Nicholas Leeper

Cardiologist, Vascular medicine specialist

Assistant Professor of Surgery (Vascular Surgery) and Medicine (Cardiovascular Medicine) at the Stanford University Medical Center

Vascular and Endovascular Care

  • 300 Pasteur Drive
  • Stanford, CA 94305
  • Phone: 650-725-5227
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Professional Education

Fellowship: Stanford University School of Medicine (2009) CA

Board Certification: Cardiovascular Disease, American Board of Internal Medicine (2009)

Residency: UCSF-Graduate Medical Education (2005) CA

Medical Education: Univ Of Chicago - Registrar (2003) IL

Board Certification: Internal Medicine, American Board of Internal Medicine (2006)

Clinical Trials

Clinical trials are research studies that evaluate a new medical approach, device, drug, or other treatment. As a Stanford Health Care patient, you have access to the latest, advanced clinical trials.

Open trials refer to studies currently accepting participants. Closed trials are not currently enrolling, but may open in the future.

Cyclin-dependent kinase inhibitor 2B regulates efferocytosis and atherosclerosis
Kojima, Y., Downing, K., Kundu, R., Miller, C., Dewey, F., & Leeper, N. J. (2014). Cyclin-dependent kinase inhibitor 2B regulates efferocytosis and atherosclerosis. JOURNAL OF CLINICAL INVESTIGATION, 124(3), 1083-1097.

Transcriptional activation of hypoxia-inducible factor-1 (HIF-1) in myeloid cells promotes angiogenesis through VEGF and S100A8
Ahn, G.-O., Seita, J., Hong, B.-J., Kim, Y.-E., Bok, S., & Brown, J. M. (2014). Transcriptional activation of hypoxia-inducible factor-1 (HIF-1) in myeloid cells promotes angiogenesis through VEGF and S100A8. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 111(7), 2698-2703.

Alternative Ankle-Brachial Index Method Identifies Additional At-Risk Individuals
Nead, K. T., Cooke, J. P., Olin, J. W., & Leeper, N. J. (2013). Alternative Ankle-Brachial Index Method Identifies Additional At-Risk Individuals. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 62(6), 553-559.

Practice-Based Evidence: Profiling the Safety of Cilostazol by Text-Mining of Clinical Notes
Leeper, N. J., Bauer-Mehren, A., Iyer, S. V., LePendu, P., Olson, C., & Shah, N. H. (2013). Practice-Based Evidence: Profiling the Safety of Cilostazol by Text-Mining of Clinical Notes. PLOS ONE, 8(5).

Loss of CDKN2B promotes p53-dependent smooth muscle cell apoptosis and aneurysm formation.
Leeper, N. J., Raiesdana, A., Kojima, Y., Kundu, R. K., Cheng, H., & Quertermous, T. (2013). Loss of CDKN2B promotes p53-dependent smooth muscle cell apoptosis and aneurysm formation. Arteriosclerosis, thrombosis, and vascular biology, 33(1), e1-e10.

Genetics of Peripheral Artery Disease
Leeper, N. J., Kullo, I. J., & Cooke, J. P. (2012). Genetics of Peripheral Artery Disease. CIRCULATION, 125(25), 3220-3228.

MicroRNA-21 Blocks Abdominal Aortic Aneurysm Development and Nicotine-Augmented Expansion
Maegdefessel, L., Azuma, J., Toh, R., Deng, A., Merk, D. R., & Tsao, P. S. (2012). MicroRNA-21 Blocks Abdominal Aortic Aneurysm Development and Nicotine-Augmented Expansion. SCIENCE TRANSLATIONAL MEDICINE, 4(122).

Inhibition of microRNA-29b reduces murine abdominal aortic aneurysm development
Maegdefessel, L., Azuma, J., Toh, R., Merk, D. R., Deng, A., & Tsao, P. S. (2012). Inhibition of microRNA-29b reduces murine abdominal aortic aneurysm development. JOURNAL OF CLINICAL INVESTIGATION, 122(2), 497-506.

MicroRNA-26a Is a Novel Regulator of Vascular Smooth Muscle Cell Function
Leeper, N. J., Raiesdana, A., Kojima, Y., Chun, H. J., Azuma, J., & Spin, J. M. (2011). MicroRNA-26a Is a Novel Regulator of Vascular Smooth Muscle Cell Function. JOURNAL OF CELLULAR PHYSIOLOGY, 226(4), 1035-1043.

MicroRNA and Mechanisms of Impaired Angiogenesis in Diabetes Mellitus
Leeper, N. J., & Cooke, J. P. (2011). MicroRNA and Mechanisms of Impaired Angiogenesis in Diabetes Mellitus. CIRCULATION, 123(3), 236-238.

Stem Cell Therapy for Vascular Regeneration Adult, Embryonic, and Induced Pluripotent Stem Cells
Leeper, N. J., Hunter, A. L., & Cooke, J. P. (2010). Stem Cell Therapy for Vascular Regeneration Adult, Embryonic, and Induced Pluripotent Stem Cells. CIRCULATION, 122(5), 517-526.

