Steven Foung

Professional Education

Residency: Stanford University School of Medicine (1980) CA

Residency: UCSF Medical Center (1977) CA

Internship: San Francisco General Hospital (1976) CA

Medical Education: UCSD Medical Center (1975) CA

Administrative Appointments

Associate Chair for Academic Affairs, Stanford University School of Medicine - Pathology, 2004

Structural basis of HCV neutralization by human monoclonal antibodies resistant to viral neutralization escape.
Krey, T., Meola, A., Keck, Z.-Y., Damier-Piolle, L., Foung, S. Kh., & Rey, F. A. (2013). Structural basis of HCV neutralization by human monoclonal antibodies resistant to viral neutralization escape. PLoS pathogens, 9(5).

Contrasting Roles of Mitogen-Activated Protein Kinases in Cellular Entry and Replication of Hepatitis C Virus: MKNK1 Facilitates Cell Entry
Kim, S., Ishida, H., Yamane, D., Yi, Mk., Swinney, D. C., & Lemon, S. M. (2013). Contrasting Roles of Mitogen-Activated Protein Kinases in Cellular Entry and Replication of Hepatitis C Virus: MKNK1 Facilitates Cell Entry. JOURNAL OF VIROLOGY, 87(8), 4214-4224.

Characterization of Hepatitis C Virus Recombinants with Chimeric E1/E2 Envelope Proteins and Identification of Single Amino Acids in the E2 Stem Region Important for Entry
Carlsen, T. Hr., Scheel, T. Kh., Ramirez, S., Foung, S. Kh., & Bukh, J. (2013). Characterization of Hepatitis C Virus Recombinants with Chimeric E1/E2 Envelope Proteins and Identification of Single Amino Acids in the E2 Stem Region Important for Entry. JOURNAL OF VIROLOGY, 87(3), 1385-1399.

Cooperativity in Virus Neutralization by Human Monoclonal Antibodies to Two Adjacent Regions Located at the Amino Terminus of Hepatitis C Virus E2 Glycoprotein
Keck, Z., Wang, W., Wang, Y., Lau, P., Carlsen, T. Hr., & Foung, S. Kh. (2013). Cooperativity in Virus Neutralization by Human Monoclonal Antibodies to Two Adjacent Regions Located at the Amino Terminus of Hepatitis C Virus E2 Glycoprotein. JOURNAL OF VIROLOGY, 87(1), 37-51.

Transient Activation of the PI3K-AKT Pathway by Hepatitis C Virus to Enhance Viral Entry
Liu, Z., Tian, Y., Machida, K., Lai, M. Mc., Luo, G., & Ou, J.- hsiung J. (2012). Transient Activation of the PI3K-AKT Pathway by Hepatitis C Virus to Enhance Viral Entry. JOURNAL OF BIOLOGICAL CHEMISTRY, 287(50), 41922-41930.

Toward a Hepatitis C Virus Vaccine: the Structural Basis of Hepatitis C Virus Neutralization by AP33, a Broadly Neutralizing Antibody
Potter, J. A., Owsianka, A. M., Jeffery, N., Matthews, D. J., Keck, Z.-Y., & Patel, A. H. (2012). Toward a Hepatitis C Virus Vaccine: the Structural Basis of Hepatitis C Virus Neutralization by AP33, a Broadly Neutralizing Antibody. JOURNAL OF VIROLOGY, 86(23), 12923-12932.

Mutations That Alter Use of Hepatitis C Virus Cell Entry Factors Mediate Escape From Neutralizing Antibodies
Fofana, I., Fafi-Kremer, S., Carolla, P., Fauvelle, C., Zahid, M. N., & Baumert, T. F. (2012). Mutations That Alter Use of Hepatitis C Virus Cell Entry Factors Mediate Escape From Neutralizing Antibodies. GASTROENTEROLOGY, 143(1), 223-U429.

Human Monoclonal Antibodies to a Novel Cluster of Conformational Epitopes on HCV E2 with Resistance to Neutralization Escape in a Genotype 2a Isolate
Keck, Z.-Y., Xia, J., Wang, Y., Wang, W., Krey, T., & Foung, S. Kh. (2012). Human Monoclonal Antibodies to a Novel Cluster of Conformational Epitopes on HCV E2 with Resistance to Neutralization Escape in a Genotype 2a Isolate. PLOS PATHOGENS, 8(4).

Affinity Maturation to Improve Human Monoclonal Antibody Neutralization Potency and Breadth against Hepatitis C Virus
Wang, Y., Keck, Z.-Y., Saha, A., Xia, J., Conrad, F., & Foung, S. Kh. (2011). Affinity Maturation to Improve Human Monoclonal Antibody Neutralization Potency and Breadth against Hepatitis C Virus. JOURNAL OF BIOLOGICAL CHEMISTRY, 286(51), 44218-44233.

Neutralizing Antibody Response to Hepatitis C Virus
Wang, Y., Keck, Z.-Y., & Foung, S. Kh. (2011). Neutralizing Antibody Response to Hepatitis C Virus. VIRUSES-BASEL, 3(11), 2127-2145.

Mapping a Region of Hepatitis C Virus E2 That Is Responsible for Escape from Neutralizing Antibodies and a Core CD81-Binding Region That Does Not Tolerate Neutralization Escape Mutations
Keck, Z.-Y., Saha, A., Xia, J., Wang, Y., Lau, P., & Foung, S. Kh. (2011). Mapping a Region of Hepatitis C Virus E2 That Is Responsible for Escape from Neutralizing Antibodies and a Core CD81-Binding Region That Does Not Tolerate Neutralization Escape Mutations. JOURNAL OF VIROLOGY, 85(20), 10451-10463.

Comprehensive linker-scanning mutagenesis of the hepatitis C virus E1 and E2 envelope glycoproteins reveals new structure-function relationships
Rychlowska, M., Owsianka, A. M., Foung, S. Kh., Dubuisson, J., Bienkowska-Szewczyk, K., & Patel, A. H. (2011). Comprehensive linker-scanning mutagenesis of the hepatitis C virus E1 and E2 envelope glycoproteins reveals new structure-function relationships. JOURNAL OF GENERAL VIROLOGY, 92, 2249-2261.

