Brian Feldman

Assistant Professor of Pediatrics (Endocrinology)

Professional Education

Fellowship: Univ of California San Francisco (2006) CA

Board Certification: Pediatrics, American Board of Pediatrics (2005)

Residency: Children's Hospital Boston (2004) MA

Medical Education: Stanford University School of Medicine (2001) CA

Board Certification: Pediatric Endocrinology, American Board of Pediatrics (2007)

Honors & Awards

Clinical Scientist Research Career Development Award, NIH/ NIDDK (2006-2011)

Clinical Scholar Award, Pediatric Endocrinology Society (2007)

Young Investigator Award, Society for Pediatric Research (2008)

NIH Director's New Innovator Award, NIH (2010-2015)

Bechtel Faculty Scholar, The Bechtel Faculty Scholar Fund (2012)

Early Investigator Award, The Endocrine Society (2013)

A plasmonic chip for biomarker discovery and diagnosis of type 1 diabetes.
Zhang, B., Kumar, R. B., Dai, H., & Feldman, B. J. (2014). A plasmonic chip for biomarker discovery and diagnosis of type 1 diabetes. Nature medicine, 20(8), 948-953.

The role of vitamin D in reducing cancer risk and progression
Feldman, D., Krishnan, A. V., Swami, S., Giovannucci, E., & Feldman, B. J. (2014). The role of vitamin D in reducing cancer risk and progression. NATURE REVIEWS CANCER, 14(5), 342-357.

Cell-Autonomous Regulation of Brown Fat Identity Gene UCP1 by Unliganded Vitamin D Receptor.
Malloy, P. J., & Feldman, B. J. (2013). Cell-Autonomous Regulation of Brown Fat Identity Gene UCP1 by Unliganded Vitamin D Receptor. Molecular endocrinology , 27(10), 1632-1642.

Circadian Rhythm Gene Period 3 Is an Inhibitor of the Adipocyte Cell Fate
Costa, M. J., So, A. Yl., Kaasik, K., Krueger, K. C., Pillsbury, M. L., & Feldman, B. J. (2011). Circadian Rhythm Gene Period 3 Is an Inhibitor of the Adipocyte Cell Fate. JOURNAL OF BIOLOGICAL CHEMISTRY, 286(11), 9063-9070.

Glucocorticoid regulation of the circadian clock modulates glucose homeostasis
So, A. Yl., Bernal, T. U., Pillsbury, M. L., Yamamoto, K. R., & Feldman, B. J. (2009). Glucocorticoid regulation of the circadian clock modulates glucose homeostasis. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 106(41), 17582-17587.

Myostatin modulates adipogenesis to generate adipocytes with favorable metabolic effects
Feldman, B. J., Streeper, R. S., Farese, R. V., & Yamamoto, K. R. (2006). Myostatin modulates adipogenesis to generate adipocytes with favorable metabolic effects. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 103(42), 15675-15680.

Nephrogenic syndrome of inappropriate antidiuresis
Feldman, B. J., Rosenthal, S. M., Vargas, G. A., Fenwick, R. G., Huang, E. A., & Gitelman, S. E. (2005). Nephrogenic syndrome of inappropriate antidiuresis. NEW ENGLAND JOURNAL OF MEDICINE, 352(18), 1884-1890.

Characterization of Three Vasopressin Receptor 2 Variants: An Apparent Polymorphism (V266A) and Two Loss-of-Function Mutations (R181C and M311V)
Armstrong, S. P., Seeber, R. M., Ayoub, M. A., Feldman, B. J., & Pfleger, K. Dg. (2013). Characterization of Three Vasopressin Receptor 2 Variants: An Apparent Polymorphism (V266A) and Two Loss-of-Function Mutations (R181C and M311V). PLOS ONE, 8(6).

Enhanced BRET Technology for the Monitoring of Agonist-Induced and Agonist-Independent Interactions between GPCRs and ß-Arrestins.
Kocan, M., Dalrymple, M. B., Seeber, R. M., Feldman, B. J., & Pfleger, K. Dg. (2010). Enhanced BRET Technology for the Monitoring of Agonist-Induced and Agonist-Independent Interactions between GPCRs and ß-Arrestins. Frontiers in endocrinology, 1, 12-?.

Agonist-Independent Interactions between beta-Arrestins and Mutant Vasopressin Type II Receptors Associated with Nephrogenic Syndrome of Inappropriate Antidiuresis
Kocan, M., See, H. B., Sampaio, N. G., Eidne, K. A., Feldman, B. J., & Pfleger, K. Dg. (2009). Agonist-Independent Interactions between beta-Arrestins and Mutant Vasopressin Type II Receptors Associated with Nephrogenic Syndrome of Inappropriate Antidiuresis. MOLECULAR ENDOCRINOLOGY, 23(4), 559-571.

Glucocorticoids Influence on Mesenchymal Stem Cells and Implications for Metabolic Disease
Feldman, B. J. (2009). Glucocorticoids Influence on Mesenchymal Stem Cells and Implications for Metabolic Disease. PEDIATRIC RESEARCH, 65(2), 249-251.

