C. Garrison Fathman

Immunologist

Immunology and Rheumatology Clinic

  • 900 Blake Wilbur Drive
  • Palo Alto, CA 94304
  • Phone: 650-723-6961
Learn More About the Clinic Getting Here Make An Appointment

Professional Education

Residency: Mary Hitchcock Mem Hosp (1971) NH

Medical Education: Washington University School of Medicine (1969) MO

Fellowship: Stanford University School of Medicine (1973) CA

Fellowship: National Institutes of Health (1975) MD

Internship: Mary Hitchcock Mem Hosp (1970) NH

B.A., Univ. Kentucky, Lexington, Pre-Med (1964)

M.D., Washington Univ., St. Louis, Medicine (1969)

Honors & Awards

Division Teaching Award, Stanford University School of Medicine, Department of Medicine (2011)

Founder's Award, Federation of Clinical immunology Societies (2010)

Master, American College of Rheumatology (2007)

President's Award, Clinical Immunology Society (2006)

Alumni Achievement Award, Washington University Medical School (1999)

Naomi M. Kanof Award for Distinguished Achievement in Clinical Investigation, Society for Investigative Dermatology (1997)

Administrative Appointments

Council, American Society for Clinical Investigation, 1984

Associate Editor, Annual Review of Immunology, 1981

Division Chief, Division of Immunology and Rheumatology, Stanford University Medical Center, 1997

Director, Center for Clinical Immunology at Stanford (CCIS), 1993

President, Federation of Clinical Immunology Societies (FOCIS), 2002

Associate Director, ITI Institute Stanford, 2008

Reduced DEAF1 function during type 1 diabetes inhibits translation in lymph node stromal cells by suppressing Eif4g3
Yip, L., Creusot, R. J., Pager, C. T., Sarnow, P., & Fathman, C. G. (2013). Reduced DEAF1 function during type 1 diabetes inhibits translation in lymph node stromal cells by suppressing Eif4g3. JOURNAL OF MOLECULAR CELL BIOLOGY, 5(2), 99-110.

New tools for classification and monitoring of autoimmune diseases
Maecker, H. T., Lindstrom, T. M., Robinson, W. H., Utz, P. J., Hale, M., & Fathman, C. G. (2012). New tools for classification and monitoring of autoimmune diseases. NATURE REVIEWS RHEUMATOLOGY, 8(6), 317-328.

Exploiting a natural conformational switch to engineer an interleukin-2 'superkine'
Levin, A. M., Bates, D. L., Ring, A. M., Krieg, C., Lin, J. T., & Garcia, K. C. (2012). Exploiting a natural conformational switch to engineer an interleukin-2 'superkine'. NATURE, 484(7395), 529-U159.

Therapeutic Effects of Systemic Administration of Chaperone alpha B-Crystallin Associated with Binding Proinflammatory Plasma Proteins
Rothbard, J. B., Kurnellas, M. P., Brownell, S., Adams, C. M., Su, L., & Steinman, L. (2012). Therapeutic Effects of Systemic Administration of Chaperone alpha B-Crystallin Associated with Binding Proinflammatory Plasma Proteins. JOURNAL OF BIOLOGICAL CHEMISTRY, 287(13), 9708-9721.

Differential mTOR and ERK pathway utilization by effector CD4 T cells suggests combinatorial drug therapy of arthritis
Lin, J. T., Stein, E. A., Wong, M. T., Kalpathy, K. J., Su, L. L., & Fathnnan, C. G. (2012). Differential mTOR and ERK pathway utilization by effector CD4 T cells suggests combinatorial drug therapy of arthritis. CLINICAL IMMUNOLOGY, 142(2), 127-138.

GRAIL: a unique mediator of CD4 T-lymphocyte unresponsiveness
Whiting, C. C., Su, L. L., Lin, J. T., & Fathman, C. G. (2011). GRAIL: a unique mediator of CD4 T-lymphocyte unresponsiveness. FEBS JOURNAL, 278(1), 47-58.

A Short Pulse of IL-4 Delivered by DCs Electroporated With Modified mRNA Can Both Prevent and Treat Autoimmune Diabetes in NOD Mice
Creusot, R. J., Chang, P., Healey, D. G., Tcherepanova, I. Y., Nicolette, C. A., & Fathman, C. G. (2010). A Short Pulse of IL-4 Delivered by DCs Electroporated With Modified mRNA Can Both Prevent and Treat Autoimmune Diabetes in NOD Mice. MOLECULAR THERAPY, 18(12), 2112-2120.

A model for harmonizing flow cytometry in clinical trials.
Maecker, H. T., McCoy, J. P., Amos, M., Elliott, J., Gaigalas, A., & Yeh, J.-H. (2010). A model for harmonizing flow cytometry in clinical trials. Nature immunology, 11(11), 975-978.

New technologies for autoimmune disease monitoring
Maecker, H. T., Nolan, G. P., & Fathman, C. G. (2010). New technologies for autoimmune disease monitoring. CURRENT OPINION IN ENDOCRINOLOGY DIABETES AND OBESITY, 17(4), 322-328.

Deaf1 isoforms control the expression of genes encoding peripheral tissue antigens in the pancreatic lymph nodes during type 1 diabetes
Yip, L., Su, L., Sheng, D., Chang, P., Atkinson, M., & Creusot, R. J. (2009). Deaf1 isoforms control the expression of genes encoding peripheral tissue antigens in the pancreatic lymph nodes during type 1 diabetes. NATURE IMMUNOLOGY, 10(9), 1026-U107.

The Transmembrane E3 Ligase GRAIL Ubiquitinates and Degrades CD83 on CD4 T Cells
Su, L. L., Iwai, H., Lin, J. T., & Fathman, C. G. (2009). The Transmembrane E3 Ligase GRAIL Ubiquitinates and Degrades CD83 on CD4 T Cells. JOURNAL OF IMMUNOLOGY, 183(1), 438-444.

Lymphoid tissue-specific homing of bone marrow-derived dendritic cells
Creusot, R. J., Yaghoubi, S. S., Chang, P., Chia, J., Contag, C. H., & Fathman, C. G. (2009). Lymphoid tissue-specific homing of bone marrow-derived dendritic cells. BLOOD, 113(26), 6638-6647.

Naive CD4 T Cell Proliferation Is Controlled by Mammalian Target of Rapainaycin Regulation of GRAIL Expression
Lin, J. T., Lineberry, N. B., Kattah, M. G., Su, L. L., Utz, P. J., & Wu, L. (2009). Naive CD4 T Cell Proliferation Is Controlled by Mammalian Target of Rapainaycin Regulation of GRAIL Expression. JOURNAL OF IMMUNOLOGY, 182(10), 5919-5928.

Tissue- and age-specific changes in gene expression during disease induction and progression in NOD mice
Kodama, K., Butte, A. J., Creusot, R. J., Su, L., Sheng, D., & Fathman, C. G. (2008). Tissue- and age-specific changes in gene expression during disease induction and progression in NOD mice. CLINICAL IMMUNOLOGY, 129(2), 195-201.

The single subunit transmembrane E3 ligase gene related to anergy in lymphocytes (GRAIL) captures and then ubiquitinates transmembrane proteins across the cell membrane
Lineberry, N., Su, L., Soares, L., & Fathman, C. G. (2008). The single subunit transmembrane E3 ligase gene related to anergy in lymphocytes (GRAIL) captures and then ubiquitinates transmembrane proteins across the cell membrane. JOURNAL OF BIOLOGICAL CHEMISTRY, 283(42), 28497-28505.