The Hepatitis C Virus E1 Glycoprotein Undergoes Productive Folding but Accelerated Degradation When Expressed as an Individual Subunit in CHO Cells
Botti, V., Bianchi, A., Foung, S. Kh., & Merola, M. (2011). The Hepatitis C Virus E1 Glycoprotein Undergoes Productive Folding but Accelerated Degradation When Expressed as an Individual Subunit in CHO Cells. PLOS ONE, 6(8).

The GB viruses: a review and proposed classification of GBV-A, GBV-C (HGV), and GBV-D in genus Pegivirus within the family Flaviviridae
Stapleton, J. T., Foung, S., Muerhoff, A. S., Bukh, J., & Simmonds, P. (2011). The GB viruses: a review and proposed classification of GBV-A, GBV-C (HGV), and GBV-D in genus Pegivirus within the family Flaviviridae. JOURNAL OF GENERAL VIROLOGY, 92, 233-246.

Hepatitis C virus e2 protein ectodomain is essential for assembly of infectious virions.
Bianchi, A., Crotta, S., Brazzoli, M., Foung, S. Kh., & Merola, M. (2011). Hepatitis C virus e2 protein ectodomain is essential for assembly of infectious virions. International journal of hepatology, 2011, 968161-?.

Hepatitis C Virus Hypervariable Region 1 Modulates Receptor Interactions, Conceals the CD81 Binding Site, and Protects Conserved Neutralizing Epitopes
Bankwitz, D., Steinmann, E., Bitzegeio, J., Ciesek, S., Friesland, M., & Pietschmann, T. (2010). Hepatitis C Virus Hypervariable Region 1 Modulates Receptor Interactions, Conceals the CD81 Binding Site, and Protects Conserved Neutralizing Epitopes. JOURNAL OF VIROLOGY, 84(11), 5751-5763.

Mutations within a Conserved Region of the Hepatitis C Virus E2 Glycoprotein That Influence Virus-Receptor Interactions and Sensitivity to Neutralizing Antibodies
Dhillon, S., Witteveldt, J., Gatherer, D., Owsianka, A. M., Zeisel, M. B., & Patel, A. H. (2010). Mutations within a Conserved Region of the Hepatitis C Virus E2 Glycoprotein That Influence Virus-Receptor Interactions and Sensitivity to Neutralizing Antibodies. JOURNAL OF VIROLOGY, 84(11), 5494-5507.

Antigen-specific Proteolysis by Hybrid Antibodies Containing Promiscuous Proteolytic Light Chains Paired with an Antigen-binding Heavy Chain
Sapparapu, G., Planque, S. A., Nishiyama, Y., Foung, S. K., & Paul, S. (2009). Antigen-specific Proteolysis by Hybrid Antibodies Containing Promiscuous Proteolytic Light Chains Paired with an Antigen-binding Heavy Chain. JOURNAL OF BIOLOGICAL CHEMISTRY, 284(36), 24622-24633.

CD81 is dispensable for hepatitis C virus cell-to-cell transmission in hepatoma cells
Witteveldt, J., Evans, M. J., Bitzegeio, J., Koutsoudakis, G., Owsianka, A. M., & Patel, A. H. (2009). CD81 is dispensable for hepatitis C virus cell-to-cell transmission in hepatoma cells. JOURNAL OF GENERAL VIROLOGY, 90, 48-58.

In vitro selection of a neutralization-resistant hepatitis C virus escape mutant
Gal-Tanamy, M., Keck, Z.-Y., Yi, Mk., McKeating, J. A., Patel, A. H., & Lemon, S. M. (2008). In vitro selection of a neutralization-resistant hepatitis C virus escape mutant. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 105(49), 19450-19455.

Hepatitis C virus (HCV)-induced immunoglobulin hypermutation reduces the affinity and neutralizing activities of antibodies against HCV envelope protein
Machida, K., Kondo, Y., Huang, J. Y., Chen, Y.-C., Cheng, K. Th., & Lai, M. Mc. (2008). Hepatitis C virus (HCV)-induced immunoglobulin hypermutation reduces the affinity and neutralizing activities of antibodies against HCV envelope protein. JOURNAL OF VIROLOGY, 82(13), 6711-6720.

A point mutation leading to hepatitis C virus escape from neutralization by a monoclonal antibody to a conserved conformational epitope
Keck, Z.-Y., Olson, O., Gal-Tanamy, M., Xia, J., Patel, A. H., & Foung, S. Kh. (2008). A point mutation leading to hepatitis C virus escape from neutralization by a monoclonal antibody to a conserved conformational epitope. JOURNAL OF VIROLOGY, 82(12), 6067-6072.

Definition of a conserved immunodominant domain on hepatitis C virus E2 glycoprotein by neutralizing human monoclonal antibodies
Keck, Z.-Y., Li, T.-K., Xia, J., Gal-Tanamy, M., Olson, O., & Foung, S. Kh. (2008). Definition of a conserved immunodominant domain on hepatitis C virus E2 glycoprotein by neutralizing human monoclonal antibodies. JOURNAL OF VIROLOGY, 82(12), 6061-6066.

Antibody-dependent enhancement of hepatitis C virus infection
Meyer, K., Ait-Goughoulte, M., Keck, Z.-Y., Foung, S., & Ray, R. (2008). Antibody-dependent enhancement of hepatitis C virus infection. JOURNAL OF VIROLOGY, 82(5), 2140-2149.

Broadly neutralizing human monoclonal antibodies to the hepatitis C virus E2 glycoprotein
Owsianka, A. M., Tarr, A. W., Keck, Z.-Y., Li, T.-K., Witteveldt, J., & Patel, A. H. (2008). Broadly neutralizing human monoclonal antibodies to the hepatitis C virus E2 glycoprotein. JOURNAL OF GENERAL VIROLOGY, 89, 653-659.

