Calvin Kuo

Hematologist

Professor of Medicine (Hematology) and, by courtesy, of Chemical and Systems Biology

Hematology Program

  • 875 Blake Wilbur Drive
  • Palo Alto, CA 94304
  • Phone: 650-498-6000
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Professional Education

Fellowship: Brigham and Women's Hospital Harvard Medical School (2000) MA

Residency: Brigham and Women's Hospital Harvard Medical School (1997) MA

Medical Education: Stanford University School of Medicine (1994) CA

A.B., Harvard College, Biochemical Sciences (1987)

M.D./Ph.D., Stanford University, Cancer Biology (1994)

Internship/ Residency, Brigham and Women's Hospital, Internal Medicine (1997)

Fellowship, Dana-Farber/Partners, Adult Oncology (2000)

Honors & Awards

Consulting Editor, JCI (2012)

American Heart Association Innovative Science Award, AHA (2012)

Research Chair, NIH Intestinal Stem Cell Consortium, NIH (2009)

Transformative R01 Award, NIH (2009)

Member, American Society for Clinical Investigation, American Society for Clinical Investigation (2007)

Samantha Janower Research Chair, Brain Tumor Society (2005)

Merck Faculty Development Award, Merck (2003)

Kimmel Foundation Scholar in Translational Science, Kimmel Foundation (2002)

Burroughs Wellcome Foundation New Investigator in Pharmacological Sciences, Burroughs Wellcome Foundation (2001)

HHMI Physician-Scientist Fellowship, HHMI (1998)

Summa cum laude, Harvard College (1987)

Administrative Appointments

Co-lead, Cancer Biology Program, Stanford Cancer Center (2012 - Present)

Oncogenic transformation of diverse gastrointestinal tissues in primary organoid culture
Li, X., Nadauld, L., Ootani, A., Corney, D. C., Pai, R. K., & Kuo, C. J. (2014). Oncogenic transformation of diverse gastrointestinal tissues in primary organoid culture. NATURE MEDICINE, 20(7), 769-777.

Interfollicular Epidermal Stem Cells Self-Renew via Autocrine Wnt Signaling
Lim, X., Tan, S. H., Koh, W. L. C., Chau, R. M. W., Yan, K. S., & Nusse, R. (2013). Interfollicular Epidermal Stem Cells Self-Renew via Autocrine Wnt Signaling. SCIENCE, 342(6163), 1226-1230.

A liver Hif-2a-Irs2 pathway sensitizes hepatic insulin signaling and is modulated by Vegf inhibition.
Wei, K., Piecewicz, S. M., McGinnis, L. M., Taniguchi, C. M., Wiegand, S. J., & Kuo, C. J. (2013). A liver Hif-2a-Irs2 pathway sensitizes hepatic insulin signaling and is modulated by Vegf inhibition. Nature medicine, 19(10), 1331-1337.

Cross-talk between hypoxia and insulin signaling through Phd3 regulates hepatic glucose and lipid metabolism and ameliorates diabetes.
Taniguchi, C. M., Finger, E. C., Krieg, A. J., Wu, C., Diep, A. N., & Giaccia, A. J. (2013). Cross-talk between hypoxia and insulin signaling through Phd3 regulates hepatic glucose and lipid metabolism and ameliorates diabetes. Nature medicine, 19(10), 1325-1330.

Restriction of intestinal stem cell expansion and the regenerative response by YAP
Barry, E. R., Morikawa, T., Butler, B. L., Shrestha, K., de la Rosa, R., & Camargo, F. D. (2013). Restriction of intestinal stem cell expansion and the regenerative response by YAP. NATURE, 493(7430), 106-?.

beta-Catenin-Driven Cancers Require a YAP1 Transcriptional Complex for Survival and Tumorigenesis
Rosenbluh, J., Nijhawan, D., Cox, A. G., Li, X., Neal, J. T., & Hahn, W. C. (2012). beta-Catenin-Driven Cancers Require a YAP1 Transcriptional Complex for Survival and Tumorigenesis. CELL, 151(7), 1457-1473.