Cutting edge: The transmembrane E3 ligase GRAIL ubiquitinates the costimulatory molecule CD40 ligand during the induction of T cell anergy
Lineberry, N. B., Su, L. L., Lin, J. T., Coffey, G. P., Seroogy, C. M., & Fathman, C. G. (2008). Cutting edge: The transmembrane E3 ligase GRAIL ubiquitinates the costimulatory molecule CD40 ligand during the induction of T cell anergy. JOURNAL OF IMMUNOLOGY, 181(3), 1622-1626.

Tissue-targeted therapy of autoimmune diabetes using dendritic cells transduced to express IL-4 in NOD mice
Creusot, R. J., Yaghoubi, S. S., Kodama, K., Dang, D. N., Dang, V. H., & Fathman, C. G. (2008). Tissue-targeted therapy of autoimmune diabetes using dendritic cells transduced to express IL-4 in NOD mice. CLINICAL IMMUNOLOGY, 127(2), 176-187.

Naive and memory T cells induce different types of graft-versus-host disease
Dutt, S., Tseng, D., Ermann, J., George, T. I., Liu, Y. P., & Strober, S. (2007). Naive and memory T cells induce different types of graft-versus-host disease. JOURNAL OF IMMUNOLOGY, 179(10), 6547-6554.

Multimodality imaging of T-cell hybridoma trafficking in collagen-induced arthritic mice: image-based estimation of the number of cells accumulating in mouse paws
Yaghoubi, S. S., Creusot, R. J., Ray, P., Fathman, C. G., & Gambhir, S. S. (2007). Multimodality imaging of T-cell hybridoma trafficking in collagen-induced arthritic mice: image-based estimation of the number of cells accumulating in mouse paws. JOURNAL OF BIOMEDICAL OPTICS, 12(6).

Molecular mechanisms of CD4(+) T-cell anergy
Fathman, C. G., & Lineberry, N. B. (2007). Molecular mechanisms of CD4(+) T-cell anergy. NATURE REVIEWS IMMUNOLOGY, 7(8), 599-609.

A novel E3 ubiquitin ligase substrate screen identifies Rho guanine dissociation inhibitor as a substrate of gene related to anergy in lymphocytes
Su, L., Lineberry, N., Huh, Y., Soares, L., & Fathman, C. G. (2006). A novel E3 ubiquitin ligase substrate screen identifies Rho guanine dissociation inhibitor as a substrate of gene related to anergy in lymphocytes. JOURNAL OF IMMUNOLOGY, 177(11), 7559-7566.

Does our current understanding of the molecular basis of immune tolerance predict new therapies for autoimmune disease?
Tarner, I. H., & Fathman, C. G. (2006). Does our current understanding of the molecular basis of immune tolerance predict new therapies for autoimmune disease?. NATURE CLINICAL PRACTICE RHEUMATOLOGY, 2(9), 491-499.

T cell anergy: Where it's LAT
Lineberry, N., & Fathman, C. G. (2006). T cell anergy: Where it's LAT. IMMUNITY, 24(5), 501-503.

CYLD: deubiquitination-induced TCR signaling
Lineberry, N., & Fathman, C. G. (2006). CYLD: deubiquitination-induced TCR signaling. NATURE IMMUNOLOGY, 7(4), 369-370.

Developing the concept of adoptive cellular gene therapy of rheumatoid arthritis
Tarner, I. H., Neumann, E., GAY, S., Fathman, C. G., & Mulller-Ladner, U. (2006). Developing the concept of adoptive cellular gene therapy of rheumatoid arthritis. AUTOIMMUNITY REVIEWS, 5(2), 148-152.

CD4(+)CD25(+) regulatory T cells and their therapeutic potential
Randolph, D. A., & Fathman, C. G. (2006). CD4(+)CD25(+) regulatory T cells and their therapeutic potential. ANNUAL REVIEW OF MEDICINE, 57, 381-402.

L-selectin and beta(7) integrin on donor CD4 T cells are required for the early migration to host mesenteric lymph nodes and acute colitis of graft-versus-host disease
Dutt, S., Ermann, J., Tseng, D., Liu, Y. P., George, T. I., & Strober, S. (2005). L-selectin and beta(7) integrin on donor CD4 T cells are required for the early migration to host mesenteric lymph nodes and acute colitis of graft-versus-host disease. BLOOD, 106(12), 4009-4015.

Targeted gene therapy of autoimmune diseases: advances and prospects.
Creusot, R. J., Fathman, C. G., Müller-Ladner, U., & Tarner, I. H. (2005). Targeted gene therapy of autoimmune diseases: advances and prospects. Expert review of clinical immunology, 1(3), 385-404.

Molecular imaging using labeled donor tissues reveals patterns of engraftment, rejection, and survival in transplantation
Cao, Y. A., Bachmann, M. H., Beilhack, A., Yang, Y., Tanaka, M., & Contag, C. H. (2005). Molecular imaging using labeled donor tissues reveals patterns of engraftment, rejection, and survival in transplantation. TRANSPLANTATION, 80(1), 134-139.

An array of possibilities for the study of autoimmunity
Fathman, C. G., Soares, L., Chan, S. M., & Utz, P. J. (2005). An array of possibilities for the study of autoimmunity. NATURE, 435(7042), 605-611.

Only the CD62L(+) subpopulation of CD4(+)CD25(+) regulatory T cells protects from lethal acute GVHD
Ermann, J., Hoffmann, P., Edinger, M., Dutt, S., Blankenberg, F. G., & Strober, S. (2005). Only the CD62L(+) subpopulation of CD4(+)CD25(+) regulatory T cells protects from lethal acute GVHD. BLOOD, 105(5), 2220-2226.

Protein microarrays for multiplex analysis of signal transduction pathways
Chan, S. M., Ermann, Joerg, Su, Leon, & Paul J. (2005). Protein microarrays for multiplex analysis of signal transduction pathways. Nature Medicine, 10.

Fostering interdisciplinary immunology
Huston, D. P., Utz Paul J., & Fathman C. Garrison. (2005). Fostering interdisciplinary immunology. Clinical Immunology, 115.

Protein microarrays for multiplex analysis of signal transduction pathways
Chan, S. M., Ermann, J., Su, L., Fathman, C. G., & Utz, P. J. (2004). Protein microarrays for multiplex analysis of signal transduction pathways. NATURE MEDICINE, 10(12), 1390-1396.

Murine CD4(+) CD25(+) regulatory T cells fail to undergo chromatin remodeling across the proximal promoter region of the IL-2 gene
Su, L., Creusot, R. J., Gallo, E. M., Chan, S. M., Utz, P. J., & Ermann, J. (2004). Murine CD4(+) CD25(+) regulatory T cells fail to undergo chromatin remodeling across the proximal promoter region of the IL-2 gene. JOURNAL OF IMMUNOLOGY, 173(8), 4994-5001.

Gene therapy for type 1 diabetes: a novel approach for targeted treatment of autoimmunity
Creusot, R. J., & Fathman, C. G. (2004). Gene therapy for type 1 diabetes: a novel approach for targeted treatment of autoimmunity. JOURNAL OF CLINICAL INVESTIGATION, 114(7), 892-894.

The gene related to anergy in lymphocytes, an E3 ubiquitin ligase, is necessary for anergy induction in CD4 T cells
Seroogy, C. M., Soares, L., Ranheim, E. A., Su, L., Holness, C., & Fathman, C. G. (2004). The gene related to anergy in lymphocytes, an E3 ubiquitin ligase, is necessary for anergy induction in CD4 T cells. JOURNAL OF IMMUNOLOGY, 173(1), 79-85.