Structural elucidation of critical residues involved in binding of human monoclonal antibodies to hepatitis C virus E2 envelope glycoprotein
Iacob, R. E., Keck, Z., Olson, O., Foung, S. Kh., & Tomer, K. B. (2008). Structural elucidation of critical residues involved in binding of human monoclonal antibodies to hepatitis C virus E2 envelope glycoprotein. BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS, 1784(3), 530-542.

Therapeutic control of hepatitis C virus: The role of neutralizing monoclonal antibodies
Keck, Z. Y., Machida, K., Lai, M. Mc., Ball, J. K., Patel, A. H., & Foung, S. Kh. (2008). Therapeutic control of hepatitis C virus: The role of neutralizing monoclonal antibodies. HUMAN ANTIBODY THERAPEUTICS FOR VIRAL DISEASE, 317, 1-38.

The neutralizing activity of anti-hepatitis C virus antibodies is modulated by specific glycans on the E2 envelope protein
Helle, F., Goffard, A., Morel, V., Duverlie, G., McKeating, J., & Voisset, C. (2007). The neutralizing activity of anti-hepatitis C virus antibodies is modulated by specific glycans on the E2 envelope protein. JOURNAL OF VIROLOGY, 81(15), 8101-8111.

Immunogenic and functional organization of hepatitis C virus (HCV) glycoprotein E2 on infectious HCV virions
Keck, Z.-Y., Xia, J., Cai, Z., Li, T.-K., Owsianka, A. M., & Foung, S. Kh. (2007). Immunogenic and functional organization of hepatitis C virus (HCV) glycoprotein E2 on infectious HCV virions. JOURNAL OF VIROLOGY, 81(2), 1043-1047.

High density lipoprotein inhibits hepatitis C virus-neutralizing antibodies by stimulating cell entry via activation of the scavenger receptor BI
Dreux, M., Pietschmann, T., Granier, C., Voisset, C., Ricard-Blum, S., & Cosset, F.-L. (2006). High density lipoprotein inhibits hepatitis C virus-neutralizing antibodies by stimulating cell entry via activation of the scavenger receptor BI. JOURNAL OF BIOLOGICAL CHEMISTRY, 281(27), 18285-18295.

Preclinical evaluation of two neutralizing human monoclonal antibodies against hepatitis C virus (HCV): A potential treatment to prevent HCV reinfection in liver transplant patients
Eren, R., Landstein, D., Terkieltaub, D., Nussbaum, O., Zauberman, A., & Dagan, S. (2006). Preclinical evaluation of two neutralizing human monoclonal antibodies against hepatitis C virus (HCV): A potential treatment to prevent HCV reinfection in liver transplant patients. JOURNAL OF VIROLOGY, 80(6), 2654-2664.

Hepatitis C virus induces toll-like receptor 4 expression, leading to enhanced production of beta interferon and interleukin-6
Machida, K., Cheng, K. Th., Sung, V. Mh., Levine, A. M., Foung, S., & Lai, M. Mc. (2006). Hepatitis C virus induces toll-like receptor 4 expression, leading to enhanced production of beta interferon and interleukin-6. JOURNAL OF VIROLOGY, 80(2), 866-874.

Analysis of a highly flexible conformational immunogenic domain a in hepatitis C virus E2
Keck, Z. Y., LI, T. K., Xia, J. M., Bartosch, B., Cosset, F. L., & Foung, S. Kh. (2005). Analysis of a highly flexible conformational immunogenic domain a in hepatitis C virus E2. JOURNAL OF VIROLOGY, 79(21), 13199-13208.

Folding and dimerization of hepatitis C virus E1 and E2 glycoproteins in stably transfected CHO cells
Brazzoli, M., HELENIUS, A., Foung, S. Kh., Houghton, M., Abrignani, S., & Merola, M. (2005). Folding and dimerization of hepatitis C virus E1 and E2 glycoproteins in stably transfected CHO cells. VIROLOGY, 332(1), 438-453.

Antibody light chain-catalyzed hydrolysis of a hepatitis C virus peptide
Taguchi, H., Keck, Z. Y., Foung, S. Kh., Paul, S., & Nishiyama, Y. (2004). Antibody light chain-catalyzed hydrolysis of a hepatitis C virus peptide. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 14(17), 4529-4532.

Hepatitis C virus E2 has three immunogenic domains containing conformational epitopes with distinct properties and biological functions
Keck, Z. Y., Op de Beeck, A., Hadlock, K. G., Xia, J. M., LI, T. K., & Foung, S. Kh. (2004). Hepatitis C virus E2 has three immunogenic domains containing conformational epitopes with distinct properties and biological functions. JOURNAL OF VIROLOGY, 78(17), 9224-9232.

Human monoclonal antibody to hepatitis C virus El glycoprotein that blocks virus attachment and viral infectivity
Keck, Z. Y., Sung, V. Mh., Perkins, S., Rowe, J., Paul, S., & Foung, S. Kh. (2004). Human monoclonal antibody to hepatitis C virus El glycoprotein that blocks virus attachment and viral infectivity. JOURNAL OF VIROLOGY, 78(13), 7257-7263.

Incomplete humoral immunity against hepatitis C virus is linked with distinct recognition of putative multiple receptors by E2 envelope glycoprotein
Heo, T. H., Chang, J. H., Lee, J. W., Foung, S. Kh., Dubuisson, J., & Kang, C. Y. (2004). Incomplete humoral immunity against hepatitis C virus is linked with distinct recognition of putative multiple receptors by E2 envelope glycoprotein. JOURNAL OF IMMUNOLOGY, 173(1), 446-455.

Characterization of functional hepatitis C virus envelope glycoproteins
De Beeck, A. O., Voisset, C., Bartosch, B., Ciczora, Y., Cocquerel, L., & Dubuisson, J. (2004). Characterization of functional hepatitis C virus envelope glycoproteins. JOURNAL OF VIROLOGY, 78(6), 2994-3002.

