Professional Summary
Education & Certifications
- Fellowship: Seattle Children's Hospital Pediatric Infectious Diseases Fellowship (1987) WA
- Residency: UCSF Pediatric Residency (1984) CA
- Internship: Seattle Childrens Hospital Pediatric Residency (1982) WA
- Medical Education: University of California at San Francisco School of Medicine (1981) CA
- Board Certification: American Board of Pediatrics, Pediatrics (1986)
- M.D., Univ.Calif at San Francisco, Medicine (1981)
- B.S., Yale University, Biology (1976)
Honors & Awards
- Henry J. Kaiser Award for Excellence in Preclinical Teaching (Immunology), Kaiser Foundation (2001)
- Henry J. Kaiser Award for Excellence in Preclinical Teaching (Immunology), Kaiser Foundation (2005)
Administrative Appointments
- Acting Associate Professor, Stanford University, Department of Pediatrics (1997 - 1997)
- Associate Professor, Stanford University, Department of Pediatrics (1997 - 2005)
- Chief, Stanford Department of Pediatrics, Division of Immunology and Allergy (2008 - Present)
- Director of the Jeffrey Modell Primary Immunodeficiency Center at Stanford, Supported by the Jeffrey Modell Foundation and the Lucile Packard Fund of Children's Health (2002 - Present)
- Professor, Stanford University, Department of Pediatrics (2005 - Present)
Publications
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Bone marrow NK1.1(-) and NK1.1(+) T cells reciprocally regulate acute graft versus host disease
Zeng, D. F., Lewis, D., Dejbakhsh-Jones, S., Lan, F. S., Garcia-Ojeda, M., Sibley, R., & Strober, S. (1999). Bone marrow NK1.1(-) and NK1.1(+) T cells reciprocally regulate acute graft versus host disease. JOURNAL OF EXPERIMENTAL MEDICINE, 189(7), 1073–1081. -
Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling
Alizadeh, A. A., Eisen, M. B., Davis, R. E., Ma, C., Lossos, I. S., Rosenwald, A., … Staudt, L. M. (2000). Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling. NATURE, 403(6769), 503–11. -
NFAT1 enhances HIV-1 gene expression in primary human CD4 T cells
Cron, R. Q., Bartz, S. R., Clausell, A., Bort, S. J., Klebanoff, S. J., & Lewis, D. B. (2000). NFAT1 enhances HIV-1 gene expression in primary human CD4 T cells. CLINICAL IMMUNOLOGY, 94(3), 179–191. -
An immunosuppressive and anti-inflammatory HLA class I-derived peptide binds vascular cell adhesion molecule-1
Ling, X. F., Tamaki, T., Xiao, Y., Kamangar, S., CLAYBERGER, C., Lewis, D. B., & KRENSKY, A. M. (2000). An immunosuppressive and anti-inflammatory HLA class I-derived peptide binds vascular cell adhesion molecule-1. TRANSPLANTATION, 70(4), 662–667. -
Local blockade of allergic airway hyperreactivity and inflammation by the poxvirus-derived pan-CC-chemokine inhibitor vCCI
Dabbagh, K., Xiao, Y., Smith, C., Stepick-Biek, P., Kim, S. G., Lamm, W. J. E., … Lewis, D. B. (2000). Local blockade of allergic airway hyperreactivity and inflammation by the poxvirus-derived pan-CC-chemokine inhibitor vCCI. JOURNAL OF IMMUNOLOGY, 165(6), 3418–22. -
Respiratory infection with influenza A virus interferes with the induction of tolerance to aeroallergens
Tsitoura, D. C., Kim, S., Dabbagh, K., Berry, G., Lewis, D. B., & Umetsu, D. T. (2000). Respiratory infection with influenza A virus interferes with the induction of tolerance to aeroallergens. JOURNAL OF IMMUNOLOGY, 165(6), 3484–91. -
A T cell-specific enhancer of the human CD40 ligand gene
Schubert, L. A., Cron, R. Q., Cleary, A. M., Brunner, M., Song, A., Lu, L. S., … Lewis, D. B. (2002). A T cell-specific enhancer of the human CD40 ligand gene. JOURNAL OF BIOLOGICAL CHEMISTRY, 277(9), 7386–7395. -
Group A streptococcal meningitis: Report of a case and review of literature since 1976
Shetty, A. K., Frankel, L. R., Maldonado, Y., Falco, D. A., & Lewis, D. B. (2001). Group A streptococcal meningitis: Report of a case and review of literature since 1976. PEDIATRIC EMERGENCY CARE, 17(6), 430–434. -
Octamer proteins inhibit IL-4 gene transcription in normal human CD4 T cells
Cron, R. Q., Zhou, B., Brunvand, M. W., & Lewis, D. B. (2001). Octamer proteins inhibit IL-4 gene transcription in normal human CD4 T cells. GENES AND IMMUNITY, 2(8), 464–468. -
Toll-like receptor 4 is required for optimal development of Th2 immune responses: Role of dendritic cells
Dabbagh, K., Dahl, M. E., Stepick-Biek, P., & Lewis, D. B. (2002). Toll-like receptor 4 is required for optimal development of Th2 immune responses: Role of dendritic cells. JOURNAL OF IMMUNOLOGY, 168(9), 4524–30. -
Simple febrile seizures - Do polymorphisms of the interleukin 1 gene cluster simplify our understanding?
Lewis, D. B. (2002). Simple febrile seizures - Do polymorphisms of the interleukin 1 gene cluster simplify our understanding? ARCHIVES OF PEDIATRICS & ADOLESCENT MEDICINE, 156(6), 529–530. -
Dynamics of CD4 and CD8 T cell responses to cytomegalovirus in healthy human donors
Dunn, H. S., Haney, D. J., Ghanekar, S. A., Stepick-Biek, P., Lewis, D. B., & Maecker, H. T. (2002). Dynamics of CD4 and CD8 T cell responses to cytomegalovirus in healthy human donors. JOURNAL OF INFECTIOUS DISEASES, 186(1), 15–22. -
Allergy immunotherapy and inhibition of Th2 immune responses: a sufficient strategy?
Lewis, D. B. (2002). Allergy immunotherapy and inhibition of Th2 immune responses: a sufficient strategy? CURRENT OPINION IN IMMUNOLOGY, 14(5), 644–51. -
Impaired accumulation and function of memory CD4 T cells in human IL-12 receptor beta 1 deficiency
Cleary, A. M., Tu, W. W., Enright, A., Giffon, T., Dewaal-Malefyt, R., Gutierrez, K., & Lewis, D. B. (2003). Impaired accumulation and function of memory CD4 T cells in human IL-12 receptor beta 1 deficiency. JOURNAL OF IMMUNOLOGY, 170(1), 597–603. -
Toll-like receptors and T-helper-1/T-helper-2 responses
Dabbagh, K., & Lewis, D. B. (2003). Toll-like receptors and T-helper-1/T-helper-2 responses. CURRENT OPINION IN INFECTIOUS DISEASES, 16(3), 199–204. -
ONTOGENY OF LYMPHOCYTE-T FUNCTION IN THE NEONATE
Wilson, C. B., Penix, L., Weaver, W. M., Melvin, A., & Lewis, D. B. (1992). ONTOGENY OF LYMPHOCYTE-T FUNCTION IN THE NEONATE. AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY, 28(3-4), 132–135. -
DECREASED GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR PRODUCTION BY HUMAN NEONATAL BLOOD MONONUCLEAR-CELLS AND T-CELLS
English, B. K., Hammond, W. P., Lewis, D. B., Brown, C. B., & Wilson, C. B. (1992). DECREASED GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR PRODUCTION BY HUMAN NEONATAL BLOOD MONONUCLEAR-CELLS AND T-CELLS. PEDIATRIC RESEARCH, 31(3), 211–216. -
Decreased CD154 expression by neonatal CD4(+) T cells is due to limitations in both proximal and distal events of T cell activation
JULLIEN, P., Cron, R. Q., Dabbagh, K., Cleary, A., Chen, L., Tran, P., … Lewis, D. B. (2003). Decreased CD154 expression by neonatal CD4(+) T cells is due to limitations in both proximal and distal events of T cell activation. INTERNATIONAL IMMUNOLOGY, 15(12), 1461–72. -
Viral-induced T helper type 1 responses enhance allergic disease by effects on lung dendritic cells
Dahl, M. E., Dabbagh, K., Liggitt, D., Kim, S., & Lewis, D. B. (2004). Viral-induced T helper type 1 responses enhance allergic disease by effects on lung dendritic cells. NATURE IMMUNOLOGY, 5(3), 337–43. -
Persistent and selective deficiency of CD4(+) T cell immunity to cytomegalovirus in immunocompetent young children
Tu, W. W., Chen, S., Sharp, M., Dekker, C., Manganello, A. M., Tongson, E. C., … Lewis, D. B. (2004). Persistent and selective deficiency of CD4(+) T cell immunity to cytomegalovirus in immunocompetent young children. JOURNAL OF IMMUNOLOGY, 172(5), 3260–67. -
Antiviral CD8 T cells in the control of primary human cytomegalovirus infection in early childhood
Chen, S. F., Tu, W. W., Sharp, M. A., Tongson, E. C., He, X. S., Greenberg, H. B., … Arvin, A. M. (2004). Antiviral CD8 T cells in the control of primary human cytomegalovirus infection in early childhood. JOURNAL OF INFECTIOUS DISEASES, 189(9), 1619–27. -
HAWKINSINURIA IN 2 FAMILIES
Borden, M., Holm, J., Leslie, J., Sweetman, L., Nyhan, W. L., Fleisher, L., … Scott, C. R. (1992). HAWKINSINURIA IN 2 FAMILIES. AMERICAN JOURNAL OF MEDICAL GENETICS, 44(1), 52–56. -
CLINICAL AND MICROBIOLOGIC CHARACTERISTICS OF CUTANEOUS INFECTION WITH YERSINIA-ENTEROCOLITICA
Krogstad, P., Mendelman, P. M., MILLER, V. L., Clausen, C., Abbott, S., WEAGANT, S., … Lewis, D. B. (1992). CLINICAL AND MICROBIOLOGIC CHARACTERISTICS OF CUTANEOUS INFECTION WITH YERSINIA-ENTEROCOLITICA. JOURNAL OF INFECTIOUS DISEASES, 165(4), 740–743. -
Thymic stromal lymphopoietin as a key initiator of allergic airway inflammation in mice
Zhou, B. H., Comeau, M. R., De Smedt, T., Liggitt, H. D., Dahl, M. E., Lewis, D. B., … Ziegler, S. F. (2005). Thymic stromal lymphopoietin as a key initiator of allergic airway inflammation in mice. NATURE IMMUNOLOGY, 6(10), 1047–1053. -
Chemotactic responses of IL-4-, IL-10-, and IFN-gamma-producing CD4(+) T cells depend on tissue origin and microbial stimulus
Debes, G. F., Dahl, M. E., Mahiny, A. J., Bonhagen, K., Campbell, D. J., Siegmund, K., … Hamann, A. (2006). Chemotactic responses of IL-4-, IL-10-, and IFN-gamma-producing CD4(+) T cells depend on tissue origin and microbial stimulus. JOURNAL OF IMMUNOLOGY, 176(1), 557–566. -
Avian flu to human influenza
Lewis, D. B. (2006). Avian flu to human influenza. ANNUAL REVIEW OF MEDICINE, 57, 139–54. -
Impaired allogeneic activation and T-helper differentiation of human cord blood naive CD4 T cells
Chen, L., Cohen, A. C., & Lewis, D. B. (2006). Impaired allogeneic activation and T-helper differentiation of human cord blood naive CD4 T cells. BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION, 12(2), 160–71. -
Newborn immunology: relevance to the clinician.