Targeted gene therapy: frontiers in the development of 'smart drugs'
Tarner, I. H., Muller-Ladner, U., & Fathman, C. G. (2004). Targeted gene therapy: frontiers in the development of 'smart drugs'. TRENDS IN BIOTECHNOLOGY, 22(6), 304-310.

Two isoforms of otubain 1 regulate T cell anergy via GRAIL
Soares, L., Seroogy, C., Skrenta, H., Anandasabapathy, N., Lovelace, P., & Fathman, C. G. (2004). Two isoforms of otubain 1 regulate T cell anergy via GRAIL. NATURE IMMUNOLOGY, 5(1), 45-54.

Costimulatory signals controlling regulatory T cells
Ermann, J., & Fathman, C. G. (2003). Costimulatory signals controlling regulatory T cells. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 100(26), 15292-15293.

CD4(+)CD25(+) regulatory T cells preserve graft-versus-tumor activity while inhibiting graft-versus-host disease after bone marrow transplantation
Edinger, M., Hoffmann, P., Ermann, J., Drago, K., Fathman, C. G., & Negrin, R. S. (2003). CD4(+)CD25(+) regulatory T cells preserve graft-versus-tumor activity while inhibiting graft-versus-host disease after bone marrow transplantation. NATURE MEDICINE, 9(9), 1144-1150.

Localized expression of an anti-TNF single-chain antibody prevents development of collagen-induced arthritis
Smith, R., Tarner, I. H., Hollenhorst, M., Lin, C., Levicnik, A. U., & Nolan, G. P. (2003). Localized expression of an anti-TNF single-chain antibody prevents development of collagen-induced arthritis. GENE THERAPY, 10(15), 1248-1257.

GRAIL: An E3 ubiquitin ligase that inhibits cytokine gene transcription is expressed in anergic CD4(+) T cells
Anandasabapathy, N., Ford, G. S., Bloom, D., Holness, C., Paragas, V., & Soares, L. (2003). GRAIL: An E3 ubiquitin ligase that inhibits cytokine gene transcription is expressed in anergic CD4(+) T cells. IMMUNITY, 18(4), 535-547.

Treatment of autoimmune disease by adoptive cellular gene therapy
Tarner, I. H., Slavin, A. J., McBride, J., Levicnik, A., Smith, R., & Fathman, C. G. (2003). Treatment of autoimmune disease by adoptive cellular gene therapy. MYASTHENIA GRAVIS AND RELATED DISORDERS, 998, 512-519.

Scratching the (T cell) surface.
Ermann, J., Chung, C. D., & Fathman, C. G. (2003). Scratching the (T cell) surface. Genome biology, 5(1), 202-?.

T-cell anergy - From phenotype to genotype and back
Seroogy, C. M., & Fathman, C. G. (2003). T-cell anergy - From phenotype to genotype and back. IMMUNOLOGIC RESEARCH, 28(3), 255-264.

Short polymers of arginine rapidly translocate into vascular cells - Effects on nitric oxide synthesis
Uemura, S., Rothbard, J. B., Matsushita, H., Tsao, P. S., Fathman, C. G., & Cooke, J. P. (2002). Short polymers of arginine rapidly translocate into vascular cells - Effects on nitric oxide synthesis. CIRCULATION JOURNAL, 66(12), 1155-1160.

Retroviral gene therapy of collagen-induced arthritis by local delivery of IL-4
Tarner, I. H., Nakajima, A., Seroogy, C. M., Ermann, J., Levicnik, A., & Fathman, C. G. (2002). Retroviral gene therapy of collagen-induced arthritis by local delivery of IL-4. CLINICAL IMMUNOLOGY, 105(3), 304-314.

CD4 T-helper cells engineered to produce IL-10 prevent allergen-induced airway hyperreactivity and inflammation
Oh, J. W., Seroogy, C. M., Meyer, E. H., Akbari, O., Berry, G., & Umetsu, D. T. (2002). CD4 T-helper cells engineered to produce IL-10 prevent allergen-induced airway hyperreactivity and inflammation. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 110(3), 460-468.

The potential for gene therapy in the treatment of autoimmune disease
Tarner, I. H., & Fathman, C. G. (2002). The potential for gene therapy in the treatment of autoimmune disease. CLINICAL IMMUNOLOGY, 104(3), 204-216.

The Subpopulation of CD4(+) CD25(+) splenocytes that delays adoptive transfer of diabetes expresses L-selectin and high levels of CCR7
Szanya, V., Ermann, J., TAYLOR, C., Holness, C., & Fathman, C. G. (2002). The Subpopulation of CD4(+) CD25(+) splenocytes that delays adoptive transfer of diabetes expresses L-selectin and high levels of CCR7. JOURNAL OF IMMUNOLOGY, 169(5), 2461-2465.

Donor-type CD4(+)CD25(+) regulatory T cells suppress lethal acute graft-versus-host disease after allogeneic bone marrow transplantation
Hoffmann, P., Ermann, J., Edinger, M., Fathman, C. G., & Strober, S. (2002). Donor-type CD4(+)CD25(+) regulatory T cells suppress lethal acute graft-versus-host disease after allogeneic bone marrow transplantation. JOURNAL OF EXPERIMENTAL MEDICINE, 196(3), 389-399.

Adoptive cellular gene therapy of autoimmune disease.
Slavin, A. J., Tarner, I. H., Nakajima, A., Urbanek-Ruiz, I., McBride, J., & Fathman, C. G. (2002). Adoptive cellular gene therapy of autoimmune disease. Autoimmunity reviews, 1(4), 213-219.

Immunomodulatory vaccination in autoimmune disease
Urbanek-Ruiz, I., Ruiz, P. J., Steinman, L., & Fathman, C. G. (2002). Immunomodulatory vaccination in autoimmune disease. ENDOCRINOLOGY AND METABOLISM CLINICS OF NORTH AMERICA, 31(2), 441-?.

A complicated relationship: fulfilling the interactive needs of the T lymphocyte and the dendritic cell.
Mcbride, J. M., & Fathman, C. G. (2002). A complicated relationship: fulfilling the interactive needs of the T lymphocyte and the dendritic cell. pharmacogenomics journal, 2(6), 367-376.

Bioluminescence imaging of lymphocyte trafficking in vivo
Hardy, J., Edinger, M., Bachmann, M. H., Negrin, R. S., Fathman, C. G., & Contag, C. H. (2001). Bioluminescence imaging of lymphocyte trafficking in vivo. EXPERIMENTAL HEMATOLOGY, 29(12), 1353-1360.

Gene therapy in autoimmune disease
Tarner, I. H., & Fathman, C. G. (2001). Gene therapy in autoimmune disease. CURRENT OPINION IN IMMUNOLOGY, 13(6), 676-682.

CD4(+)CD25(+) T cells facilitate the induction of T cell anergy
Ermann, J., Szanya, V., Ford, G. S., Paragas, V., Fathman, C. G., & Lejon, K. (2001). CD4(+)CD25(+) T cells facilitate the induction of T cell anergy. JOURNAL OF IMMUNOLOGY, 167(8), 4271-4275.

Autoimmune diseases: genes, bugs and failed regulation
Ermann, J., & Fathman, C. G. (2001). Autoimmune diseases: genes, bugs and failed regulation. NATURE IMMUNOLOGY, 2(9), 759-761.

Adoptive immunotherapy of experimental autoimmune encephalomyelitis via T cell delivery of the IL-12 p40 subunit
Costa, G. L., Sandora, M. R., Nakajima, A., Nguyen, E. V., Taylor-Edwards, C., & Benson, J. M. (2001). Adoptive immunotherapy of experimental autoimmune encephalomyelitis via T cell delivery of the IL-12 p40 subunit. JOURNAL OF IMMUNOLOGY, 167(4), 2379-2387.

