Kiki Chang

Professor of Psychiatry and Behavioral Sciences at the Stanford University Medical Center

Professional Education

Fellowship: Stanford University School of Medicine (1998) CA

Residency: University of Cincinnati (1996) OH

Internship: University of Cincinnati (1994) OH

Medical Education: Tufts University (1993) MA

Bipolar disorder and attention-deficit/hyperactivity disorder comorbidity in children and adolescents: evidence-based approach to diagnosis and treatment.
Miller, S., Chang, K. D., & Ketter, T. A. (2013). Bipolar disorder and attention-deficit/hyperactivity disorder comorbidity in children and adolescents: evidence-based approach to diagnosis and treatment. journal of clinical psychiatry, 74(6), 628-629.

Socio-emotional processing and functioning of youth at high risk for bipolar disorder.
Whitney, J., Howe, M., Shoemaker, V., Li, S., Marie Sanders, E., & Chang, K. (2013). Socio-emotional processing and functioning of youth at high risk for bipolar disorder. Journal of affective disorders, 148(1), 112-117.

Bipolar depression in pediatric populations : epidemiology and management.
Cosgrove, V. E., Roybal, D., & Chang, K. D. (2013). Bipolar depression in pediatric populations : epidemiology and management. Paediatric drugs, 15(2), 83-91.

Brain structural response in individuals at familial risk for bipolar disorder: a tale of two outcomes.
Singh, M. K., & Chang, K. D. (2013). Brain structural response in individuals at familial risk for bipolar disorder: a tale of two outcomes. Biological psychiatry, 73(2), 109-110.

Reward Processing in Adolescents With Bipolar I Disorder
Singh, M. K., Chang, K. D., Kelley, R. G., Cui, X., Sherdell, L., & Reiss, A. L. (2013). Reward Processing in Adolescents With Bipolar I Disorder. JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY, 52(1), 68-83.

Health-related quality of life as measured by the child health questionnaire in adolescents with bipolar disorder treated with olanzapine
Olsen, B. T., Ganocy, S. J., Bitter, S. M., Findling, R. L., Case, M., & DelBello, M. P. (2012). Health-related quality of life as measured by the child health questionnaire in adolescents with bipolar disorder treated with olanzapine. COMPREHENSIVE PSYCHIATRY, 53(7), 1000-1005.

The Neural Effects of Psychotropic Medications in Children and Adolescents
Singh, M. K., & Chang, K. D. (2012). The Neural Effects of Psychotropic Medications in Children and Adolescents. CHILD AND ADOLESCENT PSYCHIATRIC CLINICS OF NORTH AMERICA, 21(4), 753-?.

Volumetric reductions in the subgenual anterior cingulate cortex in adolescents with bipolar I disorder
Singh, M. K., Chang, K. D., Chen, M. C., Kelley, R. G., Garrett, A., & Gotlib, I. H. (2012). Volumetric reductions in the subgenual anterior cingulate cortex in adolescents with bipolar I disorder. BIPOLAR DISORDERS, 14(6), 585-596.

Information processing in adolescents with bipolar I disorder
Whitney, J., Joormann, J., Gotlib, I. H., Kelley, R. G., Acquaye, T., & Singh, M. K. (2012). Information processing in adolescents with bipolar I disorder. JOURNAL OF CHILD PSYCHOLOGY AND PSYCHIATRY, 53(9), 937-945.

Abnormal Amygdala and Prefrontal Cortex Activation to Facial Expressions in Pediatric Bipolar Disorder
Garrett, A. S., Reiss, A. L., Howe, M. E., Kelley, R. G., Singh, M. K., & Chang, K. D. (2012). Abnormal Amygdala and Prefrontal Cortex Activation to Facial Expressions in Pediatric Bipolar Disorder. JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY, 51(8), 821-831.

Neurometabolite Effects of Response to Quetiapine and Placebo in Adolescents with Bipolar Depression
Chang, K., DelBello, M., Chu, W.-J., Garrett, A., Kelley, R., & Strakowski, S. M. (2012). Neurometabolite Effects of Response to Quetiapine and Placebo in Adolescents with Bipolar Depression. JOURNAL OF CHILD AND ADOLESCENT PSYCHOPHARMACOLOGY, 22(4), 261-268.

