John W. Day, MD, PhD

Neuromuscular neurologist

Neurophysiologist

Neuromuscular Program

  • 211 Quarry Road
  • Palo Alto, CA 94304
  • Phone: 650-723-6469
Learn More About the Clinic Getting Here Make An Appointment

Neurodiagnostic Labs

  • 300 Pasteur Drive
  • Stanford, CA 94305
  • Phone: 650-723-6888
Learn More About the Clinic Getting Here Make An Appointment

Professional Education

Board Certification: Neuromuscular Disease, American Board of Psychiatry and Neurology (2011)

Internship: Montefiore Medical Center - Albert Einstein College of Medicine (1983) NY

Professional Education: Albert Einstein College of Medicine (1982) NY

Medical Education: University of Minnesota School of Medicine (1977) MN

Fellowship: UCSF (1987) CA

Board Certification: Neurology, American Board of Psychiatry and Neurology (1988)

Residency: UCSF (1986) CA

Ph.D, Albert Einstein College of Medicine, Neuroscience (1982)

M.D, University of Minnesota, Medicine (1977)

BA, Oberlin College, Physics (1973)

Honors & Awards

Recognized among Best Physicians in Minnesota, Twin Cities Magazine (2010)

All University Post-Baccalaureate Teaching Award, University of Minnesota (2007)

All University Post-Baccalaureate Teaching Award, All University Post-Baccalaureate Teaching Award (2007)

Distinguished Teaching Award, University of Minnesota Medical School (2005)

Outstanding Teaching Award, University of Minnesota Medical School (2005)

Distinguished Teaching Award, University of Minnesota Medical School (2003)

Leon Poliachik Humanitarian Award, University of Minnesota ALS Clinic (2002)

Distinguished Teaching Award, University of Minnesota Medical School (2001)

Distinguished Teaching Award, University of Minnesota Medical School (1996)

Clinical Investigator Development Award, NINCDS, NIH (1986)

Distinguished Teaching Award, University of California San Francisco (1985)

Grass Foundation Fellow in Neurophysiology, Marine Biological Lab, Woods Holes, MA (1978)

Administrative Appointments

Director, Neuromuscular Division and Clinics, Stanford University, 2011

Director, Paul and Sheila Wellstone Muscular Dystrophy Center, U of MN, 2003

Institute of Human Genetics, Executive Board, University of Minnesota, 1999

Associate Head for Clinical Affairs, Neurology Department, U of MN, 1999

Medical Director, Clinical, Neuroscience Research Unit, 1997

Director, Center for Muscle Disorders, University of Minnesota, 1996

Clinical Trials

Clinical trials are research studies that evaluate a new medical approach, device, drug, or other treatment. As a Stanford Hospital & Clinics patient, you have access to the latest, advanced clinical trials.

Open trials refer to studies currently accepting participants. Closed trials are not currently enrolling, but may open in the future.

United Dystrophinopathy Project. LTBP4 genotype predicts age of ambulatory loss in duchenne muscular dystrophy
JW Day. United Dystrophinopathy Project. LTBP4 genotype predicts age of ambulatory loss in duchenne muscular dystrophy, (23440719).

Role of telomere dysfunction in cardiac failure in Duchenne muscular dystrophy.
Mourkioti, F., Kustan, J., Kraft, P., Day, J. W., Zhao, M.-M., & Blau, H. M. (2013). Role of telomere dysfunction in cardiac failure in Duchenne muscular dystrophy. Nature cell biology, 15(8), 895-904.

Motor and cognitive assessment of infants and young boys with Duchenne Muscular Dystrophy: results from the Muscular Dystrophy Association DMD Clinical Research Network.
Connolly, A. M., Florence, J. M., Cradock, M. M., Malkus, E. C., Schierbecker, J. R., & Eagle, M. (2013). Motor and cognitive assessment of infants and young boys with Duchenne Muscular Dystrophy: results from the Muscular Dystrophy Association DMD Clinical Research Network. Neuromuscular disorders , 23(7), 529-539.

