Anthony G. Doufas, M.D., Ph.D.

Associate Professor of Anesthesiology, Perioperative and Pain Medicine at the Stanford University Medical Center

Professional Education

Fellowship: UCSF - Department of Anesthesia and Perioperative Care (2000) CA

Residency: University of Athens Medical School (1997) Greece

Internship: University of Athens Medical School (1993) Greece

Medical Education: Aristotle University of Thessaloniki (1991) Greece

Postdoctoral Research Fellowship, Department of Anesthesia, UCSF, Perioperative Thermoregulation (2000)

PhD, University of Athens, Greece, Endocrinology (1999)

Residency, University of Athens, Greece, Anesthesiology (1997)

MD, Aristotelian University, Greece, Medicine (1991)

Honors & Awards

Research Award, Department of Anesthesia, Stanford University School of Medicine (2011)

Research Award, Department of Anesthesia, Stanford University School of Medicine (2008)

Research Award, 28th Atlantic Anesthesiology Residents Research Conference (2002)

Research Award, International Union of Angiology (2001)

Research Award, European Society of Vascular Surgery (1998)

Research Award, Hellenic Endocrine Society (1998)

Research Award, Hellenic Society of Vascular Surgery (1997)

Research Award, Hellenic Society of Intensive Care Medicine (1997)

Research Award, Hellenic Hepatological Society (1997)

Administrative Appointments

Abstract Committee Chair, Society of Anesthesia and Sleep Medicine, 2013

Clinical Research Committee Member, Society of Anesthesia and Sleep Medicine, 2012

Abstract Committee Member, Society of Anesthesia and Sleep Medicine, 2012

Section Editor for Anesthetic Pharmacology, Current Anesthesiology Reports, 2011

Charter Member, Society of Anesthesia and Sleep Medicine, 2011

Associate Editor, International Society for Anaesthetic Pharmacology, 2011

Associate Editor, Anesthesia & Analgesia, International Anesthesia Research Society (IARS), 2008

Committee Member, Task Force for Obstructive Sleep Apnea, Stanford Hospital and Clinics, 2007

Director of Research, Department of Anesthesiology and Perioperative Medicine, University of Louisville, 2004

Clinical Trials

Clinical trials are research studies that evaluate a new medical approach, device, drug, or other treatment. As a Stanford Health Care patient, you have access to the latest, advanced clinical trials.

Open trials refer to studies currently accepting participants. Closed trials are not currently enrolling, but may open in the future.

Nocturnal Intermittent Hypoxia Is Independently Associated with Pain in Subjects Suffering from Sleep-disordered Breathing.
Doufas, A. G., Tian, L., Davies, M. F., & Warby, S. C. (2013). Nocturnal Intermittent Hypoxia Is Independently Associated with Pain in Subjects Suffering from Sleep-disordered Breathing. Anesthesiology, 119(5), 1149-1162.

Bispectral Index Dynamics During Propofol Hypnosis Is Similar in Red-Haired and Dark-Haired Subjects
Doufas, A. G., Orhan-Sungur, M., Komatsu, R., Lauber, R., Akca, O., & Sessler, D. I. (2013). Bispectral Index Dynamics During Propofol Hypnosis Is Similar in Red-Haired and Dark-Haired Subjects. ANESTHESIA AND ANALGESIA, 116(2), 319-326.

Experimental pain and opioid analgesia in volunteers at high risk for obstructive sleep apnea.
Doufas, A. G., Tian, L., Padrez, K. A., Suwanprathes, P., Cardell, J. A., & Panousis, P. (2013). Experimental pain and opioid analgesia in volunteers at high risk for obstructive sleep apnea. PloS one, 8(1).

Concordance of Sleep and Pain Outcomes of Diverse Interventions: An Umbrella Review
Doufas, A. G., Panagiotou, O. A., & Ioannidis, J. Pa. (2012). Concordance of Sleep and Pain Outcomes of Diverse Interventions: An Umbrella Review. PLOS ONE, 7(7).

