Samuel Cheshier

Neurosurgeon

Assistant Professor of Neurosurgery and, by courtesy, of Neurology at the Lucile Salter Packard Children's Hospital

Professional Education

Fellowship: Hospital for Sick Children (2010) Canada

Fellowship: Lund Strategic Research Center for Stem Cell Biology and Cell Therapy (2009)

Residency: Stanford University School of Medicine (2008) CA

Internship: Stanford University School of Medicine (2002) CA

Medical Education: Stanford University School of Medicine (2001) CA

Time-Dependent Structural Changes of the Dentatothalamic Pathway in Children Treated for Posterior Fossa Tumor
Perreault, S., Lober, R. M., Cheshier, S., Partap, S., Edwards, M. S., & Yeom, K. W. (2014). Time-Dependent Structural Changes of the Dentatothalamic Pathway in Children Treated for Posterior Fossa Tumor. AMERICAN JOURNAL OF NEURORADIOLOGY, 35(4), 803-807.

BET Bromodomain Inhibition of MYC-Amplified Medulloblastoma
Bandopadhayay, P., Bergthold, G., Nguyen, B., Schubert, S., Gholamin, S., & Cho, Y.-J. (2014). BET Bromodomain Inhibition of MYC-Amplified Medulloblastoma. CLINICAL CANCER RESEARCH, 20(4), 912-925.

Multiplex meta-analysis of medulloblastoma expression studies with external controls.
Morgan, A. A., Achrol, A. S., Li, M. D., Khatri, P. J., & Cheshier, S. H. (2014). Multiplex meta-analysis of medulloblastoma expression studies with external controls. Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing, 99-109.

Roles of PINK1, mTORC2, and mitochondria in preserving brain tumor-forming stem cells in a noncanonical Notch signaling pathway
Lee, K.-S., Wu, Z., Song, Y., Mitra, S. S., Feroze, A. H., & Lu, B. (2013). Roles of PINK1, mTORC2, and mitochondria in preserving brain tumor-forming stem cells in a noncanonical Notch signaling pathway. GENES & DEVELOPMENT, 27(24), 2642-2647.

Primary surgical management by reduction and fixation of unstable hangman's fractures with discoligamentous instability or combined fractures
Shin, J. J., Kim, S. H., Cho, Y. E., Cheshier, S. H., & Park, J. (2013). Primary surgical management by reduction and fixation of unstable hangman's fractures with discoligamentous instability or combined fractures. JOURNAL OF NEUROSURGERY-SPINE, 19(5), 569-575.

Usp16 contributes to somatic stem-cell defects in Down's syndrome.
Adorno, M., Sikandar, S., Mitra, S. S., Kuo, A., Nicolis Di Robilant, B., & Clarke, M. F. (2013). Usp16 contributes to somatic stem-cell defects in Down's syndrome. Nature, 501(7467), 380-384.

Brain Tumor Stem Cell Multipotency Correlates with Nanog Expression and Extent of Passaging in Human Glioblastoma Xenografts
Higgins, D. M., Wang, R., Milligan, B., Schroeder, M., Carlson, B., & Henley, J. R. (2013). Brain Tumor Stem Cell Multipotency Correlates with Nanog Expression and Extent of Passaging in Human Glioblastoma Xenografts. ONCOTARGET, 4(5), 792-801.

Application of diffusion tensor tractography in pediatric optic pathway glioma.
Lober, R. M., Guzman, R., Cheshier, S. H., Fredrick, D. R., Edwards, M. Sb., & Yeom, K. W. (2012). Application of diffusion tensor tractography in pediatric optic pathway glioma. Journal of neurosurgery. Pediatrics, 10(4), 273-280.

The predictive value of serum myeloperoxidase for vasospasm in patients with aneurysmal subarachnoid hemorrhage
Lim, M., Bower, R. S., Wang, Y., Sims, L., Bower, M. R., & Guccione, S. (2012). The predictive value of serum myeloperoxidase for vasospasm in patients with aneurysmal subarachnoid hemorrhage. NEUROSURGICAL REVIEW, 35(3), 413-419.

A NEUROSURGEON'S GUIDE TO STEM CELLS, CANCER STEM CELLS, AND BRAIN TUMOR STEM CELLS
Cheshier, S. H., Kalani, M. Y. S., Lim, M., Ailles, L., Huhn, S. L., & Weissman, I. L. (2009). A NEUROSURGEON'S GUIDE TO STEM CELLS, CANCER STEM CELLS, AND BRAIN TUMOR STEM CELLS. NEUROSURGERY, 65(2), 237-249.

Wnt-Signaling in Retinal Development and Disease
Lad, E. M., Cheshier, S. H., & Kalani, M. Y. S. (2009). Wnt-Signaling in Retinal Development and Disease. STEM CELLS AND DEVELOPMENT, 18(1), 7-15.

Supraorbital approach for repair of open anterior skull base fracture Case report
Szabo, K. A., Cheshier, S. H., Kalani, M. Y. S., Kim, J. W., & Guzman, R. (2008). Supraorbital approach for repair of open anterior skull base fracture Case report. JOURNAL OF NEUROSURGERY-PEDIATRICS, 2(6), 420-423.