Diffusion tensor imaging reveals widespread white matter abnormalities in children and adolescents with myotonic dystrophy type 1
Wozniak, J. R., Mueller, B. A., Bell, C. J., Muetzel, R. L., Lim, K. O., & Day, J. W. (2013). Diffusion tensor imaging reveals widespread white matter abnormalities in children and adolescents with myotonic dystrophy type 1. JOURNAL OF NEUROLOGY, 260(4), 1122-1131.

Diagnostic odyssey of patients with myotonic dystrophy.
Hilbert, J. E., Ashizawa, T., Day, J. W., Luebbe, E. A., Martens, W. B., & Moxley, R. T. (2013). Diagnostic odyssey of patients with myotonic dystrophy. Journal of neurology.

A focal domain of extreme demethylation within D4Z4 in FSHD2
Hartweck, L. M., Anderson, L. J., Lemmers, R. J., Dandapat, A., Toso, E. A., & Kyba, M. (2013). A focal domain of extreme demethylation within D4Z4 in FSHD2. NEUROLOGY, 80(4), 392-399.

Cerebral and muscle MRI abnormalities in myotonic dystrophy
Franc, D. T., Muetzel, R. L., Robinson, P. R., Rodriguez, C. P., Dalton, J. C., & Day, J. W. (2012). Cerebral and muscle MRI abnormalities in myotonic dystrophy. NEUROMUSCULAR DISORDERS, 22(6), 483-491.

Clinical and genetic features of spinocerebellar ataxia type 8.
Ikeda, Y., Ranum, L. Pw., & Day, J. W. (2012). Clinical and genetic features of spinocerebellar ataxia type 8. Handbook of clinical neurology, 103, 493-505.

Spinocerebellar ataxia type 5.
Dick, K. A., Ikeda, Y., Day, J. W., & Ranum, L. Pw. (2012). Spinocerebellar ataxia type 5. Handbook of clinical neurology, 103, 451-459.

LTBP4 genotype predicts age of ambulatory loss in duchenne muscular dystrophy.
Flanigan, K. M., Ceco, E., Lamar, K. M., Kaminoh, Y., & Dunn, D. M. (2012). LTBP4 genotype predicts age of ambulatory loss in duchenne muscular dystrophy. Annals of neurology.

2010 Marigold therapeutic strategies for myotonic dystrophy.
Blonsky, K., Monckton, D., Wieringa, B., Schoser, B., Day, J. W., & Engelen, B. van. (2012). 2010 Marigold therapeutic strategies for myotonic dystrophy. Neuromuscular disorders , 22(1), 87-94.

Randomized, blinded trial of weekend vs daily prednisone in Duchenne muscular dystrophy
Escolar, D. M., Hache, L. P., Clemens, P. R., Cnaan, A., McDonald, C. M., & Connolly, A. M. (2011). Randomized, blinded trial of weekend vs daily prednisone in Duchenne muscular dystrophy. NEUROLOGY, 77(5), 444-452.

Misregulation of miR-1 processing is associated with heart defects in myotonic dystrophy
Rau, F., Freyermuth, F., Fugier, C., Villemin, J.-P., Fischer, M.-C., & Charlet-Berguerand, N. (2011). Misregulation of miR-1 processing is associated with heart defects in myotonic dystrophy. NATURE STRUCTURAL & MOLECULAR BIOLOGY, 18(7), 840-U120.

Nonsense Mutation-Associated Becker Muscular Dystrophy: Interplay Between Exon Definition and Splicing Regulatory Elements within the DMD Gene
Flanigan, K. M., Dunn, D. M., von Niederhausern, A., Soltanzadeh, P., Howard, M. T., & Weiss, R. B. (2011). Nonsense Mutation-Associated Becker Muscular Dystrophy: Interplay Between Exon Definition and Splicing Regulatory Elements within the DMD Gene. HUMAN MUTATION, 32(3), 299-308.