Ventilator-associated pneumonia in critically ill stroke patients: Frequency, risk factors, and outcomes
Kasuya, Y., Hargett, J. L., Lenhardt, R., Heine, M. F., Doufas, A. G., & Akca, O. (2011). Ventilator-associated pneumonia in critically ill stroke patients: Frequency, risk factors, and outcomes. JOURNAL OF CRITICAL CARE, 26(3), 273-279.

Reinforcement Learning Versus Proportional-Integral-Derivative Control of Hypnosis in a Simulated Intraoperative Patient
Moore, B. L., Quasny, T. M., & Doufas, A. G. (2011). Reinforcement Learning Versus Proportional-Integral-Derivative Control of Hypnosis in a Simulated Intraoperative Patient. ANESTHESIA AND ANALGESIA, 112(2), 350-359.

Reinforcement Learning: A Novel Method for Optimal Control of Propofol-Induced Hypnosis
Moore, B. L., Doufas, A. G., & Pyeatt, L. D. (2011). Reinforcement Learning: A Novel Method for Optimal Control of Propofol-Induced Hypnosis. ANESTHESIA AND ANALGESIA, 112(2), 360-367.

An Adaptive Neural Network Filter for Improved Patient State Estimation in Closed-Loop Anesthesia Control
Borera, E. C., Moore, B. L., Doufas, A. G., & Pyeatt, L. D. (2011). An Adaptive Neural Network Filter for Improved Patient State Estimation in Closed-Loop Anesthesia Control. 2011 23RD IEEE INTERNATIONAL CONFERENCE ON TOOLS WITH ARTIFICIAL INTELLIGENCE (ICTAI 2011), 41-46.

The Performance of Compartmental and Physiologically Based Recirculatory Pharmacokinetic Models for Propofol: A Comparison Using Bolus, Continuous, and Target-Controlled Infusion Data
Masui, K., Upton, R. N., Doufas, A. G., Coetzee, J. F., Kazama, T., & Struys, M. Mrf. (2010). The Performance of Compartmental and Physiologically Based Recirculatory Pharmacokinetic Models for Propofol: A Comparison Using Bolus, Continuous, and Target-Controlled Infusion Data. ANESTHESIA AND ANALGESIA, 111(2), 368-379.

The Hippocratic Paradigm in Medicine: Origins of the Clinical Encounter
Doufas, A. G., & Saidman, L. J. (2010). The Hippocratic Paradigm in Medicine: Origins of the Clinical Encounter. ANESTHESIA AND ANALGESIA, 110(1), 4-6.

Neuromuscular Block Differentially Affects Immobility and Cortical Activation at Near-Minimum Alveolar Concentration Anesthesia
Doufas, A. G., Komatsu, R., Orhan-Sungur, M., Sengupta, P., Wadhwa, A., & Sessler, D. I. (2009). Neuromuscular Block Differentially Affects Immobility and Cortical Activation at Near-Minimum Alveolar Concentration Anesthesia. ANESTHESIA AND ANALGESIA, 109(4), 1097-1104.

Automated Responsiveness Monitor to Titrate Propofol Sedation
Doufas, A. G., Morioka, N., Mahgoub, A. N., Bjorksten, A. R., Shafer, S. L., & Sessler, D. I. (2009). Automated Responsiveness Monitor to Titrate Propofol Sedation. ANESTHESIA AND ANALGESIA, 109(3), 778-786.

Fuzzy Control for Closed-Loop, Patient-Specific Hypnosis in Intraoperative Patients: A Simulation Study
Moore, B. L., Pyeatt, L. D., & Doufas, A. G. (2009). Fuzzy Control for Closed-Loop, Patient-Specific Hypnosis in Intraoperative Patients: A Simulation Study. 2009 ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY, VOLS 1-20, 3083-3086.

Lower-body warming mimics the normal epidural-induced reduction in the shivering threshold
Doufas, A. G., Morioka, N., Maghoub, A. N., Mascha, E., & Sessler, D. I. (2008). Lower-body warming mimics the normal epidural-induced reduction in the shivering threshold. ANESTHESIA AND ANALGESIA, 106(1), 252-256.

Influence of administration rate on propofol plasma - Effect site equilibration
Struys, M. Mrf., Coppens, M. J., De Neve, N., Mortier, E. P., Doufas, A. G., & Shafer, S. L. (2007). Influence of administration rate on propofol plasma - Effect site equilibration. ANESTHESIOLOGY, 107(3), 386-396.