Conservation analysis predicts in vivo occupancy of glucocorticoid receptor-binding sequences at glucocorticoid-induced genes
So, A. Y.-L., Cooper, S. B., Feldman, B. J., Manuchehri, M., & Yamamoto, K. R. (2008). Conservation analysis predicts in vivo occupancy of glucocorticoid receptor-binding sequences at glucocorticoid-induced genes. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 105(15), 5745-5749.

Is your metabolism determined by (cell) fate?
Feldman, B. J. (2007). Is your metabolism determined by (cell) fate?. PEDIATRIC RESEARCH, 61(6), 636-639.

Report of a hurthle cell neoplasm in a peripubertal girl
Bremer, A. A., Feldman, B. J., Iezza, G., Clark, O. H., & Rosenthal, S. M. (2007). Report of a hurthle cell neoplasm in a peripubertal girl. THYROID, 17(2), 175-178.

Cardiac troponin increases among runners in the Boston Marathon
Fortescue, E. B., Shin, A. Y., Greenes, D. S., Mannix, R. C., Agarwal, S., & Almond, C. Sd. (2007). Cardiac troponin increases among runners in the Boston Marathon. ANNALS OF EMERGENCY MEDICINE, 49(2), 137-143.

Gain-of-function mutations in the V2 vasopressin receptor
Rosenthal, S. M., Gitelman, S. E., Vargas, G. A., & Feldman, B. J. (2007). Gain-of-function mutations in the V2 vasopressin receptor. HORMONE RESEARCH, 67, 121-125.

Nephrogenic syndrome of inappropriate antidiuresis (NSIAD): a paradigm for activating mutations causing endocrine dysfunction.
Rosenthal, S. M., Feldman, B. J., Vargas, G. A., & Gitelman, S. E. (2006). Nephrogenic syndrome of inappropriate antidiuresis (NSIAD): a paradigm for activating mutations causing endocrine dysfunction. Pediatric endocrinology reviews : PER, 4, 66-70.

Nephrogenic syndrome of inappropriate antidiuresis: A novel disorder in water balance in pediatric patients
Gitelman, S. E., Feldman, B. J., & Rosenthal, S. M. (2006). Nephrogenic syndrome of inappropriate antidiuresis: A novel disorder in water balance in pediatric patients. AMERICAN JOURNAL OF MEDICINE, 119, S54-S58.

Oral urea for the treatment of chronic syndrome of inappropriate antidiuresis in children
Huang, E. A., Feldman, B. J., Schwartz, I. D., Geller, D. H., Rosenthal, S. M., & Gitelman, S. E. (2006). Oral urea for the treatment of chronic syndrome of inappropriate antidiuresis in children. JOURNAL OF PEDIATRICS, 148(1), 128-131.

Nephrogenic syndrome of inappropriate antidiuresis - Reply
Gitelman, S. E., Feldman, B. J., & Rosenthal, S. M. (2005). Nephrogenic syndrome of inappropriate antidiuresis - Reply. NEW ENGLAND JOURNAL OF MEDICINE, 353(5), 530-530.

Carbohydrate-deficient glycoprotein syndrome-associated pericardial effusion treated with corticosteroids and salicylic acid
Feldman, B. J., & Rosenthal, D. (2002). Carbohydrate-deficient glycoprotein syndrome-associated pericardial effusion treated with corticosteroids and salicylic acid. PEDIATRIC CARDIOLOGY, 23(4), 469-471.

The development of androgen-independent prostate cancer
Feldman, B. J., & Feldman, D. (2001). The development of androgen-independent prostate cancer. NATURE REVIEWS CANCER, 1(1), 34-45.

A carboxy-terminal deletion mutant of Notch1 accelerates lymphoid oncogenesis in E2A-PBX1 transgenic mice
Feldman, B. J., Hampton, T., & Cleary, M. L. (2000). A carboxy-terminal deletion mutant of Notch1 accelerates lymphoid oncogenesis in E2A-PBX1 transgenic mice. BLOOD, 96(5), 1906-1913.

Pim1 cooperates with E2a-Pbx1 to facilitate the progression of thymic lymphomas in transgenic mice
Feldman, B. J., Reid, T. R., & Cleary, M. L. (1997). Pim1 cooperates with E2a-Pbx1 to facilitate the progression of thymic lymphomas in transgenic mice. ONCOGENE, 15(22), 2735-2742.

The chimeric oncoproteins E2A-PBX1 and E2A-HLF are concentrated within spherical nuclear domains
LeBrun, D. P., Matthews, B. P., Feldman, B. J., & Cleary, M. L. (1997). The chimeric oncoproteins E2A-PBX1 and E2A-HLF are concentrated within spherical nuclear domains. ONCOGENE, 15(17), 2059-2067.

A NOVEL ROLE FOR DNA PHOTOLYASE - BINDING TO DNA DAMAGED BY DRUGS IS ASSOCIATED WITH ENHANCED CYTOTOXICITY IN SACCHAROMYCES-CEREVISIAE
Fox, M. E., Feldman, B. J., & Chu, G. (1994). A NOVEL ROLE FOR DNA PHOTOLYASE - BINDING TO DNA DAMAGED BY DRUGS IS ASSOCIATED WITH ENHANCED CYTOTOXICITY IN SACCHAROMYCES-CEREVISIAE. MOLECULAR AND CELLULAR BIOLOGY, 14(12), 8071-8077.