White matter abnormalities and neurocognitive correlates in children and adolescents with myotonic dystrophy type 1: A diffusion tensor imaging study
Wozniak, J. R., Mueller, B. A., Ward, E. E., Lim, K. O., & Day, J. W. (2011). White matter abnormalities and neurocognitive correlates in children and adolescents with myotonic dystrophy type 1: A diffusion tensor imaging study. NEUROMUSCULAR DISORDERS, 21(2), 89-96.

TRAUMA, TDP-43, AND AMYOTROPHIC LATERAL SCLEROSIS
Appel, S. H., Cwik, V. A., & Day, J. W. (2010). TRAUMA, TDP-43, AND AMYOTROPHIC LATERAL SCLEROSIS. MUSCLE & NERVE, 42(6), 851-852.

Targeting parents for the treatment of pediatric obesity in boys with Duchenne muscular dystrophy: A case series
Arikian, A., Boutelle, K., Peterson, C. B., Dalton, J., Day, J. W., & Crow, S. J. (2010). Targeting parents for the treatment of pediatric obesity in boys with Duchenne muscular dystrophy: A case series. EATING AND WEIGHT DISORDERS-STUDIES ON ANOREXIA BULIMIA AND OBESITY, 15(3), E161-E165.

Mutational Spectrum of DMD Mutations in Dystrophinopathy Patients: Application of Modern Diagnostic Techniques to a Large Cohort
Flanigan, K. M., Dunn, D. M., von Niederhausern, A., Soltanzadeh, P., Gappmaier, E., & Weiss, R. B. (2009). Mutational Spectrum of DMD Mutations in Dystrophinopathy Patients: Application of Modern Diagnostic Techniques to a Large Cohort. HUMAN MUTATION, 30(12), 1657-1666.

SNP Haplotype Mapping in a Small ALS Family
Krueger, K. Ad., Tsuji, S., Fukuda, Y., Takahashi, Y., Goto, J., & Ranum, L. Pw. (2009). SNP Haplotype Mapping in a Small ALS Family. PLOS ONE, 4(5).

Congenital muscular dystrophy in a new age
Day, J. W. (2008). Congenital muscular dystrophy in a new age. NEUROLOGY, 71(5), 308-309.

Myotonic dystrophy type 2 in Japan: ancestral origin distinct from Caucasian families
Saito, T., Amakusa, Y., Kimura, T., Yahara, O., Aizawa, H., & Matsuura, T. (2008). Myotonic dystrophy type 2 in Japan: ancestral origin distinct from Caucasian families. NEUROGENETICS, 9(1), 61-63.

Heterozygosity for a protein truncation mutation of sodium channel SCN8A in a patient with cerebellar atrophy, ataxia, and mental retardation
Trudeau, M. M., DALTON, J. C., Day, J. W., Ranum, L. Pw., & Meisler, M. H. (2006). Heterozygosity for a protein truncation mutation of sodium channel SCN8A in a patient with cerebellar atrophy, ataxia, and mental retardation. JOURNAL OF MEDICAL GENETICS, 43(6), 527-530.

DM2 intronic expansions: evidence for CCUG accumulation without flanking sequence or effects on ZNF9 mRNA processing or protein expression
Margolis, J. M., Schoser, B. G., Moseley, M. L., Day, J. W., & Ranum, L. Pw. (2006). DM2 intronic expansions: evidence for CCUG accumulation without flanking sequence or effects on ZNF9 mRNA processing or protein expression. HUMAN MOLECULAR GENETICS, 15(11), 1808-1815.

Spectrin mutations cause spinocerebellar ataxia type 5
Ikeda, Y., Dick, K. A., Weatherspoon, M. R., Gincel, D., Armbrust, K. R., & Ranum, L. Pw. (2006). Spectrin mutations cause spinocerebellar ataxia type 5. NATURE GENETICS, 38(2), 184-190.

