Karl Deisseroth

Psychiatrist

D. H. Chen Professor, Professor of Bioengineering and of Psychiatry and of Behavioral Sciences
Deisseroth focuses on developing molecular and cellular tools to observe, perturb, and re-engineer brain circuits. His laboratory is based in the James H. Clark Center at Stanford and employs a range of techniques including neural stem cell and tissue engineering methods, electrophysiology, molecular biology, neural activity imaging, animal behavior, and computational neural network modeling. Also a clinician in the psychiatry department, Dr. Deisseroth employs novel electromagnetic brain stimulation techniques in human patients for therapeutic purposes.

Outpatient Psychiatry Clinic

  • 401 Quarry Road
  • Stanford, CA 94304
  • Phone: 650-498-9111
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Professional Education

Residency: Stanford University School of Medicine (2004) CA

Internship: Stanford University School of Medicine (2001) CA

Board Certification: Psychiatry, American Board of Psychiatry and Neurology (2006)

Medical Education: Stanford University School of Medicine (2000) CA

Ph.D., Stanford University, Neuroscience (1998)

M.D., Stanford University (2000)

A.B., Harvard, Biochemical Sciences (1992)

Honors & Awards

Lawrence C. Katz Prize in Neurobiology, Duke University (2008)

Schuetze Prize in Neurobiology, Columbia University (2008)

McKnight Foundation Scholar Award, McKnight Foundation (2007)

Presidential Early Career Award in Science and Engineering (PECASE), NIH (2006)

McKnight Foundation Technological Innovations in Neuroscience Award, McKnight Foundation (2005)

Klingenstein Fellowship, Klingenstein Foundation (2005)

Director's Pioneer Award, National Institutes of Health (2005)

Early Career Translational Research Award, Coulter Foundation (2005)

Culpeper Scholar Award, Rockefeller Brothers Fund, Goldman Philanthropic Partnerships (2004)

Outstanding Resident, National Institute of Mental Health (2002)

Structural and molecular interrogation of intact biological systems.
Chung, K., Wallace, J., Kim, S.-Y., Kalyanasundaram, S., Andalman, A. S., & Deisseroth, K. (2013). Structural and molecular interrogation of intact biological systems. Nature, 497(7449), 332-337.

Diverging neural pathways assemble a behavioural state from separable features in anxiety
Kim, S.-Y., Adhikari, A., Lee, S. Y., Marshel, J. H., Kim, C. K., & Deisseroth, K. (2013). Diverging neural pathways assemble a behavioural state from separable features in anxiety. NATURE, 496(7444), 219-223.

Dopamine neurons modulate neural encoding and expression of depression-related behaviour
Tye, K. M., Mirzabekov, J. J., Warden, M. R., Ferenczi, E. A., Tsai, H.-C., & Deisseroth, K. (2013). Dopamine neurons modulate neural encoding and expression of depression-related behaviour. NATURE, 493(7433), 537-?.

A prefrontal cortex-brainstem neuronal projection that controls response to behavioural challenge
Warden, M. R., Selimbeyoglu, A., Mirzabekov, J. J., Lo, M., Thompson, K. R., & Deisseroth, K. (2012). A prefrontal cortex-brainstem neuronal projection that controls response to behavioural challenge. NATURE, 492(7429), 428-432.

Crystal structure of the channelrhodopsin light-gated cation channel
Kato, H. E., Zhang, F., Yizhar, O., Ramakrishnan, C., Nishizawa, T., & Nureki, O. (2012). Crystal structure of the channelrhodopsin light-gated cation channel. NATURE, 482(7385), 369-U115.

The Microbial Opsin Family of Optogenetic Tools
Zhang, F., Vierock, J., Yizhar, O., Fenno, L. E., Tsunoda, S., & Deisseroth, K. (2011). The Microbial Opsin Family of Optogenetic Tools. CELL, 147(7), 1446-1457.

Neocortical excitation/inhibition balance in information processing and social dysfunction
Yizhar, O., Fenno, L. E., Prigge, M., Schneider, F., Davidson, T. J., & Deisseroth, K. (2011). Neocortical excitation/inhibition balance in information processing and social dysfunction. NATURE, 477(7363), 171-178.

Optogenetics in Neural Systems
Yizhar, O., Fenno, L. E., Davidson, T. J., Mogri, M., & Deisseroth, K. (2011). Optogenetics in Neural Systems. NEURON, 71(1), 9-34.

Amygdala circuitry mediating reversible and bidirectional control of anxiety
Tye, K. M., Prakash, R., Kim, S.-Y., Fenno, L. E., Grosenick, L., & Deisseroth, K. (2011). Amygdala circuitry mediating reversible and bidirectional control of anxiety. NATURE, 471(7338), 358-362.

Optogenetics
Deisseroth, K. (2011). Optogenetics. NATURE METHODS, 8(1), 26-29.

The Development and Application of Optogenetics
Fenno, L., Yizhar, O., & Deisseroth, K. (2011). The Development and Application of Optogenetics. ANNUAL REVIEW OF NEUROSCIENCE, VOL 34, 34, 389-412.

Cholinergic Interneurons Control Local Circuit Activity and Cocaine Conditioning
Witten, I. B., Lin, S.-C., Brodsky, M., Prakash, R., Diester, I., & Deisseroth, K. (2010). Cholinergic Interneurons Control Local Circuit Activity and Cocaine Conditioning. SCIENCE, 330(6011), 1677-1681.

Parvalbumin neurons and gamma rhythms enhance cortical circuit performance
Sohal, V. S., Zhang, F., Yizhar, O., & Deisseroth, K. (2009). Parvalbumin neurons and gamma rhythms enhance cortical circuit performance. NATURE, 459(7247), 698-702.

Driving fast-spiking cells induces gamma rhythm and controls sensory responses
Cardin, J. A., Carlen, M., Meletis, K., Knoblich, U., Zhang, F., & Moore, C. I. (2009). Driving fast-spiking cells induces gamma rhythm and controls sensory responses. NATURE, 459(7247), 663-U63.

Phasic Firing in Dopaminergic Neurons Is Sufficient for Behavioral Conditioning
Tsai, H.-C., Zhang, F., Adamantidis, A., Stuber, G. D., Bonci, A., & Deisseroth, K. (2009). Phasic Firing in Dopaminergic Neurons Is Sufficient for Behavioral Conditioning. SCIENCE, 324(5930), 1080-1084.

Temporally precise in vivo control of intracellular signalling
Airan, R. D., Thompson, K. R., Fenno, L. E., Bernstein, H., & Deisseroth, K. (2009). Temporally precise in vivo control of intracellular signalling. NATURE, 458(7241), 1025-1029.

Optical Deconstruction of Parkinsonian Neural Circuitry
Gradinaru, V., Mogri, M., Thompson, K. R., Henderson, J. M., & Deisseroth, K. (2009). Optical Deconstruction of Parkinsonian Neural Circuitry. SCIENCE, 324(5925), 354-359.

CLARITY for mapping the nervous system.
Chung, K., & Deisseroth, K. (2013). CLARITY for mapping the nervous system. Nature methods, 10(6), 508-513.