The functional neuroanatomy of bipolar disorder: a consensus model
Strakowski, S. M., Adler, C. M., Almeida, J., Altshuler, L. L., Blumberg, H. P., & Townsend, J. D. (2012). The functional neuroanatomy of bipolar disorder: a consensus model. BIPOLAR DISORDERS, 14(4), 313-325.

Effects of medication on neuroimaging findings in bipolar disorder: an updated review
Hafeman, D. M., Chang, K. D., Garrett, A. S., Sanders, E. M., & Phillips, M. L. (2012). Effects of medication on neuroimaging findings in bipolar disorder: an updated review. BIPOLAR DISORDERS, 14(4), 375-410.

Amygdalar, hippocampal, and thalamic volumes in youth at high risk for development of bipolar disorder
Karchemskiy, A., Garrett, A., Howe, M., Adleman, N., Simeonova, D. I., & Chang, K. (2011). Amygdalar, hippocampal, and thalamic volumes in youth at high risk for development of bipolar disorder. PSYCHIATRY RESEARCH-NEUROIMAGING, 194(3), 319-325.

Characterization and Factors Associated with Sleep Quality in Adolescents with Bipolar I Disorder
Roybal, D. J., Chang, K. D., Chen, M. C., Howe, M. E., Gotlib, I. H., & Singh, M. K. (2011). Characterization and Factors Associated with Sleep Quality in Adolescents with Bipolar I Disorder. CHILD PSYCHIATRY & HUMAN DEVELOPMENT, 42(6), 724-740.

Increased Subgenual Cingulate Cortex Volume in Pediatric Bipolar Disorder Associated with Mood Stabilizer Exposure
Mitsunaga, M. M., Garrett, A., Howe, M., Karchemskiy, A., Reiss, A., & Chang, K. (2011). Increased Subgenual Cingulate Cortex Volume in Pediatric Bipolar Disorder Associated with Mood Stabilizer Exposure. JOURNAL OF CHILD AND ADOLESCENT PSYCHOPHARMACOLOGY, 21(2), 149-155.

Neurochemical deficits in the cerebellar vermis in child offspring of parents with bipolar disorder
Singh, M. K., Spielman, D., Libby, A., Adams, E., Acquaye, T., & Chang, K. D. (2011). Neurochemical deficits in the cerebellar vermis in child offspring of parents with bipolar disorder. BIPOLAR DISORDERS, 13(2), 189-197.

Early psychosocial intervention for youth at risk for bipolar I or II disorder: a one-year treatment development trial
Miklowitz, D. J., Chang, K. D., Taylor, D. O., George, E. L., Singh, M. K., & Garber, J. (2011). Early psychosocial intervention for youth at risk for bipolar I or II disorder: a one-year treatment development trial. BIPOLAR DISORDERS, 13(1), 67-75.

Antidepressants and Psychostimulants in Pediatric Populations Is there an Association with Mania?
Goldsmith, M., Singh, M., & Chang, K. (2011). Antidepressants and Psychostimulants in Pediatric Populations Is there an Association with Mania?. PEDIATRIC DRUGS, 13(4), 225-243.

Brain glutamatergic characteristics of pediatric offspring of parents with bipolar disorder
Singh, M., Spielman, D., Adleman, N., Alegria, D., Howe, M., & Chang, K. (2010). Brain glutamatergic characteristics of pediatric offspring of parents with bipolar disorder. PSYCHIATRY RESEARCH-NEUROIMAGING, 182(2), 165-171.

Course and impact of bipolar disorder in young patients.
Chang, K. D. (2010). Course and impact of bipolar disorder in young patients. journal of clinical psychiatry, 71(2).

Neural Correlates of Response Inhibition in Pediatric Bipolar Disorder
Singh, M. K., Chang, K. D., Mazaika, P., Garrett, A., Adleman, N., & Reiss, A. (2010). Neural Correlates of Response Inhibition in Pediatric Bipolar Disorder. JOURNAL OF CHILD AND ADOLESCENT PSYCHOPHARMACOLOGY, 20(1), 15-24.