Sitting position does not alter minimum alveolar concentration for desflurane
Lin, C.-M., Wu, C.-T., Lee, S.-T., Lui, T.-N., Huang, C.-C., & Doufas, A. G. (2007). Sitting position does not alter minimum alveolar concentration for desflurane. CANADIAN JOURNAL OF ANAESTHESIA-JOURNAL CANADIEN D ANESTHESIE, 54(7), 523-530.

Tissue oxygenation response to mild hypercapnia during cardiopulmonary bypass with constant pump output
Akca, O., Sessler, D. I., Delong, D., Keijner, R., Ganzel, B., & Doufas, A. G. (2006). Tissue oxygenation response to mild hypercapnia during cardiopulmonary bypass with constant pump output. BRITISH JOURNAL OF ANAESTHESIA, 96(6), 708-714.

Postoperative coma in a patient with complete basilar syndrome after anterior cervical discectomy
Tsai, Y. F., Doufas, A. G., Huang, C. S., Liou, F. C., & Lin, C. M. (2006). Postoperative coma in a patient with complete basilar syndrome after anterior cervical discectomy. CANADIAN JOURNAL OF ANAESTHESIA-JOURNAL CANADIEN D ANESTHESIE, 53(2), 202-207.

Effects of dopexamine on lipid peroxidation during aortic surgery in pigs: Comparison with dopamine
Kostopanagiotou, G., Pandazi, A., Andreadou, I., Doufas, A., Chondroudaki, I., & Smyrniotis, V. (2005). Effects of dopexamine on lipid peroxidation during aortic surgery in pigs: Comparison with dopamine. EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY, 30(6), 648-653.

Recurrent seizure activity after epidural morphine in a post-partum woman
SHIH, C. J., Doufas, A. G., Chang, H. C., & Lin, C. M. (2005). Recurrent seizure activity after epidural morphine in a post-partum woman. CANADIAN JOURNAL OF ANAESTHESIA-JOURNAL CANADIEN D ANESTHESIE, 52(7), 727-729.

Magnesium sulphate only slightly reduces the shivering threshold in humans
Wadhwa, A., Sengupta, P., Durrani, J., Akca, O., Lenhardt, R., & Doufas, A. G. (2005). Magnesium sulphate only slightly reduces the shivering threshold in humans. BRITISH JOURNAL OF ANAESTHESIA, 94(6), 756-762.

The timing of acupuncture stimulation does not influence anesthetic requirement
Chernyak, G., Sengupta, P., Lenhardt, R., Liem, E., Doufas, A. G., & Akca, O. (2005). The timing of acupuncture stimulation does not influence anesthetic requirement. ANESTHESIA AND ANALGESIA, 100(2), 387-392.

Effects of transient myocardial ischemia on the ventricular defibrillation threshold
Anastasiou-Nana, M. I., Tsagalou, E. P., Charitos, C., Siafakas, K. X., Drakos, S., & Nanas, J. N. (2005). Effects of transient myocardial ischemia on the ventricular defibrillation threshold. PACE-PACING AND CLINICAL ELECTROPHYSIOLOGY, 28(2), 97-101.

Induction speed is not a determinant of propofol pharmacodynamics
Doufas, A. G., Bakhshandeh, M., Bjorksten, A. R., Shafer, S. L., & Sessler, D. I. (2004). Induction speed is not a determinant of propofol pharmacodynamics. ANESTHESIOLOGY, 101(5), 1112-1121.

Block-dependent sedation during epidural anaesthesia is associated with delayed brainstem conduction
Doufas, A. G., Wadhwa, A., Shah, Y. M., Lin, C. M., Haugh, G. S., & Sessler, D. I. (2004). Block-dependent sedation during epidural anaesthesia is associated with delayed brainstem conduction. BRITISH JOURNAL OF ANAESTHESIA, 93(2), 228-234.

Anesthetic requirement is increased in redheads
Liem, E. B., Lin, C. M., Suleman, M. I., Doufas, A. G., Gregg, R. G., & Sessler, D. I. (2004). Anesthetic requirement is increased in redheads. ANESTHESIOLOGY, 101(2), 279-283.