Lewis, D. B., Gern, J. E., Hill, H. R., Friedlander, S. L., La Pine, T. R., Lemanske, R. F., & Stiehm, E. R. (2006). Newborn immunology: relevance to the clinician. Current Problems in Pediatric and Adolescent Health Care, 36(5), 189–204. -
Transient deficiencies of T-cell-mediated immunity in the neonate
Randolph, D. A., & Lewis, D. B. (2006). Transient deficiencies of T-cell-mediated immunity in the neonate. Presented at the Course on Infection and Immunity in Children 2005, Oxford,ENGLAND,ENGLAND,ENGLAND,ENGLAND,ENGLAND,ENGLAND: SPRINGER-VERLAG BERLIN. -
Acute rejection and cardiac allograft vascular disease is reduced by suppression of subclinical cytomegalovirus infection
Potena, L., Holweg, C. T. J., Chin, C., Luikart, H., Weisshaar, D., Narasimhan, B., … Valantine, H. A. (2006). Acute rejection and cardiac allograft vascular disease is reduced by suppression of subclinical cytomegalovirus infection. TRANSPLANTATION, 82(3), 398–405. -
Cutting edge: Decreased accumulation and regulatory function of CD4(+)CD25(high) T cells in human STAT 5b deficiency
Cohen, A. C., Nadeau, K. C., Tu, W., Hwa, V., Dionis, K., Bezrodnik, L., … Lewis, D. B. (2006). Cutting edge: Decreased accumulation and regulatory function of CD4(+)CD25(high) T cells in human STAT 5b deficiency. JOURNAL OF IMMUNOLOGY, 177(5), 2770–74. -
Cellular immune responses in children and adults receiving inactivated or live attenuated influenza vaccines
He, X.-S., Holmes, T. H., Zhang, C., Mahmood, K., Kemble, G. W., Lewis, D. B., … Arvin, A. M. (2006). Cellular immune responses in children and adults receiving inactivated or live attenuated influenza vaccines. JOURNAL OF VIROLOGY, 80(23), 11756–66. -
T-cell immunity to subclinical cytomegalovirus infection reduces cardiac allograft disease
Tu, W., Potena, L., Stepick-Biek, P., Liu, L., Dionis, K. Y., Luikart, H., … Lewis, D. B. (2006). T-cell immunity to subclinical cytomegalovirus infection reduces cardiac allograft disease. CIRCULATION, 114(15), 1608–15. -
Humoral and cellular immune responses in children given annual immunization with trivalent inactivated influenza vaccine
Zeman, A. M., Holmes, T. H., Stamatis, S., Tu, W., He, X.-S., Bouvier, N., … Dekker, C. L. (2007). Humoral and cellular immune responses in children given annual immunization with trivalent inactivated influenza vaccine. PEDIATRIC INFECTIOUS DISEASE JOURNAL, 26(2), 107–15. -
[Coronary allograft vasculopathy: pathophysiological interaction between the immune system, infections and metabolic syndrome].
Potena, L., Ferrara, R., Mocarski, E. S., Lewis, D. B., Cooke, J. P., Grigioni, F., … Branzi, A. (2007). [Coronary allograft vasculopathy: pathophysiological interaction between the immune system, infections and metabolic syndrome]. Giornale Italiano Di Cardiologia (2006), 8(2), 73–82. -
Influenza A virus elevates active cathepsin B in primary murine DC
Burster, T., Giffon, T., Dahl, M. E., Bjorck, P., Bogy, M., Weber, E., … Mellins, E. D. (2007). Influenza A virus elevates active cathepsin B in primary murine DC. INTERNATIONAL IMMUNOLOGY, 19(5), 645–55. -
T cell development in the fetus and neonate.
Wilson, C. B., Lewis, D. B., & English, B. K. (1991). T cell development in the fetus and neonate. Advances in Experimental Medicine and Biology, 310, 17–27. -
CELLULAR AND MOLECULAR MECHANISMS FOR REDUCED INTERLEUKIN-4 AND INTERFERON-GAMMA PRODUCTION BY NEONATAL T-CELLS
Lewis, D. B., Yu, C. C., Meyer, J., English, B. K., Kahn, S. J., & Wilson, C. B. (1991). CELLULAR AND MOLECULAR MECHANISMS FOR REDUCED INTERLEUKIN-4 AND INTERFERON-GAMMA PRODUCTION BY NEONATAL T-CELLS. JOURNAL OF CLINICAL INVESTIGATION, 87(1), 194–202. -
INTERLEUKIN-4 EXPRESSED INSITU SELECTIVELY ALTERS THYMOCYTE DEVELOPMENT
Lewis, D. B., Yu, C. C., Forbush, K. A., Carpenter, J., Sato, T. A., Grossman, A., … Perlmutter, R. M. (1991). INTERLEUKIN-4 EXPRESSED INSITU SELECTIVELY ALTERS THYMOCYTE DEVELOPMENT. JOURNAL OF EXPERIMENTAL MEDICINE, 173(1), 89–100. -
A novel mutation associated with autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy
Bhui, R. D., Lewis, D. B., & Nadeau, K. C. (2008). A novel mutation associated with autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy. ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY, 100(2), 169–169. -
Asymmetric dimethylarginine and cardiac allograft vasculopathy progression: Modulation by sirolimus
Potena, L., Fearon, W. F., Sydow, K., Holweg, C., Luikart, H., Chin, C., … Cooke, J. P. (2008). Asymmetric dimethylarginine and cardiac allograft vasculopathy progression: Modulation by sirolimus. TRANSPLANTATION, 85(6), 827–33. -
Maternal T-cell engraftment associated with severe hemophagocytosis of the bone marrow in untreated X-linked severe combined immunodeficiency
Dvorak, C. C., Sandford, A., Fong, A., Cowan, M. J., George, T. L., & Lewis, D. B. (2008). Maternal T-cell engraftment associated with severe hemophagocytosis of the bone marrow in untreated X-linked severe combined immunodeficiency. JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY, 30(5), 396–400. -
Efficient generation of human alloantigen-specific CD4(+) regulatory T cells from naive precursors by CD40-activated B cells
Tu, W., Lau, Y.-L., Zheng, J., Liu, Y., Chan, P.-L., Mao, H., … Lewis, D. B. (2008). Efficient generation of human alloantigen-specific CD4(+) regulatory T cells from naive precursors by CD40-activated B cells. BLOOD, 112(6), 2554–2562. -
Focus on FOCIS: The continuing diagnostic challenge of autosomal recessive chronic granulomatous disease
Yu, G., Hong, D. K., Dionis, K. Y., Rae, J., Heyworth, P. G., Curnutte, J. T., & Lewis, D. B. (2008). Focus on FOCIS: The continuing diagnostic challenge of autosomal recessive chronic granulomatous disease. CLINICAL IMMUNOLOGY, 128(2), 117–26. -
Human CD4(+) T cell recent thymic emigrants are identified by protein tyrosine kinase 7 and have reduced immune function
Haines, C. J., Giffon, T. D., Lu, L.-S., Lu, X., Tessier-Lavigne, M., Ross, D. T., & Lewis, D. B. (2009). Human CD4(+) T cell recent thymic emigrants are identified by protein tyrosine kinase 7 and have reduced immune function. JOURNAL OF EXPERIMENTAL MEDICINE, 206(2), 275–85. -
Cationic lipid/DNA complexes (JVRS-100) combined with influenza vaccine (Fluzone (R)) increases antibody response, cellular immunity, and antigenically drifted protection
Lay, M., Callejo, B., Chang, S., Hong, D. K., Lewis, D. B., Carroll, T. D., … Fairman, J. (2009). Cationic lipid/DNA complexes (JVRS-100) combined with influenza vaccine (Fluzone (R)) increases antibody response, cellular immunity, and antigenically drifted protection. VACCINE, 27(29), 3811–20. -
Efficient Induction and Expansion of Human Alloantigen-Specific CD8 Regulatory T Cells from Naive Precursors by CD40-Activated B Cells
Zheng, J., Liu, Y., Qin, G., Chan, P.-L., Mao, H., Lam, K.-T., … Tu, W. (2009). Efficient Induction and Expansion of Human Alloantigen-Specific CD8 Regulatory T Cells from Naive Precursors by CD40-Activated B Cells. JOURNAL OF IMMUNOLOGY, 183(6), 3742–3750. -
A new genetic subgroup of chronic granulomatous disease with autosomal recessive mutations in p40(phox) and selective defects in neutrophil NADPH oxidase activity
Matute, J. D., Arias, A. A., Wright, N. A. M., Wrobel, I., Waterhouse, C. C. M., Li, X. J., … Dinauer, M. C. (2009). A new genetic subgroup of chronic granulomatous disease with autosomal recessive mutations in p40(phox) and selective defects in neutrophil NADPH oxidase activity. BLOOD, 114(15), 3309–3315. -