Psychotropic Medication Exposure and Age at Onset of Bipolar Disorder in Offspring of Parents with Bipolar Disorder
Chang, K. D., Saxena, K., Howe, M., & Simeonova, D. (2010). Psychotropic Medication Exposure and Age at Onset of Bipolar Disorder in Offspring of Parents with Bipolar Disorder. JOURNAL OF CHILD AND ADOLESCENT PSYCHOPHARMACOLOGY, 20(1), 25-32.

Atypical Antipsychotics for Acute Manic and Mixed Episodes in Children and Adolescents with Bipolar Disorder Efficacy and Tolerability
Singh, M. K., Ketter, T. A., & Chang, K. D. (2010). Atypical Antipsychotics for Acute Manic and Mixed Episodes in Children and Adolescents with Bipolar Disorder Efficacy and Tolerability. DRUGS, 70(4), 433-442.

Diagnosing bipolar disorder in children and adolescents.
Chang, K. D. (2009). Diagnosing bipolar disorder in children and adolescents. journal of clinical psychiatry, 70(11).

Atomoxetine as an Adjunct Therapy in the Treatment of Co-Morbid Attention-Deficit/Hyperactivity Disorder in Children and Adolescents with Bipolar I or II Disorder
Chang, K., Nayar, D., Howe, M., & Rana, M. (2009). Atomoxetine as an Adjunct Therapy in the Treatment of Co-Morbid Attention-Deficit/Hyperactivity Disorder in Children and Adolescents with Bipolar I or II Disorder. JOURNAL OF CHILD AND ADOLESCENT PSYCHOPHARMACOLOGY, 19(5), 547-551.

Subcortical volumetric correlates of anxiety in familial pediatric bipolar disorder: A preliminary investigation
Simeonova, D. I., Jackson, V., Attalla, A., Karchemskiy, A., Howe, M., & Chang, K. (2009). Subcortical volumetric correlates of anxiety in familial pediatric bipolar disorder: A preliminary investigation. PSYCHIATRY RESEARCH-NEUROIMAGING, 173(2), 113-120.

Limbic and Corpus Callosum Aberrations in Adolescents with Bipolar Disorder: A Tract-Based Spatial Statistics Analysis
Barnea-Goraly, N., Chang, K. D., Karchemskiy, A., Howe, M. E., & Reiss, A. L. (2009). Limbic and Corpus Callosum Aberrations in Adolescents with Bipolar Disorder: A Tract-Based Spatial Statistics Analysis. BIOLOGICAL PSYCHIATRY, 66(3), 238-244.

A Double-Blind, Randomized, Placebo-Controlled Trial of Divalproex Extended-Release in the Treatment of Bipolar Disorder in Children and Adolescents
Wagner, K. D., Redden, L., Kowatch, R. A., Wilens, T. E., Segal, S., & Saltarelli, M. (2009). A Double-Blind, Randomized, Placebo-Controlled Trial of Divalproex Extended-Release in the Treatment of Bipolar Disorder in Children and Adolescents. JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY, 48(5), 519-532.

Effect of Divalproex on Brain Morphometry, Chemistry, and Function in Youth at High-Risk for Bipolar Disorder: A Pilot Study
Chang, K., Karchemskiy, A., Kelley, R., Howe, M., Garrett, A., & Reiss, A. (2009). Effect of Divalproex on Brain Morphometry, Chemistry, and Function in Youth at High-Risk for Bipolar Disorder: A Pilot Study. JOURNAL OF CHILD AND ADOLESCENT PSYCHOPHARMACOLOGY, 19(1), 51-59.

Challenges in the diagnosis and treatment of pediatric bipolar depression.
Chang, K. (2009). Challenges in the diagnosis and treatment of pediatric bipolar depression. Dialogues in clinical neuroscience, 11(1), 73-80.

The role of the amygdala in bipolar disorder development
Garrett, A., & Chang, K. (2008). The role of the amygdala in bipolar disorder development. DEVELOPMENT AND PSYCHOPATHOLOGY, 20(4), 1285-1296.