DC-SIGN and L-SIGN are high affinity binding receptors for hepatitis C virus glycoprotein E2
Lozach, P. Y., Lortat-Jacob, H., de Lavalette, A. D., Staropoli, I., Foung, S., & Altmeyer, R. (2003). DC-SIGN and L-SIGN are high affinity binding receptors for hepatitis C virus glycoprotein E2. JOURNAL OF BIOLOGICAL CHEMISTRY, 278(22), 20358-20366.

Recognition of native hepatitis C virus E1E2 heterodimers by a human monoclonal antibody
Cocquerel, L., Quinn, E. R., Flint, M., Hadlock, K. G., Foung, S. Kh., & Levy, S. (2003). Recognition of native hepatitis C virus E1E2 heterodimers by a human monoclonal antibody. JOURNAL OF VIROLOGY, 77(2), 1604-1609.

Structural features of envelope proteins on hepatitis C virus-like particles as determined by anti-envelope monoclonal antibodies and CD81 binding
Triyatni, M., Vergalla, J., Davis, A. R., Hadlock, K. G., Foung, S. Kh., & Liang, T. J. (2002). Structural features of envelope proteins on hepatitis C virus-like particles as determined by anti-envelope monoclonal antibodies and CD81 binding. VIROLOGY, 298(1), 124-132.

Epitope mapping of human monoclonal antibodies recognizing conformational epitopes within HTLV type 1 gp46, employing HTLV type 1/2 envelope chimeras
Hadlock, K. G., Yang, Q., Rowe, J., & Foung, S. Kh. (2002). Epitope mapping of human monoclonal antibodies recognizing conformational epitopes within HTLV type 1 gp46, employing HTLV type 1/2 envelope chimeras. AIDS RESEARCH AND HUMAN RETROVIRUSES, 18(1), 57-70.

The B-cell receptor of a hepatitis C virus (HCV)-associated non-Hodgkin lymphoma binds the viral E2 envelope protein, implicating HCV in lymphomagenesis
Quinn, E. R., Chan, C. H., Hadlock, K. G., Foung, S. Kh., Flint, M., & Levy, S. (2001). The B-cell receptor of a hepatitis C virus (HCV)-associated non-Hodgkin lymphoma binds the viral E2 envelope protein, implicating HCV in lymphomagenesis. BLOOD, 98(13), 3745-3749.

Cross-reactivity and clinical impact of the antibody response to hepatitis C virus second envelope glycoprotein (E2)
Hadlock, K. G., Gish, R., Rowe, J., Rajyaguru, S. S., Newsom, M., & Foung, S. Kh. (2001). Cross-reactivity and clinical impact of the antibody response to hepatitis C virus second envelope glycoprotein (E2). JOURNAL OF MEDICAL VIROLOGY, 65(1), 23-29.

V(H)1-69 gene is preferentially used by hepatitis C virus-associated B cell lymphomas and by normal B cells responding to the E2 viral antigen
Chan, C. H., Hadlock, K. G., Foung, S. Kh., & Levy, S. (2001). V(H)1-69 gene is preferentially used by hepatitis C virus-associated B cell lymphomas and by normal B cells responding to the E2 viral antigen. BLOOD, 97(4), 1023-1026.

Human monoclonal antibodies that inhibit binding of hepatitis C virus E2 protein to CD81 and recognize conserved conformational epitopes
Hadlock, K. G., Lanford, R. E., Perkins, S., Rowe, J., Yang, Q., & Foung, S. Kh. (2000). Human monoclonal antibodies that inhibit binding of hepatitis C virus E2 protein to CD81 and recognize conserved conformational epitopes. JOURNAL OF VIROLOGY, 74(22), 10407-10416.

The humoral immune response to human T-cell lymphotropic virus type 1 envelope glycoprotein gp46 is directed primarily against conformational epitopes
Hadlock, K. G., Rowe, J., & Foung, S. Kh. (1999). The humoral immune response to human T-cell lymphotropic virus type 1 envelope glycoprotein gp46 is directed primarily against conformational epitopes. JOURNAL OF VIROLOGY, 73(2), 1205-1212.

Large granular lymphocyte leukaemia occurring after renal transplantation
Gentile, T. C., Hadlock, K. G., Uner, A. H., Delal, B., Squiers, E., & Loughran, T. P. (1998). Large granular lymphocyte leukaemia occurring after renal transplantation. BRITISH JOURNAL OF HAEMATOLOGY, 101(3), 507-512.

Epitope mapping of HTLV envelope seroreactivity in LGL leukaemia
Loughran, T. P., Hadlock, K. G., Perzova, R., Gentile, T. C., Yang, Q., & Poiesz, B. J. (1998). Epitope mapping of HTLV envelope seroreactivity in LGL leukaemia. BRITISH JOURNAL OF HAEMATOLOGY, 101(2), 318-324.

GBV-C/HGV: A new virus within the Flaviviridae and its clinical implications
Hadlock, K. G., & Foung, S. Kh. (1998). GBV-C/HGV: A new virus within the Flaviviridae and its clinical implications. TRANSFUSION MEDICINE REVIEWS, 12(2), 94-108.

Experimental infection of chimpanzees with hepatitis G virus and genetic analysis of the virus
Bukh, J., Kim, J. P., Govindarajan, S., Apgar, C. L., Foung, S. Kh., & Purcell, R. H. (1998). Experimental infection of chimpanzees with hepatitis G virus and genetic analysis of the virus. JOURNAL OF INFECTIOUS DISEASES, 177(4), 855-862.

Seroreactivity to an envelope protein of human T-cell leukemia/lymphoma virus in patients with CD3(-) (natural killer) lymphoproliferative disease of granular lymphocytes
Loughran, T. P., Hadlock, K. G., Yang, Q., Perzova, R., Zambello, R., & Poiesz, B. J. (1997). Seroreactivity to an envelope protein of human T-cell leukemia/lymphoma virus in patients with CD3(-) (natural killer) lymphoproliferative disease of granular lymphocytes. BLOOD, 90(5), 1977-1981.

