Eric R. Gross

Professional Education

Internship: St Joseph's Regional Medical Center (2008) WI

Residency: Stanford University (2011) CA

Medical Education: Medical College of Wisconsin (2007) WI

Anesthesiology, Stanford University, Anesthesiology (2011)

MD, Medical College of Wisconsin, Medicine (2007)

PhD, Medical College of Wisconsin, Pharmacology (2005)

MS, Marquette University, Biomedical Engineering (2000)

BS, Marquette University, Biomedical Engineering (1997)

Honors & Awards

Best Overall Abstract of Meeting- Basic Science, International Anesthesia Research Society (IARS) Annual Meeting (2013)

K99/R00 Award, NHLBI (2011-Pres)

Kosaka Award Finalist, International Anesthesia Research Society (IARS) Annual Meeting (2010)

Resident Research Award, 1st Place, New York Society of Anesthesiologists (2010)

Young Investigator Award, Runner-Up, International Society For Heart Research (ISHR) Annual Meeting (2005)

Administrative Appointments

Director, Stanford Anesthesia Research Seminars (FNR), 2012

Member, Stanford Society of Physician Scholars, 2010

Member, Stanford Pharmacy and Therapeutics Committee, 2009

TARGETING ALDEHYDE DEHYDROGENASE 2: NEW THERAPEUTIC OPPORTUNITIES
Chen, C.-H., Batista Ferreira, J. C., Gross, E. R., & Mochly-Rosen, D. (2014). TARGETING ALDEHYDE DEHYDROGENASE 2: NEW THERAPEUTIC OPPORTUNITIES. PHYSIOLOGICAL REVIEWS, 94(1), 1-34.

Nociceptive-induced myocardial remote conditioning is mediated by neuronal gamma protein kinase C.
Gross, E. R., Hsu, A. K., Urban, T. J., Mochly-Rosen, D., & Gross, G. J. (2013). Nociceptive-induced myocardial remote conditioning is mediated by neuronal gamma protein kinase C. Basic research in cardiology, 108(5), 381-?.

Factors Mediating Remote Preconditioning of Trauma in the Rat Heart: Central Role of the Cytochrome P450 Epoxygenase Pathway in Mediating Infarct Size Reduction
Gross, G. J., Hsu, A., Gross, E. R., Falck, J. R., & Nithipatikom, K. (2013). Factors Mediating Remote Preconditioning of Trauma in the Rat Heart: Central Role of the Cytochrome P450 Epoxygenase Pathway in Mediating Infarct Size Reduction. JOURNAL OF CARDIOVASCULAR PHARMACOLOGY AND THERAPEUTICS, 18(1), 38-45.

Hunter Syndrome in an Adult: Beware of Tracheal Stenosis
Gross, E. R., & Lemmens, H. Jm. (2010). Hunter Syndrome in an Adult: Beware of Tracheal Stenosis. ANESTHESIA AND ANALGESIA, 110(2), 642-643.

Acute Methadone Treatment Reduces Myocardial Infarct Size via the delta-Opioid Receptor in Rats During Reperfusion
Gross, E. R., Hsu, A. K., & Gross, G. J. (2009). Acute Methadone Treatment Reduces Myocardial Infarct Size via the delta-Opioid Receptor in Rats During Reperfusion. ANESTHESIA AND ANALGESIA, 109(5), 1395-1402.

Activation of kappa-opioid receptors at reperfusion affords cardioprotection in both rat and mouse hearts
Peart, J. N., Gross, E. R., Reichelt, M. E., Hsu, A., Headrick, J. P., & Gross, G. J. (2008). Activation of kappa-opioid receptors at reperfusion affords cardioprotection in both rat and mouse hearts. BASIC RESEARCH IN CARDIOLOGY, 103(5), 454-463.

Delayed cardioprotection afforded by the glycogen synthase kinase 3 inhibitor SB-216763 occurs via a K-ATP- and MPTP-dependent mechanism at reperfusion
Gross, E. R., Hsu, A. K., & Gross, G. J. (2008). Delayed cardioprotection afforded by the glycogen synthase kinase 3 inhibitor SB-216763 occurs via a K-ATP- and MPTP-dependent mechanism at reperfusion. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 294(3), H1497-H1500.

Pharmacologic therapeutics for cardiac reperfusion injury
Gross, E. R., & Gross, G. J. (2007). Pharmacologic therapeutics for cardiac reperfusion injury. EXPERT OPINION ON EMERGING DRUGS, 12(3), 367-388.

GSK3 beta inhibition and K-ATP channel opening mediate acute opioid-induced cardioprotection at reperfusion
Gross, E. R., Hsu, A. K., & Gross, G. J. (2007). GSK3 beta inhibition and K-ATP channel opening mediate acute opioid-induced cardioprotection at reperfusion. BASIC RESEARCH IN CARDIOLOGY, 102(4), 341-349.