Prevention of bipolar disorder in at-risk children: Theoretical assumptions and empirical foundations
Miklowitz, D. J., & Chang, K. D. (2008). Prevention of bipolar disorder in at-risk children: Theoretical assumptions and empirical foundations. DEVELOPMENT AND PSYCHOPATHOLOGY, 20(3), 881-897.

A preliminary functional magnetic resonance imaging study of prefrontal-amygdalar activation changes in adolescents with bipolar depression treated with lamotrigine
Chang, K. D., Wagner, C., Garrett, A., Howe, M., & Reiss, A. (2008). A preliminary functional magnetic resonance imaging study of prefrontal-amygdalar activation changes in adolescents with bipolar depression treated with lamotrigine. BIPOLAR DISORDERS, 10(3), 426-431.

The bipolar spectrum in children and adolescents: developmental issues.
Chang, K. D. (2008). The bipolar spectrum in children and adolescents: developmental issues. journal of clinical psychiatry, 69(3).

The use of atypical antipsychotics in pediatric bipolar disorder
Chang, K. D. (2008). The use of atypical antipsychotics in pediatric bipolar disorder. JOURNAL OF CLINICAL PSYCHIATRY, 69, 4-8.

Divalproex sodium for the treatment of PTSD and conduct disordered youth: A pilot randomized controlled clinical trial
Steiner, H., Saxena, K. S., Carrion, V., Khanzode, L. A., Silverman, M., & Chang, K. (2007). Divalproex sodium for the treatment of PTSD and conduct disordered youth: A pilot randomized controlled clinical trial. CHILD PSYCHIATRY & HUMAN DEVELOPMENT, 38(3), 183-193.

Adult bipolar disorder is continuous with pediatric bipolar disorder
Chang, K. (2007). Adult bipolar disorder is continuous with pediatric bipolar disorder. CANADIAN JOURNAL OF PSYCHIATRY-REVUE CANADIENNE DE PSYCHIATRIE, 52(7), 418-425.

A pilot study of antidepressant-induced mania in pediatric bipolar disorder: Characteristics, risk factors, and the serotonin transporter gene
Baumer, F. M., Howe, M., Gallelli, K., Simeonova, D. L., Hallmayer, J., & Chang, K. D. (2006). A pilot study of antidepressant-induced mania in pediatric bipolar disorder: Characteristics, risk factors, and the serotonin transporter gene. BIOLOGICAL PSYCHIATRY, 60(9), 1005-1012.

Will neuroimaging ever be used to diagnose pediatric bipolar disorder?
Chang, K., Adleman, N., Wagner, C., Barnea-Goraly, N., & Garrett, A. (2006). Will neuroimaging ever be used to diagnose pediatric bipolar disorder?. DEVELOPMENT AND PSYCHOPATHOLOGY, 18(4), 1133-1146.

Efficacy profiles of psychopharmacology: Divalproex sodium in conduct disorder
Khanzode, L. A., Saxena, K., Kraemer, H., Chang, K., & Steiner, H. (2006). Efficacy profiles of psychopharmacology: Divalproex sodium in conduct disorder. CHILD PSYCHIATRY & HUMAN DEVELOPMENT, 37(1), 55-64.

Treatment of aggression with risperidone in children and adolescents with bipolar disorder: a case series
Saxena, K., Chang, K., & Steiner, H. (2006). Treatment of aggression with risperidone in children and adolescents with bipolar disorder: a case series. BIPOLAR DISORDERS, 8(4), 405-410.

Divalproex sodium reduces overall aggression in youth at high risk for bipolar disorder
Saxena, K., Howe, M., Simeonova, D., Steiner, H., & Chang, K. (2006). Divalproex sodium reduces overall aggression in youth at high risk for bipolar disorder. JOURNAL OF CHILD AND ADOLESCENT PSYCHOPHARMACOLOGY, 16(3), 252-259.

An open-label study of lamotrigine adjunct or monotherapy for the treatment of adolescents with bipolar depression
Chang, K., Saxena, K., & Howe, M. (2006). An open-label study of lamotrigine adjunct or monotherapy for the treatment of adolescents with bipolar depression. JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY, 45(3), 298-304.