Immunization with DNA encoding an immunodominant peptide of insulin prevents diabetes in NOD mice
Urbanek-Ruiz, I., Ruiz, P. J., Paragas, V., Garren, H., Steinman, L., & Fathman, C. G. (2001). Immunization with DNA encoding an immunodominant peptide of insulin prevents diabetes in NOD mice. CLINICAL IMMUNOLOGY, 100(2), 164-171.

Antigen-specific T cell-mediated gene therapy in collagen-induced arthritis
Nakajima, A., Seroogy, C. M., Sandora, M. R., Tarner, I. H., Costa, G. L., & Fathman, C. G. (2001). Antigen-specific T cell-mediated gene therapy in collagen-induced arthritis. JOURNAL OF CLINICAL INVESTIGATION, 107(10), 1293-1301.

T cell receptor (TCR)-mediated repertoire selection and loss of TCR V beta diversity during the initiation of a CD4(+) T cell response in vivo
Fasso, M., Anandasabapathy, N., Crawford, F., Kappler, J., Fathman, C. G., & Ridgway, W. M. (2000). T cell receptor (TCR)-mediated repertoire selection and loss of TCR V beta diversity during the initiation of a CD4(+) T cell response in vivo. JOURNAL OF EXPERIMENTAL MEDICINE, 192(12), 1719-1730.

Rapid and efficient vascular transport of arginine polymers inhibits myointimal hyperplasia
Uemura, S., Fathman, C. G., Rothbard, J. B., & Cooke, J. P. (2000). Rapid and efficient vascular transport of arginine polymers inhibits myointimal hyperplasia. CIRCULATION, 102(21), 2629-2635.

Polyarginine enters cells more efficiently than other polycationic homopolymers
Mitchell, D. J., Kim, D. T., Steinman, L., Fathman, C. G., & Rothbard, J. B. (2000). Polyarginine enters cells more efficiently than other polycationic homopolymers. JOURNAL OF PEPTIDE RESEARCH, 56(5), 318-325.

Targeting rare populations of murine antigen-specific T lymphocytes by retroviral transduction for potential application in gene therapy for autoimmune disease
Costa, G. L., Benson, J. M., Seroogy, C. M., Achacoso, P., Fathman, C. G., & Nolan, G. P. (2000). Targeting rare populations of murine antigen-specific T lymphocytes by retroviral transduction for potential application in gene therapy for autoimmune disease. JOURNAL OF IMMUNOLOGY, 164(7), 3581-3590.

Gene therapy for autoimmune disease
Fathman, C. G., Costa, G. L., & Seroogy, C. M. (2000). Gene therapy for autoimmune disease. CLINICAL IMMUNOLOGY, 95(1), S39-S43.

Identification and characterization of the antigen-specific subpopulation of alloreactive CD4+T cells in vitro and in vivo
Krieger, N. R., Fathman, C. G., Shaw, M. K., & Ridgway, W. M. (2000). Identification and characterization of the antigen-specific subpopulation of alloreactive CD4+T cells in vitro and in vivo. TRANSPLANTATION, 69(4), 605-609.

Application of gene therapy in autoimmune disease.
Fathman, C. G., & Seroogy, C. M. (2000). Application of gene therapy in autoimmune disease. Current directions in autoimmunity, 2, 189-202.

The application of gene therapy in autoimmune diseases
Seroogy, C. M., & Fathman, C. G. (2000). The application of gene therapy in autoimmune diseases. GENE THERAPY, 7(1), 9-13.

Isolation of self antigen-reactive cells from inflamed islets of nonobese diabetic mice using CD4(high) expression as a marker
Lejon, K., & Fathman, C. G. (1999). Isolation of self antigen-reactive cells from inflamed islets of nonobese diabetic mice using CD4(high) expression as a marker. JOURNAL OF IMMUNOLOGY, 163(10), 5708-5714.

A new look at MHC and autoimmune disease.
Ridgway, W. M., Fassò, M., & Fathman, C. G. (1999). A new look at MHC and autoimmune disease. Science , 284(5415), 749-?.

Suppressive immunization with DNA encoding a self-peptide prevents autoimmune disease: Modulation of T cell costimulation
Ruiz, P. J., Garren, H., Ruiz, I. U., Hirschberg, D. L., Nguyen, L. Vt., & Steinman, L. (1999). Suppressive immunization with DNA encoding a self-peptide prevents autoimmune disease: Modulation of T cell costimulation. JOURNAL OF IMMUNOLOGY, 162(6), 3336-3341.

Local delivery of TNF by retrovirus-transduced T lymphocytes exacerbates experimental autoimmune encephalomyelitis
Dal Canto, R. A., Shaw, M. K., Nolan, G. P., Steinman, L., & Fathman, C. G. (1999). Local delivery of TNF by retrovirus-transduced T lymphocytes exacerbates experimental autoimmune encephalomyelitis. CLINICAL IMMUNOLOGY, 90(1), 10-14.

Analysis of the role of variation of major histocompatibility complex class II expression on nonobese diabetic (NOD) peripheral T cell response
Ridgway, W. M., Ito, H., Fasso, M., Yu, C., & Fathman, C. G. (1998). Analysis of the role of variation of major histocompatibility complex class II expression on nonobese diabetic (NOD) peripheral T cell response. JOURNAL OF EXPERIMENTAL MEDICINE, 188(12), 2267-2275.

T cell receptor (TCR) engagement leads to activation-induced splicing of tumor necrosis factor (TNF) nuclear pre-mRNA
Yang, Y., Chang, J. F., Parnes, J. R., & Fathman, C. G. (1998). T cell receptor (TCR) engagement leads to activation-induced splicing of tumor necrosis factor (TNF) nuclear pre-mRNA. JOURNAL OF EXPERIMENTAL MEDICINE, 188(2), 247-254.

Following antigen challenge, T cells up-regulate cell surface expression of CD4 in vitro and in vivo
Ridgway, W., Fasso, M., & Fathman, C. G. (1998). Following antigen challenge, T cells up-regulate cell surface expression of CD4 in vitro and in vivo. JOURNAL OF IMMUNOLOGY, 161(2), 714-720.

Prolongation of cardiac graft survival with anti-CD4Ig plus hCTLA4Ig in primates
Krieger, N. R., Yuh, D., McIntyre, W. B., Flavin, T. F., Yin, D. P., & Fathman, C. G. (1998). Prolongation of cardiac graft survival with anti-CD4Ig plus hCTLA4Ig in primates. JOURNAL OF SURGICAL RESEARCH, 76(2), 174-178.

Regulation of programmed cell death following T cell activation in vivo
Yang, Y., Kim, D., & Fathman, C. G. (1998). Regulation of programmed cell death following T cell activation in vivo. INTERNATIONAL IMMUNOLOGY, 10(2), 175-183.

A gene therapy approach to treatment of autoimmune disease
Seroogy, C. M., & Fathman, C. G. (1998). A gene therapy approach to treatment of autoimmune disease. IMMUNOLOGIC RESEARCH, 18(1), 15-26.

The association of MHC with autoimmune diseases: Understanding the pathogenesis of autoimmune diabetes
Ridgway, W. M., & Fathman, C. G. (1998). The association of MHC with autoimmune diseases: Understanding the pathogenesis of autoimmune diabetes. CLINICAL IMMUNOLOGY AND IMMUNOPATHOLOGY, 86(1), 3-10.