DEVELOPMENTAL REGULATION OF LCK GENE-EXPRESSION IN LYMPHOCYTES-T
Wildin, R. S., Garvin, A. M., Pawar, S., Lewis, D. B., Abraham, K. M., Forbush, K. A., … Perlmutter, R. M. (1991). DEVELOPMENTAL REGULATION OF LCK GENE-EXPRESSION IN LYMPHOCYTES-T. JOURNAL OF EXPERIMENTAL MEDICINE, 173(2), 383–393. -
Adult-onset presentations of genetic immunodeficiencies: genes can throw slow curves
Nelson, K. S., & Lewis, D. B. (2010). Adult-onset presentations of genetic immunodeficiencies: genes can throw slow curves. CURRENT OPINION IN INFECTIOUS DISEASES, 23(4), 359–64. -
Alternate Mechanisms of Initial Pattern Recognition Drive Differential Immune Responses to Related Poxviruses
O'Gorman, W. E., Sampath, P., Simonds, E. F., Sikorski, R., O'Malley, M., Krutzik, P. O., … Nolan, G. P. (2010). Alternate Mechanisms of Initial Pattern Recognition Drive Differential Immune Responses to Related Poxviruses. CELL HOST & MICROBE, 8(2), 174–85. -
CROSS-REACTIVE NEUTRALIZING ANTIBODY AGAINST PANDEMIC 2009 H1N1 INFLUENZA A VIRUS IN INTRAVENOUS IMMUNOGLOBULIN PREPARATIONS
Hong, D. K., Tremoulet, A. H., Burns, J. C., & Lewis, D. B. (2011). CROSS-REACTIVE NEUTRALIZING ANTIBODY AGAINST PANDEMIC 2009 H1N1 INFLUENZA A VIRUS IN INTRAVENOUS IMMUNOGLOBULIN PREPARATIONS. PEDIATRIC INFECTIOUS DISEASE JOURNAL, 30(1), 67–69. -
Cationic Lipid/DNA Complex-Adjuvanted Influenza A Virus Vaccination Induces Robust Cross-Protective Immunity
Hong, D. K., Chang, S., Botham, C. M., Giffon, T. D., Fairman, J., & Lewis, D. B. (2010). Cationic Lipid/DNA Complex-Adjuvanted Influenza A Virus Vaccination Induces Robust Cross-Protective Immunity. JOURNAL OF VIROLOGY, 84(24), 12691–702. -
Revisiting Human IL-12R beta 1 Deficiency A Survey of 141 Patients From 30 Countries
de Beaucoudrey, L., Samarina, A., Bustamante, J., Cobat, A., Boisson-Dupuis, S., Feinberg, J., … Casanova, J.-L. (2010). Revisiting Human IL-12R beta 1 Deficiency A Survey of 141 Patients From 30 Countries. MEDICINE, 89(6), 381–402. -
REGULATION OF IMMUNOGLOBULIN (IG)E SYNTHESIS IN THE HYPER-IGE SYNDROME
Vercelli, D., Jabara, H. H., CUNNINGHAMRUNDLES, C., Abrams, J. S., Lewis, D. B., Meyer, J., … Geha, R. S. (1990). REGULATION OF IMMUNOGLOBULIN (IG)E SYNTHESIS IN THE HYPER-IGE SYNDROME. JOURNAL OF CLINICAL INVESTIGATION, 85(5), 1666–1671. -
BASIS AND IMPLICATIONS OF SELECTIVELY DIMINISHED CYTOKINE PRODUCTION IN NEONATAL SUSCEPTIBILITY TO INFECTION
Wilson, C. B., & Lewis, D. B. (1990). BASIS AND IMPLICATIONS OF SELECTIVELY DIMINISHED CYTOKINE PRODUCTION IN NEONATAL SUSCEPTIBILITY TO INFECTION. Presented at the SYMP ON NEONATAL SEPSIS AND THE ROLE OF IMMUNOTHERAPY, HURON,OH: UNIV CHICAGO PRESS. -
GAMMA-INTERFERON - AN IMMUNOREGULATORY LYMPHOKINE WITH IMMUNOTHERAPEUTIC POTENTIAL
Lewis, D. B., & Wilson, C. B. (1990). GAMMA-INTERFERON - AN IMMUNOREGULATORY LYMPHOKINE WITH IMMUNOTHERAPEUTIC POTENTIAL. PEDIATRIC INFECTIOUS DISEASE JOURNAL, 9(9), 642–651. -
Protein tyrosine kinase 7: a novel surface marker for human recent thymic emigrants with potential clinical utility
Lewis, D. B., Haines, C., & Ross, D. (2011). Protein tyrosine kinase 7: a novel surface marker for human recent thymic emigrants with potential clinical utility. JOURNAL OF PERINATOLOGY, 31, S72–S81. -
Genotype, phenotype, and outcomes of nine patients with T-B plus NK plus SCID
Yu, G. P., Nadeau, K. C., Berk, D. R., de Saint Basile, G., Lambert, N., Knapnougel, P., … Cowan, M. J. (2011). Genotype, phenotype, and outcomes of nine patients with T-B plus NK plus SCID. PEDIATRIC TRANSPLANTATION, 15(7), 733–41. -
Human Neonatal Naive CD4(+) T Cells Have Enhanced Activation-Dependent Signaling Regulated by the MicroRNA miR-181a
Palin, A. C., Ramachandran, V., Acharya, S., & Lewis, D. B. (2013). Human Neonatal Naive CD4(+) T Cells Have Enhanced Activation-Dependent Signaling Regulated by the MicroRNA miR-181a. JOURNAL OF IMMUNOLOGY, 190(6), 2682–91. -
LYMPHOCYTE-ACTIVATION PROVOKES MODIFICATION OF A LYMPHOCYTE-SPECIFIC PROTEIN TYROSINE KINASE (P56LCK)
Marth, J. D., Lewis, D. B., Cooke, M. P., Mellins, E. D., GEARN, M. E., Samelson, L. E., … Perlmutter, R. M. (1989). LYMPHOCYTE-ACTIVATION PROVOKES MODIFICATION OF A LYMPHOCYTE-SPECIFIC PROTEIN TYROSINE KINASE (P56LCK). JOURNAL OF IMMUNOLOGY, 142(7), 2430–2437. -
DECREASED PRODUCTION OF INTERFERON-GAMMA BY HUMAN NEONATAL CELLS - INTRINSIC AND REGULATORY DEFICIENCIES
Wilson, C. B., Westall, J., Johnston, L., Lewis, D. B., Dower, S. K., & ALPERT, A. R. (1986). DECREASED PRODUCTION OF INTERFERON-GAMMA BY HUMAN NEONATAL CELLS - INTRINSIC AND REGULATORY DEFICIENCIES. JOURNAL OF CLINICAL INVESTIGATION, 77(3), 860–867. -
REDUCED INTERFERON-GAMMA MESSENGER-RNA LEVELS IN HUMAN NEONATES - EVIDENCE FOR AN INTRINSIC T-CELL DEFICIENCY INDEPENDENT OF OTHER GENES INVOLVED IN T-CELL ACTIVATION
Lewis, D. B., Larsen, A., & Wilson, C. B. (1986). REDUCED INTERFERON-GAMMA MESSENGER-RNA LEVELS IN HUMAN NEONATES - EVIDENCE FOR AN INTRINSIC T-CELL DEFICIENCY INDEPENDENT OF OTHER GENES INVOLVED IN T-CELL ACTIVATION. JOURNAL OF EXPERIMENTAL MEDICINE, 163(4), 1018–1023. -
REGULATION OF PP56LCK DURING T-CELL ACTIVATION - FUNCTIONAL IMPLICATIONS FOR THE SRC-LIKE PROTEIN TYROSINE KINASES
Marth, J. D., Lewis, D. B., Wilson, C. B., GEARN, M. E., Krebs, E. G., & Perlmutter, R. M. (1987). REGULATION OF PP56LCK DURING T-CELL ACTIVATION - FUNCTIONAL IMPLICATIONS FOR THE SRC-LIKE PROTEIN TYROSINE KINASES. EMBO JOURNAL, 6(9), 2727–2734. -
RESTRICTED PRODUCTION OF INTERLEUKIN-4 BY ACTIVATED HUMAN T-CELLS
Lewis, D. B., Prickett, K. S., Larsen, A., Grabstein, K., Weaver, M., & Wilson, C. B. (1988). RESTRICTED PRODUCTION OF INTERLEUKIN-4 BY ACTIVATED HUMAN T-CELLS. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 85(24), 9743–9747. -
STRUCTURE AND EXPRESSION OF ICK - TRANSCRIPTS IN HUMAN LYMPHOID-CELLS
Perlmutter, R. M., Marth, J. D., Lewis, D. B., Peet, R., Ziegler, S. F., & Wilson, C. B. (1988). STRUCTURE AND EXPRESSION OF ICK - TRANSCRIPTS IN HUMAN LYMPHOID-CELLS. JOURNAL OF CELLULAR BIOCHEMISTRY, 38(2), 117–126. -
NOVEL PROTEIN-TYROSINE KINASE GENE (HCK) PREFERENTIALLY EXPRESSED IN CELLS OF HEMATOPOIETIC ORIGIN
Ziegler, S. F., Marth, J. D., Lewis, D. B., & Perlmutter, R. M. (1987). NOVEL PROTEIN-TYROSINE KINASE GENE (HCK) PREFERENTIALLY EXPRESSED IN CELLS OF HEMATOPOIETIC ORIGIN. MOLECULAR AND CELLULAR BIOLOGY, 7(6), 2276–2285. -
DIMINISHED EXPRESSION OF CD40 LIGAND BY ACTIVATED NEONATAL T-CELLS
Nonoyama, S., Penix, L. A., Edwards, C. P., Lewis, D. B., Ito, S., Aruffo, A., … Ochs, H. D. (1995). DIMINISHED EXPRESSION OF CD40 LIGAND BY ACTIVATED NEONATAL T-CELLS. JOURNAL OF CLINICAL INVESTIGATION, 95(1), 66–75. -
HYPOMETHYLATION OF THE INTERFERON-GAMMA GENE CORRELATES WITH ITS EXPRESSION BY PRIMARY T-LINEAGE CELLS
Melvin, A. J., MCGURN, M. E., Bort, S. J., Gibson, C., & Lewis, D. B. (1995). HYPOMETHYLATION OF THE INTERFERON-GAMMA GENE CORRELATES WITH ITS EXPRESSION BY PRIMARY T-LINEAGE CELLS. EUROPEAN JOURNAL OF IMMUNOLOGY, 25(2), 426–430. -
OSTEOPOROSIS INDUCED IN MICE BY OVERPRODUCTION OF INTERLEUKIN-4
Lewis, D. B., Liggitt, H. D., Effmann, E. L., Motley, S. T., Teitelbaum, S. L., Jepsen, K. J., … Perlmutter, R. M. (1993). OSTEOPOROSIS INDUCED IN MICE BY OVERPRODUCTION OF INTERLEUKIN-4. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 90(24), 11618–11622. -
