Andrew R. Hoffman

Neuroendocrinologist

Professor of Medicine (Endocrinology)

Pituitary Center

  • 300 Pasteur Drive
  • Stanford, CA 94305
  • Phone: 650-721-1020
Learn More About the Clinic Getting Here Make An Appointment

Endocrinology Clinic

  • 300 Pasteur Drive
  • Stanford, CA 94305
  • Phone: 650-723-6961
Learn More About the Clinic Getting Here Make An Appointment

Professional Education

Board Certification: Endocrinology, Diabetes and Metabolism, American Board of Internal Medicine (1981)

Internship: Massachusetts General Hosp Harvard Med School (1977) MA

Fellowship: Massachusetts General Hospital (1982) MA

Fellowship: National Institutes of Health (1980) MD

Residency: Massachusetts General Hospital (1978) MA

Board Certification: Internal Medicine, American Board of Internal Medicine (1979)

Medical Education: Stanford University School of Medicine (1976) CA

BA, University of Michigan, History (1971)

MD, Stanford, Medicine (1976)

Administrative Appointments

Vice Chair for Academic Affairs, Department of Medicine, Stanford (2004 - Present)

Clinical Trials

Clinical trials are research studies that evaluate a new medical approach, device, drug, or other treatment. As a Stanford Health Care patient, you have access to the latest, advanced clinical trials.

Open trials refer to studies currently accepting participants. Closed trials are not currently enrolling, but may open in the future.

Long noncoding RNA-mediated intrachromosomal interactions promote imprinting at the Kcnq1 locus
Zhang, H., Zeitz, M. J., Wang, H., Niu, B., Ge, Sf., & Hu, J.-F. (2014). Long noncoding RNA-mediated intrachromosomal interactions promote imprinting at the Kcnq1 locus. JOURNAL OF CELL BIOLOGY, 204(1), 61-75.

Implications of COMT long-range interactions on the phenotypic variability of 22q11.2 deletion syndrome
Zeitz, M. J., Lerner, P. P., Ay, F., Van Nostrand, E., Heidmann, J. D., & Hoffman, A. R. (2013). Implications of COMT long-range interactions on the phenotypic variability of 22q11.2 deletion syndrome. NUCLEUS-AUSTIN, 4(6), 487-493.

Genomic Interaction Profiles in Breast Cancer Reveal Altered Chromatin Architecture
Zeitz, M. J., Ay, F., Heidmann, J. D., Lerner, P. L., Noble, W. S., & Hoffman, A. R. (2013). Genomic Interaction Profiles in Breast Cancer Reveal Altered Chromatin Architecture. PLOS ONE, 8(9).

Intrachromosomal Looping Is Required for Activation of Endogenous Pluripotency Genes during Reprogramming
Zhang, H., Jiao, W., Sun, L., Fan, J., Chen, M., & Hu, J.-F. (2013). Intrachromosomal Looping Is Required for Activation of Endogenous Pluripotency Genes during Reprogramming. CELL STEM CELL, 13(1), 30-35.

Interruption of intrachromosomal looping by CCCTC binding factor decoy proteins abrogates genomic imprinting of human insulin-like growth factor II
Zhang, H., Niu, B., Hu, J.-F., Ge, Sf., Wang, H., & Hoffman, A. R. (2011). Interruption of intrachromosomal looping by CCCTC binding factor decoy proteins abrogates genomic imprinting of human insulin-like growth factor II. JOURNAL OF CELL BIOLOGY, 193(3), 475-487.

Systematic review: The safety and efficacy of growth hormone in the healthy elderly
Liu, H., Bravata, D. M., Olkin, I., Nayak, S., Roberts, B., & Hoffman, A. R. (2007). Systematic review: The safety and efficacy of growth hormone in the healthy elderly. ANNALS OF INTERNAL MEDICINE, 146(2), 104-115.