Hypothalamic neurotensin projections promote reward by enhancing glutamate transmission in the VTA.
Kempadoo, K. A., Tourino, C., Cho, S. L., Magnani, F., Leinninger, G.-M., & Bonci, A. (2013). Hypothalamic neurotensin projections promote reward by enhancing glutamate transmission in the VTA. journal of neuroscience , 33(18), 7618-7626.

Multiple Sources of Striatal Inhibition Are Differentially Affected in Huntington's Disease Mouse Models.
Cepeda, C., Galvan, L., Holley, S. M., Rao, S. P., André, V. M., & Levine, M. S. (2013). Multiple Sources of Striatal Inhibition Are Differentially Affected in Huntington's Disease Mouse Models. journal of neuroscience , 33(17), 7393-7406.

Optogenetic Delay of Status Epilepticus Onset in an In Vivo Rodent Epilepsy Model
Sukhotinsky, I., Chan, A. M., Ahmed, O. J., Rao, V. R., Gradinaru, V., & Cash, S. S. (2013). Optogenetic Delay of Status Epilepticus Onset in an In Vivo Rodent Epilepsy Model. PLOS ONE, 8(4).

Making Waves: Initiation and Propagation of Corticothalamic Ca2+ Waves In Vivo
Stroh, A., Adelsberger, H., Groh, A., Ruehlmann, C., Fischer, S., & Konnerth, A. (2013). Making Waves: Initiation and Propagation of Corticothalamic Ca2+ Waves In Vivo. NEURON, 77(6), 1136-1150.

Making waves: initiation and propagation of corticothalamic Ca2+ waves in vivo.
Stroh, A., Adelsberger, H., Groh, A., Rühlmann, C., Fischer, S., & Konnerth, A. (2013). Making waves: initiation and propagation of corticothalamic Ca2+ waves in vivo. Neuron, 77(6), 1136-1150.

The Brain Activity Map
Alivisatos, A. P., Chun, M., Church, G. M., Deisseroth, K., Donoghue, J. P., & Yuste, R. (2013). The Brain Activity Map. SCIENCE, 339(6125), 1284-1285.

Neuroscience. The brain activity map.
Alivisatos, A. P., Chun, M., Church, G. M., Deisseroth, K., Donoghue, J. P., & Yuste, R. (2013). Neuroscience. The brain activity map. Science , 339(6125), 1284-1285.

Nanotools for Neuroscience and Brain Activity Mapping
Alivisatos, A. P., Andrews, A. M., Boyden, E. S., Chun, M., Church, G. M., & Zhuang, X. (2013). Nanotools for Neuroscience and Brain Activity Mapping. ACS NANO, 7(3), 1850-1866.

Posttraining optogenetic manipulations of basolateral amygdala activity modulate consolidation of inhibitory avoidance memory in rats
Huff, M. L., Miller, R. L., Deisseroth, K., Moorman, D. E., & LaLumiere, R. T. (2013). Posttraining optogenetic manipulations of basolateral amygdala activity modulate consolidation of inhibitory avoidance memory in rats. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 110(9), 3597-3602.

Rapid regulation of depression-related behaviours by control of midbrain dopamine neurons
Chaudhury, D., Walsh, J. J., Friedman, A. K., Juarez, B., Ku, S. M., & Han, M.-H. (2013). Rapid regulation of depression-related behaviours by control of midbrain dopamine neurons. NATURE, 493(7433), 532-?.

Glutamatergic neurotransmission between the C1 neurons and the parasympathetic preganglionic neurons of the dorsal motor nucleus of the vagus.
DePuy, S. D., Stornetta, R. L., Bochorishvili, G., Deisseroth, K., Witten, I., & Guyenet, P. G. (2013). Glutamatergic neurotransmission between the C1 neurons and the parasympathetic preganglionic neurons of the dorsal motor nucleus of the vagus. journal of neuroscience , 33(4), 1486-1497.

Optogenetic Inhibition of Dorsal Medial Prefrontal Cortex Attenuates Stress-Induced Reinstatement of Palatable Food Seeking in Female Rats
Calu, D. J., Kawa, A. B., Marchant, N. J., Navarre, B. M., Henderson, M. J., & Shaham, Y. (2013). Optogenetic Inhibition of Dorsal Medial Prefrontal Cortex Attenuates Stress-Induced Reinstatement of Palatable Food Seeking in Female Rats. JOURNAL OF NEUROSCIENCE, 33(1), 214-U626.

Closed-loop optogenetic control of thalamus as a tool for interrupting seizures after cortical injury
Paz, J. T., Davidson, T. J., Frechette, E. S., Delord, B., Parada, I., & Huguenard, J. R. (2013). Closed-loop optogenetic control of thalamus as a tool for interrupting seizures after cortical injury. NATURE NEUROSCIENCE, 16(1), 64-U98.

Cortico-Striatal Stimulation Generates Persistent OCD-Like Behavior.
Ahmari, S. E., Spellman, T., Douglass, N. L., Kheirbek, M. A., Simpson, H. B., & Deisseroth, K. (2013). Cortico-Striatal Stimulation Generates Persistent OCD-Like Behavior. Science., 340.

A unique population of ventral tegmental area neurons inhibits the lateral habenula to promote reward.
Stamatakis, A. M., Jennings, J. H., Ung, R. L., Blair, G. A., Weinberg, R. J., & Deisseroth, K. (2013). A unique population of ventral tegmental area neurons inhibits the lateral habenula to promote reward. Neuron..

A causal link between prediction errors, dopamine neurons and learning
Steinberg, E. E., Keiflin, R., Boivin, J. R., Witten, I. B., Deisseroth, K., & Janak, P. H. (2013). A causal link between prediction errors, dopamine neurons and learning. Nature Neuroscience. Advance Online Pulbication.

Engineering approaches to illuminating brain structure and dynamics.
Deisseroth, K., & Schnitzer, M. J. (2013). Engineering approaches to illuminating brain structure and dynamics. Neuron..

Causal interactions between fronto-parietal central executive and default-mode networks in humans.
Chen, A. C., Oathes, D. J., Chang, C., Bradley, T., Zhou, Z.-W., & Deisseroth, K. (2013). Causal interactions between fronto-parietal central executive and default-mode networks in humans. PNAS..

Optogenetics.
Williams, S. C. P., & Deisseroth, K. (2013). Optogenetics. PNAS..

Light microscopy mapping of connections in the intact brain.
Kim, S.-Y., Chung, K., & Deisseroth, K. (2013). Light microscopy mapping of connections in the intact brain. Trends in Cognitive Sciences..

Optogenetics in the behaving rat: integration of diverse new technologies in a vital animal model.
Zalocusky, K., & Deisseroth, K. (2013). Optogenetics in the behaving rat: integration of diverse new technologies in a vital animal model. Optogenetics..

Optogenetic activation of an inhibitory network enhances feedforward functional connectivity in auditory cortex.
Hamilton, L. S., Sohl-Dickstein, J., Huth, A. G., Carels, V. M., Deisseroth, K., & Bao, S. (2013). Optogenetic activation of an inhibitory network enhances feedforward functional connectivity in auditory cortex. Neuron..