LYMPHOKINE REGULATION AND THE ROLE OF ABNORMAL REGULATION IN IMMUNODEFICIENCY
Wilson, C. B., Penix, L., Melvin, A., & Lewis, D. B. (1993). LYMPHOKINE REGULATION AND THE ROLE OF ABNORMAL REGULATION IN IMMUNODEFICIENCY. CLINICAL IMMUNOLOGY AND IMMUNOPATHOLOGY, 67(3), S25–S32. -
THE HUMAN GP39 PROMOTER - 2 DISTINCT NUCLEAR FACTORS OF ACTIVATED T-CELL PROTEIN-BINDING ELEMENTS CONTRIBUTE INDEPENDENTLY TO TRANSCRIPTIONAL ACTIVATION
Schubert, L. A., King, G., Cron, R. Q., Lewis, D. B., Aruffo, A., & Hollenbaugh, D. (1995). THE HUMAN GP39 PROMOTER - 2 DISTINCT NUCLEAR FACTORS OF ACTIVATED T-CELL PROTEIN-BINDING ELEMENTS CONTRIBUTE INDEPENDENTLY TO TRANSCRIPTIONAL ACTIVATION. JOURNAL OF BIOLOGICAL CHEMISTRY, 270(50), 29624–29627. -
Coexpression of the interleukin-13 and interleukin-4 genes correlates with their physical linkage in the cytokine gene cluster on human chromosome 5q23-31
Dolganov, G., Bort, S., LOVETT, M., Burr, J., Schubert, L., Short, D., … Lewis, D. B. (1996). Coexpression of the interleukin-13 and interleukin-4 genes correlates with their physical linkage in the cytokine gene cluster on human chromosome 5q23-31. BLOOD, 87(8), 3316–3326. -
The importance of leukotrienes in airway inflammation in a mouse model of asthma
Henderson, W. R., Lewis, D. B., Albert, R. K., Zhang, Y., Lamm, W. J. E., Chiang, G. K. S., … Chi, E. Y. (1996). The importance of leukotrienes in airway inflammation in a mouse model of asthma. JOURNAL OF EXPERIMENTAL MEDICINE, 184(4), 1483–1494. -
beta 2-microglobulin-dependent T cells are dispensable for allergen-induced T helper 2 responses
Zhang, Y., Rogers, K. H., & Lewis, D. B. (1996). beta 2-microglobulin-dependent T cells are dispensable for allergen-induced T helper 2 responses. JOURNAL OF EXPERIMENTAL MEDICINE, 184(4), 1507–1512. -
Influence of the route of allergen administration and genetic background on the murine allergic pulmonary response
Zhang, Y., Lamm, W. J. E., Albert, R. K., Chi, E. Y., Henderson, W. R., & Lewis, D. B. (1997). Influence of the route of allergen administration and genetic background on the murine allergic pulmonary response. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 155(2), 661–669. -
Consistent transient transfection of DNA into non-transformed human and murine T-lymphocytes
Cron, R. Q., Schubert, L. A., Lewis, D. B., & HUGHES, C. C. W. (1997). Consistent transient transfection of DNA into non-transformed human and murine T-lymphocytes. JOURNAL OF IMMUNOLOGICAL METHODS, 205(2), 145–150. -
T cell priming enhances IL-4 gene expression by increasing nuclear factor of activated T cells
Cron, R. Q., Bort, S. J., Wang, Y. X., Brunvand, M. W., & Lewis, D. B. (1999). T cell priming enhances IL-4 gene expression by increasing nuclear factor of activated T cells. JOURNAL OF IMMUNOLOGY, 162(2), 860–870. -
Reduced elastogenesis: a clue to the arteriosclerosis and emphysematous changes in Schimke immuno-osseous dysplasia?
Morimoto, M., Yu, Z., Stenzel, P., Clewing, J. M., Najafian, B., Mayfield, C., … Boerkoel, C. F. (2012). Reduced elastogenesis: a clue to the arteriosclerosis and emphysematous changes in Schimke immuno-osseous dysplasia? ORPHANET JOURNAL OF RARE DISEASES, 7. -
ICOS-ICOSL regulates the generation and function of CD4(+) Treg in a CTLA-4 dependent manner
Zheng, J., Chan, P. L., Liu, Y., Qin, G., Xiang, Z., Lam, K. T., … Tu, W. (2012). ICOS-ICOSL regulates the generation and function of CD4(+) Treg in a CTLA-4 dependent manner. Presented at the European Congress of Immunology, GLASGOW,SCOTLAND: WILEY-BLACKWELL. -
Generation of human Th1-like regulatory CD4(+) T cells by an intrinsic IFN-gamma- and T-bet-dependent pathway
Zheng, J., Liu, Y., Qin, G., Lam, K.-T., Guan, J., Xiang, Z., … Tu, W. (2011). Generation of human Th1-like regulatory CD4(+) T cells by an intrinsic IFN-gamma- and T-bet-dependent pathway. EUROPEAN JOURNAL OF IMMUNOLOGY, 41(1), 128–139. -
Human CD8(+) Regulatory T Cells Inhibit GVHD and Preserve General Immunity in Humanized Mice
Zheng, J., Liu, Y., Liu, Y., Liu, M., Xiang, Z., Lam, K.-T., … Tu, W. (2013). Human CD8(+) Regulatory T Cells Inhibit GVHD and Preserve General Immunity in Humanized Mice. SCIENCE TRANSLATIONAL MEDICINE, 5(168). -
Mechanisms for decreased CD40-ligand (CD154) expression by human neonatal CD4 T cells
JULLIEN, P., Cron, R. Q., Dabbagh, K., Tran, P., Brown, R., Stepick-Biek, P., & Lewis, D. B. (2000). Mechanisms for decreased CD40-ligand (CD154) expression by human neonatal CD4 T cells. FASEB JOURNAL, 14(6), A929–A929. -
Deficient cytomegalovirus-specific Th1 responses in young children with urine virus shedding
Tu, W. W., Chen, S. R., Sharp, M., Dekker, C., Manganello, A. M., Maecker, H., … Lewis, D. B. (2003). Deficient cytomegalovirus-specific Th1 responses in young children with urine virus shedding. FASEB JOURNAL, 17(7), C301–C301. -
Diminished expression of CD40 ligand may contribute to the defective humoral immunity in patients with MHC class II deficiency
Nonoyama, S., Etzioni, A., Toru, H., Ruggerie, D. P., Lewis, D., Pollack, S., … Ochs, H. D. (1998). Diminished expression of CD40 ligand may contribute to the defective humoral immunity in patients with MHC class II deficiency. EUROPEAN JOURNAL OF IMMUNOLOGY, 28(2), 589–598. -
DIFFERENTIATION OF THE T-HELPER PHENOTYPES BY ANALYSIS OF THE METHYLATION STATE OF THE IFN-GAMMA GENE
Young, H. A., Ghosh, P., Ye, J. P., Lederer, J., Lichtman, A., GERARD, J. R., … Taub, D. D. (1994). DIFFERENTIATION OF THE T-HELPER PHENOTYPES BY ANALYSIS OF THE METHYLATION STATE OF THE IFN-GAMMA GENE. JOURNAL OF IMMUNOLOGY, 153(8), 3603–3610. -
Retinoic Acid Hypersensitivity Promotes Peripheral Tolerance in Recent Thymic Emigrants
Bhaumik, S., Giffon, T., Bolinger, D., Kirkman, R., Lewis, D. B., Weaver, C. T., & Randolph, D. A. (2013). Retinoic Acid Hypersensitivity Promotes Peripheral Tolerance in Recent Thymic Emigrants. JOURNAL OF IMMUNOLOGY, 190(6), 2603–2613. -
Systemic inflammation links impaired glucose metabolism to cardiac allograft vasculopathy development
Potena, L., Biadi, O., Fearon, W. B., Holweg, C. T., Luikart, H. I., Mocarski, E. S., … Valantine, H. A. (2004). Systemic inflammation links impaired glucose metabolism to cardiac allograft vasculopathy development. CIRCULATION. NEW ORLEANS,LA,LA,LA,LA,LA: LIPPINCOTT WILLIAMS & WILKINS. -
Cytomegalovirus infectious burden is proportional to cardiac allograft vasculopathy in heart transplant recipients
Potena, L., Magelli, C., Ortolani, P., Fearon, W. F., Grigioni, F., Magnani, G., … Valantine, H. A. (2004). Cytomegalovirus infectious burden is proportional to cardiac allograft vasculopathy in heart transplant recipients. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY. NEW ORLEANS,LA,LA,LA,LA,LA,LA,LA: ELSEVIER SCIENCE INC. -
Prevention of subclinical CMV infection reduces cardiac allograft disease progression by positively affecting coronary remodeling
Potena, L., Fearon, W., Holweg, C., Luikart, H., Chin, C., Cooke, J., … Valantine, H. (2006). Prevention of subclinical CMV infection reduces cardiac allograft disease progression by positively affecting coronary remodeling. JOURNAL OF HEART AND LUNG TRANSPLANTATION, 25(2), S138–S139. -
Asymptomatic cytomegalovirus activation leads to acute rejection in heart transplant recipients despite anti-viral prophylaxis.