Impaired p38 MAPK/HSP27 signaling underlies aging-related failure in opioid-mediated cardioprotection
Peart, J. N., Gross, E. R., Headrick, J. P., & Gross, G. J. (2007). Impaired p38 MAPK/HSP27 signaling underlies aging-related failure in opioid-mediated cardioprotection. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, 42(5), 972-980.

Diabetes abolishes morphine-induced cardioprotection via multiple pathways upstream of glycogen synthase kinase-3 beta
Gross, E. R., Hsu, A. K., & Gross, G. J. (2007). Diabetes abolishes morphine-induced cardioprotection via multiple pathways upstream of glycogen synthase kinase-3 beta. DIABETES, 56(1), 127-136.

Ischemic Preconditioning And Myocardial Infarction: An Update and Perspective.
Gross, E. R., & Gross, G. J. (2007). Ischemic Preconditioning And Myocardial Infarction: An Update and Perspective. Drug discovery today. Disease mechanisms, 4(3), 165-174.

The JAK/STAT pathway is essential for opioid-induced cardioprotection: JAK2 as a mediator of STAT3, Akt, and GSK-3 beta
Gross, E. R., Hsu, A. K., & Gross, G. J. (2006). The JAK/STAT pathway is essential for opioid-induced cardioprotection: JAK2 as a mediator of STAT3, Akt, and GSK-3 beta. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 291(2), H827-H834.

Ligand triggers of classical preconditioning and postconditioning
Gross, E. R., & Gross, G. J. (2006). Ligand triggers of classical preconditioning and postconditioning. CARDIOVASCULAR RESEARCH, 70(2), 212-221.

Association of intravenous morphine use and outcomes in acute coronary syndromes: results from the CRUSADE Quality Improvement Initiative.
Gross, G. J., Gross, E. R., & Peart, J. N. (2005). Association of intravenous morphine use and outcomes in acute coronary syndromes: results from the CRUSADE Quality Improvement Initiative. American heart journal, 150(6).

Untitled
Gross, G. J., Gross, E. R., & Peart, J. N. (2005). Untitled. AMERICAN HEART JOURNAL, 150(6).

Cytochrome P450 and arachidonic acid metabolites: Role in myocardial ischemia/reperfusion injury revisited
Gross, G. J., Falck, J. R., Gross, E. R., Isbell, M., Moore, J., & Nithipatikom, K. (2005). Cytochrome P450 and arachidonic acid metabolites: Role in myocardial ischemia/reperfusion injury revisited. CARDIOVASCULAR RESEARCH, 68(1), 18-25.

Extending the cardioprotective window using a novel delta-opioid agonist fentanyl isothiocyanate via the PI3-kinase pathway
Gross, E. R., Peart, J. N., Hsu, A. K., Auchampach, J. A., & Gross, G. J. (2005). Extending the cardioprotective window using a novel delta-opioid agonist fentanyl isothiocyanate via the PI3-kinase pathway. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 288(6), H2744-H2749.

Opioid-induced preconditioning: Recent advances and future perspectives
Peart, J. N., Gross, E. R., & Gross, G. J. (2005). Opioid-induced preconditioning: Recent advances and future perspectives. VASCULAR PHARMACOLOGY, 42(5-6), 211-218.

Sarcolemmal K-ATP channel triggers delayed ischemic preconditioning in rats
Patel, H. H., Gross, E. R., Peart, J. N., Hsu, A. K., & Gross, G. J. (2005). Sarcolemmal K-ATP channel triggers delayed ischemic preconditioning in rats. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 288(1), H445-H447.

Cytochrome P450 omega-hydroxylase inhibition reduces infarct size during reperfusion via the sarcolemmal K-ATP channel
Gross, E. R., Nithipatikom, K., Hsu, A. K., Peart, J. N., Falck, J. R., & Gross, G. J. (2004). Cytochrome P450 omega-hydroxylase inhibition reduces infarct size during reperfusion via the sarcolemmal K-ATP channel. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, 37(6), 1245-1249.

Inhibition of cytochrome P450 omega-hydroxylase - A novel endogenous cardioprotective pathway
Nithipatikom, K., Gross, E. R., Endsley, M. P., Moore, J. M., Isbell, M. A., & Gross, G. J. (2004). Inhibition of cytochrome P450 omega-hydroxylase - A novel endogenous cardioprotective pathway. CIRCULATION RESEARCH, 95(8), E65-E71.

Acute aspirin treatment abolishes, whereas acute ibuprofen treatment enhances morphine-induced cardioprotection: Role of 12-lipoxygenase
Gross, E. R., Hsu, A. K., & Gross, G. J. (2004). Acute aspirin treatment abolishes, whereas acute ibuprofen treatment enhances morphine-induced cardioprotection: Role of 12-lipoxygenase. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 310(1), 185-191.

Opioid-induced cardioprotection occurs via glycogen synthase kinase beta inhibition during reperfusion in intact rat hearts
Gross, E. R., Hsu, A. K., & Gross, G. J. (2004). Opioid-induced cardioprotection occurs via glycogen synthase kinase beta inhibition during reperfusion in intact rat hearts. CIRCULATION RESEARCH, 94(7), 960-966.