CTCF mediates interchromosomal colocalization between Igf2/H19 and Wsb1/Nf1
Ling, J. Q., Li, T., Hu, J. F., Vu, T. H., Chen, H. L., & Hoffman, A. R. (2006). CTCF mediates interchromosomal colocalization between Igf2/H19 and Wsb1/Nf1. SCIENCE, 312(5771), 269-272.

A methylated oligonucleotide inhibits IGF2 expression and enhances survival in a model of hepatocellular carcinoma
Yao, X. M., Hu, J. F., Daniels, M., Shiran, H., Zhou, X. J., & Hoffman, A. R. (2003). A methylated oligonucleotide inhibits IGF2 expression and enhances survival in a model of hepatocellular carcinoma. JOURNAL OF CLINICAL INVESTIGATION, 111(2), 265-273.

Imprinting of the Angelman syndrome gene, UBE3A, is restricted to brain
Vu, T. H., & Hoffman, A. R. (1997). Imprinting of the Angelman syndrome gene, UBE3A, is restricted to brain. NATURE GENETICS, 17(1), 12-13.

PROMOTER-SPECIFIC IMPRINTING OF THE HUMAN INSULIN-LIKE GROWTH FACTOR-II GENE
Vu, T. H., & Hoffman, A. R. (1994). PROMOTER-SPECIFIC IMPRINTING OF THE HUMAN INSULIN-LIKE GROWTH FACTOR-II GENE. NATURE, 371(6499), 714-717.

A novel antisense long noncoding RNA within the IGF1R gene locus is imprinted in hematopoietic malignancies.
Sun, J., Li, W., Sun, Y., Yu, D., Wen, X., & Hu, J.-F. (2014). A novel antisense long noncoding RNA within the IGF1R gene locus is imprinted in hematopoietic malignancies. Nucleic acids research, 42(15), 9588-9601.

ASSOCIATION BETWEEN THYROID FUNCTION AND OBJECTIVE AND SUBJECTIVE SLEEP QUALITY IN OLDER MEN: THE OSTEOPOROTIC FRACTURES IN MEN (MROS) STUDY
Akatsu, H., Ewing, S. K., Stefanick, M. L., Fink, H. A., Stone, K. L., & Hoffman, A. R. (2014). ASSOCIATION BETWEEN THYROID FUNCTION AND OBJECTIVE AND SUBJECTIVE SLEEP QUALITY IN OLDER MEN: THE OSTEOPOROTIC FRACTURES IN MEN (MROS) STUDY. ENDOCRINE PRACTICE, 20(6), 576-586.

Association Between Thyroid Function and Objective and Subjective Sleep Quality in Older Men: The Osteoporotic Fractures in Men (MrOS) Study.
Akatsu, H., Ewing, S. K., Stefanick, M. L., Fink, H. A., Stone, K. L., & For The Osteoporotic Fractures In Men MrOS Research Group. (2014). Association Between Thyroid Function and Objective and Subjective Sleep Quality in Older Men: The Osteoporotic Fractures in Men (MrOS) Study. Endocrine practice , 20(6), 576-586.

Rapid and Efficient Conversion of Integration-Free Human Induced Pluripotent Stem Cells to GMP-Grade Culture Conditions
Durruthy-Durruthy, J., Briggs, S. F., Awe, J., Ramathal, C. Y., Karumbayaram, S., & Sebastiano, V. (2014). Rapid and Efficient Conversion of Integration-Free Human Induced Pluripotent Stem Cells to GMP-Grade Culture Conditions. PLOS ONE, 9(4).

Epigenetic reprogramming reverses the malignant epigenotype of the MMP/TIMP axis genes in tumor cells
Zhang, S., Zhong, B., Chen, M., Yang, L., Yang, G., & Hu, J. (2014). Epigenetic reprogramming reverses the malignant epigenotype of the MMP/TIMP axis genes in tumor cells. INTERNATIONAL JOURNAL OF CANCER, 134(7), 1583-1594.