Potena, L., Holweg, C., Luikart, H. I., Mocarski, E. S., Cooke, J. P., Lewis, D. B., & Valantine, H. A. (2004). Asymptomatic cytomegalovirus activation leads to acute rejection in heart transplant recipients despite anti-viral prophylaxis. Presented at the 5th American Transplant Congress, BOSTON,MA,MA,MA: WILEY-BLACKWELL. -
A novel missense mutation in CYBB gene in chronic granulomatous disease
DeMore, J. P., Dong, Y., Lewis, D. B., Gern, J. E., & Seroogy, C. M. (2007). A novel missense mutation in CYBB gene in chronic granulomatous disease. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 119(1), S257–S257. -
Toxicopathology of the Developing Immune System: Investigative and Development Strategies
Weinstock, D., Lewis, D. B., Parker, G. A., Beyer, J., Collinge, M., Brown, T. P., & Dybdal, N. (2010). Toxicopathology of the Developing Immune System: Investigative and Development Strategies. TOXICOLOGIC PATHOLOGY, 38(7), 1111–17. -
Newborn screening for severe combined immunodeficiency and T-cell lymphopenia in California: Results of the first 2 years
Kwan, A., Church, J. A., Cowan, M. J., Agarwal, R., Kapoor, N., Kohn, D. B., … Puck, J. M. (2013). Newborn screening for severe combined immunodeficiency and T-cell lymphopenia in California: Results of the first 2 years. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 132(1), 140–U245. -
Defective sphingosine 1-phosphate receptor 1 (S1P1) phosphorylation exacerbates TH17-mediated autoimmune neuroinflammation.
Garris, C. S., Wu, L., Acharya, S., Arac, A., Blaho, V. A., Huang, Y. X., … Han, M. H. (2013). Defective sphingosine 1-phosphate receptor 1 (S1P1) phosphorylation exacerbates TH17-mediated autoimmune neuroinflammation. Nature Immunology, 14(11), 1166–72. -
ICOS Regulates the Generation and Function of Human CD4(+) Treg in a CTLA-4 Dependent Manner
Zheng, J., Chan, P.-L., Liu, Y., Qin, G., Xiang, Z., Lam, K.-T., … Tu, W. (2013). ICOS Regulates the Generation and Function of Human CD4(+) Treg in a CTLA-4 Dependent Manner. PLOS ONE, 8(12). -
Somatic reversion in dedicator of cytokinesis 8 immunodeficiency modulates disease phenotype.
Jing, H., Zhang, Q., Zhang, Y., Hill, B. J., Dove, C. G., Gelfand, E. W., … Su, H. C. (2014). Somatic reversion in dedicator of cytokinesis 8 immunodeficiency modulates disease phenotype. Journal of Allergy and Clinical Immunology, 133(6), 1667–75. -
Defective sphingosine 1-phosphate receptor 1 (S1P1) phosphorylation exacerbates TH17-mediated autoimmune neuroinflammation.
Garris, C. S., Wu, L., Acharya, S., Arac, A., Blaho, V. A., Huang, Y. X., … Han, M. H. (2013). Defective sphingosine 1-phosphate receptor 1 (S1P1) phosphorylation exacerbates TH17-mediated autoimmune neuroinflammation. Nature Immunology, 14(11), 1166–1172. -
Bayesian immunological model development from the literature: Example investigation of recent thymic emigrants.
Holmes, T. H., & Lewis, D. B. (2014). Bayesian immunological model development from the literature: Example investigation of recent thymic emigrants. Journal of Immunological Methods, 414, 32–50. -
Dental Abnormalities in Schimke Immuno-osseous Dysplasia
Morimoto, M., Kerouredan, O., Gendronneau, M., Shuen, C., Baradaran-Heravi, A., Asakura, Y., … Boerkoel, C. F. (2012). Dental Abnormalities in Schimke Immuno-osseous Dysplasia. JOURNAL OF DENTAL RESEARCH, 91(7), S29–S37. -
Heme oxygenase and the immune system in normal and pathological pregnancies.
Ozen, M., Zhao, H., Lewis, D. B., Wong, R. J., & Stevenson, D. K. (2015). Heme oxygenase and the immune system in normal and pathological pregnancies. Frontiers in Pharmacology, 6, 84-? -
Single-cell systems-level analysis of human Toll-like receptor activation defines a chemokine signature in patients with systemic lupus erythematosus
O'Gorman, W. E., Hsieh, E. W. Y., Savig, E. S., Gherardini, P. F., Hernandez, J. D., Hansmann, L., … Davis, M. M. (2015). Single-cell systems-level analysis of human Toll-like receptor activation defines a chemokine signature in patients with systemic lupus erythematosus. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 136(5), 1326–36. -
Implementing Mass Cytometry at the Bedside to Study the Immunological Basis of Human Diseases: Distinctive Immune Features in Patients with a History of Term or Preterm Birth
Gaudilliere, B., Ganio, E. A., Tingle, M., Lancero, H. L., Fragiadakis, G. K., Baca, Q. J., … Angst, M. S. (2015). Implementing Mass Cytometry at the Bedside to Study the Immunological Basis of Human Diseases: Distinctive Immune Features in Patients with a History of Term or Preterm Birth. CYTOMETRY PART A, 87A(9), 817–29. -
Heightened risk of preterm birth and growth restriction after a first-born son
Bruckner, T. A., Mayo, J. A., Gould, J. B., Stevenson, D. K., Lewis, D. B., Shaw, G. M., & Carmichael, S. L. (2015). Heightened risk of preterm birth and growth restriction after a first-born son. ANNALS OF EPIDEMIOLOGY, 25(10), 743–47. -
Lack of IL7Ra expression in T cells is a hallmark of T-cell immunodeficiency in Schimke immuno-osseous dysplasia (SIOD).
Sanyal, M., Morimoto, M., Baradaran-Heravi, A., Choi, K., Kambham, N., Jensen, K., … Boerkoel, C. F. (2015). Lack of IL7Ra expression in T cells is a hallmark of T-cell immunodeficiency in Schimke immuno-osseous dysplasia (SIOD). Clinical Immunology , 161(2), 355–65. -
Dental abnormalities in Schimke immuno-osseous dysplasia.
Morimoto, M., Kérourédan, O., Gendronneau, M., Shuen, C., Baradaran-Heravi, A., Asakura, Y., … Boerkoel, C. F. (2012). Dental abnormalities in Schimke immuno-osseous dysplasia. Journal of Dental Research, 91(7), 29S–37S. -
A cationic liposome-DNA complexes adjuvant (JVRS-100) enhances the immunogenicity and cross-protective efficacy of pre-pandemic influenza A (H5N1) vaccine in ferrets
Liu, F., Sun, X., Fairman, J., Lewis, D. B., Katz, J. M., Levine, M., … Lu, X. (2016). A cationic liposome-DNA complexes adjuvant (JVRS-100) enhances the immunogenicity and cross-protective efficacy of pre-pandemic influenza A (H5N1) vaccine in ferrets. VIROLOGY, 492, 197–203. -
Treatment of CGD-associated Colitis with the IL-23 Blocker Ustekinumab.
Butte, M. J., Park, K. T., & Lewis, D. B. (2016). Treatment of CGD-associated Colitis with the IL-23 Blocker Ustekinumab. Journal of Clinical Immunology, 36(7), 619–20. -
Mapping the Fetomaternal Peripheral Immune System at Term Pregnancy.
Fragiadakis, G. K., Baca, Q. J., Gherardini, P. F., Ganio, E. A., Gaudilliere, D. K., Tingle, M., … Gaudilliere, B. L. (2016). Mapping the Fetomaternal Peripheral Immune System at Term Pregnancy. Journal of Immunology . -
Longitudinal Kinetics of Cytomegalovirus-Specific T-Cell Immunity and Viral Replication in Infants With Congenital Cytomegalovirus Infection.