Wnt-mediated self-renewal of neural stem/progenitor cells
Kalani, M. Y. S., Cheshier, S. H., Cord, B. J., Bababeygy, S. R., Vogel, H., & Nusse, R. (2008). Wnt-mediated self-renewal of neural stem/progenitor cells. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 105(44), 16970-16975.

Stereotactic radiosurgery for a cardiac sarcoma: A case report
Soltys, S. G., Kalani, M. Y. S., Cheshier, S. H., Szabo, K. A., Lo, A., & Chang, S. D. (2008). Stereotactic radiosurgery for a cardiac sarcoma: A case report. TECHNOLOGY IN CANCER RESEARCH & TREATMENT, 7(5), 363-367.

Two-year-old girl with cervicomedullary junction stenosis and an unknown type of skeletal dysplasia
Cheshier, S. H., Kalani, M. Y. S., Pendakaur, A., Higgins, D., Kahn, D., & Shuer, L. (2008). Two-year-old girl with cervicomedullary junction stenosis and an unknown type of skeletal dysplasia. JOURNAL OF NEUROSURGERY-PEDIATRICS, 2(3), 200-202.

Radiation therapy and CyberKnife radiosurgery in the management of craniopharyngiomas
Lee, M., Kalani, M. Y. S., Cheshier, S., Gibbs, I. C., Adler, J. R., & Chang, S. D. (2008). Radiation therapy and CyberKnife radiosurgery in the management of craniopharyngiomas. NEUROSURGICAL FOCUS, 24(5).

Intracarotid injection of fluorescence activated cell-sorted CD49d-positive neural stem cells improves targeted cell delivery and behavior after stroke in a mouse stroke model
Guzman, R., De Los Angeles, A., Cheshier, S., Choi, R., Hoang, S., & Steinberg, G. (2008). Intracarotid injection of fluorescence activated cell-sorted CD49d-positive neural stem cells improves targeted cell delivery and behavior after stroke in a mouse stroke model. STROKE, 39(4), 1300-1306.

Hematopoietic stem cell-derived pericytic cells in brain tumor angio-architecture
Bababeygy, S. R., Cheshier, S. H., Hou, L. C., Higgins, D. Mo., Weissman, I. L., & Tse, V. Ck. (2008). Hematopoietic stem cell-derived pericytic cells in brain tumor angio-architecture. STEM CELLS AND DEVELOPMENT, 17(1), 11-18.

The effect of bleeding on hematopoietic stem cell cycling and self-renewal
Cheshier, S. H., Prohaska, S. S., & Weissman, I. L. (2007). The effect of bleeding on hematopoietic stem cell cycling and self-renewal. STEM CELLS AND DEVELOPMENT, 16(5), 707-717.

Cyberknife radiosurgery for lesions of the foramen magnum
Cheshier, S. H., Hanft, S. J., Adler, J. R., & Chang, S. D. (2007). Cyberknife radiosurgery for lesions of the foramen magnum. TECHNOLOGY IN CANCER RESEARCH & TREATMENT, 6(4), 329-335.

Cerebral myiasis associated with angiosarcoma of the scalp: case report.
Cheshier, S. H., Bababeygy, S. R., Higgins, D., Parsonnet, J., & Huhn, S. L. (2007). Cerebral myiasis associated with angiosarcoma of the scalp: case report. Neurosurgery, 61(1), E167-?.

CD90 expression segregates tumor-sphere forming cells in human glioblastoma multiforme
Cheshier, S. H., Ailles, L., Higgins, D. Mo., Lim, M., Kalani, M. Y. S., & Weissman, I. L. (2006). CD90 expression segregates tumor-sphere forming cells in human glioblastoma multiforme. NEURO-ONCOLOGY, 8(4), 471-471.

Incorporation of bone marrow-derived Flk-1-expressing CD34+ cells in the endothelium of tumor vessels in the mouse brain
Santarelli, J. G., Udani, V., Yung, Y. C., Cheshier, S., Wagers, A., & Tse, V. (2006). Incorporation of bone marrow-derived Flk-1-expressing CD34+ cells in the endothelium of tumor vessels in the mouse brain. NEUROSURGERY, 59(2), 374-381.

New vessel formation in the central nervous system during tumor growth, vascular malformations, and Moyamoya
Lim, M., Cheshier, S., & Steinberg, G. K. (2006). New vessel formation in the central nervous system during tumor growth, vascular malformations, and Moyamoya. CURRENT NEUROVASCULAR RESEARCH, 3(3), 237-245.

Differential expression of angiopoietin-1 and angiopoietin-2 may enhance recruitment of bone marrow-derived endothelial precursor cells into brain tumors
Udani, V., Santarelli, J., Yung, Y., Cheshier, S., Andrews, A., & Tse, V. (2005). Differential expression of angiopoietin-1 and angiopoietin-2 may enhance recruitment of bone marrow-derived endothelial precursor cells into brain tumors. NEUROLOGICAL RESEARCH, 27(8), 801-806.