CD45RB(high) CD4(+) T cells from IFN-gamma knockout mice do not induce wasting disease
Ito, H., & Fathman, C. G. (1997). CD45RB(high) CD4(+) T cells from IFN-gamma knockout mice do not induce wasting disease. JOURNAL OF AUTOIMMUNITY, 10(5), 455-459.

Introduction of soluble proteins into the MHC class I pathway by conjugation to an HIV tat peptide
Kim, D. T., Mitchell, D. J., Brockstedt, D. G., Fong, L., Nolan, G. P., & Rothbard, J. B. (1997). Introduction of soluble proteins into the MHC class I pathway by conjugation to an HIV tat peptide. JOURNAL OF IMMUNOLOGY, 159(4), 1666-1668.

Rat pancreatic islet and skin xenograft survival in CD4 and CD8 knockout mice
Krieger, N. R., Ito, H., & Fathman, C. G. (1997). Rat pancreatic islet and skin xenograft survival in CD4 and CD8 knockout mice. JOURNAL OF AUTOIMMUNITY, 10(3), 309-315.

Local delivery of interleukin 4 by retrovirus-transduced T lymphocytes ameliorates experimental autoimmune encephalomyelitis
Shaw, M. K., Lorens, J. B., Dhawan, A., DalCanto, R., Tse, H. Y., & Fathman, C. G. (1997). Local delivery of interleukin 4 by retrovirus-transduced T lymphocytes ameliorates experimental autoimmune encephalomyelitis. JOURNAL OF EXPERIMENTAL MEDICINE, 185(9), 1711-1714.

The use of CD4 and CD8 knockout mice to study the role of T-cell subsets in allotransplant rejection
Krieger, N. R., & Fathman, C. G. (1997). The use of CD4 and CD8 knockout mice to study the role of T-cell subsets in allotransplant rejection. JOURNAL OF HEART AND LUNG TRANSPLANTATION, 16(3), 263-267.

Induction of tolerance to small bowel allografts in high-responder rats by combining anti-CD4 with CTLA4Ig
Yin, D. P., Sankary, H. N., Williams, J., Krieger, N., & Fathman, C. G. (1996). Induction of tolerance to small bowel allografts in high-responder rats by combining anti-CD4 with CTLA4Ig. TRANSPLANTATION, 62(11), 1537-1539.

CD4(+) but not CD8(+) cells are essential for allorejection
Krieger, N. R., Yin, D. P., & Fathman, C. G. (1996). CD4(+) but not CD8(+) cells are essential for allorejection. JOURNAL OF EXPERIMENTAL MEDICINE, 184(5), 2013-2018.

beta-cell destruction may be a late consequence of the autoimmune process in nonobese diabetic mice
Shimada, A., Charlton, B., TAYLOREDWARDS, C., & Fathman, C. G. (1996). beta-cell destruction may be a late consequence of the autoimmune process in nonobese diabetic mice. DIABETES, 45(8), 1063-1067.

Quantitative analysis of T cell activation - Role of TCR ligand density and TCR affinity
Kim, D. T., Rothbard, J. B., Bloom, D. D., & Fathman, C. G. (1996). Quantitative analysis of T cell activation - Role of TCR ligand density and TCR affinity. JOURNAL OF IMMUNOLOGY, 156(8), 2737-2742.

Breaking self-tolerance in nonobese diabetic mice
Ridgway, W. M., Fasso, M., LANCTOT, A., Garvey, C., & Fathman, C. G. (1996). Breaking self-tolerance in nonobese diabetic mice. JOURNAL OF EXPERIMENTAL MEDICINE, 183(4), 1657-1662.

Immune regulation in type 1 diabetes
Shimada, A., Charlton, B., Rohane, P., TAYLOREDWARDS, C., & Fathman, C. G. (1996). Immune regulation in type 1 diabetes. JOURNAL OF AUTOIMMUNITY, 9(2), 263-269.

Monoclonal T cells identified in early NOD islet infiltrates
Yang, Y., Charlton, B., Shimada, A., DalCanto, R., & Fathman, C. G. (1996). Monoclonal T cells identified in early NOD islet infiltrates. IMMUNITY, 4(2), 189-194.

Treatment of experimental encephalomyelitis with a peptide analogue of myelin basic protein
Brocke, S., Gijbels, K., Allegretta, M., Ferber, I., Piercy, C., & Steinman, L. (1996). Treatment of experimental encephalomyelitis with a peptide analogue of myelin basic protein. NATURE, 379(6563), 343-346.

Pathogenic and protective roles of CD45RB(low) CD4(+) cells correlate with cytokine profiles in the spontaneously autoimmune diabetic mouse
Shimada, A., Rohane, P., Fathman, C. G., & Charlton, B. (1996). Pathogenic and protective roles of CD45RB(low) CD4(+) cells correlate with cytokine profiles in the spontaneously autoimmune diabetic mouse. DIABETES, 45(1), 71-78.

Mice with a disrupted IFN-gamma gene are susceptible to the induction of experimental autoimmune encephalolmyelitis (EAE)
Ferber, I. A., Brocke, S., TAYLOREDWARDS, C., Ridgway, W., Dinisco, C., & Fathman, C. G. (1996). Mice with a disrupted IFN-gamma gene are susceptible to the induction of experimental autoimmune encephalolmyelitis (EAE). JOURNAL OF IMMUNOLOGY, 156(1), 5-7.

Tissue-specific effects of anti-CD4 therapy in induction of allograft unresponsiveness in high and low responder rats.
Yin, D., & Fathman, C. G. (1995). Tissue-specific effects of anti-CD4 therapy in induction of allograft unresponsiveness in high and low responder rats. Transplant immunology, 3(3), 258-264.

TERNARY COMPLEX THERAPY FOR AUTOIMMUNE-DISEASE
Fathman, C. G. (1995). TERNARY COMPLEX THERAPY FOR AUTOIMMUNE-DISEASE. HOSPITAL PRACTICE, 30(8), 57-?.

INDUCTION OF TOLERANCE TO HEART ALLOGRAFTS IN HIGH RESPONDER RATS BY COMBINING ANTI-CD4 WITH CTLA4IG
Yin, D. P., & Fathman, C. G. (1995). INDUCTION OF TOLERANCE TO HEART ALLOGRAFTS IN HIGH RESPONDER RATS BY COMBINING ANTI-CD4 WITH CTLA4IG. JOURNAL OF IMMUNOLOGY, 155(4), 1655-1659.

CD4-POSITIVE SUPPRESSOR CELLS BLOCK ALLOTRANSPLANT REJECTION
Yin, D. P., & Fathman, C. G. (1995). CD4-POSITIVE SUPPRESSOR CELLS BLOCK ALLOTRANSPLANT REJECTION. JOURNAL OF IMMUNOLOGY, 154(12), 6339-6345.

ISLET-INFILTRATING LYMPHOCYTES FROM PREDIABETIC NOD MICE RAPIDLY TRANSFER DIABETES TO NOD-SCID/SCID MICE
Rohane, P. W., Shimada, A., Kim, D. T., Edwards, C. T., Charlton, B., & Fathman, C. G. (1995). ISLET-INFILTRATING LYMPHOCYTES FROM PREDIABETIC NOD MICE RAPIDLY TRANSFER DIABETES TO NOD-SCID/SCID MICE. DIABETES, 44(5), 550-554.

REGULATION OF AUTOIMMUNE-RESPONSE
Ridgway, W. M., Weiner, H. L., & Fathman, C. G. (1994). REGULATION OF AUTOIMMUNE-RESPONSE. CURRENT OPINION IN IMMUNOLOGY, 6(6), 946-955.