Chromatin looping is needed for iPSC induction.
Hu, J.-F., & Hoffman, A. R. (2014). Chromatin looping is needed for iPSC induction. Cell cycle , 13(1), 1-2.

Targeted gene suppression by inducing de novo DNA methylation in the gene promoter.
Ma, A.-N., Wang, H., Guo, R., Wang, Y.-X., Li, W., & Hu, J.-F. (2014). Targeted gene suppression by inducing de novo DNA methylation in the gene promoter. Epigenetics & chromatin, 7, 20-?.

Rapid and efficient conversion of integration-free human induced pluripotent stem cells to GMP-grade culture conditions.
Durruthy-Durruthy, J., Briggs, S. F., Awe, J., Ramathal, C. Y., Karumbayaram, S., & Sebastiano, V. (2014). Rapid and efficient conversion of integration-free human induced pluripotent stem cells to GMP-grade culture conditions. PloS one, 9(4).

Promoter histone H3K27 methylation in the control of IGF2 imprinting in human tumor cell lines
Li, T., Chen, H., Li, W., Cui, J., Wang, G., & Hu, J. (2014). Promoter histone H3K27 methylation in the control of IGF2 imprinting in human tumor cell lines. HUMAN MOLECULAR GENETICS, 23(1), 117-128.

Abdominal Myosteatosis Is Independently Associated with Hyperinsulinemia and Insulin Resistance Among Older Men Without Diabetes
Miljkovic, I., Cauley, J. A., Wang, P. Y., Holton, K. F., Lee, C. G., & Marshall, L. M. (2013). Abdominal Myosteatosis Is Independently Associated with Hyperinsulinemia and Insulin Resistance Among Older Men Without Diabetes. OBESITY, 21(10), 2118-2125.

Cyclic Hypobaric Hypoxia Improves Markers of Glucose Metabolism in Middle-Aged Men
Marquez, J. L., Rubinstein, S., Fattor, J. A., Shah, O., Hoffman, A. R., & Friedlander, A. L. (2013). Cyclic Hypobaric Hypoxia Improves Markers of Glucose Metabolism in Middle-Aged Men. HIGH ALTITUDE MEDICINE & BIOLOGY, 14(3), 263-272.

Gene therapy for colorectal cancer by an oncolytic adenovirus that targets loss of the insulin-like growth factor 2 imprinting system
Nie, Z.-L., Pan, Y.-Q., He, B.-S., Gu, L., Chen, L.-P., & Hu, F. (2012). Gene therapy for colorectal cancer by an oncolytic adenovirus that targets loss of the insulin-like growth factor 2 imprinting system. MOLECULAR CANCER, 11.

The Association of Concurrent Vitamin D and Sex Hormone Deficiency With Bone Loss and Fracture Risk in Older Men: The Osteoporotic Fractures in Men (MrOS) Study
Barrett-Connor, E., Laughlin, G. A., Li, H., Nielson, C. M., Wang, P. Y., & Orwoll, E. S. (2012). The Association of Concurrent Vitamin D and Sex Hormone Deficiency With Bone Loss and Fracture Risk in Older Men: The Osteoporotic Fractures in Men (MrOS) Study. JOURNAL OF BONE AND MINERAL RESEARCH, 27(11), 2306-2313.

Successful long-term treatment of Cushing disease with mifepristone (RU486).
Basina, M., Liu, H., Hoffman, A. R., & Feldman, D. (2012). Successful long-term treatment of Cushing disease with mifepristone (RU486). Endocrine practice , 18(5), e114-20.

Promotion of the induction of cell pluripotency through metabolic remodeling by thyroid hormone triiodothyronine-activated PI3K/AKT signal pathway
Chen, M., Zhang, H., Wu, J., Xu, L., Xu, D., & Li, T. (2012). Promotion of the induction of cell pluripotency through metabolic remodeling by thyroid hormone triiodothyronine-activated PI3K/AKT signal pathway. BIOMATERIALS, 33(22), 5514-5523.