Prevention of pediatric bipolar disorder - Integration of neurobiological and psychosocial processes
Chang, K., Howe, M., Gallelli, K., & Miklowitz, D. (2006). Prevention of pediatric bipolar disorder - Integration of neurobiological and psychosocial processes. RESILIENCE IN CHILDREN, 1094, 235-247.

Bipolar disorder in children and adolescents: international perspective on epidemiology and phenomenology
Soutullo, C. A., Chang, K. D., Diez-Suarez, A., Figueroa-Quintana, A., Escamilla-Canales, I., & Ortuno, F. (2005). Bipolar disorder in children and adolescents: international perspective on epidemiology and phenomenology. BIPOLAR DISORDERS, 7(6), 497-506.

N-acetylaspartate levels in bipolar offspring with and at high-risk for bipolar disorder
Gallelli, K. A., Wagner, C. M., Karchemskiy, A., Howe, M., Spielman, D., & Chang, K. D. (2005). N-acetylaspartate levels in bipolar offspring with and at high-risk for bipolar disorder. BIPOLAR DISORDERS, 7(6), 589-597.

Baseline predictors of response to divalproex in conduct disorder
Saxena, K., Silverman, M. A., Chang, K., Khanzode, L., & Steiner, H. (2005). Baseline predictors of response to divalproex in conduct disorder. JOURNAL OF CLINICAL PSYCHIATRY, 66(12), 1541-1548.

Atomoxetine for the treatment of attention-deficit/hyperactivity disorder in children and adolescents with bipolar disorders
Hah, M., & Chang, K. K. (2005). Atomoxetine for the treatment of attention-deficit/hyperactivity disorder in children and adolescents with bipolar disorders. JOURNAL OF CHILD AND ADOLESCENT PSYCHOPHARMACOLOGY, 15(6), 996-1004.

Creativity in familial bipolar disorder
Simeonova, D. I., Chang, K. D., Strong, C., & Ketter, T. A. (2005). Creativity in familial bipolar disorder. JOURNAL OF PSYCHIATRIC RESEARCH, 39(6), 623-631.

Cortical magnetic resonance imaging findings in familial pediatric bipolar disorder
Chang, K., Barnea-Goraly, N., Karchemskiy, A., Simeonova, D. I., Barnes, P., & Reiss, A. L. (2005). Cortical magnetic resonance imaging findings in familial pediatric bipolar disorder. BIOLOGICAL PSYCHIATRY, 58(3), 197-203.

Reduced amygdalar gray matter volume in familial pediatric bipolar disorder
Chang, K., Karchemskiy, A., Barnea-Goraly, N., Garrett, A., Simeonova, D. I., & Reiss, A. (2005). Reduced amygdalar gray matter volume in familial pediatric bipolar disorder. JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY, 44(6), 565-573.

Divalproex sodium in the treatment of pediatric psychiatric disorders.
Rana, M., Khanzode, L., Karnik, N., Saxena, K., Chang, K., & Steiner, H. (2005). Divalproex sodium in the treatment of pediatric psychiatric disorders. Expert review of neurotherapeutics, 5(2), 165-176.

Attention and memory biases in the offspring of parents with bipolar disorder: indications from a pilot study
Gotlib, I. H., Traill, S. K., Montoya, R. L., Joormann, J., & Chang, K. (2005). Attention and memory biases in the offspring of parents with bipolar disorder: indications from a pilot study. JOURNAL OF CHILD PSYCHOLOGY AND PSYCHIATRY, 46(1), 84-93.

Practical Clues to Early Recognition of Bipolar Disorder: A Primary Care Approach.
Swann, A. C., Geller, B., Post, R. M., Altshuler, L., Chang, K. D., & Juster, I. A. (2005). Practical Clues to Early Recognition of Bipolar Disorder: A Primary Care Approach. Primary care companion to the Journal of clinical psychiatry, 7(1), 15-21.

Anomalous prefrontal-subcortical activation in familial pediatric bipolar disorder - A functional magnetic resonance imaging investigation
Chang, K., Adleman, N. E., Dienes, K., Simeonova, D. I., Menon, V., & Reiss, A. (2004). Anomalous prefrontal-subcortical activation in familial pediatric bipolar disorder - A functional magnetic resonance imaging investigation. ARCHIVES OF GENERAL PSYCHIATRY, 61(8), 781-792.

