Kay Chang

Pediatric otolaryngologist

Dr. Chang's clinical practice is based at the Lucile Packard Children's Hospital, and is focused on Pediatric Otology. He has specific clinical interests in congenital hearing loss, congenital ear anomalies, microtia and atresia reconstruction, and pediatric cochlear implantation. His research interests are also in hearing loss, and include neonatal hearing screening, genetics of hearing loss, otoacoustic emissions, auditory physiology, and ototoxicity. He is actively involved in several human clinical trials looking at the prevention of cisplatin ototoxicity that may drastically decrease the number of children developing hearing loss after chemotherapy, and also presented the Chang Ototoxicity Scale in Journal of Clinical Oncology. His current research interests include the radiologic evaluation of congenital inner ear anomalies, and the analysis of how Connexin-based mutations can alter management of infants with congenital hearing loss.

Dr. Chang received his B.A. magna cum laude at Brown University, graduating Phi Beta Kappa. He continued there for his M.D. degree, receiving the Henry Randall Prize and the Sigma Xi Award. He completed his Otolaryngology residency in Seattle, at the University of Washington. This was followed by a fellowship in Pediatric Otolaryngology at the Children's Hospital of Pittsburgh. He joined the faculty at Stanford University in 2000.

Specialties: Pediatric Otology, Auditory Research, Ototoxicity, Pediatric Cochlear Implantation, Microtia Reconstruction, Canal Atresia Reconstruction, Medical Device Research and Development

Professional Education

Fellowship: Children's Hospital of Pittsburgh (2000) PA

Board Certification: Otolaryngology, American Board of Otolaryngology (1999)

Residency: University of Washington Medical Center (1998) WA

Internship: University of Washington Medical Center (1993) WA

Medical Education: Brown University - School of Medicine (1992) RI

B.A., Brown University, Cognitive Science (1989)

Honors & Awards

American Otological Society (AOS), - (2014)

AAO-HNS Foundation Honor Award, American Acad of Otolaryngology - Head & Neck Surg (2013)

Acceptance of Triologic Thesis, Triological Society (2011)

Castle Connolly's Top Doctors, Castle Connolly (2012)

Top Ten Doctors, Vitals (2012)

Patients' Choice Award, - (2011-2012)

Resident Teaching Award, Stanford Otolaryngology (2010)

Best Doctors in America, Best Doctors (2005)

"Excellence in Teaching" award, Stanford University School of Medicine (2004)

Resident Teaching Award, Stanford Otolaryngology (2003)

Sigma Xi Award, Sigma Xi (1992)

Henry Randall Prize, Brown University (1992)

Leonard H. Campbell Scholarship, Brown University School of Medicine (1991)

Milton Hamolsky Prize, Brown University (1989)

Magna Cum Laude, Brown University (1989)

Phi Beta Kappa, Phi Beta Kappa (1988)

Presidential Scholar, USA (1985)

Administrative Appointments

Editorial Board, Otology Neurotology, 2012

Finance Committee Chair, American Society of Pediatric Otolaryngology (ASPO), 2012

Editorial Board, Otolaryngology - Head and Neck Surgery, 2009

Ped/OB FPO Finance Committee, LPCH, 2005

Executive Steering Committee, LPCH Enterprise-Wide Scheduling Initiative, 2012

Advanced Stanford Leadership Development Program, Stanford University, 2012

Chair, Ototoxicity Consensus Conference, International Society of Pediatric Oncology (SIOP), 2010

Stanford Faculty Fellows Program, Stanford University, 2009

Faculty Senate, Stanford University School of Medicine, 2005

Policy Committee, LPCH, 2004

Director of Medical Student Programs, Stanford Otolaryngology, 2002

Care Improvement Committee, LPCH, 2001

Analysis of Growth Curves in Children After Adenotonsillectomy
Czechowicz, J. A., & Chang, K. W. (2014). Analysis of Growth Curves in Children After Adenotonsillectomy. JAMA OTOLARYNGOLOGY-HEAD & NECK SURGERY, 140(6), 491-496.

Concordance between the chang and the International Society of Pediatric Oncology (SIOP) ototoxicity grading scales in patients treated with cisplatin for medulloblastoma.
Bass, J. K., Huang, J., Onar-Thomas, A., Chang, K. W., Bhagat, S. P., & Gurney, J. G. (2014). Concordance between the chang and the International Society of Pediatric Oncology (SIOP) ototoxicity grading scales in patients treated with cisplatin for medulloblastoma. Pediatric blood & cancer, 61(4), 601-605.