Chen, S. F., Holmes, T. H., Slifer, T., Ramachandran, V., Mackey, S., Hebson, C., … Dekker, C. L. (2016). Longitudinal Kinetics of Cytomegalovirus-Specific T-Cell Immunity and Viral Replication in Infants With Congenital Cytomegalovirus Infection. Journal of the Pediatric Infectious Diseases Society, 5(1), 14–20. -
Angiotensin-Converting Enzyme Inhibition Early After Heart Transplantation.
Fearon, W. F., Okada, K., Kobashigawa, J. A., Kobayashi, Y., Luikart, H., Sana, S., … Khush, K. (2017). Angiotensin-Converting Enzyme Inhibition Early After Heart Transplantation. Journal of the American College of Cardiology, 69(23), 2832–41. -
A Case Report of Hypoglycemia and Hypogammaglobulinemia: DAVID syndrome in a patient with a novel NFKB2 mutation.
Lal, R. A., Bachrach, L. K., Hoffman, A. R., Inlora, J., Rego, S., Snyder, M. P., & Lewis, D. B. (2017). A Case Report of Hypoglycemia and Hypogammaglobulinemia: DAVID syndrome in a patient with a novel NFKB2 mutation. Journal of Clinical Endocrinology and Metabolism. -
An immune clock of human pregnancy.
Aghaeepour, N., Ganio, E. A., Mcilwain, D., Tsai, A. S., Tingle, M., Van Gassen, S., … Gaudilliere, B. (2017). An immune clock of human pregnancy. Science Immunology, 2(15). -
Different patterns of migration and expansion of blood and marrow CD4 T cells in lymphoid and non-lymphoid tissues result in a different capacity to induce graft-vs-host disease
Zeng, D. F., Liu, Y. P., Dutt, S., Li, Z. Q., Higgins, J., Lewis, D. B., & Strober, S. (2003). Different patterns of migration and expansion of blood and marrow CD4 T cells in lymphoid and non-lymphoid tissues result in a different capacity to induce graft-vs-host disease. FASEB JOURNAL, 17(7), C59. -
Somatic Reversion in Dock8 Immunodeficiency Modulates Disease Phenotype
Jing, H., Zhang, Q., Zhang, Y., Hill, B. J., Dove, C., Gelfand, E. W., … Su, H. (2014). Somatic Reversion in Dock8 Immunodeficiency Modulates Disease Phenotype. JOURNAL OF CLINICAL IMMUNOLOGY, 34(3), 361. -
Immunodeficiency associated with a STAT-5b mutation and growth hormone insensitivity.
Cleary, A. M., Hwa, Tu, W. W., Dionis, K., Bezrodnik, L., Teper, A., … Lewis, D. B. (2004). Immunodeficiency associated with a STAT-5b mutation and growth hormone insensitivity. BLOOD, 104(11), 374A. -
Lack of NFAT1 correlates with decreased cytokine production by neonatal T cells.
Cron, R. Q., Bort, S. J., & Lewis, D. B. (1999). Lack of NFAT1 correlates with decreased cytokine production by neonatal T cells. FASEB JOURNAL, 13(4), A617. -
Decreased generation and function of CD4+CD25(hi) T regulatory cells in human STAT5b deficiency.
Cleary, A., Nadeau, K., Tu, W. W., Hwa, Dionis, K. Y., Bezrodnik, L., … Lewis, D. B. (2005). Decreased generation and function of CD4+CD25(hi) T regulatory cells in human STAT5b deficiency. BLOOD, 106(11), 227A. -
EXPRESSION PATTERNS OF HEME OXYGENASE-1 IN IMMUNE CELLS DURING LATE GESTATIONAL INFLAMMATION
Ozen, M., Zhao, H., Kalish, F., Yang, Y., Lewis, D. B., Wong, R. J., & Stevenson, D. K. (2016). EXPRESSION PATTERNS OF HEME OXYGENASE-1 IN IMMUNE CELLS DURING LATE GESTATIONAL INFLAMMATION. JOURNAL OF INVESTIGATIVE MEDICINE, 64(1), 281. -
Acute Subclinical Maternal Inflammation in Late Pregnancy
Ozen, M., Zhao, H., Winn, V. D., Lewis, D. B., Kalish, F., Palmer, T. D., … Stevenson, D. K. (2015). Acute Subclinical Maternal Inflammation in Late Pregnancy. REPRODUCTIVE SCIENCES. SAGE PUBLICATIONS INC. -
Genetic analyses and outcomes of hematopoietic cell transplantation in 10 patients with T-B plus NK plus SCID
Grace, P., Nadeau, K., Berk, D., de Saint Basile, G., Lambert, N., Knapnougel, P., … Cowan, M. (2010). Genetic analyses and outcomes of hematopoietic cell transplantation in 10 patients with T-B plus NK plus SCID. ALLERGY, 65, 478–79. -
Immunotherapy of Acute Leukemia with Cationic Lipid DNA Complexes (JVRS-100)
Chang, S., Herse, Z., Claxton, D., Giffon, T., Lewis, D., & Fairman, J. (2008). Immunotherapy of Acute Leukemia with Cationic Lipid DNA Complexes (JVRS-100). FASEB JOURNAL, 22. -
Cytomegalovirus-specific CD4 T-cell immunity is associated with protection from human cardiac allograft rejection and negative coronary-artery remodeling.
Tu, W., Potena, L., Stepick-Biek, P., Liu, L., Dionis, K. Y., Bashyam, L., … Lewis, D. B. (2005). Cytomegalovirus-specific CD4 T-cell immunity is associated with protection from human cardiac allograft rejection and negative coronary-artery remodeling. CLINICAL IMMUNOLOGY, 115, S277. -
IL-12 receptor beta 1 deficiency: Insights into memory CD4 T cell generation/maintenance and receptor expression.
Cleary, A. M., Tu, W. W., de Waal Malefyt, R., & Lewis, D. B. (2002). IL-12 receptor beta 1 deficiency: Insights into memory CD4 T cell generation/maintenance and receptor expression. BLOOD, 100(11), 188A–189A. -
Abstract Submission
Acharya, S., Petersen, K. Y. D., Golubkov, V., Kwong, M., Adams, C. M., Jackson, P. K., & Lewis, D. B. (2015). Abstract Submission. CANCER RESEARCH, 75. -
Decreased generation and function of CD4+CD25(hi) T regulatory cells in human STAT5b deficiency.
Cohen, A., Nadeau, K., Tu, W., Hwa, V., Dionis, K., Bezrodnik, L., … Lewis, D. (2006). Decreased generation and function of CD4+CD25(hi) T regulatory cells in human STAT5b deficiency. CLINICAL IMMUNOLOGY, 119, S135. -
Defective sphingosine-1-phosphate receptor 1 (S1PR(1)) internalization exacerbates autoimmune neuroinflammation by enhancing Stat3-mediated Th17 polarization
Garris, C. S., Acharya, S., Axtell, R., Lewis, D., Sobel, R. A., Steinman, L., … Han, M. H. (2012). Defective sphingosine-1-phosphate receptor 1 (S1PR(1)) internalization exacerbates autoimmune neuroinflammation by enhancing Stat3-mediated Th17 polarization. MULTIPLE SCLEROSIS JOURNAL, 18, 510. -
CMV-Specific T-Cell Responses in Lung Transplant Patients Using a Monocyte-Derived Dendritic Cell (MDDC) Assay.
Chen, S. F., Liu, L. X., Dhillon, G., de Leon, V., Weill, D., & Lewis, D. B. (2009). CMV-Specific T-Cell Responses in Lung Transplant Patients Using a Monocyte-Derived Dendritic Cell (MDDC) Assay. AMERICAN JOURNAL OF TRANSPLANTATION, 9, 551. -
Identification of an enhancer element located downstream of the CD40-ligand gene.
Cron, R. Q., Schubert, L. A., & Lewis, D. B. (1998). Identification of an enhancer element located downstream of the CD40-ligand gene. ARTHRITIS AND RHEUMATISM, 41(9), S235. -
Novel nonsense gain-of-function NFKB2 mutations associated with a combined immunodeficiency phenotype
Kuehn, H. S., Niemela, J. E., Sreedhara, K., Stoddard, J. L., Grossman, J., Wysocki, C. A., … Rosenzweig, S. D. (2017). Novel nonsense gain-of-function NFKB2 mutations associated with a combined immunodeficiency phenotype. BLOOD, 130(13), 1553–64. -
Enhanced in vivo immunity and protection provided by cationic lipid-DNA complex adjuvanted influenza vaccination is independent of Toll-like receptor 9
Botham, C., Hong, D., Giffon, T., Draghi, M., Fairman, J., & Lewis, D. (2011). Enhanced in vivo immunity and protection provided by cationic lipid-DNA complex adjuvanted influenza vaccination is independent of Toll-like receptor 9. JOURNAL OF IMMUNOLOGY. AMER ASSOC IMMUNOLOGISTS. -
ICOS engagement of CD4 T-cells following pulmonary influenza infection: Evidence for negative regulation of T-cell effector function.
Dahl, M. E., Coyle, A., & Lewis, D. B. (2005). ICOS engagement of CD4 T-cells following pulmonary influenza infection: Evidence for negative regulation of T-cell effector function. CLINICAL IMMUNOLOGY, 115, S35. -
Role of protein tyrosine kinase seven in human recent thymic emigrant cell survival
Acharya, S., Ramachandran, V., Dionis, K., & Lewis, D. (2012). Role of protein tyrosine kinase seven in human recent thymic emigrant cell survival. JOURNAL OF IMMUNOLOGY, 188. -
Generation of conditional NFAT1 transgenic mice.