Validation of FRC, a Fracture Risk Assessment Tool, in a Cohort of Older Men: The Osteoporotic Fractures in Men (MrOS) Study
Ettinger, B., Liu, H., Blackwell, T., Hoffman, A. R., Ensrud, K. E., & Orwoll, E. S. (2012). Validation of FRC, a Fracture Risk Assessment Tool, in a Cohort of Older Men: The Osteoporotic Fractures in Men (MrOS) Study. JOURNAL OF CLINICAL DENSITOMETRY, 15(3), 334-342.

Thyroid Function and Mortality in Older Men: A Prospective Study
Waring, A. C., Harrison, S., Samuels, M. H., Ensrud, K. E., LeBlanc, E. S., & Bauer, D. C. (2012). Thyroid Function and Mortality in Older Men: A Prospective Study. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 97(3), 862-870.

Long-Term Surveillance of Growth Hormone Therapy
Rosenfeld, R. G., Cohen, P., Robison, L. L., Bercu, B. B., Clayton, P., & Wit, J. M. (2012). Long-Term Surveillance of Growth Hormone Therapy. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 97(1), 68-72.

Higher Testosterone Levels Are Associated with Less Loss of Lean Body Mass in Older Men
LeBlanc, E. S., Wang, P. Y., Lee, C. G., Barrett-Connor, E., Cauley, J. A., & Orwoll, E. S. (2011). Higher Testosterone Levels Are Associated with Less Loss of Lean Body Mass in Older Men. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 96(12), 3855-3863.

IGFBP-2 Enhances VEGF Gene Promoter Activity and Consequent Promotion of Angiogenesis by Neuroblastoma Cells
Azar, W. J., Azar, S. Hx., Higgins, S., Hu, J.-F., Hoffman, A. R., & Russo, V. C. (2011). IGFBP-2 Enhances VEGF Gene Promoter Activity and Consequent Promotion of Angiogenesis by Neuroblastoma Cells. ENDOCRINOLOGY, 152(9), 3332-3342.

Optimized clinical performance of growth hormone with an expanded genetic code
Cho, H., Daniel, T., Buechler, Y. J., Litzinger, D. C., Maio, Z., & Kimmel, B. E. (2011). Optimized clinical performance of growth hormone with an expanded genetic code. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 108(22), 9060-9065.

Mortality Risk in Older Men Associated with Changes in Weight, Lean Mass, and Fat Mass
Lee, C. G., Boyko, E. J., Nielson, C. M., Stefanick, M. L., Bauer, D. C., & Orwoll, E. S. (2011). Mortality Risk in Older Men Associated with Changes in Weight, Lean Mass, and Fat Mass. JOURNAL OF THE AMERICAN GERIATRICS SOCIETY, 59(2), 233-240.

Putative Tumor Suppressor miR-145 Inhibits Colon Cancer Cell Growth by Targeting Oncogene Friend Leukemia Virus Integration 1 Gene
Zhang, J., Guo, H., Zhang, H., Wang, H., Qian, G., & Ge, S. (2011). Putative Tumor Suppressor miR-145 Inhibits Colon Cancer Cell Growth by Targeting Oncogene Friend Leukemia Virus Integration 1 Gene. CANCER, 117(1), 86-95.

Serum 25-OH vitamin D levels and risk of developing prostate cancer in older men
Barnett, C. M., Nielson, C. M., Shannon, J., Chan, J. M., Shikany, J. M., & Beer, T. M. (2010). Serum 25-OH vitamin D levels and risk of developing prostate cancer in older men. CANCER CAUSES & CONTROL, 21(8), 1297-1303.

Targeted tumor gene therapy based on loss of IGF2 imprinting
Pan, Y., He, B., Li, T., Zhu, C., Zhang, L., & Hu, J. (2010). Targeted tumor gene therapy based on loss of IGF2 imprinting. CANCER BIOLOGY & THERAPY, 10(3).