GJB2-Associated Hearing Loss: Systematic Review of Worldwide Prevalence, Genotype, and Auditory Phenotype
Chan, D. K., & Chang, K. W. (2014). GJB2-Associated Hearing Loss: Systematic Review of Worldwide Prevalence, Genotype, and Auditory Phenotype. LARYNGOSCOPE, 124(2), E34-E53.

The proximal bronchoplasty retrieval technique for removal of embedded distal airway foreign bodies.
Hoff, S. R., & Chang, K. W. (2014). The proximal bronchoplasty retrieval technique for removal of embedded distal airway foreign bodies. International journal of pediatric otorhinolaryngology, 78(1), 148-151.

Hearing outcomes of atresia surgery versus osseointegrated bone conduction device in patients with congenital aural atresia: a systematic review.
Nadaraja, G. S., Gurgel, R. K., Kim, J., & Chang, K. W. (2013). Hearing outcomes of atresia surgery versus osseointegrated bone conduction device in patients with congenital aural atresia: a systematic review. Otology & neurotology , 34(8), 1394-1399.

Lip Abscess Associated With Isotretinoin Treatment of Acne Vulgaris
Huoh, K. C., & Chang, K. W. (2013). Lip Abscess Associated With Isotretinoin Treatment of Acne Vulgaris. JAMA DERMATOLOGY, 149(8), 960-961.

beta-Adrenergic receptor expression in vascular tumors
Chisholm, K. M., Chang, K. W., Truong, M. T., Kwok, S., West, R. B., & Heerema-McKenney, A. E. (2012). beta-Adrenergic receptor expression in vascular tumors. MODERN PATHOLOGY, 25(11), 1446-1451.

Platinum-Induced Ototoxicity in Children: A Consensus Review on Mechanisms, Predisposition, and Protection, Including a New International Society of Pediatric Oncology Boston Ototoxicity Scale
Brock, P. R., Knight, K. R., Freyer, D. R., Campbell, K. Cm., Steyger, P. S., & Neuwelt, E. A. (2012). Platinum-Induced Ototoxicity in Children: A Consensus Review on Mechanisms, Predisposition, and Protection, Including a New International Society of Pediatric Oncology Boston Ototoxicity Scale. JOURNAL OF CLINICAL ONCOLOGY, 30(19), 2408-2417.

Is It Valid to Calculate the 3-Kilohertz Threshold by Averaging 2 and 4 Kilohertz?
Gurgel, R. K., Popelka, G. R., Oghalai, J. S., Blevins, N. H., Chang, K. W., & Jackler, R. K. (2012). Is It Valid to Calculate the 3-Kilohertz Threshold by Averaging 2 and 4 Kilohertz?. OTOLARYNGOLOGY-HEAD AND NECK SURGERY, 147(1), 102-104.

CT Analysis Demonstrates That Cochlear Height Does Not Change with Age
Mori, M. C., & Chang, K. W. (2012). CT Analysis Demonstrates That Cochlear Height Does Not Change with Age. AMERICAN JOURNAL OF NEURORADIOLOGY, 33(1), 119-123.

Clinically Accurate Assessment and Grading of Ototoxicity
Chang, K. W. (2011). Clinically Accurate Assessment and Grading of Ototoxicity. LARYNGOSCOPE, 121(12), 2649-2657.

Diagnostic Yield in the Workup of Congenital Sensorineural Hearing Loss Is Dependent on Patient Ethnicity
Chan, D. K., Schrijver, I., & Chang, K. W. (2011). Diagnostic Yield in the Workup of Congenital Sensorineural Hearing Loss Is Dependent on Patient Ethnicity. OTOLOGY & NEUROTOLOGY, 32(1), 81-87.

Propranolol for the treatment of airway hemangiomas: A case series and treatment algorithm
Truong, M. T., Perkins, J. A., Messner, A. H., & Chang, K. W. (2010). Propranolol for the treatment of airway hemangiomas: A case series and treatment algorithm. INTERNATIONAL JOURNAL OF PEDIATRIC OTORHINOLARYNGOLOGY, 74(9), 1043-1048.

Practical Grading System for Evaluating Cisplatin Ototoxicity in Children
Chang, K. W., & Chinosornvatana, N. (2010). Practical Grading System for Evaluating Cisplatin Ototoxicity in Children. JOURNAL OF CLINICAL ONCOLOGY, 28(10), 1788-1795.