The new perilaryngeal airway (CobraPLA (TM)) is as efficient as the laryngeal mask airway (LMA (TM)) but provides better airway sealing pressures
Akca, O., Wadhwa, A., Sengupta, P., Durrani, J., Hanni, K., & Sessler, D. I. (2004). The new perilaryngeal airway (CobraPLA (TM)) is as efficient as the laryngeal mask airway (LMA (TM)) but provides better airway sealing pressures. ANESTHESIA AND ANALGESIA, 99(1), 272-278.

Dantrolene reduces the threshold and gain for shivering
Lin, C. M., Neeru, S., Doufas, A. G., Liem, E., Shah, Y. M., & Kurz, A. (2004). Dantrolene reduces the threshold and gain for shivering. ANESTHESIA AND ANALGESIA, 98(5), 1318-1324.

Time course of fibrillation and defibrillation thresholds after an intravenous bolus of amiodarone - an experimental study
Tsagalou, E. P., Anastasiou-Nana, M. I., Charitos, C. E., Siafakas, C. X., Drakos, S. G., & Nanas, J. N. (2004). Time course of fibrillation and defibrillation thresholds after an intravenous bolus of amiodarone - an experimental study. RESUSCITATION, 61(1), 83-89.

Physiology and clinical relevance of induced hypothermia
Doufas, A. G., & Sessler, D. I. (2004). Physiology and clinical relevance of induced hypothermia. NEUROCRITICAL CARE, 1(4), 489-498.

Midazolam causes less sedation in volunteers with red hair
Chua, M. V., Tsueda, K., & Doufas, A. G. (2004). Midazolam causes less sedation in volunteers with red hair. CANADIAN JOURNAL OF ANAESTHESIA-JOURNAL CANADIEN D ANESTHESIE, 51(1), 25-30.

Consequences of inadvertent perioperative hypothermia.
Doufas, A. G. (2003). Consequences of inadvertent perioperative hypothermia. Best practice & research. Clinical anaesthesiology, 17(4), 535-549.

Women have the same desflurane minimum alveolar concentration as men - A prospective study
Wadhwa, A., Durrani, J., Sengupta, P., Doufas, A. G., & Sessler, D. I. (2003). Women have the same desflurane minimum alveolar concentration as men - A prospective study. ANESTHESIOLOGY, 99(5), 1062-1065.

T-4 but not T-3 administration is associated with increased recurrence of Graves' disease after successful medical therapy
Mastorakos, G., Doufas, A. G., Mantzos, E., Mantzos, J., & Koutras, D. A. (2003). T-4 but not T-3 administration is associated with increased recurrence of Graves' disease after successful medical therapy. JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION, 26(10), 979-984.

A new system to target the effect-site during propofol sedation
Doufas, A. G., Bakhshandeh, M., Bjorksten, A. R., Greif, R., & Sessler, D. I. (2003). A new system to target the effect-site during propofol sedation. ACTA ANAESTHESIOLOGICA SCANDINAVICA, 47(8), 944-950.

Automated responsiveness test and bispectral index monitoring during propofol and propofol/N2O sedation
Doufas, A. G., Bakhshandeh, M., Haugh, G. S., Bjorksten, A. R., Greif, R., & Sessler, D. I. (2003). Automated responsiveness test and bispectral index monitoring during propofol and propofol/N2O sedation. ACTA ANAESTHESIOLOGICA SCANDINAVICA, 47(8), 951-957.

Blood pressure response to thermoregulatory vasoconstriction during isoflurane and desflurane anesthesia
Greif, R., Laciny, S., Rajek, A., Doufas, A. G., & Sessler, D. I. (2003). Blood pressure response to thermoregulatory vasoconstriction during isoflurane and desflurane anesthesia. ACTA ANAESTHESIOLOGICA SCANDINAVICA, 47(7), 847-852.

Neither arm nor face warming reduces the shivering threshold in unanesthetized humans
Doufas, A. G., Wadhwa, A., Lin, C. M., Shah, Y. M., Hanni, K., & Sessler, D. I. (2003). Neither arm nor face warming reduces the shivering threshold in unanesthetized humans. STROKE, 34(7), 1736-1740.