Targeted knockdown of Bcl2 in tumor cells using a synthetic TRAIL 3 '-UTR microRNA
Zhang, J., Huang, S., Zhang, H., Wang, H., Guo, H., & Ge, S. (2010). Targeted knockdown of Bcl2 in tumor cells using a synthetic TRAIL 3 '-UTR microRNA. INTERNATIONAL JOURNAL OF CANCER, 126(9), 2229-2239.

Transient in vitro epigenetic reprogramming of skin fibroblasts into multipotent cells
Zhu, X.-Q., Pan, X.-H., Wang, W., Chen, Q., Pang, R.-Q., & Hu, J.-F. (2010). Transient in vitro epigenetic reprogramming of skin fibroblasts into multipotent cells. BIOMATERIALS, 31(10), 2779-2787.

Loss of IGF2 imprinting is associated with abrogation of long-range intrachromosomal interactions in human cancer cells
Vu, T. H., Nguyen, A. H., & Hoffman, A. R. (2010). Loss of IGF2 imprinting is associated with abrogation of long-range intrachromosomal interactions in human cancer cells. HUMAN MOLECULAR GENETICS, 19(5), 901-919.

Serum 25-Hydroxyvitamin D and the Risk of Hip and Nonspine Fractures in Older Men
Cauley, J. A., Parimi, N., Ensrud, K. E., Bauer, D. C., Cawthon, P. M., & Orwoll, E. (2010). Serum 25-Hydroxyvitamin D and the Risk of Hip and Nonspine Fractures in Older Men. JOURNAL OF BONE AND MINERAL RESEARCH, 25(3), 545-553.

Bone Mass and Strength in Older Men With Type 2 Diabetes: The Osteoporotic Fractures in Men Study
Petit, M. A., Paudel, M. L., Taylor, B. C., Hughes, J. M., Strotmeyer, E. S., & Ensrud, K. E. (2010). Bone Mass and Strength in Older Men With Type 2 Diabetes: The Osteoporotic Fractures in Men Study. JOURNAL OF BONE AND MINERAL RESEARCH, 25(2), 285-291.

Nocturnal Arrhythmias Across a Spectrum of Obstructive and Central Sleep-Disordered Breathing in Older Men Outcomes of Sleep Disorders in Older Men (MrOS Sleep) Study
Mehra, R., Stone, K. L., Varosy, P. D., Hoffman, A. R., Marcus, G. M., & Redline, S. (2009). Nocturnal Arrhythmias Across a Spectrum of Obstructive and Central Sleep-Disordered Breathing in Older Men Outcomes of Sleep Disorders in Older Men (MrOS Sleep) Study. ARCHIVES OF INTERNAL MEDICINE, 169(12), 1147-1155.

Vitamin D Deficiency in Older Men
Orwoll, E., Nielson, C. M., Marshall, L. M., Lambert, L., Holton, K. F., & Cauley, J. A. (2009). Vitamin D Deficiency in Older Men. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 94(4), 1214-1222.

CTCF regulates allelic expression of Igf2 by orchestrating a promoter-polycomb repressive complex 2 intrachromosomal loop
Li, T., Hu, J.-F., Qiu, X., Ling, J., Chen, H., & Hoffman, A. R. (2008). CTCF regulates allelic expression of Igf2 by orchestrating a promoter-polycomb repressive complex 2 intrachromosomal loop. MOLECULAR AND CELLULAR BIOLOGY, 28(20), 6473-6482.

A complex deoxyribonucleic acid looping configuration associated with the silencing of the maternal Igf2 allele
Qiu, X., Vu, T. H., Lu, Q., Ling, J. Q., Li, T., & Hoffman, A. R. (2008). A complex deoxyribonucleic acid looping configuration associated with the silencing of the maternal Igf2 allele. MOLECULAR ENDOCRINOLOGY, 22(6), 1476-1488.