Gene symbol: SCN8A. Disease: Ataxia. Accession #Hd0520.
Meisler, M. H., Trudeau, M. M., DALTON, J. C., Day, J. W., & Ranum, L. Pw. (2006). Gene symbol: SCN8A. Disease: Ataxia. Accession #Hd0520. Human genetics, 118(6), 776-?.

Dominant non-coding repeat expansions in human disease.
Dick, K. A., Margolis, J. M., Day, J. W., & Ranum, L. Pw. (2006). Dominant non-coding repeat expansions in human disease. Genome dynamics, 1, 67-83.

Genetics and molecular pathogenesis of the myotonic dystrophies.
Day, J. W., & Ranum, L. Pw. (2005). Genetics and molecular pathogenesis of the myotonic dystrophies. Current neurology and neuroscience reports, 5(1), 55-59.

RNA pathogenesis of the myotonic dystrophies
Day, J. W., & Ranum, L. Pw. (2005). RNA pathogenesis of the myotonic dystrophies. NEUROMUSCULAR DISORDERS, 15(1), 5-16.

Sudden cardiac death in myotonic dystrophy type 2
Schoser, B. Gh., Ricker, K., Schneider-Gold, C., Hengstenberg, C., Durre, J., & Ranum, L. Pw. (2004). Sudden cardiac death in myotonic dystrophy type 2. NEUROLOGY, 63(12), 2402-2404.

Spinocerebellar ataxia type 8: Molecular genetic comparisons and haplotype analysis of 37 families with ataxia
Ikeda, Y., DALTON, J. C., Moseley, M. L., Gardner, K. L., Bird, T. D., & Ranum, L. Pw. (2004). Spinocerebellar ataxia type 8: Molecular genetic comparisons and haplotype analysis of 37 families with ataxia. AMERICAN JOURNAL OF HUMAN GENETICS, 75(1), 3-16.

Myotonic dystrophy: RNA pathogenesis comes into focus
Ranum, L. Pw., & Day, J. W. (2004). Myotonic dystrophy: RNA pathogenesis comes into focus. AMERICAN JOURNAL OF HUMAN GENETICS, 74(5), 793-804.

Rapid resolution of quadriplegic CIDP by combined plasmapheresis and IVIg
Walk, D., Li, L. Yj., Parry, G. J., & Day, J. W. (2004). Rapid resolution of quadriplegic CIDP by combined plasmapheresis and IVIg. NEUROLOGY, 62(1), 155-156.

Myotonic dystrophy type 2: Human founder haplotype and evolutionary conservation of the repeat tract
Liquori, C. L., Ikeda, Y., Weatherspoon, M., Ricker, K., Schoser, B. Gh., & Ranum, L. Pw. (2003). Myotonic dystrophy type 2: Human founder haplotype and evolutionary conservation of the repeat tract. AMERICAN JOURNAL OF HUMAN GENETICS, 73(4), 849-862.

Autoimmune rippling muscle
Muley, S. A., & Day, J. W. (2003). Autoimmune rippling muscle. NEUROLOGY, 61(6), 869-870.

Myotonic dystrophy type 2 - Molecular, diagnostic and clinical spectrum
Day, J. W., Ricker, K., Jacobsen, J. F., Rasmussen, L. J., Dick, K. A., & Ranum, L. Pw. (2003). Myotonic dystrophy type 2 - Molecular, diagnostic and clinical spectrum. NEUROLOGY, 60(4), 657-664.

Molecular genetics of spinocerebellar ataxia type 8 (SCA8)
Mosemiller, A. K., DALTON, J. C., Day, J. W., & Ranum, L. Pw. (2003). Molecular genetics of spinocerebellar ataxia type 8 (SCA8). CYTOGENETIC AND GENOME RESEARCH, 100(1-4), 175-183.

Randomized, controlled trial of intravenous immunoglobulin in myasthenia gravis
Wolfe, G. I., Barohn, R. J., Foster, B. M., Jackson, C. E., Kissel, J. T., & Mendell, J. R. (2002). Randomized, controlled trial of intravenous immunoglobulin in myasthenia gravis. MUSCLE & NERVE, 26(4), 549-552.