Experimental surgery in infrarenal aorta and sigmoid ischemia
Katsenis, K., Kotsis, T., Pafiti, A., Doufas, A., & Dimakakos, P. (2003). Experimental surgery in infrarenal aorta and sigmoid ischemia. INTERNATIONAL ANGIOLOGY, 22(2), 159-163.

Effect of intra-operative end-tidal carbon dioxide partial pressure on tissue oxygenation
Akca, O., Liem, E., Suleman, M. I., Doufas, A. G., Galandiuk, S., & Sessler, D. I. (2003). Effect of intra-operative end-tidal carbon dioxide partial pressure on tissue oxygenation. ANAESTHESIA, 58(6), 536-542.

Dexmedetomidine and meperidine additively reduce the shivering threshold in humans
Doufas, A. G., Lin, C. M., Suleman, M. I., Liem, E. B., Lenhardt, R., & Sessler, D. I. (2003). Dexmedetomidine and meperidine additively reduce the shivering threshold in humans. STROKE, 34(5), 1218-1223.

Initial experience with a novel heat-exchanging catheter in neurosurgical patients
Doufas, A. G., Akca, O., Barry, A., Petrusca, D. A., Suleman, M. I., & Sessler, D. I. (2002). Initial experience with a novel heat-exchanging catheter in neurosurgical patients. ANESTHESIA AND ANALGESIA, 95(6), 1752-1756.

Hypercapnia improves tissue oxygenation
Akca, O., Doufas, A. G., Morioka, N., Iscoe, S., Fisher, J., & Sessler, D. I. (2002). Hypercapnia improves tissue oxygenation. ANESTHESIOLOGY, 97(4), 801-806.

Electro-acupuncture at the Zusanli, Yanglingquan, and Kunlun points does not reduce anesthetic requirement
Morioka, N., Akca, O., Doufas, A. G., Chernyak, G., & Sessler, D. I. (2002). Electro-acupuncture at the Zusanli, Yanglingquan, and Kunlun points does not reduce anesthetic requirement. ANESTHESIA AND ANALGESIA, 95(1), 98-102.

Insufficiency in a new temporal-artery thermometer for adult and pediatric patients
Suleman, M. I., Doufas, A. G., Akca, O., Ducharme, M., & Sessler, D. I. (2002). Insufficiency in a new temporal-artery thermometer for adult and pediatric patients. ANESTHESIA AND ANALGESIA, 95(1), 67-71.

Use of selective opiate receptor inhibitors to prevent postoperative ileus.
Akça, O., Doufas, A. G., & Sessler, D. I. (2002). Use of selective opiate receptor inhibitors to prevent postoperative ileus. Minerva anestesiologica, 68(4), 162-165.

The threshold and gain of thermoregulatory vasoconstriction differs during anesthesia in the dependent and upper arms in the lateral position
Greif, R., Laciny, S., Rajek, A., Doufas, A. G., & Sessler, D. I. (2002). The threshold and gain of thermoregulatory vasoconstriction differs during anesthesia in the dependent and upper arms in the lateral position. ANESTHESIA AND ANALGESIA, 94(4), 1019-1022.

Oxygen free radicals in abdominal aortic surgery - An experimental study
Dimakakos, P. B., Kotsis, T., Kondi-Pafiti, A., Katsenis, K., Doufas, A., & Kouskouni, E. (2002). Oxygen free radicals in abdominal aortic surgery - An experimental study. JOURNAL OF CARDIOVASCULAR SURGERY, 43(1), 77-82.

Transcutaneous electrical stimulation of an auricular acupuncture point decreases anesthetic requirement
Greif, R., Laciny, S., Mokhtarani, M., Doufas, A. G., Bakhshandeh, M., & Sessler, D. I. (2002). Transcutaneous electrical stimulation of an auricular acupuncture point decreases anesthetic requirement. ANESTHESIOLOGY, 96(2), 306-312.