Identification of phenotypic neural stem cells in a pediatric astroblastoma
Huhn, S. L., Yung, Y., Cheshier, S., Harsh, G., Ailles, L., & Tse, V. (2005). Identification of phenotypic neural stem cells in a pediatric astroblastoma. JOURNAL OF NEUROSURGERY, 103(5), 446-450.

Hematopoietic stem cells give rise to perivascular endothelial-like cells during brain tumor angiogenesis
Udani, M., Santarelli, G., Yung, Y. C., Wagers, A. J., Cheshier, S. H., & Tse, V. (2005). Hematopoietic stem cells give rise to perivascular endothelial-like cells during brain tumor angiogenesis. STEM CELLS AND DEVELOPMENT, 14(5), 478-486.

alpha(v)beta(3) integrin in central nervous system tumors
Lim, M., Guccione, S., Haddix, T., Sims, L., Cheshier, S., & Harsh, G. (2005). alpha(v)beta(3) integrin in central nervous system tumors. HUMAN PATHOLOGY, 36(6), 665-669.

Preuss Resident Research Award: bone marrow-derived Flk-1-expressing CD34+ cells contribute to the endothelium of tumor vessels in mouse brain.
Santarelli, J. G., Udani, V., Yung, C. Y., Cheshier, S., Wagers, A., & Tse, V. (2005). Preuss Resident Research Award: bone marrow-derived Flk-1-expressing CD34+ cells contribute to the endothelium of tumor vessels in mouse brain. Clinical neurosurgery, 52, 384-388.

Incorporation of naive bone marrow derived cells into the vascular architecture of brain tumor
Yung, Y. C., Cheshier, S., Santarelli, J. G., Huang, Z., Wagers, A., & Tse, V. (2004). Incorporation of naive bone marrow derived cells into the vascular architecture of brain tumor. MICROCIRCULATION, 11(8), 699-708.

Telomerase activation and rejuvenation of telomere length in stimulated T cells derived from serially transplanted hematopoietic stem cells
Allsopp, R. C., Cheshier, S., & Weissman, I. L. (2002). Telomerase activation and rejuvenation of telomere length in stimulated T cells derived from serially transplanted hematopoietic stem cells. JOURNAL OF EXPERIMENTAL MEDICINE, 196(11), 1427-1433.

Telomere shortening accompanies increased cell cycle activity during serial transplantation of hematopoietic stem cells
Allsopp, R. C., Cheshier, S., & Weissman, I. L. (2001). Telomere shortening accompanies increased cell cycle activity during serial transplantation of hematopoietic stem cells. JOURNAL OF EXPERIMENTAL MEDICINE, 193(8), 917-924.

Cyclophosphamide/granulocyte colony-stimulating factor causes selective mobilization of bone marrow hematopoietic stem cells into the blood after M phase of the cell cycle
Wright, D. E., Cheshier, S. H., Wagers, A. J., Randall, T. D., Christensen, J. L., & Weissman, I. L. (2001). Cyclophosphamide/granulocyte colony-stimulating factor causes selective mobilization of bone marrow hematopoietic stem cells into the blood after M phase of the cell cycle. BLOOD, 97(8), 2278-2285.

Inactivation of a GFP retrovirus occurs at multiple levels in long-term repopulating stem cells and their differentiated progeny
Klug, C. A., Cheshier, S., & Weissman, I. L. (2000). Inactivation of a GFP retrovirus occurs at multiple levels in long-term repopulating stem cells and their differentiated progeny. BLOOD, 96(3), 894-901.

The role of apoptosis in the regulation of hematopoietic stem cells: Overexpression of BCL-2 increases both their number and repopulation potential
Domen, J., Cheshier, S. H., & Weissman, I. L. (2000). The role of apoptosis in the regulation of hematopoietic stem cells: Overexpression of BCL-2 increases both their number and repopulation potential. JOURNAL OF EXPERIMENTAL MEDICINE, 191(2), 253-263.

In vivo proliferation and cell cycle kinetics of long-term self-renewing hematopoietic stem cells
Cheshier, S. P., Morrison, S. J., Liao, X. S., & Weissman, I. L. (1999). In vivo proliferation and cell cycle kinetics of long-term self-renewing hematopoietic stem cells. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 96(6), 3120-3125.

Lymphoid development from stem cells and the common lymphocyte progenitors
Akashi, K., Kondo, M., Cheshier, S., Shizuru, J., Gandy, K., & Weissman, I. L. (1999). Lymphoid development from stem cells and the common lymphocyte progenitors. COLD SPRING HARBOR SYMPOSIA ON QUANTITATIVE BIOLOGY, 64, 1-12.

Hematopoietic stem cells: Challenges to expectations
Morrison, S. J., Wright, D. E., Cheshier, S. H., & Weissman, I. L. (1997). Hematopoietic stem cells: Challenges to expectations. CURRENT OPINION IN IMMUNOLOGY, 9(2), 216-221.