Neutralizing human monoclonal antibodies to conformational epitopes of human T-cell lymphotropic virus type 1 and 2 gp46
Hadlock, K. G., Rowe, J., Perkins, S., Bradshaw, P., Song, G. Y., & Foung, S. Kh. (1997). Neutralizing human monoclonal antibodies to conformational epitopes of human T-cell lymphotropic virus type 1 and 2 gp46. JOURNAL OF VIROLOGY, 71(8), 5828-5840.

A source of glycosylated human T-cell lymphotropic virus type 1 envelope protein: Expression of gp46 by the vaccinia virus T7 polymerase system
Arp, J., LEVATTE, M., Rowe, J., Perkins, S., King, E., & Dekaban, G. K. (1996). A source of glycosylated human T-cell lymphotropic virus type 1 envelope protein: Expression of gp46 by the vaccinia virus T7 polymerase system. JOURNAL OF VIROLOGY, 70(11), 7349-7359.

Molecular cloning and disease association of hepatitis G virus: A transfusion-transmissible agent
Linnen, J., Wages, J., ZHANGKECK, Z. Y., Fry, K. E., KRAWCZYNSKI, K. Z., & Kim, J. P. (1996). Molecular cloning and disease association of hepatitis G virus: A transfusion-transmissible agent. SCIENCE, 271(5248), 505-508.

ENHANCED SPECIFICITY OF TRUNCATED TRANSMEMBRANE PROTEIN FOR SEROLOGIC CONFIRMATION OF HUMAN T-CELL LYMPHOTROPIC VIRUS TYPE-1 (HTLV-1) AND HTLV-2 INFECTIONS BY WESTERN-BLOT (IMMUNOBLOT) ASSAY CONTAINING RECOMBINANT ENVELOPE GLYCOPROTEINS
Varma, M., Rudolph, D. L., KNUCHEL, M., Switzer, W. M., Hadlock, K. G., & Lal, R. B. (1995). ENHANCED SPECIFICITY OF TRUNCATED TRANSMEMBRANE PROTEIN FOR SEROLOGIC CONFIRMATION OF HUMAN T-CELL LYMPHOTROPIC VIRUS TYPE-1 (HTLV-1) AND HTLV-2 INFECTIONS BY WESTERN-BLOT (IMMUNOBLOT) ASSAY CONTAINING RECOMBINANT ENVELOPE GLYCOPROTEINS. JOURNAL OF CLINICAL MICROBIOLOGY, 33(12), 3239-3244.

DELINEATION OF AN IMMUNODOMINANT AND HUMAN T-CELL LYMPHOTROPIC VIRUS (HTLV)-SPECIFIC EPITOPE WITHIN THE HTLV-I TRANSMEMBRANE GLYCOPROTEIN
Hadlock, K. G., Goh, C. J., BRADSHAW, P. A., Perkins, S., Lo, J., & Foung, S. Kh. (1995). DELINEATION OF AN IMMUNODOMINANT AND HUMAN T-CELL LYMPHOTROPIC VIRUS (HTLV)-SPECIFIC EPITOPE WITHIN THE HTLV-I TRANSMEMBRANE GLYCOPROTEIN. BLOOD, 86(4), 1392-1399.

Stabilizing antibody secretion of human Epstein Barr virus-activated B-lymphocytes with hybridoma formation by electrofusion.
Perkins, S., & FOUNG, S. K. (1995). Stabilizing antibody secretion of human Epstein Barr virus-activated B-lymphocytes with hybridoma formation by electrofusion. Methods in molecular biology (Clifton, N.J.), 48, 295-307.

LOCALIZATION OF ANTIGENIC SITES ON HUMAN CYTOMEGALOVIRUS VIRION STRUCTURAL PROTEINS ENCODED BY UL48 AND UL56
BRADSHAW, P. A., DURANGUARINO, M. R., Perkins, S., ROWE, J. I., Fernandez, J., & Foung, S. Kh. (1994). LOCALIZATION OF ANTIGENIC SITES ON HUMAN CYTOMEGALOVIRUS VIRION STRUCTURAL PROTEINS ENCODED BY UL48 AND UL56. VIROLOGY, 205(1), 321-328.

IMMUNOGLOBULIN PROPHYLAXIS AGAINST HUMAN T-CELL LYMPHOTROPIC VIRUS TYPE-II IN RABBITS
Morishita, N., Ishii, K., Tanaka, Y., Sawada, T., Hoshino, H., & Miyoshi, I. (1994). IMMUNOGLOBULIN PROPHYLAXIS AGAINST HUMAN T-CELL LYMPHOTROPIC VIRUS TYPE-II IN RABBITS. JOURNAL OF INFECTIOUS DISEASES, 169(3), 620-623.

AMPLIFICATION AND DETECTION OF A SINGLE-MOLECULE OF HUMAN-IMMUNODEFICIENCY-VIRUS RNA
Nakamura, S., Katamine, S., Yamamoto, T., Foung, S. Kh., Kurata, T., & Miyamoto, T. (1993). AMPLIFICATION AND DETECTION OF A SINGLE-MOLECULE OF HUMAN-IMMUNODEFICIENCY-VIRUS RNA. VIRUS GENES, 7(4), 325-338.

HUMAN T-LYMPHOTROPIC VIRUS TYPE-I/II IN LAKE LINDU VALLEY, CENTRAL SULAWESI, INDONESIA
Lal, R. B., LIPKA, J. J., Foung, S. Kh., Hadlock, K. G., Reyes, G. R., & Carney, W. P. (1993). HUMAN T-LYMPHOTROPIC VIRUS TYPE-I/II IN LAKE LINDU VALLEY, CENTRAL SULAWESI, INDONESIA. JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES AND HUMAN RETROVIROLOGY, 6(9), 1067-1068.