Optogenetic inhibition of cocaine seeking in rats
Stefanik, M. T., Moussawi, K., Kupchik, Y. M., Smith, K. C., Miller, R. L., & LaLumiere, R. T. (2013). Optogenetic inhibition of cocaine seeking in rats. ADDICTION BIOLOGY, 18(1), 50-53.

Prefrontal D1 dopamine signaling is required for temporal control
Narayanan, N. S., Land, B. B., Solder, J. E., Deisseroth, K., & DiLeone, R. J. (2012). Prefrontal D1 dopamine signaling is required for temporal control. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 109(50), 20726-20731.

Two-photon optogenetic toolbox for fast inhibition, excitation and bistable modulation
Prakash, R., Yizhar, O., Grewe, B., Ramakrishnan, C., Wang, N., & Deisseroth, K. (2012). Two-photon optogenetic toolbox for fast inhibition, excitation and bistable modulation. NATURE METHODS, 9(12), 1171-U132.

Two-photon optogenetics of dendritic spines and neural circuits
Packer, A. M., Peterka, D. S., Hirtz, J. J., Prakash, R., Deisseroth, K., & Yuste, R. (2012). Two-photon optogenetics of dendritic spines and neural circuits. NATURE METHODS, 9(12), 1202-U103.

Optogenetic and Potassium Channel Gene Therapy in a Rodent Model of Focal Neocortical Epilepsy
Wykes, R. C., Heeroma, J. H., Mantoan, L., Zheng, K., Macdonald, D. C., & Kullmann, D. M. (2012). Optogenetic and Potassium Channel Gene Therapy in a Rodent Model of Focal Neocortical Epilepsy. SCIENCE TRANSLATIONAL MEDICINE, 4(161).

Reversible online control of habitual behavior by optogenetic perturbation of medial prefrontal cortex
Smith, K. S., Virkud, A., Deisseroth, K., & Graybiel, A. M. (2012). Reversible online control of habitual behavior by optogenetic perturbation of medial prefrontal cortex. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 109(46), 18932-18937.

Input-specific control of reward and aversion in the ventral tegmental area
Lammel, S., Lim, B. K., Ran, C., Huang, K. W., Betley, M. J., & Malenka, R. C. (2012). Input-specific control of reward and aversion in the ventral tegmental area. NATURE, 491(7423), 212-?.

High-Frequency Hippocampal Oscillations Activated by Optogenetic Stimulation of Transplanted Human ESC-Derived Neurons
Pina-Crespo, J. C., Talantova, M., Cho, E.-G., Soussou, W., Dolatabadi, N., & Lipton, S. A. (2012). High-Frequency Hippocampal Oscillations Activated by Optogenetic Stimulation of Transplanted Human ESC-Derived Neurons. JOURNAL OF NEUROSCIENCE, 32(45), 15837-15842.

Color-tuned Channelrhodopsins for Multiwavelength Optogenetics
Prigge, M., Schneider, F., Tsunoda, S. P., Shilyansky, C., Wietek, J., & Hegemann, P. (2012). Color-tuned Channelrhodopsins for Multiwavelength Optogenetics. JOURNAL OF BIOLOGICAL CHEMISTRY, 287(38), 31804-31812.

Neuronal circuitry mechanism regulating adult quiescent neural stem-cell fate decision
Song, J., Zhong, C., Bonaguidi, M. A., Sun, G. J., Hsu, D., & Song, H. (2012). Neuronal circuitry mechanism regulating adult quiescent neural stem-cell fate decision. NATURE, 489(7414), 150-U216.

Photothermal Genetic Engineering
Anikeeva, P., & Deisseroth, K. (2012). Photothermal Genetic Engineering. ACS NANO, 6(9), 7548-7552.

Activation of specific interneurons improves V1 feature selectivity and visual perception
Lee, S.-H., Kwan, A. C., Zhang, S., Phoumthipphavong, V., Flannery, J. G., & Dan, Y. (2012). Activation of specific interneurons improves V1 feature selectivity and visual perception. NATURE, 488(7411), 379-?.

When the electricity (and the lights) go out: transient changes in excitability
Ferenczi, E., & Deisseroth, K. (2012). When the electricity (and the lights) go out: transient changes in excitability. NATURE NEUROSCIENCE, 15(8), 1058-1060.

Expanding the Repertoire of Optogenetically Targeted Cells with an Enhanced Gene Expression System
Tanaka, K. F., Matsui, K., Sasaki, T., Sano, H., Sugio, S., & Yamanaka, A. (2012). Expanding the Repertoire of Optogenetically Targeted Cells with an Enhanced Gene Expression System. CELL REPORTS, 2(2), 397-406.

Striatal Dopamine Release Is Triggered by Synchronized Activity in Cholinergic Interneurons
Threlfell, S., Lalic, T., Platt, N. J., Jennings, K. A., Deisseroth, K., & Cragg, S. J. (2012). Striatal Dopamine Release Is Triggered by Synchronized Activity in Cholinergic Interneurons. NEURON, 75(1), 58-64.

Altered profile of basket cell afferent synapses in hyper-excitable dentate gyrus revealed by optogenetic and two-pathway stimulations
Ledri, M., Nikitidou, L., Erdelyi, F., Szabo, G., Kirik, D., & Kokaia, M. (2012). Altered profile of basket cell afferent synapses in hyper-excitable dentate gyrus revealed by optogenetic and two-pathway stimulations. EUROPEAN JOURNAL OF NEUROSCIENCE, 36(1), 1971-1983.

Optogenetics and Psychiatry: Applications, Challenges, and Opportunities
Deisseroth, K. (2012). Optogenetics and Psychiatry: Applications, Challenges, and Opportunities. BIOLOGICAL PSYCHIATRY, 71(12), 1030-1032.

A critical role for NMDA receptors in parvalbumin interneurons for gamma rhythm induction and behavior
Carlen, M., Meletis, K., Siegle, J. H., Cardin, J. A., Futai, K., & Tsai, L.-H. (2012). A critical role for NMDA receptors in parvalbumin interneurons for gamma rhythm induction and behavior. MOLECULAR PSYCHIATRY, 17(5), 537-548.

Optogenetic stimulation of a hippocampal engram activates fear memory recall
Liu, X., Ramirez, S., Pang, P. T., Puryear, C. B., Govindarajan, A., & Tonegawa, S. (2012). Optogenetic stimulation of a hippocampal engram activates fear memory recall. NATURE, 484(7394), 381-U415.

Synaptic Activity Unmasks Dopamine D2 Receptor Modulation of a Specific Class of Layer V Pyramidal Neurons in Prefrontal Cortex
Gee, S., Ellwood, I., Patel, T., Luongo, F., Deisseroth, K., & Sohal, V. S. (2012). Synaptic Activity Unmasks Dopamine D2 Receptor Modulation of a Specific Class of Layer V Pyramidal Neurons in Prefrontal Cortex. JOURNAL OF NEUROSCIENCE, 32(14), 4959-4971.

Optogenetic investigation of neural circuits underlying brain disease in animal models
Tye, K. M., & Deisseroth, K. (2012). Optogenetic investigation of neural circuits underlying brain disease in animal models. NATURE REVIEWS NEUROSCIENCE, 13(4), 251-266.