Systematic review: The effects of growth hormone on athletic performance
Liu, H., Bravata, D. M., Olkin, I., Friedlander, A., Liu, V., & Hoffman, A. R. (2008). Systematic review: The effects of growth hormone on athletic performance. ANNALS OF INTERNAL MEDICINE, 148(10), 747-U59.

Effects of growth hormone and pioglitazone in viscerally obese adults with impaired glucose tolerance: A factorial clinical trial
Attallah, H., Friedlander, A. L., Nino-Murcia, M., & Hoffman, A. R. (2007). Effects of growth hormone and pioglitazone in viscerally obese adults with impaired glucose tolerance: A factorial clinical trial. PLOS CLINICAL TRIALS, 2(5).

Correction of aberrant imprinting of IGF2 in human tumors by nuclear transfer-induced epigenetic reprogramming
Chen, H. L., Li, T., Qiu, X. W., Wu, J., Ling, J. Q., & Hu, J.-F. (2006). Correction of aberrant imprinting of IGF2 in human tumors by nuclear transfer-induced epigenetic reprogramming. EMBO JOURNAL, 25(22), 5329-5338.

Endocrine responses to acute and chronic high-altitude exposure (4,300 meters): modulating effects of caloric restriction
Barnholt, K. E., Hoffman, A. R., Rock, P. B., Muza, S. R., Fulco, C. S., & Friedlander, A. L. (2006). Endocrine responses to acute and chronic high-altitude exposure (4,300 meters): modulating effects of caloric restriction. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, 290(6), E1078-E1088.

Efficacy of a long-acting growth hormone (GH) preparation in patients with adult GH deficiency
Hoffman, A. R., Biller, B. Mk., Cook, D., Baptista, J., Silverman, B. L., & Lippe, B. (2005). Efficacy of a long-acting growth hormone (GH) preparation in patients with adult GH deficiency. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 90(12), 6431-6440.

Promoter-restricted histone code, not the differentially methylated DNA regions or antisense transcripts, marks the imprinting status of IGF2R in human and mouse
Vu, T. H., Li, T., & Hoffman, A. R. (2004). Promoter-restricted histone code, not the differentially methylated DNA regions or antisense transcripts, marks the imprinting status of IGF2R in human and mouse. HUMAN MOLECULAR GENETICS, 13(19), 2233-2245.

Activating and silencing histone modifications form independent allelic switch regions in the imprinted Gnas gene
Li, T., Vu, T. H., Yang, Y. W., Hu, J. F., & Hoffman, A. R. (2004). Activating and silencing histone modifications form independent allelic switch regions in the imprinted Gnas gene. HUMAN MOLECULAR GENETICS, 13(7), 741-750.

An imprinted PEG1/MEST antisense expressed predominantly in human testis and in mature spermatozoa
Li, T., Vu, T. H., Lee, K. O., Yang, Y. W., Nguyen, C. V., & Hoffman, A. R. (2002). An imprinted PEG1/MEST antisense expressed predominantly in human testis and in mature spermatozoa. JOURNAL OF BIOLOGICAL CHEMISTRY, 277(16), 13518-13527.

One year of insulin-like growth factor I treatment does not affect bone density, body composition, or psychological measures in postmenopausal women
Friedlander, A. L., Butterfield, E., Moynihan, S., Grillo, J., Pollack, M., & Hoffman, A. R. (2001). One year of insulin-like growth factor I treatment does not affect bone density, body composition, or psychological measures in postmenopausal women. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 86(4), 1496-1503.

DELAYED INCREASE OF ADRENAL TH AND PNMT ACTIVITIES FOLLOWING COLD STRESS IN MOUSE
Hoffman, A., Harbaugh, R., Erdelyi, E., DORNBUSCH, J., CIARANELLO, R., & BARCHAS, J. (1975). DELAYED INCREASE OF ADRENAL TH AND PNMT ACTIVITIES FOLLOWING COLD STRESS IN MOUSE. LIFE SCIENCES, 17(4), 557-562.