Cron, R. Q., Lee, P., & Lewis, D. B. (2000). Generation of conditional NFAT1 transgenic mice. FASEB JOURNAL, 14(6), A1082. -
Lack of IL-7 Receptor Alpha Chain (CD127) Expression In T Cells Is a Hallmark of T-Cell Immunodeficiency In Schimke Immuno-Osseous Dysplasia (SIOD)
Sanyal, M., Dionis, K. Y., Baradaran-Heravi, A., Dekel, B., Boekenkamp, A., Boerkoel, C. F., & Lewis, D. B. (2010). Lack of IL-7 Receptor Alpha Chain (CD127) Expression In T Cells Is a Hallmark of T-Cell Immunodeficiency In Schimke Immuno-Osseous Dysplasia (SIOD). BLOOD, 116(21), 1141. -
Protein tyrosine kinase 7 promotes PI3K/AKT signaling and survival in primary and neoplastic CD4+T-lineage cells.
Acharya, S., Dionis-Petersen, K., Jackson, P., Admas, C., & Lewis, D. (2014). Protein tyrosine kinase 7 promotes PI3K/AKT signaling and survival in primary and neoplastic CD4+T-lineage cells. JOURNAL OF IMMUNOLOGY, 192. -
Impaired accumulation and function of effector memory CD4T cells in human IL-12 receptor beta 1 deficiency
Cleary, A. M., Tu, W. W., Enright, A., Giffon, T., Dewaal-Malefyt, R., Gutierrez, K., & Lewis, D. B. (2002). Impaired accumulation and function of effector memory CD4T cells in human IL-12 receptor beta 1 deficiency. PEDIATRIC RESEARCH. INT PEDIATRIC RESEARCH FOUNDATION, INC. -
Neonatal naive CD4+T cells have increased calcium flux and higher expression of miR-181a relative to adult naive CD4+T cells
Paulin, A., Venkatasubrahmanyam, S., Butte, A., & Lewis, D. (2011). Neonatal naive CD4+T cells have increased calcium flux and higher expression of miR-181a relative to adult naive CD4+T cells. JOURNAL OF IMMUNOLOGY, 186. -
Identification of a partial autosomal dominant form of IL-12R beta 1 chain deficiency.
Cleary, A. M., Hwang, N., & Lewis, D. B. (2003). Identification of a partial autosomal dominant form of IL-12R beta 1 chain deficiency. BLOOD, 102(11), 280A. -
Surveying the Influenza-specific Cytotoxic T Cell Response in Humans and Mice Using Mass-cytometry (CyTOF) and Combinatorial Tetramer Staining
Newell, E., Bendall, S., Hong, D., Lewis, D., Nolan, G., & Davis, M. (2010). Surveying the Influenza-specific Cytotoxic T Cell Response in Humans and Mice Using Mass-cytometry (CyTOF) and Combinatorial Tetramer Staining. CLINICAL IMMUNOLOGY. ACADEMIC PRESS INC ELSEVIER SCIENCE. -
Inverse relationship between innate and acquired immune responsiveness in mice initially dosed with cationic lipid DNA complexes (JVRS-100)
Lay, M., Callejo, B., Giffon, T., Lewis, D., Chang, S., & Fairman, J. (2008). Inverse relationship between innate and acquired immune responsiveness in mice initially dosed with cationic lipid DNA complexes (JVRS-100). FASEB JOURNAL, 22. -
Expression of Heme Oxygenase-1 in Immune Cells During Late Gestational Inflammation.
Ozen, M., Zhao, H., Kalish, F., Yang, Y., Lewis, D. B., Wong, R. J., & Stevenson, D. K. (2016). Expression of Heme Oxygenase-1 in Immune Cells During Late Gestational Inflammation. REPRODUCTIVE SCIENCES. SAGE PUBLICATIONS INC. -
Subclinical cytomegalovirus infection modulates systemic inflammation and graft coronary remodeling one year after heart transplantation.
Potena, L., Biadi, O., Holweg, C., Fearon, W., Cooke, J., Lewis, D., … Valantine, H. (2005). Subclinical cytomegalovirus infection modulates systemic inflammation and graft coronary remodeling one year after heart transplantation. AMERICAN JOURNAL OF TRANSPLANTATION, 5, 382. -
The role of IL-12 and IL-23 in the generation and maintenance of memory CD4+T cells
Cleary, A. M., & Lewis, D. B. (2004). The role of IL-12 and IL-23 in the generation and maintenance of memory CD4+T cells. BLOOD, 104(11), 728A. -
Severe hypogammaglobulinemia and absent B cells in an adult patient: A case report
Iyengar, S. R., Blackbum, B. G., & Lewis, D. B. (2007). Severe hypogammaglobulinemia and absent B cells in an adult patient: A case report. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 119(1), S256. -
A block in Th1 pathway differentiation presenting as recurrent viral infections.
Cleary, A. M., Hwang, N., Marincola, J., Zloof, J., & Lewis, D. B. (2003). A block in Th1 pathway differentiation presenting as recurrent viral infections. BLOOD, 102(11), 48B. -
Allergic Diseases and Immune-Mediated Food Disorders in Pediatric Acute-Onset Neuropsychiatric Syndrome
Rosa, J. S., Hernandez, J. D., Sherr, J. A., Smith, B. M., Brown, K. D., Farhadian, B., … Frankovich, J. D. (2018). Allergic Diseases and Immune-Mediated Food Disorders in Pediatric Acute-Onset Neuropsychiatric Syndrome. PEDIATRIC ALLERGY IMMUNOLOGY AND PULMONOLOGY, 31(3), 158–65. -
Multiomics modeling of the immunome, transcriptome, microbiome, proteome and metabolome adaptations during human pregnancy.
Ghaemi, M. S., DiGiulio, D. B., Contrepois, K., Callahan, B., Ngo, T. T., Lee-McMullen, B., … Aghaeepour, N. (2019). Multiomics modeling of the immunome, transcriptome, microbiome, proteome and metabolome adaptations during human pregnancy. Bioinformatics (Oxford, England), 35(1), 95–103. -
The Clinical Spectrum of Hypomorphic IL2RG Severe Combined Immunodeficiency (SCID)
Lippner, E., & Lewis, D. B. (2019). The Clinical Spectrum of Hypomorphic IL2RG Severe Combined Immunodeficiency (SCID). JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 143(2), AB119. -
A Case of Disseminated Pneumocystis Jiroveci in a Non-Human Immunodeficiency Virus Infected Patient
Siddiqi, A. E., Sacha, J., Saenz, R., Liu, A., Kunder, C., Uzel, G., … Gernez-Goldhammer, Y. (2019). A Case of Disseminated Pneumocystis Jiroveci in a Non-Human Immunodeficiency Virus Infected Patient. JOURNAL OF CLINICAL IMMUNOLOGY. SPRINGER/PLENUM PUBLISHERS. -
Novel CDC42 Mutation Causes Severe Autoinflammatory Syndrome Responsive to IL-1 Inhibition
Gernez, Y., Kirbey, M., Balagas, J. M., Macaubas, C. I., Canna, S., Lewis, D. B., … Weinacht, K. G. (2019). Novel CDC42 Mutation Causes Severe Autoinflammatory Syndrome Responsive to IL-1 Inhibition. JOURNAL OF CLINICAL IMMUNOLOGY, 39, S69. -
Telomeres in Schimke Immuno-Osseous Dysplasia: Comparing Telomere Length in Individuals with Homozygous and Heterozygous SMARCAL1 Mutations
Lippner, E. A., Aubert, G., Ramachandran, V., & Lewis, D. B. (2019). Telomeres in Schimke Immuno-Osseous Dysplasia: Comparing Telomere Length in Individuals with Homozygous and Heterozygous SMARCAL1 Mutations. JOURNAL OF CLINICAL IMMUNOLOGY, 39, S70–S71. -
Allergic Diseases and Immune-Mediated Food Disorders in Pediatric Acute-Onset Neuropsychiatric Syndrome.
Rosa, J. S., Hernandez, J. D., Sherr, J. A., Smith, B. M., Brown, K. D., Farhadian, B., … Frankovich, J. D. (2018). Allergic Diseases and Immune-Mediated Food Disorders in Pediatric Acute-Onset Neuropsychiatric Syndrome. Pediatric Allergy, Immunology, and Pulmonology, 31(3), 158–165. -
Multiomics modeling of the immunome, transcriptome, microbiome, proteome and metabolome adaptations during human pregnancy
Ghaemi, M. S., DiGiulio, D. B., Contrepois, K., Callahan, B., Ngo, T. T. M., Lee-McMullen, B., … Aghaeepour, N. (2019). Multiomics modeling of the immunome, transcriptome, microbiome, proteome and metabolome adaptations during human pregnancy. BIOINFORMATICS, 35(1), 95–103. -
An immune clock of human pregnancy
Aghaeepour, N., Ganio, E. A., Mcilwain, D., Tsai, A. S., Tingle, M., Van Gassen, S., … Gaudilliere, B. (2017). An immune clock of human pregnancy. SCIENCE IMMUNOLOGY, 2(15). -
Paraneoplastic and Therapy-Related Immune Complications in Thymic Malignancies.
Lippner, E. A., Lewis, D. B., Robinson, W. H., & Katsumoto, T. R. (2019). Paraneoplastic and Therapy-Related Immune Complications in Thymic Malignancies. Current Treatment Options in Oncology, 20(7), 62. -
Severe autoinflammation in four patients with C-terminal variants in CDC42 successfully treated with IL-1beta inhibition.
Gernez, Y., de Jesus, A. A., Alsaleem, H., Macaubas, C., Roy, A., Lovell, D., … Weinacht, K. G. (2019). Severe autoinflammation in four patients with C-terminal variants in CDC42 successfully treated with IL-1beta inhibition. The Journal of Allergy and Clinical Immunology. -
The ratio of circulating regulatory cluster of differentiation 4 T cells to endothelial progenitor cells predicts clinically significant acute rejection after heart transplantation
Choi, D.-H., Chmura, S. A., Ramachandran, V., Dionis-Petersen, K. Y., Kobayashi, Y., Nishi, T., … Fearon, W. F. (2018). The ratio of circulating regulatory cluster of differentiation 4 T cells to endothelial progenitor cells predicts clinically significant acute rejection after heart transplantation. JOURNAL OF HEART AND LUNG TRANSPLANTATION, 37(4), 496–502. -
Durable multitransgene expression in vivo using systemic, nonviral DNA delivery.