ASSOCIATION OF (TROPICAL) ATAXIC NEUROPATHY WITH HTLV-II
Sheremata, W. A., Harrington, W. J., BRADSHAW, P. A., Foung, S. Kh., Raffanti, S. P., & Poiesz, B. J. (1993). ASSOCIATION OF (TROPICAL) ATAXIC NEUROPATHY WITH HTLV-II. VIRUS RESEARCH, 29(1), 71-77.

ISOTYPIC AND IGG SUBCLASS RESTRICTION OF THE HUMORAL IMMUNE-RESPONSES TO HUMAN T-LYMPHOTROPIC VIRUS TYPE-I
Lal, R. B., Buckner, C., Khabbaz, R. F., Kaplan, J. E., Reyes, G., & Coligan, J. E. (1993). ISOTYPIC AND IGG SUBCLASS RESTRICTION OF THE HUMORAL IMMUNE-RESPONSES TO HUMAN T-LYMPHOTROPIC VIRUS TYPE-I. CLINICAL IMMUNOLOGY AND IMMUNOPATHOLOGY, 67(1), 40-49.

SPASTIC ATAXIA ASSOCIATED WITH HUMAN T-CELL LYMPHOTROPIC VIRUS TYPE-II INFECTION
Harrington, W. J., Sheremata, W., Hjelle, B., Dube, D. K., Bradshaw, P., & Poiesz, B. (1993). SPASTIC ATAXIA ASSOCIATED WITH HUMAN T-CELL LYMPHOTROPIC VIRUS TYPE-II INFECTION. ANNALS OF NEUROLOGY, 33(4), 411-414.

EVALUATION OF AN IMMUNOBLOT ASSAY FOR SEROLOGICAL CONFIRMATION AND DIFFERENTIATION OF HUMAN T-CELL LYMPHOTROPIC VIRUS TYPE-I AND TYPE-II
Roberts, B. D., Foung, S. Kh., LIPKA, J. J., Kaplan, J. E., Hadlock, K. G., & Khabbaz, R. F. (1993). EVALUATION OF AN IMMUNOBLOT ASSAY FOR SEROLOGICAL CONFIRMATION AND DIFFERENTIATION OF HUMAN T-CELL LYMPHOTROPIC VIRUS TYPE-I AND TYPE-II. JOURNAL OF CLINICAL MICROBIOLOGY, 31(2), 260-264.

NEUTRALIZING ANTIBODY TO VESICULAR STOMATITIS-VIRUS (HTLV-I) PSEUDOTYPE IN INFANTS BORN TO SEROPOSITIVE MOTHERS
Iwahara, Y., Sawada, T., Taguchi, H., Hoshino, H., Umemoto, M., & Miyoshi, I. (1993). NEUTRALIZING ANTIBODY TO VESICULAR STOMATITIS-VIRUS (HTLV-I) PSEUDOTYPE IN INFANTS BORN TO SEROPOSITIVE MOTHERS. JAPANESE JOURNAL OF CANCER RESEARCH, 84(2), 114-116.

IMMUNE RESPONSIVENESS TO THE IMMUNODOMINANT RECOMBINANT ENVELOPE EPITOPES OF HUMAN T-LYMPHOTROPIC VIRUS TYPE-1 AND TYPE-2 IN DIVERSE GEOGRAPHIC POPULATIONS
Buckner, C., ROBERTS, C. R., Foung, S. Kh., Lipka, J., Reyes, G. R., & Lal, R. B. (1992). IMMUNE RESPONSIVENESS TO THE IMMUNODOMINANT RECOMBINANT ENVELOPE EPITOPES OF HUMAN T-LYMPHOTROPIC VIRUS TYPE-1 AND TYPE-2 IN DIVERSE GEOGRAPHIC POPULATIONS. JOURNAL OF INFECTIOUS DISEASES, 166(5), 1160-1163.

CLONING AND ANALYSIS OF A RECOMBINANT ANTIGEN CONTAINING AN EPITOPE SPECIFIC FOR HUMAN T-CELL LYMPHOTROPIC VIRUS TYPE-II
Hadlock, K. G., LIPKA, J. J., Chow, T. P., Foung, S. Kh., & Reyes, G. R. (1992). CLONING AND ANALYSIS OF A RECOMBINANT ANTIGEN CONTAINING AN EPITOPE SPECIFIC FOR HUMAN T-CELL LYMPHOTROPIC VIRUS TYPE-II. BLOOD, 79(10), 2789-2796.

SEROLOGIC CONFIRMATION OF SIMIAN T-LYMPHOTROPIC VIRUS TYPE-I INFECTION BY USING IMMUNOASSAYS DEVELOPED FOR HUMAN T-LYMPHOTROPIC VIRUS-ANTIBODY DETECTION
Rudolph, D. L., Yee, J., Mone, J., Foung, S. Kh., LIPKA, J. J., & Lal, R. B. (1992). SEROLOGIC CONFIRMATION OF SIMIAN T-LYMPHOTROPIC VIRUS TYPE-I INFECTION BY USING IMMUNOASSAYS DEVELOPED FOR HUMAN T-LYMPHOTROPIC VIRUS-ANTIBODY DETECTION. JOURNAL OF CLINICAL MICROBIOLOGY, 30(4), 858-861.

ANTIBODIES TO HEPATITIS-C VIRUS IN LOW-RISK BLOOD-DONORS - IMPLICATIONS FOR COUNSELING POSITIVE DONORS
Hsu, H. H., Gonzalez, M., Foung, S. Kh., Feinstone, S. M., & Greenberg, H. B. (1991). ANTIBODIES TO HEPATITIS-C VIRUS IN LOW-RISK BLOOD-DONORS - IMPLICATIONS FOR COUNSELING POSITIVE DONORS. GASTROENTEROLOGY, 101(6), 1724-1727.