PREVENTION OF DIABETES AND INSULITIS BY NEONATAL INTRATHYMIC ISLET ADMINISTRATION IN NOD MICE
Charlton, B., TAYLOREDWARDS, C., Tisch, R., & Fathman, C. G. (1994). PREVENTION OF DIABETES AND INSULITIS BY NEONATAL INTRATHYMIC ISLET ADMINISTRATION IN NOD MICE. JOURNAL OF AUTOIMMUNITY, 7(5), 549-560.

CD4-POSITIVE HEAT-STABLE ANTIGEN-POSITIVE THYMOCYTES CAUSE GRAFT-VERSUS-HOST DISEASE ACROSS NONMAJOR HISTOCOMPATIBILITY COMPLEX INCOMPATIBILITIES
Charlton, B., Meltzer, J., & Fathman, C. G. (1994). CD4-POSITIVE HEAT-STABLE ANTIGEN-POSITIVE THYMOCYTES CAUSE GRAFT-VERSUS-HOST DISEASE ACROSS NONMAJOR HISTOCOMPATIBILITY COMPLEX INCOMPATIBILITIES. EUROPEAN JOURNAL OF IMMUNOLOGY, 24(7), 1706-1709.

IMMUNOTHERAPEUTIC STRATEGIES DIRECTED AT THE TRIMOLECULAR COMPLEX
Gaur, A., & Fathman, C. G. (1994). IMMUNOTHERAPEUTIC STRATEGIES DIRECTED AT THE TRIMOLECULAR COMPLEX. ADVANCES IN IMMUNOLOGY, VOLUME 56, 56, 219-265.

MECHANISMS OF TRANSPLANTATION TOLERANCE
Charlton, B., Auchincloss, H., & Fathman, C. G. (1994). MECHANISMS OF TRANSPLANTATION TOLERANCE. ANNUAL REVIEW OF IMMUNOLOGY, 12, 707-734.

SELECTION FOR AMINO-ACID-SEQUENCE AND J-BETA-ELEMENT USAGE IN THE BETA-CHAIN OF DBA 2V BETA(B)-DERIVED AND DBA 2V BETA(A)-DERIVED MYOGLOBIN-SPECIFIC T-CELL CLONES
Ruberti, G., Paragas, V., Kim, D., & Fathman, C. G. (1993). SELECTION FOR AMINO-ACID-SEQUENCE AND J-BETA-ELEMENT USAGE IN THE BETA-CHAIN OF DBA 2V BETA(B)-DERIVED AND DBA 2V BETA(A)-DERIVED MYOGLOBIN-SPECIFIC T-CELL CLONES. JOURNAL OF IMMUNOLOGY, 151(11), 6185-6194.

PEPTIDES AS THERAPY OF AUTOIMMUNE-DISEASE
Fathman, C. G. (1993). PEPTIDES AS THERAPY OF AUTOIMMUNE-DISEASE. DIABETES-METABOLISM REVIEWS, 9(4), 239-244.

INDUCTION OF RELAPSING PARALYSIS IN EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS BY BACTERIAL SUPERANTIGEN
Brocke, S., Gaur, A., Piercy, C., Gautam, A., Gijbels, K., & Steinman, L. (1993). INDUCTION OF RELAPSING PARALYSIS IN EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS BY BACTERIAL SUPERANTIGEN. NATURE, 365(6447), 642-644.

EVIDENCE THAT CLONAL ANERGY IS INDUCED IN THYMIC MIGRANT CELLS AFTER ANTI-CD4-MEDIATED TRANSPLANTATION TOLERANCE
Alters, S. E., Song, H. K., & Fathman, C. G. (1993). EVIDENCE THAT CLONAL ANERGY IS INDUCED IN THYMIC MIGRANT CELLS AFTER ANTI-CD4-MEDIATED TRANSPLANTATION TOLERANCE. TRANSPLANTATION, 56(3), 633-638.

SEB INDUCED ANERGY - MODULATION OF IMMUNE-RESPONSE TO T-CELL DETERMINANTS OF MYOGLOBIN AND MYELIN BASIC-PROTEIN
Gaur, A., Fathman, C. G., Steinman, L., & Brocke, S. (1993). SEB INDUCED ANERGY - MODULATION OF IMMUNE-RESPONSE TO T-CELL DETERMINANTS OF MYOGLOBIN AND MYELIN BASIC-PROTEIN. JOURNAL OF IMMUNOLOGY, 150(7), 3062-3069.

THE USE OF GRANZYME A AS A MARKER OF HEART-TRANSPLANT REJECTION IN CYCLOSPORINE OR ANTI-CD4 MONOCLONAL ANTIBODY-TREATED RATS
CHEN, R. H., IVENS, K. W., Alpert, S., Billingham, M. E., Fathman, C. G., & Griffiths, G. M. (1993). THE USE OF GRANZYME A AS A MARKER OF HEART-TRANSPLANT REJECTION IN CYCLOSPORINE OR ANTI-CD4 MONOCLONAL ANTIBODY-TREATED RATS. TRANSPLANTATION, 55(1), 146-153.

REQUIREMENT FOR CD8+ CELLS IN T-CELL RECEPTOR PEPTIDE-INDUCED CLONAL UNRESPONSIVENESS
Gaur, A., Haspel, R., Mayer, J. P., & Fathman, C. G. (1993). REQUIREMENT FOR CD8+ CELLS IN T-CELL RECEPTOR PEPTIDE-INDUCED CLONAL UNRESPONSIVENESS. SCIENCE, 259(5091), 91-94.

EVIDENCE THAT ANTI-CD8 ABROGATES ANTI-CD4 MEDIATED CLONAL ANERGY BUT ALLOWS ALLOGRAFT SURVIVAL IN MICE
Song, H. K., Alters, S. E., & Fathman, C. G. (1993). EVIDENCE THAT ANTI-CD8 ABROGATES ANTI-CD4 MEDIATED CLONAL ANERGY BUT ALLOWS ALLOGRAFT SURVIVAL IN MICE. TRANSPLANTATION, 55(1), 133-139.

Anti-CD4 antibodies in diabetes.
Shizuru, J. A., & Fathman, C. G. (1993). Anti-CD4 antibodies in diabetes. Immunology series, 59, 237-252.

AMELIORATION OF AUTOIMMUNE ENCEPHALOMYELITIS BY MYELIN BASIC-PROTEIN SYNTHETIC PEPTIDE INDUCED ANERGY
Gaur, A., WIERS, B., Liu, A., Rothbard, J., & Fathman, C. G. (1992). AMELIORATION OF AUTOIMMUNE ENCEPHALOMYELITIS BY MYELIN BASIC-PROTEIN SYNTHETIC PEPTIDE INDUCED ANERGY. SCIENCE, 258(5087), 1491-1494.

IMMUNOTHERAPY OF RHEUMATIC DISEASES BASED ON UNDERSTANDING GENETIC PREDISPOSITION TO THE DEVELOPMENT OF THESE DISEASES
Fathman, C. G. (1992). IMMUNOTHERAPY OF RHEUMATIC DISEASES BASED ON UNDERSTANDING GENETIC PREDISPOSITION TO THE DEVELOPMENT OF THESE DISEASES. RHEUMATIC DISEASE CLINICS OF NORTH AMERICA, 18(4), 915-926.

ANTI-CD4 MONOCLONAL-ANTIBODIES IN THERAPY - CREATION OF NONCLASSICAL TOLERANCE IN THE ADULT
Shizuru, J. A., Alters, S. E., & Fathman, C. G. (1992). ANTI-CD4 MONOCLONAL-ANTIBODIES IN THERAPY - CREATION OF NONCLASSICAL TOLERANCE IN THE ADULT. IMMUNOLOGICAL REVIEWS, 129, 105-130.

