
Yang, X. L., Chang, H. Y., & Baltimore, D. (1998). Essential role of CED-4 oligomerization in CED-3 activation and apoptosis. SCIENCE, 281(5381), 1355-1357.

Autoproteolytic activation of pro-caspases by oligomerization
Yang, X. L., Chang, H. Y., & Baltimore, D. (1998). Autoproteolytic activation of pro-caspases by oligomerization. MOLECULAR CELL, 1(2), 319-325.

Daxx, a novel Fas-binding protein that activates JNK and apoptosis
Yang, X. L., KHOSRAVIFAR, R., Chang, H. Y., & Baltimore, D. (1997). Daxx, a novel Fas-binding protein that activates JNK and apoptosis. CELL, 89(7), 1067-1076.

ASYMMETRIC RETRACTION OF GROWTH CONE FILOPODIA FOLLOWING FOCAL INACTIVATION OF CALCINEURIN
Chang, H. Y., Takei, K., SYDOR, A. M., Born, T., Rusnak, F., & Jay, D. G. (1995). ASYMMETRIC RETRACTION OF GROWTH CONE FILOPODIA FOLLOWING FOCAL INACTIVATION OF CALCINEURIN. NATURE, 376(6542), 686-690.

ACTIVATION OF CLN1 AND CLN2 G(1) CYCLIN GENE-EXPRESSION BY BCK2
DICOMO, C. J., Chang, H., & Arndt, K. T. (1995). ACTIVATION OF CLN1 AND CLN2 G(1) CYCLIN GENE-EXPRESSION BY BCK2. MOLECULAR AND CELLULAR BIOLOGY, 15(4), 1835-1846.

ACTIVE-SITE MUTANTS OF HUMAN CYCLOPHILIN-A SEPARATE PEPTIDYL-PROLYL ISOMERASE ACTIVITY FROM CYCLOSPORINE-A BINDING AND CALCINEURIN INHIBITION
ZYDOWSKY, L. D., Etzkorn, F. A., Chang, H. Y., Ferguson, S. B., STOLZ, L. A., & Walsh, C. T. (1992). ACTIVE-SITE MUTANTS OF HUMAN CYCLOPHILIN-A SEPARATE PEPTIDYL-PROLYL ISOMERASE ACTIVITY FROM CYCLOSPORINE-A BINDING AND CALCINEURIN INHIBITION. PROTEIN SCIENCE, 1(9), 1092-1099.

CYCLOSPORINE-MEDIATED INHIBITION OF BOVINE CALCINEURIN BY CYCLOPHILIN-A AND CYCLOPHILIN-B
SWANSON, S. Kh., Born, T., ZYDOWSKY, L. D., Cho, H. J., Chang, H. Y., & Rusnak, F. (1992). CYCLOSPORINE-MEDIATED INHIBITION OF BOVINE CALCINEURIN BY CYCLOPHILIN-A AND CYCLOPHILIN-B. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 89(9), 3741-3745.