The intestinal stem cell markers Bmi1 and Lgr5 identify two functionally distinct populations
Yan, K. S., Chia, L. A., Li, X., Ootani, A., Su, J., & Kuo, C. J. (2012). The intestinal stem cell markers Bmi1 and Lgr5 identify two functionally distinct populations. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 109(2), 466-471.

Essential Regulation of CNS Angiogenesis by the Orphan G Protein-Coupled Receptor GPR124
Kuhnert, F., Mancuso, M. R., Shamloo, A., Wang, H.-T., Choksi, V., & Kuo, C. J. (2010). Essential Regulation of CNS Angiogenesis by the Orphan G Protein-Coupled Receptor GPR124. SCIENCE, 330(6006), 985-989.

Sustained in vitro intestinal epithelial culture within a Wnt-dependent stem cell niche.
Ootani, A., Li, X., Sangiorgi, E., Ho, Q. T., Ueno, H., & Kuo, C. J. (2009). Sustained in vitro intestinal epithelial culture within a Wnt-dependent stem cell niche. Nature medicine, 15(6), 701-706.

Engineering of three-dimensional microenvironments to promote contractile behavior in primary intestinal organoids
Dimarco, R. L., Su, J., Yan, K. S., Dewi, R., Kuo, C. J., & Heilshorn, S. C. (2014). Engineering of three-dimensional microenvironments to promote contractile behavior in primary intestinal organoids. INTEGRATIVE BIOLOGY, 6(2), 127-142.

Partial Proteasome Inhibitors Induce Hair Follicle Growth by Stabilizing b-Catenin
Yucel, G., Van Arnam, J., Means, P. C., Huntzicker, E., Altindag, B., & Oro, A. E. (2014). Partial Proteasome Inhibitors Induce Hair Follicle Growth by Stabilizing b-Catenin. STEM CELLS, 32(1), 85-92.

A multicenter study to standardize reporting and analyses of fluorescence-activated cell-sorted murine intestinal epithelial cells
Magness, S. T., Puthoff, B. J., Crissey, M. A., Dunn, J., Henning, S. J., & Wong, M. H. (2013). A multicenter study to standardize reporting and analyses of fluorescence-activated cell-sorted murine intestinal epithelial cells. AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, 305(8), G542-G551.

A multicenter study to standardize reporting and analyses of fluorescence-activated cell-sorted murine intestinal epithelial cells
Magness, S. T., Puthoff, B. J., Crissey, M. A., Dunn, J., Henning, S. J., & Wong, M. H. (2013). A multicenter study to standardize reporting and analyses of fluorescence-activated cell-sorted murine intestinal epithelial cells. AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, 305(8), G542-G551.

The HIF Signaling Pathway in Osteoblasts Directly Modulates Erythropoiesis through the Production of EPO
Rankin, E. B., Wu, C., Khatri, R., Wilson, T. Ls., Andersen, R., & Giaccia, A. J. (2012). The HIF Signaling Pathway in Osteoblasts Directly Modulates Erythropoiesis through the Production of EPO. CELL, 149(1), 63-74.

PDGF-B exploits stromal EPO
McGinnis, L. M., & Kuo, C. J. (2012). PDGF-B exploits stromal EPO. NATURE MEDICINE, 18(1), 22-24.

Reversible cell-cycle entry in adult kidney podocytes through regulated control of telomerase and Wnt signaling
Shkreli, M., Sarin, K. Y., Pech, M. F., Papeta, N., Chang, W., & Artandi, S. E. (2012). Reversible cell-cycle entry in adult kidney podocytes through regulated control of telomerase and Wnt signaling. NATURE MEDICINE, 18(1), 111-119.

Endochondral ossification is required for haematopoietic stem-cell niche formation
Chan, C. Kf., Chen, C.-C., Luppen, C. A., Kim, J.-B., DeBoer, A. T., & Weissman, I. L. (2009). Endochondral ossification is required for haematopoietic stem-cell niche formation. NATURE, 457(7228), 490-U9.