Effect of exogenous kappa-opioid receptor activation in rat model of myocardial infarction
Peart, J. N., Gross, E. R., & Gross, G. J. (2004). Effect of exogenous kappa-opioid receptor activation in rat model of myocardial infarction. JOURNAL OF CARDIOVASCULAR PHARMACOLOGY, 43(3), 410-415.

K-ATP opener-induced delayed cardioprotection: involvement of sarcolemmal and mitochondrial K-ATP channels, free radicals and MEK1/2
Gross, E. R., Peart, J. N., Hsu, A. K., Grover, G. J., & Gross, G. J. (2003). K-ATP opener-induced delayed cardioprotection: involvement of sarcolemmal and mitochondrial K-ATP channels, free radicals and MEK1/2. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, 35(8), 985-992.

Reactive oxygen species modulate coronary wall shear stress and endothelial function during hyperglycemia
Gross, E. R., LaDisa, J. F., Weihrauch, D., Olson, L. E., Kress, T. T., & Kersten, J. R. (2003). Reactive oxygen species modulate coronary wall shear stress and endothelial function during hyperglycemia. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 284(5), H1552-H1559.

12-lipoxygenase in opioid-induced delayed cardioprotection - Gene array, mass spectrometric, and pharmacological analyses
Patel, H. H., Fryer, R. M., Gross, E. R., Bundey, R. A., Hsu, A. K., & Gross, G. J. (2003). 12-lipoxygenase in opioid-induced delayed cardioprotection - Gene array, mass spectrometric, and pharmacological analyses. CIRCULATION RESEARCH, 92(6), 676-682.

Stent implantation alters coronary artery hemodynamics and wall shear stress during maximal vasodilation
LaDisa, J. F., Hettrick, D. A., Olson, L. E., Guler, I., Gross, E. R., & Pagel, P. S. (2002). Stent implantation alters coronary artery hemodynamics and wall shear stress during maximal vasodilation. JOURNAL OF APPLIED PHYSIOLOGY, 93(6), 1939-1946.

Heat shock protein 90 mediates the balance of nitric oxide and superoxide anion from endothelial nitric-oxide synthase
Pritchard, K. A., Ackerman, A. W., Gross, E. R., Stepp, D. W., Shi, Y. H., & Sessa, W. C. (2001). Heat shock protein 90 mediates the balance of nitric oxide and superoxide anion from endothelial nitric-oxide synthase. JOURNAL OF BIOLOGICAL CHEMISTRY, 276(21), 17621-17624.

Diabetes and hyperglycemia impair activation of mitochondrial K-ATP channels
Kersten, J. R., MONTGOMERY, M. W., Ghassemi, T., Gross, E. R., Toller, W. G., & Warltier, D. C. (2001). Diabetes and hyperglycemia impair activation of mitochondrial K-ATP channels. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 280(4), H1744-H1750.

Ethanol enhances the functional recovery of stunned myocardium independent of K-ATP channels in dogs
Gross, E. R., Gare, M., Toller, W. G., Kersten, J. R., Warltier, D. C., & Pagel, P. S. (2001). Ethanol enhances the functional recovery of stunned myocardium independent of K-ATP channels in dogs. ANESTHESIA AND ANALGESIA, 92(2), 299-305.

K-ATP channels mediate the beneficial effects of chronic ethanol ingestion
Pagel, P. S., Toller, W. G., Gross, E. R., Gare, M., Kersten, J. R., & Warltier, D. C. (2000). K-ATP channels mediate the beneficial effects of chronic ethanol ingestion. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 279(5), H2574-H2579.

Sarcolemmal and mitochondrial adenosine triphosphate-dependent potassium channels - Mechanism of desflurane-induced cardioprotection
Toller, W. G., Gross, E. R., Kersten, J. R., Pagel, P. S., Gross, G. J., & Warltier, D. C. (2000). Sarcolemmal and mitochondrial adenosine triphosphate-dependent potassium channels - Mechanism of desflurane-induced cardioprotection. ANESTHESIOLOGY, 92(6), 1731-1739.

Isoflurane preconditions myocardium against infarction via activation of inhibitory guanine nucleotide binding proteins
Toller, W. G., Kersten, J. R., Gross, E. R., Pagel, P. S., & Warltier, D. C. (2000). Isoflurane preconditions myocardium against infarction via activation of inhibitory guanine nucleotide binding proteins. ANESTHESIOLOGY, 92(5), 1400-1407.

Diabetes abolishes ischemic preconditioning: role of glucose, insulin, and osmolality
Kersten, J. R., Toller, W. G., Gross, E. R., Pagel, P. S., & Warltier, D. C. (2000). Diabetes abolishes ischemic preconditioning: role of glucose, insulin, and osmolality. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 278(4), H1218-H1224.