Myotonic dystrophy: clinical and molecular parallels between myotonic dystrophy type 1 and type 2.
Ranum, L. Pw., & Day, J. W. (2002). Myotonic dystrophy: clinical and molecular parallels between myotonic dystrophy type 1 and type 2. Current neurology and neuroscience reports, 2(5), 465-470.

Force assessment in periodic paralysis after electrical muscle stimulation
Day, J. W., Sakamoto, C., Parry, G. J., Lehmann-Horn, F., & Iaizzo, P. A. (2002). Force assessment in periodic paralysis after electrical muscle stimulation. MAYO CLINIC PROCEEDINGS, 77(3), 232-240.

Myotonic dystrophy type 2 caused by a CCTG expansion in intron 1 of ZNF9
Liquori, C. L., Ricker, K., Moseley, M. L., Jacobsen, J. F., Kress, W., & Ranum, L. Pw. (2001). Myotonic dystrophy type 2 caused by a CCTG expansion in intron 1 of ZNF9. SCIENCE, 293(5531), 864-867.

Clinical illness due to parvovirus B19 infection after infusion of solvent/detergent-treated pooled plasma
Koenigbauer, U. F., Eastlund, T., & Day, J. W. (2000). Clinical illness due to parvovirus B19 infection after infusion of solvent/detergent-treated pooled plasma. TRANSFUSION, 40(10), 1203-1206.

Spinocerebellar ataxia type 8 - Clinical features in a large family
Day, J. W., Schut, L. J., Moseley, M. L., Durand, A. C., & Ranum, L. Pw. (2000). Spinocerebellar ataxia type 8 - Clinical features in a large family. NEUROLOGY, 55(5), 649-657.

SCA8 CTG repeat: en masse contractions in sperm and intergenerational sequence changes may play a role in reduced penetrance
Moseley, M. L., Schut, M. J., Bird, T. D., Koob, M. D., Day, J. W., & Ranum, L. Pw. (2000). SCA8 CTG repeat: en masse contractions in sperm and intergenerational sequence changes may play a role in reduced penetrance. HUMAN MOLECULAR GENETICS, 9(14), 2125-2130.

Clinical and genetic characteristics of a five-generation family with a novel form of myotonic dystrophy (DM2)
Day, J. W., Roelofs, R., Leroy, B., Pech, I., Benzow, K., & Ranum, L. Pw. (1999). Clinical and genetic characteristics of a five-generation family with a novel form of myotonic dystrophy (DM2). NEUROMUSCULAR DISORDERS, 9(1), 19-27.

Genetic mapping of a second myotonic dystrophy locus
Ranum, L. Pw., Rasmussen, P. F., Benzow, K. A., Koob, M. D., & Day, J. W. (1998). Genetic mapping of a second myotonic dystrophy locus. NATURE GENETICS, 19(2), 196-198.

Genetic manipulation of AChR responses suggests multiple causes of weakness in slow-channel syndrome.
GOMEZ, C. M., Maselli, R., Williams, J. M., Bhattacharyya, B. B., Wollmann, R. L., & Day, J. W. (1998). Genetic manipulation of AChR responses suggests multiple causes of weakness in slow-channel syndrome. Annals of the New York Academy of Sciences, 841, 167-180.

Rapid cloning of expanded trinucleotide repeat sequences from genomic DNA
Koob, M. D., Benzow, K. A., Bird, T. D., Day, J. W., Moseley, M. L., & Ranum, L. Pw. (1998). Rapid cloning of expanded trinucleotide repeat sequences from genomic DNA. NATURE GENETICS, 18(1), 72-75.

Desensitization of mutant acetylcholine receptors in transgenic mice reduces the amplitude of neuromuscular synaptic currents
Bhattacharyya, B. J., Day, J. W., Gundeck, J. E., Leonard, S., Wollmann, R. L., & GOMEZ, C. M. (1997). Desensitization of mutant acetylcholine receptors in transgenic mice reduces the amplitude of neuromuscular synaptic currents. SYNAPSE, 27(4), 367-377.