GABA Neurons of the VTA Drive Conditioned Place Aversion
Tan, K. R., Yvon, C., Turiault, M., Mirzabekov, J. J., Doehner, J., & Luescher, C. (2012). GABA Neurons of the VTA Drive Conditioned Place Aversion. NEURON, 73(6), 1173-1183.

Structural Model of Channelrhodopsin
Watanabe, H. C., Welke, K., Schneider, F., Tsunoda, S., Zhang, F., & Elstner, M. (2012). Structural Model of Channelrhodopsin. JOURNAL OF BIOLOGICAL CHEMISTRY, 287(10), 7456-7466.

Integrated device for combined optical neuromodulation and electrical recording for chronic in vivo applications
Wang, J., Wagner, F., Borton, D. A., Zhang, J., Ozden, I., & Deisseroth, K. (2012). Integrated device for combined optical neuromodulation and electrical recording for chronic in vivo applications. JOURNAL OF NEURAL ENGINEERING, 9(1).

Principles for applying optogenetic tools derived from direct comparative analysis of microbial opsins.
Mattis, J., Tye, K. M., Ferenczi, E. A., Ramakrishnan, C., O'Shea, D. J., & Deisseroth, K. (2012). Principles for applying optogenetic tools derived from direct comparative analysis of microbial opsins. Nature methods, 9(2), 159-172.

Optetrode: a multichannel readout for optogenetic control in freely moving mice.
Anikeeva, P., Andalman, A. S., Witten, I., Warden, M., Goshen, I., & Deisseroth, K. (2012). Optetrode: a multichannel readout for optogenetic control in freely moving mice. Nature neuroscience, 15(1), 163-170.

GABAergic circuits mediate the reinforcement-related signals of striatal cholinergic interneurons.
English, D. F., Ibanez-Sandoval, O., Stark, E., Tecuapetla, F., Buzsáki, G., & Koos, T. (2012). GABAergic circuits mediate the reinforcement-related signals of striatal cholinergic interneurons. Nature neuroscience, 15(1), 123-130.

GABAergic circuits mediate the reinforcement-related signals of striatal cholinergic interneurons
English, D. F., Ibanez-Sandoval, O., Stark, E., Tecuapetla, F., Buzsaki, G., & Koos, T. (2012). GABAergic circuits mediate the reinforcement-related signals of striatal cholinergic interneurons. NATURE NEUROSCIENCE, 15(1), 123-U155.

Optetrode: a multichannel readout for optogenetic control in freely moving mice
Anikeeva, P., Andalman, A. S., Witten, I., Warden, M., Goshen, I., & Deisseroth, K. (2012). Optetrode: a multichannel readout for optogenetic control in freely moving mice. NATURE NEUROSCIENCE, 15(1), 163-U204.

A critical role for NMDA receptors in parvalbumin interneurons for gamma rhythm induction and behavior.
Carlén, M., Meletis, K., Siegle, J. H., Cardin, J. A., Futai, K., & Deisseroth, K. (2012). A critical role for NMDA receptors in parvalbumin interneurons for gamma rhythm induction and behavior. Mol Psychiatry., 5(17).

Recombinase-Driver Rat Lines: Tools, Techniques, and Optogenetic Application to Dopamine-Mediated Reinforcement
Witten, I. B., Steinberg, E. E., Lee, S. Y., Davidson, T. J., Zalocusky, K. A., & Deisseroth, K. (2011). Recombinase-Driver Rat Lines: Tools, Techniques, and Optogenetic Application to Dopamine-Mediated Reinforcement. NEURON, 72(5), 721-733.

Leptin regulates the reward value of nutrient
Domingos, A. I., Vaynshteyn, J., Voss, H. U., Ren, X., Gradinaru, V., & Friedman, J. (2011). Leptin regulates the reward value of nutrient. NATURE NEUROSCIENCE, 14(12), 1562-U92.

Neuronal filtering of multiplexed odour representations
Blumhagen, F., Zhu, P., Shum, J., Schaerer, Y.-P. Z., Yaksi, E., & Friedrich, R. W. (2011). Neuronal filtering of multiplexed odour representations. NATURE, 479(7374), 493-U215.

SNCA Triplication Parkinson's Patient's iPSC-derived DA Neurons Accumulate alpha-Synuclein and Are Susceptible to Oxidative Stress
Byers, B., Cord, B., Ha Nam Nguyen, H. N., Schuele, B., Fenno, L., & Palmer, T. D. (2011). SNCA Triplication Parkinson's Patient's iPSC-derived DA Neurons Accumulate alpha-Synuclein and Are Susceptible to Oxidative Stress. PLOS ONE, 6(11).

Hemisphere-specific optogenetic stimulation reveals left-right asymmetry of hippocampal plasticity
Kohl, M. M., Shipton, O. A., Deacon, R. M., Rawlins, J. N. P., Deisseroth, K., & Paulsen, O. (2011). Hemisphere-specific optogenetic stimulation reveals left-right asymmetry of hippocampal plasticity. NATURE NEUROSCIENCE, 14(11), 1413-1415.

Dynamics of Retrieval Strategies for Remote Memories
Goshen, I., Brodsky, M., Prakash, R., Wallace, J., Gradinaru, V., & Deisseroth, K. (2011). Dynamics of Retrieval Strategies for Remote Memories. CELL, 147(3), 678-689.

Differential Modulation of Excitatory and Inhibitory Striatal Synaptic Transmission by Histamine
Ellender, T. J., Huerta-Ocampo, I., Deisseroth, K., Capogna, M., & Bolam, J. P. (2011). Differential Modulation of Excitatory and Inhibitory Striatal Synaptic Transmission by Histamine. JOURNAL OF NEUROSCIENCE, 31(43), 15340-15351.

In Vivo Optogenetic Stimulation of Neocortical Excitatory Neurons Drives Brain-State-Dependent Inhibition
Mateo, C., Avermann, M., Gentet, L. J., Zhang, F., Deisseroth, K., & Petersen, C. Ch. (2011). In Vivo Optogenetic Stimulation of Neocortical Excitatory Neurons Drives Brain-State-Dependent Inhibition. CURRENT BIOLOGY, 21(19), 1593-1602.

Multiscale Computational Models for Optogenetic Control of Cardiac Function
Abilez, O. J., Wong, J., Prakash, R., Deisseroth, K., Zarins, C. K., & Kuhl, E. (2011). Multiscale Computational Models for Optogenetic Control of Cardiac Function. BIOPHYSICAL JOURNAL, 101(6), 1326-1334.

Cell type-specific channelrhodopsin-2 transgenic mice for optogenetic dissection of neural circuitry function
Zhao, S., Ting, J. T., Atallah, H. E., Qiu, L., Tan, J., & Feng, G. (2011). Cell type-specific channelrhodopsin-2 transgenic mice for optogenetic dissection of neural circuitry function. NATURE METHODS, 8(9), 745-U91.

A new mode of corticothalamic transmission revealed in the Gria4(-/-) model of absence epilepsy
Paz, J. T., Bryant, A. S., Peng, K., Fenno, L., Yizhar, O., & Huguenard, J. R. (2011). A new mode of corticothalamic transmission revealed in the Gria4(-/-) model of absence epilepsy. NATURE NEUROSCIENCE, 14(9), 1167-U225.