Connexin-26-associated deafness: Phenotypic variability and progression of hearing loss
Chan, D. K., Schrijver, I., & Chang, K. W. (2010). Connexin-26-associated deafness: Phenotypic variability and progression of hearing loss. GENETICS IN MEDICINE, 12(3), 174-181.

Propranolol for the Treatment of a Life-Threatening Subglottic and Mediastinal Infantile Hemangioma
Truong, M. T., Chang, K. W., Berk, D. R., Heerema-McKenney, A., & Bruckner, A. L. (2010). Propranolol for the Treatment of a Life-Threatening Subglottic and Mediastinal Infantile Hemangioma. JOURNAL OF PEDIATRICS, 156(2), 335-338.

Amifostine Does Not Prevent Platinum-Induced Hearing Loss Associated With the Treatment of Children With Hepatoblastoma
Katzenstein, H. M., Chang, K. W., Krailo, M., Chen, Z., Finegold, M. J., & Malogolowkin, M. (2009). Amifostine Does Not Prevent Platinum-Induced Hearing Loss Associated With the Treatment of Children With Hepatoblastoma. CANCER, 115(24), 5828-5835.

Otorrhea in Infants With Tympanostomy Tubes Before and After Surgical Repair of a Cleft Palate
Curtin, G., Messner, A. H., & Chang, K. W. (2009). Otorrhea in Infants With Tympanostomy Tubes Before and After Surgical Repair of a Cleft Palate. ARCHIVES OF OTOLARYNGOLOGY-HEAD & NECK SURGERY, 135(8), 748-751.

Evaluation of unilateral referrals on neonatal hearing screening
Chang, K. W., O-Lee, T. J., & Price, M. (2009). Evaluation of unilateral referrals on neonatal hearing screening. JOURNAL OF MEDICAL SCREENING, 16(1), 17-21.

Intracapsular versus subcapsular coblation tonsillectomy
Chang, K. W. (2008). Intracapsular versus subcapsular coblation tonsillectomy. OTOLARYNGOLOGY-HEAD AND NECK SURGERY, 138(2), 153-157.

Utility of temporal bone computed tomographic measurements in the evaluation of inner ear malformations
Chen, J. L., Gittleman, A., Barnes, P. D., & Chang, K. W. (2008). Utility of temporal bone computed tomographic measurements in the evaluation of inner ear malformations. ARCHIVES OF OTOLARYNGOLOGY-HEAD & NECK SURGERY, 134(1), 50-56.

Recovery from cisplatin-induced ototoxicity.
Truong, M. T., Winzelberg, J., & Chang, K. W. (2007). Recovery from cisplatin-induced ototoxicity. Int J Pediatr Otorhinolaryngol, 71(10).

Two patients with the V371/235delC genotype: Are radiographic cochlear anomalies part of the phenotype?
Schrijver, I., & Chang, K. W. (2006). Two patients with the V371/235delC genotype: Are radiographic cochlear anomalies part of the phenotype?. INTERNATIONAL JOURNAL OF PEDIATRIC OTORHINOLARYNGOLOGY, 70(12), 2109-2113.

Amifostine does not protect against the ototoxicity of high-dose cisplatin combined with etoposide and bleomycin in pediatric germ-cell tumors - A children's Oncology Group study
Marina, N., Chang, K. W., Malogolowkin, M., London, W. B., Frazier, A. L., & Olson, T. A. (2005). Amifostine does not protect against the ototoxicity of high-dose cisplatin combined with etoposide and bleomycin in pediatric germ-cell tumors - A children's Oncology Group study. CANCER, 104(4), 841-847.

Not your routine foreign body: Endobronchial tuberculosis in an infant
Agarwal, S., Hong, D. K., Soslow, J., & Chang, K. W. (2005). Not your routine foreign body: Endobronchial tuberculosis in an infant. PEDIATRICS, 116(1), 246-248.

Randomized controlled trial of Coblation versus electrocautery tonsillectomy
Chang, K. W. (2005). Randomized controlled trial of Coblation versus electrocautery tonsillectomy. OTOLARYNGOLOGY-HEAD AND NECK SURGERY, 132(2), 273-280.

Prevention of cisplatin ototoxicity using transtympanic N-acetylcysteine and lactate
Choe, W. T., Chinosornvatana, N., & Chang, K. W. (2004). Prevention of cisplatin ototoxicity using transtympanic N-acetylcysteine and lactate. OTOLOGY & NEUROTOLOGY, 25(6), 910-915.