Review of magnetic resonance imaging and spectroscopy studies in children with bipolar disorder.
Adleman, N. E., Barnea-Goraly, N., & Chang, K. D. (2004). Review of magnetic resonance imaging and spectroscopy studies in children with bipolar disorder. Expert review of neurotherapeutics, 4(1), 69-77.

Studies of offspring of parents with bipolar disorder
Chang, K., Steiner, H., & Ketter, T. (2003). Studies of offspring of parents with bipolar disorder. AMERICAN JOURNAL OF MEDICAL GENETICS PART C-SEMINARS IN MEDICAL GENETICS, 123C(1), 26-35.

Temperament characteristics of child and adolescent bipolar offspring
Chang, K. D., Blasey, C. M., Ketter, T. A., & Steiner, H. (2003). Temperament characteristics of child and adolescent bipolar offspring. JOURNAL OF AFFECTIVE DISORDERS, 77(1), 11-19.

Divalproex monotherapy in the treatment of bipolar offspring with mood and behavioral disorders and at least mild affective symptoms
Chang, K. D., Dienes, K., Blasey, C., Adleman, N., Ketter, T., & Steiner, H. (2003). Divalproex monotherapy in the treatment of bipolar offspring with mood and behavioral disorders and at least mild affective symptoms. JOURNAL OF CLINICAL PSYCHIATRY, 64(8), 936-942.

Decreased N-acetylaspartate in children with familial bipolar disorder
Chang, K., Adleman, N., Dienes, K., Barnea-Goraly, N., Reiss, A., & Ketter, T. (2003). Decreased N-acetylaspartate in children with familial bipolar disorder. BIOLOGICAL PSYCHIATRY, 53(11), 1059-1065.

Bipolar offspring: A window into bipolar disorder evolution
Chang, K., Steiner, H., Dienes, K., Adleman, N., & Ketter, T. (2003). Bipolar offspring: A window into bipolar disorder evolution. BIOLOGICAL PSYCHIATRY, 53(11), 945-951.

Psychopharmacologic strategies for the treatment of aggression in juveniles
Steiner, H., Saxena, K., & Chang, K. (2003). Psychopharmacologic strategies for the treatment of aggression in juveniles. CNS SPECTRUMS, 8(4), 298-308.

Characterization of children of bipolar parents by parent report CBCL
Dienes, K. A., Chang, K. D., Blasey, C. M., Adleman, N. E., & Steiner, H. (2002). Characterization of children of bipolar parents by parent report CBCL. JOURNAL OF PSYCHIATRIC RESEARCH, 36(5), 337-345.

Special issues in the treatment of paediatric bipolar disorder.
Chang, K. D., & Ketter, T. A. (2001). Special issues in the treatment of paediatric bipolar disorder. Expert opinion on pharmacotherapy, 2(4), 613-622.

Family environment of children and adolescents with bipolar parents
Chang, K. D., Blasey, C., Ketter, T. A., & Steiner, H. (2001). Family environment of children and adolescents with bipolar parents. BIPOLAR DISORDERS, 3(2), 73-78.

Psychiatric phenomenology of child and adolescent bipolar offspring
Chang, K. Kd., Steiner, H., & Ketter, T. A. (2000). Psychiatric phenomenology of child and adolescent bipolar offspring. JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY, 39(4), 453-460.

Mood stabilizer augmentation with olanzapine in acutely manic children
Chang, K. D., & Ketter, T. A. (2000). Mood stabilizer augmentation with olanzapine in acutely manic children. JOURNAL OF CHILD AND ADOLESCENT PSYCHOPHARMACOLOGY, 10(1), 45-49.

Differences in thyroid function between bipolar manic and mixed states
Chang, K. D., Keck, P. E., Stanton, S. P., McElroy, S. L., Strakowski, S. M., & Geracioti, T. D. (1998). Differences in thyroid function between bipolar manic and mixed states. BIOLOGICAL PSYCHIATRY, 43(10), 730-733.