MODIFIED WESTERN-BLOT ASSAY FOR CONFIRMATION AND DIFFERENTIATION OF HUMAN T-CELL LYMPHOTROPIC VIRUS TYPE-I AND TYPE-II
LIPKA, J. J., Santiago, P., Chan, L., Reyes, G. R., Samuel, K. P., & Foung, S. Kh. (1991). MODIFIED WESTERN-BLOT ASSAY FOR CONFIRMATION AND DIFFERENTIATION OF HUMAN T-CELL LYMPHOTROPIC VIRUS TYPE-I AND TYPE-II. JOURNAL OF INFECTIOUS DISEASES, 164(2), 400-403.

Parameters to enhance human hybridoma formation with hypoosmolar electrofusion.
Perkins, S., Zimmermann, U., & FOUNG, S. K. (1991). Parameters to enhance human hybridoma formation with hypoosmolar electrofusion. Human antibodies and hybridomas, 2(3), 155-159.

HTLV-I-ASSOCIATED MYELOPATHY IN A CALIFORNIAN - DIAGNOSIS BY REACTIVITY TO A VIRAL RECOMBINANT ANTIGEN
Honig, L. S., LIPKA, J. J., Young, K. Y., Weiss, J. H., & Foung, S. Kh. (1991). HTLV-I-ASSOCIATED MYELOPATHY IN A CALIFORNIAN - DIAGNOSIS BY REACTIVITY TO A VIRAL RECOMBINANT ANTIGEN. NEUROLOGY, 41(3), 448-450.

SIGNIFICANCE OF HUMAN T-LYMPHOTROPIC VIRUS TYPE-I INDETERMINANT SEROLOGICAL FINDINGS AMONG HEALTHY-INDIVIDUALS
LIPKA, J. J., Young, K. Ky., Kwok, S. Y., Reyes, G. R., Sninsky, J. J., & Foung, S. Kh. (1991). SIGNIFICANCE OF HUMAN T-LYMPHOTROPIC VIRUS TYPE-I INDETERMINANT SEROLOGICAL FINDINGS AMONG HEALTHY-INDIVIDUALS. VOX SANGUINIS, 61(3), 171-176.

DEVELOPMENT OF MICROFUSION TECHNIQUES TO GENERATE HUMAN HYBRIDOMAS
Foung, S., Perkins, S., Kafadar, K., Gessner, P., & Zimmermann, U. (1990). DEVELOPMENT OF MICROFUSION TECHNIQUES TO GENERATE HUMAN HYBRIDOMAS. JOURNAL OF IMMUNOLOGICAL METHODS, 134(1), 35-42.

EFFICIENT HYBRIDIZATION OF MOUSE-HUMAN CELL-LINES BY MEANS OF HYPOOSMOLAR ELECTROFUSION
Zimmermann, U., Gessner, P., Schnettler, R., Perkins, S., & Foung, S. Kh. (1990). EFFICIENT HYBRIDIZATION OF MOUSE-HUMAN CELL-LINES BY MEANS OF HYPOOSMOLAR ELECTROFUSION. JOURNAL OF IMMUNOLOGICAL METHODS, 134(1), 43-50.

LOW INCIDENCE OF HTLV INFECTIONS IN RANDOM BLOOD-DONORS WITH INDETERMINATE WESTERN-BLOT PATTERNS
Kwok, S., LIPKA, J. J., McKinney, N., KELLOGG, D. E., Poiesz, B., & Sninsky, J. J. (1990). LOW INCIDENCE OF HTLV INFECTIONS IN RANDOM BLOOD-DONORS WITH INDETERMINATE WESTERN-BLOT PATTERNS. TRANSFUSION, 30(6), 491-494.

GENERATION OF A HUMAN HYBRIDOMA PRODUCING A PURE ANTI-HLA-A2 MONOCLONAL-ANTIBODY
WALLACE, E. F., Foung, S. Kh., Bradbury, K., PASK, S. L., & GRUMET, F. C. (1990). GENERATION OF A HUMAN HYBRIDOMA PRODUCING A PURE ANTI-HLA-A2 MONOCLONAL-ANTIBODY. HUMAN IMMUNOLOGY, 28(1), 65-69.

HUMAN MONOCLONAL-ANTIBODIES TO HUMAN CYTOMEGALO-VIRUS
Foung, S. Kh., Perkins, S., Bradshaw, P., Rowe, J., RABIN, L. B., & Lennette, E. T. (1989). HUMAN MONOCLONAL-ANTIBODIES TO HUMAN CYTOMEGALO-VIRUS. JOURNAL OF INFECTIOUS DISEASES, 159(3), 436-443.

ELECTRIC FIELD-INDUCED CELL-FUSION AND HUMAN MONOCLONAL-ANTIBODIES
Foung, S. Kh., & Perkins, S. (1989). ELECTRIC FIELD-INDUCED CELL-FUSION AND HUMAN MONOCLONAL-ANTIBODIES. JOURNAL OF IMMUNOLOGICAL METHODS, 116(1), 117-122.

INITIAL IDENTIFICATION AND MAPPING OF DISTINCT RH0 (D) EPITOPES
Rodriguez, L., WINN, L., & Foung, S. Kh. (1988). INITIAL IDENTIFICATION AND MAPPING OF DISTINCT RH0 (D) EPITOPES. REVUE FRANCAISE DE TRANSFUSION ET IMMUNO-HEMATOLOGIE, 31(2), 223-231.

THE EFFICACY OF PLA1-NEGATIVE PLATELET TRANSFUSION THERAPY IN POSTTRANSFUSION PURPURA
Lippman, S. M., LIZAK, G. E., Foung, S. Kh., & GRUMET, F. C. (1988). THE EFFICACY OF PLA1-NEGATIVE PLATELET TRANSFUSION THERAPY IN POSTTRANSFUSION PURPURA. WESTERN JOURNAL OF MEDICINE, 148(1), 86-88.

HUMAN MONOCLONAL-ANTIBODIES TO RH0(D)
Foung, S. Kh., Blunt, J. A., Wu, P. S., AHEARN, P., WINN, L. C., & GRUMET, F. C. (1987). HUMAN MONOCLONAL-ANTIBODIES TO RH0(D). VOX SANGUINIS, 53(1), 44-47.