LIMITED T-CELL RECEPTOR BETA-CHAIN USAGE IN THE SPERM WHALE MYOGLOBIN 110-121/E-ALPHA(D)A-BETA(D) RESPONSE BY H-2(D) CONGENIC MOUSE STRAINS
Sellins, K. S., Danska, J. S., Paragas, V., & Fathman, C. G. (1992). LIMITED T-CELL RECEPTOR BETA-CHAIN USAGE IN THE SPERM WHALE MYOGLOBIN 110-121/E-ALPHA(D)A-BETA(D) RESPONSE BY H-2(D) CONGENIC MOUSE STRAINS. JOURNAL OF IMMUNOLOGY, 149(7), 2323-2327.

What a rheumatologist needs to know about T cell receptor structure and function.
Fathman, C. G. (1992). What a rheumatologist needs to know about T cell receptor structure and function. journal of rheumatology. Supplement, 32, 12-15.

PRESENTATION OF ANTIGEN BY MIXED ISOTYPE CLASS-II MOLECULES IN NORMAL H-2D MICE
Ruberti, G., Sellins, K. S., Hill, C. M., Germain, R. N., Fathman, C. G., & Livingstone, A. (1992). PRESENTATION OF ANTIGEN BY MIXED ISOTYPE CLASS-II MOLECULES IN NORMAL H-2D MICE. JOURNAL OF EXPERIMENTAL MEDICINE, 175(1), 157-162.

ANTI-CD8 ABROGATES EFFECT OF ANTI-CD4-MEDIATED ISLET ALLOGRAFT SURVIVAL IN RAT MODEL
SEYDEL, K., Shizuru, J., Grossman, D., Wu, A., Alters, S., & Fathman, C. G. (1991). ANTI-CD8 ABROGATES EFFECT OF ANTI-CD4-MEDIATED ISLET ALLOGRAFT SURVIVAL IN RAT MODEL. DIABETES, 40(11), 1430-1434.

GENETIC DISSECTION OF T-CELL RECEPTOR-V-BETA GENE REQUIREMENTS FOR SPONTANEOUS MURINE DIABETES
Shizuru, J. A., TAYLOREDWARDS, C., Livingstone, A., & Fathman, C. G. (1991). GENETIC DISSECTION OF T-CELL RECEPTOR-V-BETA GENE REQUIREMENTS FOR SPONTANEOUS MURINE DIABETES. JOURNAL OF EXPERIMENTAL MEDICINE, 174(3), 633-638.

THE T-CELL RECEPTOR REPERTOIRE INFLUENCES V-BETA ELEMENT USAGE IN RESPONSE TO MYOGLOBIN
Ruberti, G., Gaur, A., Fathman, C. G., & Livingstone, A. M. (1991). THE T-CELL RECEPTOR REPERTOIRE INFLUENCES V-BETA ELEMENT USAGE IN RESPONSE TO MYOGLOBIN. JOURNAL OF EXPERIMENTAL MEDICINE, 174(1), 83-92.

ANALYSIS OF THE TERNARY COMPLEX OF ANTIGEN, MHC AND T-CELL RECEPTOR - THE INFLUENCE OF THE T-CELL RECEPTOR V-BETA REPERTOIRE ON THE V-BETA GENE ELEMENT USAGE
Ruberti, G., Livingstone, A., Danska, J. S., Gaur, A., & Fathman, C. G. (1991). ANALYSIS OF THE TERNARY COMPLEX OF ANTIGEN, MHC AND T-CELL RECEPTOR - THE INFLUENCE OF THE T-CELL RECEPTOR V-BETA REPERTOIRE ON THE V-BETA GENE ELEMENT USAGE. RESEARCH IN IMMUNOLOGY, 142(5-6), 491-493.

MOLECULAR ANALYSIS OF THE ROLE OF THE HLA CLASS-II GENES DRB1, DQA1, DQB1, AND DPB1 IN SUSCEPTIBILITY TO LYME ARTHRITIS
Ruberti, G., Begovich, A. B., STEERE, A. C., Klitz, W., Erlich, H. A., & Fathman, C. G. (1991). MOLECULAR ANALYSIS OF THE ROLE OF THE HLA CLASS-II GENES DRB1, DQA1, DQB1, AND DPB1 IN SUSCEPTIBILITY TO LYME ARTHRITIS. HUMAN IMMUNOLOGY, 31(1), 20-27.

ANTI-CD4 MEDIATES CLONAL ANERGY DURING TRANSPLANTATION TOLERANCE INDUCTION
Alters, S. E., Shizuru, J. A., Ackerman, J., Grossman, D., Seydel, K. B., & Fathman, C. G. (1991). ANTI-CD4 MEDIATES CLONAL ANERGY DURING TRANSPLANTATION TOLERANCE INDUCTION. JOURNAL OF EXPERIMENTAL MEDICINE, 173(2), 491-494.

GENETIC-ANALYSIS OF DIABETES IN THE NONOBESE DIABETIC MOUSE .1. MHC AND T-CELL RECEPTOR BETA-GENE EXPRESSION
Livingstone, A., Edwards, C. T., Shizuru, J. A., & Fathman, C. G. (1991). GENETIC-ANALYSIS OF DIABETES IN THE NONOBESE DIABETIC MOUSE .1. MHC AND T-CELL RECEPTOR BETA-GENE EXPRESSION. JOURNAL OF IMMUNOLOGY, 146(2), 529-534.

DRB1-STAR-LY10 - A NEW DRB1 ALLELE AND ITS HAPLOTYPIC ASSOCIATION
MCCLURE, G. R., Ruberti, G., Fathman, C. G., Erlich, H. A., & Begovich, A. B. (1990). DRB1-STAR-LY10 - A NEW DRB1 ALLELE AND ITS HAPLOTYPIC ASSOCIATION. IMMUNOGENETICS, 32(3), 214-217.

T-CELL RECEPTOR-MEDIATED NEGATIVE SELECTION OF AUTOREACTIVE LYMPHOCYTE-T PRECURSORS OCCURS AFTER COMMITMENT TO THE CD4 OR CD8 LINEAGES
Guidos, C. J., Danska, J. S., Fathman, C. G., & Weissman, I. L. (1990). T-CELL RECEPTOR-MEDIATED NEGATIVE SELECTION OF AUTOREACTIVE LYMPHOCYTE-T PRECURSORS OCCURS AFTER COMMITMENT TO THE CD4 OR CD8 LINEAGES. JOURNAL OF EXPERIMENTAL MEDICINE, 172(3), 835-845.

INDUCTION OF DONOR-SPECIFIC UNRESPONSIVENESS TO CARDIAC ALLOGRAFTS IN RATS BY PRETRANSPLANT ANTI-CD4 MONOCLONAL-ANTIBODY THERAPY
Shizuru, J. A., Seydel, K. B., Flavin, T. F., Wu, A. P., Kong, C. C., & Fathman, C. G. (1990). INDUCTION OF DONOR-SPECIFIC UNRESPONSIVENESS TO CARDIAC ALLOGRAFTS IN RATS BY PRETRANSPLANT ANTI-CD4 MONOCLONAL-ANTIBODY THERAPY. TRANSPLANTATION, 50(3), 366-373.