Optogenetic Interrogation of Dopaminergic Modulation of the Multiple Phases of Reward-Seeking Behavior
Adamantidis, A. R., Tsai, H.-C., Boutrel, B., Zhang, F., Stuber, G. D., & de Lecea, L. (2011). Optogenetic Interrogation of Dopaminergic Modulation of the Multiple Phases of Reward-Seeking Behavior. JOURNAL OF NEUROSCIENCE, 31(30), 10829-10835.

Excitatory transmission from the amygdala to nucleus accumbens facilitates reward seeking
Stuber, G. D., Sparta, D. R., Stamatakis, A. M., van Leeuwen, W. A., Hardjoprajitno, J. E., & Bonci, A. (2011). Excitatory transmission from the amygdala to nucleus accumbens facilitates reward seeking. NATURE, 475(7356), 377-U129.

OPTOGENETICS: BACKGROUND AND CONCEPTS FOR NEUROSURGERY
Lin, S.-C., Deisseroth, K., & Henderson, J. M. (2011). OPTOGENETICS: BACKGROUND AND CONCEPTS FOR NEUROSURGERY. NEUROSURGERY, 69(1), 1-3.

Challenges and Opportunities for Next-Generation Intracortically Based Neural Prostheses
Gilja, V., Chestek, C. A., Diester, I., Henderson, J. M., Deisseroth, K., & Shenoy, K. V. (2011). Challenges and Opportunities for Next-Generation Intracortically Based Neural Prostheses. IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING, 58(7), 1891-1899.

High-efficiency channelrhodopsins for fast neuronal stimulation at low light levels
Berndt, A., Schoenenberger, P., Mattis, J., Tye, K. M., Deisseroth, K., & Oertner, T. G. (2011). High-efficiency channelrhodopsins for fast neuronal stimulation at low light levels. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 108(18), 7595-7600.

Functional Integration of Grafted Neural Stem Cell-Derived Dopaminergic Neurons Monitored by Optogenetics in an In Vitro Parkinson Model
Tonnesen, J., Parish, C. L., Sorensen, A. T., Andersson, A., Lundberg, C., & Kokaia, M. (2011). Functional Integration of Grafted Neural Stem Cell-Derived Dopaminergic Neurons Monitored by Optogenetics in an In Vitro Parkinson Model. PLOS ONE, 6(3).

An optogenetic toolbox designed for primates
Diester, I., Kaufman, M. T., Mogri, M., Pashaie, R., Goo, W., & Shenoy, K. V. (2011). An optogenetic toolbox designed for primates. NATURE NEUROSCIENCE, 14(3), 387-397.

Active Expiration Induced by Excitation of Ventral Medulla in Adult Anesthetized Rats
Pagliardini, S., Janczewski, W. A., Tan, W., Dickson, C. T., Deisseroth, K., & Feldman, J. L. (2011). Active Expiration Induced by Excitation of Ventral Medulla in Adult Anesthetized Rats. JOURNAL OF NEUROSCIENCE, 31(8), 2895-2905.

An Implantable Optical Stimulation Delivery System for Actuating an Excitable Biosubstrate
Paralikar, K., Cong, P., Yizhar, O., Fenno, L. E., Santa, W., & Denison, T. (2011). An Implantable Optical Stimulation Delivery System for Actuating an Excitable Biosubstrate. IEEE JOURNAL OF SOLID-STATE CIRCUITS, 46(1), 321-332.

Tracking Stem Cell Differentiation in the Setting of Automated Optogenetic Stimulation
Stroh, A., Tsai, H.-C., Wang, L.-P., Zhang, F., Kressel, J., & Schneider, M. B. (2011). Tracking Stem Cell Differentiation in the Setting of Automated Optogenetic Stimulation. STEM CELLS, 29(1), 78-88.

Optogenetics.
Deisseroth, K. (2011). Optogenetics. Nat Methods., 1(8).

Amygdala circuitry mediating reversible and bidirectional control of anxiety.
Tye, K. M., Prakash, R., Kim, S. Y., Fenno, L. E., Grosenick, L., & Deisseroth, K. (2011). Amygdala circuitry mediating reversible and bidirectional control of anxiety. Nature., 7338(471).

High-efficiency channelrhodopsins for fast neuronal stimulation at low light levels.
A, B., P, S., J, M., KM, T., K, D., & P, H. (2011). High-efficiency channelrhodopsins for fast neuronal stimulation at low light levels. Proc Natl Acad Sci U S A. 2011 May 3, 108.

Drug-Driven AMPA Receptor Redistribution Mimicked by Selective Dopamine Neuron Stimulation
Brown, M. Tc., Bellone, C., Mameli, M., Labouebe, G., Bocklisch, C., & Luescher, C. (2010). Drug-Driven AMPA Receptor Redistribution Mimicked by Selective Dopamine Neuron Stimulation. PLOS ONE, 5(12).

Tuning arousal with optogenetic modulation of locus coeruleus neurons
Carter, M. E., Yizhar, O., Chikahisa, S., Nguyen, H., Adamantidis, A., & de Lecea, L. (2010). Tuning arousal with optogenetic modulation of locus coeruleus neurons. NATURE NEUROSCIENCE, 13(12), 1526-U117.

Antidepressant Effect of Optogenetic Stimulation of the Medial Prefrontal Cortex
Covington, H. E., Lobo, M. K., Maze, I., Vialou, V., Hyman, J. M., & Nestler, E. J. (2010). Antidepressant Effect of Optogenetic Stimulation of the Medial Prefrontal Cortex. JOURNAL OF NEUROSCIENCE, 30(48), 16082-16090.

Encoding of conditioned fear in central amygdala inhibitory circuits
Ciocchi, S., Herry, C., Grenier, F., Wolff, S. Be., Letzkus, J. J., & Luethi, A. (2010). Encoding of conditioned fear in central amygdala inhibitory circuits. NATURE, 468(7321), 277-U239.

Genetic dissection of an amygdala microcircuit that gates conditioned fear
Haubensak, W., Kunwar, P. S., Cai, H., Ciocchi, S., Wall, N. R., & Anderson, D. J. (2010). Genetic dissection of an amygdala microcircuit that gates conditioned fear. NATURE, 468(7321), 270-U230.

Functional Control of Transplantable Human ESC-Derived Neurons via Optogenetic Targeting
Weick, J. P., Johnson, M. A., Skroch, S. P., Williams, J. C., Deisseroth, K., & Zhang, S.-C. (2010). Functional Control of Transplantable Human ESC-Derived Neurons via Optogenetic Targeting. STEM CELLS, 28(11), 2008-2016.

Cell Type-Specific Loss of BDNF Signaling Mimics Optogenetic Control of Cocaine Reward
Lobo, M. K., Covington, H. E., Chaudhury, D., Friedman, A. K., Sun, H., & Nestler, E. J. (2010). Cell Type-Specific Loss of BDNF Signaling Mimics Optogenetic Control of Cocaine Reward. SCIENCE, 330(6002), 385-390.

Orderly recruitment of motor units under optical control in vivo
Llewellyn, M. E., Thompson, K. R., Deisseroth, K., & Delp, S. L. (2010). Orderly recruitment of motor units under optical control in vivo. NATURE MEDICINE, 16(10), 1161-U144.