HUMAN MONOCLONAL ANTI-T-CELL ANTIBODY FROM A PATIENT WITH JUVENILE RHEUMATOID-ARTHRITIS
ALPERT, S. D., Turek, P. J., Foung, S. Kh., & Engleman, E. G. (1987). HUMAN MONOCLONAL ANTI-T-CELL ANTIBODY FROM A PATIENT WITH JUVENILE RHEUMATOID-ARTHRITIS. JOURNAL OF IMMUNOLOGY, 138(1), 104-108.

EARLY IMMUNE-RESPONSE IN HEALTHY AND IMMUNOCOMPROMISED SUBJECTS WITH PRIMARY VARICELLA-ZOSTER VIRUS-INFECTION
Arvin, A. M., Koropchak, C. M., Williams, B. Rg., GRUMET, F. C., & Foung, S. Kh. (1986). EARLY IMMUNE-RESPONSE IN HEALTHY AND IMMUNOCOMPROMISED SUBJECTS WITH PRIMARY VARICELLA-ZOSTER VIRUS-INFECTION. JOURNAL OF INFECTIOUS DISEASES, 154(3), 422-429.

A MONOCLONAL-ANTIBODY AGAINST HLA-A11 AND A24
Foung, S. Kh., Taidi, B., Ness, D., & GRUMET, F. C. (1986). A MONOCLONAL-ANTIBODY AGAINST HLA-A11 AND A24. HUMAN IMMUNOLOGY, 15(3), 316-319.

A HUMAN MONOCLONAL-ANTIBODY TO RHG
Foung, S. Kh., Blunt, J., Perkins, S., WINN, L., & GRUMET, F. C. (1986). A HUMAN MONOCLONAL-ANTIBODY TO RHG. VOX SANGUINIS, 50(3), 160-163.

GENERATION OF HUMAN MONOCLONAL-ANTIBODIES BY FUSION OF EBV-ACTIVATED B-CELLS TO A HUMAN MOUSE HYBRIDOMA
Foung, S. Kh., Engleman, E. G., & GRUMET, F. C. (1986). GENERATION OF HUMAN MONOCLONAL-ANTIBODIES BY FUSION OF EBV-ACTIVATED B-CELLS TO A HUMAN MOUSE HYBRIDOMA. METHODS IN ENZYMOLOGY, 121, 168-174.

HUMAN MONOCLONAL-ANTIBODIES NEUTRALIZING VARICELLA-ZOSTER VIRUS
Foung, S. Kh., Perkins, S., KOROPCHAK, C., Fishwild, D. M., Wittek, A. E., & Arvin, A. M. (1985). HUMAN MONOCLONAL-ANTIBODIES NEUTRALIZING VARICELLA-ZOSTER VIRUS. JOURNAL OF INFECTIOUS DISEASES, 152(2), 280-285.

HUMAN MONOCLONAL-ANTIBODIES AGAINST GROUP-A RED BLOOD-CELLS
Raubitschek, A., SENYK, G., LARRICK, J., LIZAK, G., & Foung, S. (1985). HUMAN MONOCLONAL-ANTIBODIES AGAINST GROUP-A RED BLOOD-CELLS. VOX SANGUINIS, 48(5), 305-308.

A NEW APPROACH TO THE DIAGNOSIS OF ACTIVE RH0(D) IMMUNIZATION IN PASSIVELY IMMUNIZED PREGNANT-WOMEN
Foung, S. Kh., Perkins, S., MCCALLUM, W. D., Tom, S., Engleman, E. G., & GRUMET, F. C. (1985). A NEW APPROACH TO THE DIAGNOSIS OF ACTIVE RH0(D) IMMUNIZATION IN PASSIVELY IMMUNIZED PREGNANT-WOMEN. VOX SANGUINIS, 49(3), 206-210.

RESCUE OF HUMAN MONOCLONAL-ANTIBODY PRODUCTION FROM AN EBV-TRANSFORMED B-CELL LINE BY FUSION TO A HUMAN-MOUSE HYBRIDOMA
Foung, S. Kh., Perkins, S., Raubitschek, A., LARRICK, J., LIZAK, G., & GRUMET, F. C. (1984). RESCUE OF HUMAN MONOCLONAL-ANTIBODY PRODUCTION FROM AN EBV-TRANSFORMED B-CELL LINE BY FUSION TO A HUMAN-MOUSE HYBRIDOMA. JOURNAL OF IMMUNOLOGICAL METHODS, 70(1), 83-90.

MONOCLONAL-ANTIBODY (B27M2) SUBDIVIDING HLA-B27
GRUMET, F. C., Fendly, B. M., Fish, L., Foung, S., & Engleman, E. G. (1982). MONOCLONAL-ANTIBODY (B27M2) SUBDIVIDING HLA-B27. HUMAN IMMUNOLOGY, 5(1), 61-72.

PRODUCTION OF FUNCTIONAL HUMAN T-T-HYBRIDOMAS IN SELECTION MEDIUM LACKING AMINOPTERIN AND THYMIDINE
Foung, S. Kh., Sasaki, D. T., GRUMET, F. C., & Engleman, E. G. (1982). PRODUCTION OF FUNCTIONAL HUMAN T-T-HYBRIDOMAS IN SELECTION MEDIUM LACKING AMINOPTERIN AND THYMIDINE. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 79(23), 7484-7488.

EOSINOPHILIA IN CHILDREN
Foung, S., & Glader, B. E. (1979). EOSINOPHILIA IN CHILDREN. PEDIATRIC ANNALS, 8(6), 39-?.

EFFECTS OF STARVATION AND REFEEDING ON MUSCLE PROTEIN-SYNTHESIS AND CATABOLISM IN YOUNG RAT
Ogata, E. S., Foung, S. Kh., & Holliday, M. A. (1978). EFFECTS OF STARVATION AND REFEEDING ON MUSCLE PROTEIN-SYNTHESIS AND CATABOLISM IN YOUNG RAT. JOURNAL OF NUTRITION, 108(5), 759-765.