Handumrongkul, C., Ye, A. L., Chmura, S. A., Soroceanu, L., Mack, M., Ice, R. J., … Debs, R. (2019). Durable multitransgene expression in vivo using systemic, nonviral DNA delivery. Science Advances, 5(11), eaax0217. -
Disseminated Pneumocystis jirovecii Infection with Osteomyelitis in a Patient with CTLA-4 Haploinsufficiency.
Siddiqi, A. E., Liu, A. Y., Charville, G. W., Kunder, C. A., Uzel, G., Sadighi Akha, A. A., … Gernez, Y. (2020). Disseminated Pneumocystis jirovecii Infection with Osteomyelitis in a Patient with CTLA-4 Haploinsufficiency. Journal of Clinical Immunology. -
A beta T-Cell/CD19 B-Cell Depleted Haploidentical Stem Cell Transplantation: A New Platform for Curing Rare and Monogenic Disorders
Bertaina, A., Bacchetta, R., Lewis, D. B., Grimm, P. C., Shah, A. J., Agarwal, R., … Roncarolo, M. G. (2020). A beta T-Cell/CD19 B-Cell Depleted Haploidentical Stem Cell Transplantation: A New Platform for Curing Rare and Monogenic Disorders. BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION, 26(3), S288. -
Development of CRISPR as an Antiviral Strategy to Combat SARS-CoV-2 and Influenza.
Abbott, T. R., Dhamdhere, G., Liu, Y., Lin, X., Goudy, L., Zeng, L., … Qi, L. S. (2020). Development of CRISPR as an Antiviral Strategy to Combat SARS-CoV-2 and Influenza. Cell. -
COVID-19 and cardiovascular disease: from basic mechanisms to clinical perspectives.
Nishiga, M., Wang, D. W., Han, Y., Lewis, D. B., & Wu, J. C. (2020). COVID-19 and cardiovascular disease: from basic mechanisms to clinical perspectives. Nature Reviews. Cardiology. -
Novel nonsense IKBKG Mutation in an Infant Presenting with Pneumocysti s Jiroveci Pneumonia and Disseminated Mycobacterium Szulgai Infection
Lo, R., Rosenthal, A., Shah, A., Chen, S., Eguiguren, L., Siddiqi, A., … Lewis, D. (2020). Novel nonsense IKBKG Mutation in an Infant Presenting with Pneumocysti s Jiroveci Pneumonia and Disseminated Mycobacterium Szulgai Infection. JOURNAL OF CLINICAL IMMUNOLOGY. SPRINGER/PLENUM PUBLISHERS. -
A case of Spondyloenchondrodysplasia with immune dysregulation presenting as Systemic Lupus Erythematous
Camacho, J. V., Singh, D., Bacchetta, R., Weinberg, K., Cepika, A.-M., Narula, M., … Weinacht, K. (2021). A case of Spondyloenchondrodysplasia with immune dysregulation presenting as Systemic Lupus Erythematous. JOURNAL OF CLINICAL IMMUNOLOGY. SPRINGER/PLENUM PUBLISHERS. -
Increased double-negative aß+ T-cells reveal adult-onset autoimmune lymphoproliferative syndrome in a patient with IgG4-related disease.
Brar, N., Spinner, M. A., Baker, M. C., Advani, R. H., Natkunam, Y., Lewis, D. B., & Silva, O. (2021). Increased double-negative aß+ T-cells reveal adult-onset autoimmune lymphoproliferative syndrome in a patient with IgG4-related disease. Haematologica. -
Single-Cell Analysis of the Neonatal Immune System Across the Gestational Age Continuum.
Peterson, L. S., Hedou, J., Ganio, E. A., Stelzer, I. A., Feyaerts, D., Harbert, E., … Gaudilliere, B. (2021). Single-Cell Analysis of the Neonatal Immune System Across the Gestational Age Continuum. Frontiers in Immunology, 12, 714090. -
Immunogenicity and Tolerability of COVID-19 mRNA Vaccines in PID patients with functional B-cell defects.
Pham, M. N., Murugesan, K., Banaei, N., Pinsky, B. A., Tang, M., Hoyte, E., … Gernez, Y. (1800). Immunogenicity and Tolerability of COVID-19 mRNA Vaccines in PID patients with functional B-cell defects. The Journal of Allergy and Clinical Immunology. -
Increased double-negative alpha beta plus T cells reveal adult-onset autoimmune lymphoproliferative syndrome in a patient with IgG4-related disease
Brar, N., Spinner, M. A., Baker, M. C., Advani, R. H., Natkunam, Y., Lewis, D. B., & Silva, O. (2022). Increased double-negative alpha beta plus T cells reveal adult-onset autoimmune lymphoproliferative syndrome in a patient with IgG4-related disease. HAEMATOLOGICA, 107(1), 347–350. -
Immunogenicity of a Third COVID-19 mRNA Vaccine Dose in PID Patients with Functional B-cell Defects.
Gernez, Y., Murugesan, K., Cortales, C. R., Banaei, N., Hoyte, L., Pinsky, B. A., … Pham, M. (2022). Immunogenicity of a Third COVID-19 mRNA Vaccine Dose in PID Patients with Functional B-cell Defects. The Journal of Allergy and Clinical Immunology. In Practice. -
Sequential hematopoietic stem cell transplantation (HSCT) followed by kidney transplant-3 children who received ABT-cell/CD19 B-cell depleted HSCT followed by kidney transplant from same parental donor are rejection free and immunosuppression free with donor specific tolerance > 1year post kidney transplant
Grimm, P., Lewis, D. B., Al-Uzri, A., Fathallah-Shaykh, S., Shah, A., Agarwal, R., … Bertaina, A. (2022). Sequential hematopoietic stem cell transplantation (HSCT) followed by kidney transplant-3 children who received ABT-cell/CD19 B-cell depleted HSCT followed by kidney transplant from same parental donor are rejection free and immunosuppression free with donor specific tolerance > 1year post kidney transplant. PEDIATRIC TRANSPLANTATION. WILEY. -
Broad-spectrum CRISPR-mediated inhibition of SARS-CoV-2 variants and endemic coronaviruses in vitro.
Zeng, L., Liu, Y., Nguyenla, X. H., Abbott, T. R., Han, M., Zhu, Y., … Qi, L. S. (2022). Broad-spectrum CRISPR-mediated inhibition of SARS-CoV-2 variants and endemic coronaviruses in vitro. Nature Communications, 13(1), 2766. -
Sequential Stem Cell-Kidney Transplantation in Schimke Immuno-osseous Dysplasia.
Bertaina, A., Grimm, P. C., Weinberg, K., Parkman, R., Kristovich, K. M., Barbarito, G., … Lewis, D. B. (2022). Sequential Stem Cell-Kidney Transplantation in Schimke Immuno-osseous Dysplasia. The New England Journal of Medicine, 386(24), 2295–2302. -
Functional Immune Tolerance Induced By Sequential Hematopoietic Stem Cell-Solid Organ Transplantation
Bertaina, A., Barbarito, G., Ramachandran, V. V., Kristovich, K., Lippner, E. A., Fathallah-Shaykh, S., … Grimm, P. C. (2021). Functional Immune Tolerance Induced By Sequential Hematopoietic Stem Cell-Solid Organ Transplantation. BLOOD. AMER SOC HEMATOLOGY. -
POST-TRANSPLANT LYMPHOPROLIFERATIVE DISEASE IN A PATIENT WITH SCHIMKE IMMUNO-OSSEOUS DYSPLASIA
Rao, R., Grimm, P., Lewis, D., Spunt, S., & Marks, L. (2023). POST-TRANSPLANT LYMPHOPROLIFERATIVE DISEASE IN A PATIENT WITH SCHIMKE IMMUNO-OSSEOUS DYSPLASIA. PEDIATRIC BLOOD & CANCER. WILEY. -
Single-cell Transcriptomics Reveal Different Maturation Stages and Sublineages Commitment of Human Thymic Invariant Natural Killer T cells.
Maas-Bauer, K., Köhler, N., Stell, A.-V. V., Zwick, M., Acharya, S., Rensing-Ehl, A., … Simonetta, F. (2023). Single-cell Transcriptomics Reveal Different Maturation Stages and Sublineages Commitment of Human Thymic Invariant Natural Killer T cells. Journal of Leukocyte Biology.
Practice Locations
LPCH- Allergy (Palo Alto) Palo Alto, CA
Palo Alto, CAImportant Information about Our Organizations and Physician Affiliation
Stanford Health Care, Stanford Health Care Tri-Valley, and Stanford Medicine Partners are each independent nonprofit organizations that are affiliated with but separate from each other and from Stanford University. The physicians who provide care at facilities operated by Stanford Health Care, Stanford Health Care Tri-Valley, and Stanford Medicine Partners are faculty, foundation, or community physicians who are not employees, representatives, or agents of Stanford Health Care, Stanford Health Care Tri- Valley, or Stanford Medicine Partners. Stanford Health Care, Stanford Health Care Tri-Valley, and Stanford Medicine Partners do not exercise control over the care provided by such faculty, foundation, and community physicians and are not responsible for their actions.
Referring Physicians
PHYSICIAN HELPLINE
Fax: 650-320-9443
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You may also submit a web referral or complete a referral form and fax it to 650-320-9443 or email the Referral Center at ReferralCenter@stanfordhealthcare.org.
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