Astrocytes Control Breathing Through pH-Dependent Release of ATP
Gourine, A. V., Kasymov, V., Marina, N., Tang, F., Figueiredo, M. F., & Kasparov, S. (2010). Astrocytes Control Breathing Through pH-Dependent Release of ATP. SCIENCE, 329(5991), 571-575.

Regulation of parkinsonian motor behaviours by optogenetic control of basal ganglia circuitry
Kravitz, A. V., Freeze, B. S., Parker, P. Rl., Kay, K., Thwin, M. T., & Kreitzer, A. C. (2010). Regulation of parkinsonian motor behaviours by optogenetic control of basal ganglia circuitry. NATURE, 466(7306), 622-U7.

Genetic Reactivation of Cone Photoreceptors Restores Visual Responses in Retinitis Pigmentosa
Busskamp, V., Duebel, J., Balya, D., Fradot, M., Viney, T. J., & Roska, B. (2010). Genetic Reactivation of Cone Photoreceptors Restores Visual Responses in Retinitis Pigmentosa. SCIENCE, 329(5990), 413-417.

Optical activation of lateral amygdala pyramidal cells instructs associative fear learning
Johansen, J. P., Hamanaka, H., Monfils, M. H., Behnia, R., Deisseroth, K., & LeDoux, J. E. (2010). Optical activation of lateral amygdala pyramidal cells instructs associative fear learning. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 107(28), 12692-12697.

Global and local fMRI signals driven by neurons defined optogenetically by type and wiring
Lee, J. H., Durand, R., Gradinaru, V., Zhang, F., Goshen, I., & Deisseroth, K. (2010). Global and local fMRI signals driven by neurons defined optogenetically by type and wiring. NATURE, 465(7299), 788-792.

Glutamatergic Signaling by Mesolimbic Dopamine Neurons in the Nucleus Accumbens
Tecuapetla, F., Patel, J. C., Xenias, H., English, D., Tadros, I., & Koos, T. (2010). Glutamatergic Signaling by Mesolimbic Dopamine Neurons in the Nucleus Accumbens. JOURNAL OF NEUROSCIENCE, 30(20), 7105-7110.

Dlx5 and Dlx6 Regulate the Development of Parvalbumin-Expressing Cortical Interneurons
Wang, Y., Dye, C. A., Sohal, V., Long, J. E., Estrada, R. C., & Rubenstein, J. Lr. (2010). Dlx5 and Dlx6 Regulate the Development of Parvalbumin-Expressing Cortical Interneurons. JOURNAL OF NEUROSCIENCE, 30(15), 5334-5345.

Molecular and Cellular Approaches for Diversifying and Extending Optogenetics
Gradinaru, V., Zhang, F., Ramakrishnan, C., Mattis, J., Prakash, R., & Deisseroth, K. (2010). Molecular and Cellular Approaches for Diversifying and Extending Optogenetics. CELL, 141(1), 154-165.

Ultrafast optogenetic control
Gunaydin, L. A., Yizhar, O., Berndt, A., Sohal, V. S., Deisseroth, K., & Hegemann, P. (2010). Ultrafast optogenetic control. NATURE NEUROSCIENCE, 13(3), 387-U27.

Orderly recruitment of motor units under optical control in vivo.
Llewellyn, M. E., Thompson, K. R., Deisseroth, K., & Delp, S. L. (2010). Orderly recruitment of motor units under optical control in vivo. Nat Med., 10(16).

Targeted optogenetic stimulation and recording of neurons in vivo using cell-type-specific expression of Channelrhodopsin-2
Cardin, J. A., Carlen, M., Meletis, K., Knoblich, U., Zhang, F., & Moore, C. I. (2010). Targeted optogenetic stimulation and recording of neurons in vivo using cell-type-specific expression of Channelrhodopsin-2. NATURE PROTOCOLS, 5(2), 247-254.

Optogenetic interrogation of neural circuits: technology for probing mammalian brain structures
Zhang, F., Gradinaru, V., Adamantidis, A. R., Durand, R., Airan, R. D., & Deisseroth, K. (2010). Optogenetic interrogation of neural circuits: technology for probing mammalian brain structures. NATURE PROTOCOLS, 5(3), 439-456.

Controlling the brain with light
Deisseroth, K. (2010). Controlling the brain with light. Sci Am., 5(303).

Optical activation of lateral amygdala pyramidal cells instructs associative fear leaJohansen JP, Hamanaka H, Monfils MH, Behnia R, Deisseroth K, Blair HT, LeDoux JE. rning.
JP, J., H, H., MH, M., R, B., K, D., & HT, B. (2010). Optical activation of lateral amygdala pyramidal cells instructs associative fear leaJohansen JP, Hamanaka H, Monfils MH, Behnia R, Deisseroth K, Blair HT, LeDoux JE. rning. Proc Natl Acad Sci U S A. 2010 Jul 13, 28.107.

Special issue on optical neural engineering: advances in optical stimulation technology.
Shoham, S., & Deisseroth, K. (2010). Special issue on optical neural engineering: advances in optical stimulation technology. J Neural Eng., 4(7).

Optogenetic dissection of neuronal circuits in zebrafish using viral gene transfer and the Tet system
Zhu, P., Narita, Y., Bundschuh, S. T., Fajardo, O., Schaerer, Y.-P. Z., & Friedrich, R. W. (2009). Optogenetic dissection of neuronal circuits in zebrafish using viral gene transfer and the Tet system. FRONTIERS IN NEURAL CIRCUITS, 3.

Integrated device for optical stimulation and spatiotemporal electrical recording of neural activity in light-sensitized brain tissue
Zhang, J., Laiwalla, F., Kim, J. A., Urabe, H., Van Wagenen, R., & Nurmikko, A. V. (2009). Integrated device for optical stimulation and spatiotemporal electrical recording of neural activity in light-sensitized brain tissue. JOURNAL OF NEURAL ENGINEERING, 6(5).

Sleep Homeostasis Modulates Hypocretin-Mediated Sleep-to-Wake Transitions
Carter, M. E., Adamantidis, A., Ohtsu, H., Deisseroth, K., & de Lecea, L. (2009). Sleep Homeostasis Modulates Hypocretin-Mediated Sleep-to-Wake Transitions. JOURNAL OF NEUROSCIENCE, 29(35), 10939-10949.

Optogenetic control of epileptiform activity
Tonnesen, J., Sorensen, A. T., Deisseroth, K., Lundberg, C., & Kokaia, M. (2009). Optogenetic control of epileptiform activity. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 106(29), 12162-12167.

Induced chromosome deletions cause hypersociability and other features of Williams-Beuren syndrome in mice
Li, H. H., Roy, M., Kuscuoglu, U., Spencer, C. M., Halm, B., & Francke, U. (2009). Induced chromosome deletions cause hypersociability and other features of Williams-Beuren syndrome in mice. EMBO MOLECULAR MEDICINE, 1(1), 50-65.

Bi-stable neural state switches
Berndt, A., Yizhar, O., Gunaydin, L. A., Hegemann, P., & Deisseroth, K. (2009). Bi-stable neural state switches. NATURE NEUROSCIENCE, 12(2), 229-234.