A randomized study of platinum-based chemotherapy with or without amifostine for the treatment of children with hepatoblastoma: A report of the Intergroup Hepatoblastoma Study P9645.
Katzenstein HM, Chang K, Krailo M, & et al. (2004). A randomized study of platinum-based chemotherapy with or without amifostine for the treatment of children with hepatoblastoma: A report of the Intergroup Hepatoblastoma Study P9645. Proc Am Soc Clin Oncol, 22.

Pediatric residents' clinical diagnostic accuracy of otitis media
Steinbach, W. J., Sectish, T. C., Benjamin, D. K., Chang, K. W., & Messner, A. H. (2002). Pediatric residents' clinical diagnostic accuracy of otitis media. PEDIATRICS, 109(6), 993-998.

Efferently mediated changes in the quadratic distortion product (f2-f1)
Chang, K. W., & Norton, S. J. (1997). Efferently mediated changes in the quadratic distortion product (f2-f1). JOURNAL OF THE ACOUSTICAL SOCIETY OF AMERICA, 102(3), 1719-1733.

The effects of continuous versus interrupted noise exposures on distortion product otoacoustic emissions in guinea pigs
Chang, K. W., & Norton, S. J. (1996). The effects of continuous versus interrupted noise exposures on distortion product otoacoustic emissions in guinea pigs. HEARING RESEARCH, 96(1-2), 1-12.

EXTERNAL AND MIDDLE-EAR STATUS RELATED TO EVOKED OTOACOUSTIC EMISSION IN NEONATES
Chang, K. W., Vohr, B. R., Norton, S. J., & LEKAS, M. D. (1993). EXTERNAL AND MIDDLE-EAR STATUS RELATED TO EVOKED OTOACOUSTIC EMISSION IN NEONATES. ARCHIVES OF OTOLARYNGOLOGY-HEAD & NECK SURGERY, 119(3), 276-282.

Wegener's granulomatosis in an adolescent presenting with pachymeningitis, mastoid effusion and Horner's syndrome
Kohlberg, G. D., Truong, M. T., & Chang, K. W. (2011). Wegener's granulomatosis in an adolescent presenting with pachymeningitis, mastoid effusion and Horner's syndrome. Int J Pediatr Otorhinolaryngol Extra, 6(2).

Salivary Gland Anlage Tumor in a Neonate Presenting with Respiratory Distress: Radiographic and Pathologic Correlation
Mogensen, M. A., Lin, A. C., Chang, K. W., Berry, G. J., Barnes, P. D., & Fischbein, N. J. (2009). Salivary Gland Anlage Tumor in a Neonate Presenting with Respiratory Distress: Radiographic and Pathologic Correlation. AMERICAN JOURNAL OF NEURORADIOLOGY, 30(5), 1022-1023.

Third branchial cleft fistula infected with Actinomyces
Chang, K. W., Lee, B. G., & Gutierrez, K. M. (2008). Third branchial cleft fistula infected with Actinomyces. Int J Pediatr Otorhinolaryngol Extra, 3(1).

Familial laryngomalacia in two siblings with syndromic features
Chen, J. L., Messner, A. H., & Chang, K. W. (2006). Familial laryngomalacia in two siblings with syndromic features. INTERNATIONAL JOURNAL OF PEDIATRIC OTORHINOLARYNGOLOGY, 70(9), 1651-1655.

Posttransplantation lymphoproliferative disorder of the paranasal sinuses in a child
Rosen, F. S., Bingham, D., & Chang, K. W. (2006). Posttransplantation lymphoproliferative disorder of the paranasal sinuses in a child. Int J Pediatr Otorhinolaryngol Extra, 1(1).

Evaluation and management of hoarseness in children.
Chang, K. W., & Inglis, A. F. (1996). Evaluation and management of hoarseness in children. Current Opinion Oto Head Neck Surg, 4.

IATROGENIC HYPONATREMIA - A CAUSE OF DEATH FOLLOWING PEDIATRIC TONSILLECTOMY
MCRAE, R. G., WEISSBURG, A. J., & Chang, K. W. (1994). IATROGENIC HYPONATREMIA - A CAUSE OF DEATH FOLLOWING PEDIATRIC TONSILLECTOMY. INTERNATIONAL JOURNAL OF PEDIATRIC OTORHINOLARYNGOLOGY, 30(3), 227-232.