Attribution of vascular phenotypes of the murine Egfl7 locus to the microRNA miR-126
Kuhnert, F., Mancuso, M. R., Hampton, J., Stankunas, K., Asano, T., & Kuo, C. J. (2008). Attribution of vascular phenotypes of the murine Egfl7 locus to the microRNA miR-126. DEVELOPMENT, 135(24), 3989-3993.

Soluble receptor-mediated selective inhibition of VEGFR and PDGFR beta signaling during physiologic and tumor angiogenesis
Kuhnert, F., Tam, B. Yy., Sennino, B., Gray, J. T., Yuan, J., & Kuo, C. J. (2008). Soluble receptor-mediated selective inhibition of VEGFR and PDGFR beta signaling during physiologic and tumor angiogenesis. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 105(29), 10185-10190.

Recombinant adenovirus as a methodology for exploration of physiologic functions of growth factor pathways
Wei, K., Kuhnert, F., & Kuo, C. J. (2008). Recombinant adenovirus as a methodology for exploration of physiologic functions of growth factor pathways. JOURNAL OF MOLECULAR MEDICINE-JMM, 86(2), 161-169.

Augmented Wnt signaling in a mammalian model of accelerated aging
Liu, H., Fergusson, M. M., Castilho, R. M., Liu, J., Cao, L., & Finkel, T. (2007). Augmented Wnt signaling in a mammalian model of accelerated aging. SCIENCE, 317(5839), 803-806.

Increased Wnt signaling during aging alters muscle stem cell fate and increases fibrosis
Brack, A. S., Conboy, M. J., Roy, S., Lee, M., Kuo, C. J., & Rando, T. A. (2007). Increased Wnt signaling during aging alters muscle stem cell fate and increases fibrosis. SCIENCE, 317(5839), 807-810.

VEGF modulates erythropoiesis through regulation of adult hepatic erythropoietin synthesis
Tam, B. Yy., Wei, K., Rudge, J. S., Hoffman, J., Holash, J., & Kuo, C. J. (2006). VEGF modulates erythropoiesis through regulation of adult hepatic erythropoietin synthesis. NATURE MEDICINE, 12(7), 793-800.

Apc tumor suppressor gene is the "zonation-keeper" of mouse liver
Benhamouche, S., Decaens, T., Godard, C., Chambrey, R., Rickman, D. S., & Colnot, S. (2006). Apc tumor suppressor gene is the "zonation-keeper" of mouse liver. DEVELOPMENTAL CELL, 10(6), 759-770.

Essential requirement for Wnt signaling in proliferation of adult small intestine and colon revealed by adenoviral expression of Dickkopf-1
Kuhnert, F., DAVIS, C. R., Wang, H. T., Chu, P., Lee, M., & Kuo, C. J. (2004). Essential requirement for Wnt signaling in proliferation of adult small intestine and colon revealed by adenoviral expression of Dickkopf-1. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 101(1), 266-271.

Comparative evaluation of the antitumor activity of antiangiogenic proteins delivered by gene transfer
Kuo, C. J., Farnebo, F., Yu, E. Y., Christofferson, R., Swearingen, R. A., & Mulligan, R. C. (2001). Comparative evaluation of the antitumor activity of antiangiogenic proteins delivered by gene transfer. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 98(8), 4605-4610.

RAPAMYCIN SELECTIVELY INHIBITS INTERLEUKIN-2 ACTIVATION OF P70 S6 KINASE
Kuo, C. J., Chung, J. K., Fiorentino, D. F., Flanagan, W. M., Blenis, J., & Crabtree, G. R. (1992). RAPAMYCIN SELECTIVELY INHIBITS INTERLEUKIN-2 ACTIVATION OF P70 S6 KINASE. NATURE, 358(6381), 70-73.

A TRANSCRIPTIONAL HIERARCHY INVOLVED IN MAMMALIAN CELL-TYPE SPECIFICATION
Kuo, C. J., Conley, P. B., Chen, L., Sladek, F. M., Darnell, J. E., & Crabtree, G. R. (1992). A TRANSCRIPTIONAL HIERARCHY INVOLVED IN MAMMALIAN CELL-TYPE SPECIFICATION. NATURE, 355(6359), 457-461.