Escape behavior elicited by single, Channelrhodopsin-2-evoked spikes in zebrafish somatosensory neurons
Douglass, A. D., Kraves, S., Deisseroth, K., Schier, A. F., & Engert, F. (2008). Escape behavior elicited by single, Channelrhodopsin-2-evoked spikes in zebrafish somatosensory neurons. CURRENT BIOLOGY, 18(15), 1133-1137.

eNpHR: a Natronomonas halorhodopsin enhanced for optogenetic applications
Gradinaru, V., Thompson, K. R., & Deisseroth, K. (2008). eNpHR: a Natronomonas halorhodopsin enhanced for optogenetic applications. BRAIN CELL BIOLOGY, 36(1-4), 129-139.

Improved expression of halorhodopsin for light-induced silencing of neuronal activity
Zhao, S., Cunha, C., Zhang, F., Liu, Q., Gloss, B., & Feng, G. (2008). Improved expression of halorhodopsin for light-induced silencing of neuronal activity. BRAIN CELL BIOLOGY, 36(1-4), 141-154.

Brain circuit dynamics
Hu, E. S., Airan, R. D., Vijaykumar, R., & Deisseroth, K. (2008). Brain circuit dynamics. AMERICAN JOURNAL OF PSYCHIATRY, 165(7), 800-800.

Red-shifted optogenetic excitation: a tool for fast neural control derived from Volvox carteri
Zhang, F., Prigge, M., Beyriere, F., Tsunoda, S. P., Mattis, J., & Deisseroth, K. (2008). Red-shifted optogenetic excitation: a tool for fast neural control derived from Volvox carteri. NATURE NEUROSCIENCE, 11(6), 631-633.

Controlling neuronal activity
Tamminga, C. A., Schneider, M. B., Gradinaru, V., Zhang, F., & Deisseroth, K. (2008). Controlling neuronal activity. AMERICAN JOURNAL OF PSYCHIATRY, 165(5), 562-562.

Red-shifted optogenetic excitation: a tool for fast neural control derived from Volvox carteri.
Zhang, F., Prigge, M., Beyriere, F., Tsunoda, S. P., Mattis, J., & Deisseroth, K. (2008). Red-shifted optogenetic excitation: a tool for fast neural control derived from Volvox carteri. Nat Neurosci., 6(11).

Brain circuit dynamics
Hu, E. S., Airan, R. D., Vijaykumar, R., & Deisseroth, K. (2008). Brain circuit dynamics. Am J Psychiatry., 7(165).

Targeting and readout strategies for fast optical neural control in vitro and in vivo
Gradinaru, V., Thompson, K. R., Zhang, F., Mogri, M., Kay, K., & Deisseroth, K. (2007). Targeting and readout strategies for fast optical neural control in vitro and in vivo. JOURNAL OF NEUROSCIENCE, 27(52), 14231-14238.

Nociceptive neurons protect Drosophila larvae from parasitoid wasps
Hwang, R. Y., Zhong, L., Xu, Y., Johnson, T., Zhang, F., & Tracey, W. D. (2007). Nociceptive neurons protect Drosophila larvae from parasitoid wasps. CURRENT BIOLOGY, 17(24), 2105-2116.

Neural substrates of awakening probed with optogenetic control of hypocretin neurons
Adamantidis, A. R., Zhang, F., Aravanis, A. M., Deisseroth, K., & de Lecea, L. (2007). Neural substrates of awakening probed with optogenetic control of hypocretin neurons. NATURE, 450(7168), 420-U9.

Integration of light-controlled neuronal firing and fast circuit imaging
Airan, R. D., Hu, E. S., Vijaykumar, R., Roy, M., Meltzer, L. A., & Deisseroth, K. (2007). Integration of light-controlled neuronal firing and fast circuit imaging. CURRENT OPINION IN NEUROBIOLOGY, 17(5), 587-592.

An optical neural interface: in vivo control of rodent motor cortex with integrated fiberoptic and optogenetic technology
Aravanis, A. M., Wang, L.-P., Zhang, F., Meltzer, L. A., Mogri, M. Z., & Deisseroth, K. (2007). An optical neural interface: in vivo control of rodent motor cortex with integrated fiberoptic and optogenetic technology. JOURNAL OF NEURAL ENGINEERING, 4(3), S143-S156.

High-speed Imaging reveals neurophysiological links to behavior in an animal model of depression
Airan, R. D., Meltzer, L. A., Roy, M., Gong, Y., Chen, H., & Deisseroth, K. (2007). High-speed Imaging reveals neurophysiological links to behavior in an animal model of depression. SCIENCE, 317(5839), 819-823.

Circuit-breakers: optical technologies for probing neural signals and systems
Zhang, F., Aravanis, A. M., Adamantidis, A., de Lecea, L., & Deisseroth, K. (2007). Circuit-breakers: optical technologies for probing neural signals and systems. NATURE REVIEWS NEUROSCIENCE, 8(8), 577-581.

High-speed mapping of synaptic connectivity using photostimulation in Channel rhodopsin-2 transgenic mice
Wang, H., Peca, J., Matsuzaki, M., Matsuzaki, K., Noguchi, J., & Augustine, G. J. (2007). High-speed mapping of synaptic connectivity using photostimulation in Channel rhodopsin-2 transgenic mice. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 104(19), 8143-8148.

In vivo light-induced activation of neural circuitry in transgenic mice expressing channelrhodopsin-2
Arenkiel, B. R., Peca, J., Davison, I. G., Feliciano, C., Deisseroth, K., & Feng, G. (2007). In vivo light-induced activation of neural circuitry in transgenic mice expressing channelrhodopsin-2. NEURON, 54(2), 205-218.

Multimodal fast optical interrogation of neural circuitry
Zhang, F., Wang, L.-P., Brauner, M., Liewald, J. F., Kay, K., & Deisseroth, K. (2007). Multimodal fast optical interrogation of neural circuitry. NATURE, 446(7136), 633-U4.

High-speed mapping of synaptic connectivity using photostimulation in Channelrhodopsin-2 transgenic mice.
H, W., J, P., M, M., K, M., J, N., & Deisseroth, K. (2007). High-speed mapping of synaptic connectivity using photostimulation in Channelrhodopsin-2 transgenic mice. Proc Natl Acad Sci U S A. 2007 May 8, 19.109.

Next-generation optical technologies for illuminating genetically targeted brain circuits
Deisseroth, K., Feng, G., Majewska, A. K., Miesenbock, G., Ting, A., & Schnitzer, M. J. (2006). Next-generation optical technologies for illuminating genetically targeted brain circuits. JOURNAL OF NEUROSCIENCE, 26(41), 10380-10386.

Channelrhodopsin-2 and optical control of excitable cells
Zhang, F., Wang, L.-P., Boyden, E. S., & Deisseroth, K. (2006). Channelrhodopsin-2 and optical control of excitable cells. NATURE METHODS, 3(10), 785-792.

A role for circuit homeostasis in adult neurogenesis
Meltzer, L. A., Yabaluri, R., & Deisseroth, K. (2005). A role for circuit homeostasis in adult neurogenesis. TRENDS IN NEUROSCIENCES, 28(12), 653-660.