Buspirone and meperidine synergistically reduce the shivering threshold
Mokhtarani, M., Mahgoub, A. N., Morioka, N., Doufas, A. G., Dae, M., & Sessler, D. L. (2001). Buspirone and meperidine synergistically reduce the shivering threshold. ANESTHESIA AND ANALGESIA, 93(5), 1233-1239.

Neither nalbuphine nor atropine posses special antishivering activity
Greif, R., Laciny, S., Rajek, A. M., Larson, M. D., Bjorksten, A. R., & Sessler, D. I. (2001). Neither nalbuphine nor atropine posses special antishivering activity. ANESTHESIA AND ANALGESIA, 93(3), 620-627.

Use of an isolated pancreatic graft (ex vivo) of swine as model for drug studies
Papalois, A., Smyrniotis, V., Papadimitriou, L., Syriou, V., Konstantellou, E., & Tolis, G. (2001). Use of an isolated pancreatic graft (ex vivo) of swine as model for drug studies. TRANSPLANTATION PROCEEDINGS, 33(3), 2298-2299.

Automated responsiveness test (ART) predicts loss of consciousness and adverse physiologic responses during propofol conscious sedation
Doufas, A. G., Bakhshandeh, M., Bjorksten, A. R., Greif, R., & Sessler, D. I. (2001). Automated responsiveness test (ART) predicts loss of consciousness and adverse physiologic responses during propofol conscious sedation. ANESTHESIOLOGY, 94(4), 585-592.

Effect of balloon angioplasty and stenting following clips vs suture arterial stenosis: an experimental study
Dimakakos, P. B., Kotsis, T., Doufas, A., Pafiti-Condi, A., Tsiligiris, B., & Mourikis, D. (2000). Effect of balloon angioplasty and stenting following clips vs suture arterial stenosis: an experimental study. VASA-JOURNAL OF VASCULAR DISEASES, 29(1), 35-39.

The hypothalamic-pituitary-thyroid axis and the female reproductive system
Doufas, A. G., & Mastorakos, G. (2000). The hypothalamic-pituitary-thyroid axis and the female reproductive system. YOUNG WOMAN AT THE RISE OF THE 21ST CENTURY: GYNECOLOGICAL AND REPRODUCTIVE ISSUES IN HEALTH AND DISEASE, 900, 65-76.

Predominant form of non-toxic goiter in Greece is now autoimmune thyroiditis
Doufas, A. G., Mastorakos, G., Chatziioannou, S., Tseleni-Balafouta, S., Piperingos, G., & Koutras, D. A. (1999). Predominant form of non-toxic goiter in Greece is now autoimmune thyroiditis. EUROPEAN JOURNAL OF ENDOCRINOLOGY, 140(6), 505-511.

Venous repair with vascular clips and conventional suture: A comparative experimental study
Dimakakos, P. B., Pafiti-Kondi, A., Doufas, A., Kotsis, T., Mourikis, D., & Rizos, D. (1999). Venous repair with vascular clips and conventional suture: A comparative experimental study. PHLEBOLOGY, 14(2), 65-70.

The cerebral effects of carbon dioxide during digital subtraction angiography in the aortic arch and its branches in rabbits
Dimakakos, P. B., Stefanopoulos, T., Doufas, A. G., Papasava, M., Gouliamos, A., & Deligiorgi, H. (1998). The cerebral effects of carbon dioxide during digital subtraction angiography in the aortic arch and its branches in rabbits. AMERICAN JOURNAL OF NEURORADIOLOGY, 19(2), 261-266.

Hyperthyroidism in McCune-Albright syndrome with a review of thyroid abnormalities sixty years after the first report
Mastorakos, G., Mitsiades, N. S., Doufas, A. G., & Koutras, D. A. (1997). Hyperthyroidism in McCune-Albright syndrome with a review of thyroid abnormalities sixty years after the first report. THYROID, 7(3), 433-439.

First experimental study of carbon dioxide digital subtraction lymphangiography
Dimakakos, P. B., Papasavva, M., Stefanopoulos, T., Mourikis, D., Kostopanagiotou, G., & Doufas, A. (1997). First experimental study of carbon dioxide digital subtraction lymphangiography. EUROPEAN JOURNAL OF PLASTIC SURGERY, 20(3), 132-135.