Slow-channel transgenic mice: A model of postsynaptic organellar degeneration at the neuromuscular junction
GOMEZ, C. M., Maselli, R., Gundeck, J. E., Chao, M., Day, J. W., & Wollmann, R. L. (1997). Slow-channel transgenic mice: A model of postsynaptic organellar degeneration at the neuromuscular junction. JOURNAL OF NEUROSCIENCE, 17(11), 4170-4179.

An improved method for muscle force neuromuscular disease assessment
Brass, T. J., Loushin, M. Kh., Day, J. W., & Iaizzo, P. A. (1996). An improved method for muscle force neuromuscular disease assessment. JOURNAL OF MEDICAL ENGINEERING & TECHNOLOGY, 20(2), 67-74.

Transgenic mouse model of the slow-channel syndrome
GOMEZ, C. M., Bhattacharyya, B. B., Charnet, P., Day, J. W., Labarca, C., & Lambert, E. H. (1996). Transgenic mouse model of the slow-channel syndrome. MUSCLE & NERVE, 19(1), 79-87.

NICOTINIC ACETYLCHOLINE-RECEPTOR DESENSITIZATION IS REGULATED BY ACTIVATION-INDUCED EXTRACELLULAR ADENOSINE ACCUMULATION
Pitchford, S., Day, J. W., Gordon, A., & MOCHLYROSEN, D. (1992). NICOTINIC ACETYLCHOLINE-RECEPTOR DESENSITIZATION IS REGULATED BY ACTIVATION-INDUCED EXTRACELLULAR ADENOSINE ACCUMULATION. JOURNAL OF NEUROSCIENCE, 12(11), 4540-4544.

NORMOCALCEMIC TETANY ABOLISHED BY CALCIUM INFUSION
Day, J. W., & Parry, G. J. (1990). NORMOCALCEMIC TETANY ABOLISHED BY CALCIUM INFUSION. ANNALS OF NEUROLOGY, 27(4), 438-440.

THUNDERCLAP HEADACHE - SYMPTOM OF UNRUPTURED CEREBRAL ANEURYSM
Day, J. W., & Raskin, N. H. (1986). THUNDERCLAP HEADACHE - SYMPTOM OF UNRUPTURED CEREBRAL ANEURYSM. LANCET, 2(8518), 1247-1248.

TIME COURSE OF MINIATURE POSTSYNAPTIC POTENTIALS AT THE MAUTHNER FIBER GIANT SYNAPSE OF THE HATCHETFISH
Day, J. W., Huse, W. D., & Bennett, M. Vl. (1985). TIME COURSE OF MINIATURE POSTSYNAPTIC POTENTIALS AT THE MAUTHNER FIBER GIANT SYNAPSE OF THE HATCHETFISH. BRAIN RESEARCH, 325(1-2), 115-128.

POSTSYNAPTIC CURRENTS AT THE MAUTHNER FIBER GIANT SYNAPSE OF THE HATCHETFISH
Huse, W. D., Day, J. W., & Bennett, M. Vl. (1985). POSTSYNAPTIC CURRENTS AT THE MAUTHNER FIBER GIANT SYNAPSE OF THE HATCHETFISH. BRAIN RESEARCH, 325(1-2), 129-141.

POSTSYNAPTIC DEPRESSION OF MAUTHNER CELL-MEDIATED STARTLE REFLEX, A POSSIBLE CONTRIBUTOR TO HABITUATION
ALJURE, E., Day, J. W., & Bennett, M. Vl. (1980). POSTSYNAPTIC DEPRESSION OF MAUTHNER CELL-MEDIATED STARTLE REFLEX, A POSSIBLE CONTRIBUTOR TO HABITUATION. BRAIN RESEARCH, 188(1), 261-268.