GABA excitation in the adult brain: A mechanism for excitation-neurogenesis coupling
Deisseroth, K., & Malenka, R. C. (2005). GABA excitation in the adult brain: A mechanism for excitation-neurogenesis coupling. NEURON, 47(6), 775-777.

Millisecond-timescale, genetically targeted optical control of neural activity
Boyden, E. S., Zhang, F., Bamberg, E., Nagel, G., & Deisseroth, K. (2005). Millisecond-timescale, genetically targeted optical control of neural activity. NATURE NEUROSCIENCE, 8(9), 1263-1268.

Excitation-neurogenesis coupling in adult neural stem/progenitor cells
Deisseroth, K., Singla, S., Toda, H., Monje, M., Palmer, T. D., & Malenka, R. C. (2004). Excitation-neurogenesis coupling in adult neural stem/progenitor cells. NEURON, 42(4), 535-552.

Signaling from synapse to nucleus: the logic behind the mechanisms
Deisseroth, K., Mermelstein, P. G., Xia, H. H., & Tsien, R. W. (2003). Signaling from synapse to nucleus: the logic behind the mechanisms. CURRENT OPINION IN NEUROBIOLOGY, 13(3), 354-365.

Dynamic multiphosphorylation passwords for activity-dependent gene expression
Deisseroth, K., & Tsien, R. W. (2002). Dynamic multiphosphorylation passwords for activity-dependent gene expression. NEURON, 34(2), 179-182.

Calmodulin priming: Nuclear translocation of a calmodulin complex and the memory of prior neuronal activity
Mermelstein, P. G., Deisseroth, K., Dasgupta, N., Isaksen, A. L., & Tsien, R. W. (2001). Calmodulin priming: Nuclear translocation of a calmodulin complex and the memory of prior neuronal activity. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 98(26), 15342-15347.

Activity-dependent CREB phosphorylation: Convergence of a fast, sensitive calmodulin kinase pathway and a slow, less sensitive mitogen-activated protein kinase pathway
Wu, G. Y., Deisseroth, K., & Tsien, R. W. (2001). Activity-dependent CREB phosphorylation: Convergence of a fast, sensitive calmodulin kinase pathway and a slow, less sensitive mitogen-activated protein kinase pathway. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 98(5), 2808-2813.

Spaced stimuli stabilize MAPK pathway activation and its effects on dendritic morphology
Wu, G. Y., Deisseroth, K., & Tsien, R. W. (2001). Spaced stimuli stabilize MAPK pathway activation and its effects on dendritic morphology. NATURE NEUROSCIENCE, 4(2), 151-158.

Critical dependence of cAMP response element-binding protein phosphorylation on L-type calcium channels supports a selective response to EPSPs in preference to action potentials
Mermelstein, P. G., Bito, H., Deisseroth, K., & Tsien, R. W. (2000). Critical dependence of cAMP response element-binding protein phosphorylation on L-type calcium channels supports a selective response to EPSPs in preference to action potentials. JOURNAL OF NEUROSCIENCE, 20(1), 266-273.

L-type calcium channels and GSK-3 regulate the activity of NF-ATc4 in hippocampal neurons
Graef, I. A., Mermelstein, P. G., Stankunas, K., Neilson, J. R., Deisseroth, K., & Crabtree, G. R. (1999). L-type calcium channels and GSK-3 regulate the activity of NF-ATc4 in hippocampal neurons. NATURE, 401(6754), 703-708.

Calmodulin supports both inactivation and facilitation of L-type calcium channels
Zuhlke, R. D., Pitt, G. S., Deisseroth, K., Tsien, R. W., & Reuter, H. (1999). Calmodulin supports both inactivation and facilitation of L-type calcium channels. NATURE, 399(6732), 159-162.

Translocation of calmodulin to the nucleus supports CREB phosphorylation in hippocampal neurons
Deisseroth, K., Heist, E. K., & Tsien, R. W. (1998). Translocation of calmodulin to the nucleus supports CREB phosphorylation in hippocampal neurons. NATURE, 392(6672), 198-202.

Ca2+-dependent regulation in neuronal gene expression
Bito, H., Deisseroth, K., & Tsien, R. W. (1997). Ca2+-dependent regulation in neuronal gene expression. CURRENT OPINION IN NEUROBIOLOGY, 7(3), 419-429.

CREB phosphorylation and dephosphorylation: A Ca2(+)- and stimulus duration-dependent switch for hippocampal gene expression
Bito, H., Deisseroth, K., & Tsien, R. W. (1996). CREB phosphorylation and dephosphorylation: A Ca2(+)- and stimulus duration-dependent switch for hippocampal gene expression. CELL, 87(7), 1203-1214.

Signaling from synapse to nucleus: Postsynaptic CREB phosphorylation during multiple forms of hippocampal synaptic plasticity
Deisseroth, K., Bito, H., & Tsien, R. W. (1996). Signaling from synapse to nucleus: Postsynaptic CREB phosphorylation during multiple forms of hippocampal synaptic plasticity. NEURON, 16(1), 89-101.

Synaptic plasticity: A molecular mechanism for metaplasticity
Deisseroth, K., Bito, H., Schulman, H., & Tsien, R. W. (1995). Synaptic plasticity: A molecular mechanism for metaplasticity. CURRENT BIOLOGY, 5(12), 1334-1338.

IDENTIFICATION OF A POINT MUTATION IN THE TOPOISOMERASE-II GENE FROM A HUMAN LEUKEMIA-CELL LINE CONTAINING AN AMSACRINE-RESISTANT FORM OF TOPOISOMERASE-II
Hinds, M., Deisseroth, K., Mayes, J., Altschuler, E., Jansen, R., & Zwelling, L. A. (1991). IDENTIFICATION OF A POINT MUTATION IN THE TOPOISOMERASE-II GENE FROM A HUMAN LEUKEMIA-CELL LINE CONTAINING AN AMSACRINE-RESISTANT FORM OF TOPOISOMERASE-II. CANCER RESEARCH, 51(17), 4729-4731.

Cross-resistance of an amsacrine-resistant human leukemia line to topoisomerase II reactive DNA intercalating agents. Evidence for two topoisomerase II directed drug actions.
Zwelling, L. A., Mayes, J., Hinds, M., Chan, D., Altschuler, E., & Seligman, M. (1991). Cross-resistance of an amsacrine-resistant human leukemia line to topoisomerase II reactive DNA intercalating agents. Evidence for two topoisomerase II directed drug actions. Biochemistry, 30(16), 4048-4055.

A RESTRICTION-FRAGMENT-LENGTH-POLYMORPHISM FOR HUMAN TOPOISOMERASE .2. POSSIBLE RELATIONSHIP TO DRUG-RESISTANCE
Zwelling, L. A., Mayes, J., Deisseroth, K., Hinds, M., GRANT, G., & Hittelman, W. (1990). A RESTRICTION-FRAGMENT-LENGTH-POLYMORPHISM FOR HUMAN TOPOISOMERASE .2. POSSIBLE RELATIONSHIP TO DRUG-RESISTANCE. CANCER COMMUNICATIONS, 2(11), 357-361.