THE PRESUMPTIVE CDR3 REGIONS OF BOTH T-CELL RECEPTOR ALPHA-CHAIN AND BETA-CHAIN DETERMINE T-CELL SPECIFICITY FOR MYOGLOBIN PEPTIDES
Danska, J. S., Livingstone, A. M., Paragas, V., Ishihara, T., & Fathman, C. G. (1990). THE PRESUMPTIVE CDR3 REGIONS OF BOTH T-CELL RECEPTOR ALPHA-CHAIN AND BETA-CHAIN DETERMINE T-CELL SPECIFICITY FOR MYOGLOBIN PEPTIDES. JOURNAL OF EXPERIMENTAL MEDICINE, 172(1), 27-33.

SHARED MOLECULAR MARKERS OF GENETIC PREDISPOSITION TO SEROPOSITIVE RHEUMATOID-ARTHRITIS
Morel, P. A., HORN, G. T., Budd, R. C., Erlich, H. A., & Fathman, C. G. (1990). SHARED MOLECULAR MARKERS OF GENETIC PREDISPOSITION TO SEROPOSITIVE RHEUMATOID-ARTHRITIS. HUMAN IMMUNOLOGY, 27(2), 90-99.

CARDIAC ALLOGRAFT PROLONGATION IN MICE TREATED WITH COMBINED POSTTRANSPLANTATION TOTAL-LYMPHOID IRRADIATION AND ANTI-L3T4 ANTIBODY THERAPY
TRAGER, D. K., Banks, B. A., Rosenbaum, G. E., HOLM, B. I., Shizuru, J. A., & Fathman, C. G. (1989). CARDIAC ALLOGRAFT PROLONGATION IN MICE TREATED WITH COMBINED POSTTRANSPLANTATION TOTAL-LYMPHOID IRRADIATION AND ANTI-L3T4 ANTIBODY THERAPY. TRANSPLANTATION, 47(4), 587-591.

A SUBSET OF MEMORY CD4+ HELPER LYMPHOCYTES-T IDENTIFIED BY EXPRESSION OF PGP-1
Butterfield, K., Fathman, C. G., & Budd, R. C. (1989). A SUBSET OF MEMORY CD4+ HELPER LYMPHOCYTES-T IDENTIFIED BY EXPRESSION OF PGP-1. JOURNAL OF EXPERIMENTAL MEDICINE, 169(4), 1461-1466.

ENHANCED CELL-MEDIATED PROTECTION AGAINST FATAL ESCHERICHIA-COLI SEPTICEMIA INDUCED BY TREATMENT WITH RECOMBINANT IL-2
GORONZY, J., WEYAND, C., Quan, J., Fathman, C. G., & OHANLEY, P. (1989). ENHANCED CELL-MEDIATED PROTECTION AGAINST FATAL ESCHERICHIA-COLI SEPTICEMIA INDUCED BY TREATMENT WITH RECOMBINANT IL-2. JOURNAL OF IMMUNOLOGY, 142(4), 1134-1138.

A NEW LOOK AT THE SHARED EPITOPE HYPOTHESIS
Morel, P. A., Erlich, H. A., & Fathman, C. G. (1988). A NEW LOOK AT THE SHARED EPITOPE HYPOTHESIS. AMERICAN JOURNAL OF MEDICINE, 85(6A), 20-22.

USE OF ANTI-L3T4 AND ANTI-IA TREATMENTS FOR PROLONGATION OF XENOGENEIC ISLET TRANSPLANTS
Kaufman, D. S., Kong, C. S., Shizuru, J. A., Gregory, A. K., & Fathman, C. G. (1988). USE OF ANTI-L3T4 AND ANTI-IA TREATMENTS FOR PROLONGATION OF XENOGENEIC ISLET TRANSPLANTS. TRANSPLANTATION, 46(2), 210-215.

IMMUNOTHERAPY OF THE NONOBESE DIABETIC MOUSE - TREATMENT WITH AN ANTIBODY TO T-HELPER LYMPHOCYTES
Shizuru, J. A., TAYLOREDWARDS, C., Banks, B. A., Gregory, A. K., & Fathman, C. G. (1988). IMMUNOTHERAPY OF THE NONOBESE DIABETIC MOUSE - TREATMENT WITH AN ANTIBODY TO T-HELPER LYMPHOCYTES. SCIENCE, 240(4852), 659-662.

ADMINISTRATION INVIVO OF RECOMBINANT INTERLEUKIN-2 PROTECTS MICE AGAINST SEPTIC DEATH
WEYAND, C., GORONZY, J., Fathman, C. G., & OHANLEY, P. (1987). ADMINISTRATION INVIVO OF RECOMBINANT INTERLEUKIN-2 PROTECTS MICE AGAINST SEPTIC DEATH. JOURNAL OF CLINICAL INVESTIGATION, 79(6), 1756-1763.

MODULATION OF CD4 BY ANTIGENIC ACTIVATION
Weyand, C. M., GORONZY, J., & Fathman, C. G. (1987). MODULATION OF CD4 BY ANTIGENIC ACTIVATION. JOURNAL OF IMMUNOLOGY, 138(5), 1351-1354.

CLONING OF HUMAN ALLOREACTIVE T-CELLS
GORONZY, J., WEYAND, C., & Fathman, C. G. (1987). CLONING OF HUMAN ALLOREACTIVE T-CELLS. METHODS IN ENZYMOLOGY, 150, 333-341.

LONG-TERM HUMORAL UNRESPONSIVENESS INVIVO, INDUCED BY TREATMENT WITH MONOCLONAL-ANTIBODY AGAINST L3T4
GORONZY, J., Weyand, C. M., & Fathman, C. G. (1986). LONG-TERM HUMORAL UNRESPONSIVENESS INVIVO, INDUCED BY TREATMENT WITH MONOCLONAL-ANTIBODY AGAINST L3T4. JOURNAL OF EXPERIMENTAL MEDICINE, 164(3), 911-925.

GENE CONVERSION - A MECHANISM TO EXPLAIN HLA-D REGION AND DISEASE ASSOCIATION
Fathman, C. G., GORONZY, J., & WEYAND, C. (1986). GENE CONVERSION - A MECHANISM TO EXPLAIN HLA-D REGION AND DISEASE ASSOCIATION. ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, 475, 24-31.

SHARED T-CELL RECOGNITION SITES ON HUMAN HISTOCOMPATIBILITY LEUKOCYTE ANTIGEN CLASS-II MOLECULES OF PATIENTS WITH SEROPOSITIVE RHEUMATOID-ARTHRITIS
GORONZY, J., Weyand, C. M., & Fathman, C. G. (1986). SHARED T-CELL RECOGNITION SITES ON HUMAN HISTOCOMPATIBILITY LEUKOCYTE ANTIGEN CLASS-II MOLECULES OF PATIENTS WITH SEROPOSITIVE RHEUMATOID-ARTHRITIS. JOURNAL OF CLINICAL INVESTIGATION, 77(3), 1042-1049.

HUMAN T-CELL CLONES USED TO DEFINE FUNCTIONAL EPITOPES ON HLA CLASS-II MOLECULES
Weyand, C. M., GORONZY, J., & Fathman, C. G. (1986). HUMAN T-CELL CLONES USED TO DEFINE FUNCTIONAL EPITOPES ON HLA CLASS-II MOLECULES. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 83(3), 762-766.

HUMAN T-CELL CLONES AS DIAGNOSTIC-TOOLS AND POTENTIAL THERAPEUTIC REAGENTS
WEYAND, C., GORONZY, J., & Fathman, C. G. (1986). HUMAN T-CELL CLONES AS DIAGNOSTIC-TOOLS AND POTENTIAL THERAPEUTIC REAGENTS. IMMUNOLOGICAL INVESTIGATIONS, 15(7), 591-624.