Upregulation of the apelin-APJ pathway promotes neointima formation in the carotid ligation model in mouse
Kojima, Y., Kundu, R. K., Cox, C. M., Leeper, N. J., Anderson, J. A., & Quertermous, T. (2010). Upregulation of the apelin-APJ pathway promotes neointima formation in the carotid ligation model in mouse. CARDIOVASCULAR RESEARCH, 87(1), 156-165.

Apelin prevents aortic aneurysm formation by inhibiting macrophage inflammation
Leeper, N. J., Tedesco, M. M., Kojima, Y., Schultz, G. M., Kundu, R. K., & Quertermous, T. (2009). Apelin prevents aortic aneurysm formation by inhibiting macrophage inflammation. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 296(5), H1329-H1335.

Clinical problem-solving. Fool's Gold.
Leeper, N. J., Dhaliwal, G., Saint, S., & Witteles, R. M. (2008). Clinical problem-solving. Fool's Gold. New England journal of medicine, 359(19), 2035-2041.

Apelin signaling antagonizes Ang II effects in mouse models of atherosclerosis
Chun, H. J., Ali, Z. A., Kojima, Y., Kundu, R. K., Sheikh, A. Y., & Quertermous, T. (2008). Apelin signaling antagonizes Ang II effects in mouse models of atherosclerosis. JOURNAL OF CLINICAL INVESTIGATION, 118(10), 3343-3354.

Statin use in patients with extremely low low-density lipoprotein levels is associated with improved survival
Leeper, N. J., Ardehali, R., DeGoma, E. M., & Heidenreich, P. A. (2007). Statin use in patients with extremely low low-density lipoprotein levels is associated with improved survival. CIRCULATION, 116(6), 613-618.

Prognostic value of heart rate increase at onset of exercise testing
Leeper, N. J., Dewey, F. E., Ashley, E. A., Sandri, M., Tan, S. Y., & Froelicher, V. (2007). Prognostic value of heart rate increase at onset of exercise testing. CIRCULATION, 115(4), 468-474.

One surprise after another
Leeper, N. J., Wener, L. S., Dhaliwal, G., Saint, S., & Wachter, R. M. (2005). One surprise after another. NEW ENGLAND JOURNAL OF MEDICINE, 352(14), 1474-1479.

Cloning of a unique lipase from endothelial cells extends the lipase gene family
Hirata, K., Dichek, H. L., Cioffi, J. A., Choi, S. Y., Leeper, N. J., & Quertermous, T. (1999). Cloning of a unique lipase from endothelial cells extends the lipase gene family. JOURNAL OF BIOLOGICAL CHEMISTRY, 274(20), 14170-14175.

Clinical and socioeconomic factors associated with unrecognized peripheral artery disease
Chang, P., Nead, K. T., Olin, J. W., Cooke, J. P., & Leeper, N. J. (2014). Clinical and socioeconomic factors associated with unrecognized peripheral artery disease. VASCULAR MEDICINE, 19(4), 289-296.

Coronary heart disease-associated variation in TCF21 disrupts a miR-224 binding site and miRNA-mediated regulation.
Miller, C. L., Haas, U., Diaz, R., Leeper, N. J., Kundu, R. K., & Sczakiel, G. (2014). Coronary heart disease-associated variation in TCF21 disrupts a miR-224 binding site and miRNA-mediated regulation. PLoS genetics, 10(3).

Coronary Heart Disease-Associated Variation in TCF21 Disrupts a miR-224 Binding Site and miRNA-Mediated Regulation
Miller, C. L., Haas, U., Diaz, R., Leeper, N. J., Kundu, R. K., & Sczakiel, G. (2014). Coronary Heart Disease-Associated Variation in TCF21 Disrupts a miR-224 Binding Site and miRNA-Mediated Regulation. PLOS GENETICS, 10(3).

Self-Reported History of Childhood Smoking Is Associated with an Increased Risk for Peripheral Arterial Disease Independent of Lifetime Smoking Burden
Priest, J. R., Nead, K. T., Wehner, M. R., Cooke, J. P., & Leeper, N. J. (2014). Self-Reported History of Childhood Smoking Is Associated with an Increased Risk for Peripheral Arterial Disease Independent of Lifetime Smoking Burden. PLOS ONE, 9(2).

The combination of 9p21.3 genotype and biomarker profile improves a peripheral artery disease risk prediction model
Downing, K. P., Nead, K. T., Kojima, Y., Assimes, T., Maegdefessel, L., & Leeper, N. J. (2014). The combination of 9p21.3 genotype and biomarker profile improves a peripheral artery disease risk prediction model. VASCULAR MEDICINE, 19(1), 3-8.

Self-reported history of childhood smoking is associated with an increased risk for peripheral arterial disease independent of lifetime smoking burden.
Priest, J. R., Nead, K. T., Wehner, M. R., Cooke, J. P., & Leeper, N. J. (2014). Self-reported history of childhood smoking is associated with an increased risk for peripheral arterial disease independent of lifetime smoking burden. PloS one, 9(2).

Association of lower extremity performance with cardiovascular and all-cause mortality in patients with peripheral artery disease: a systematic review and meta-analysis.
Morris, D. R., Rodriguez, A. J., Moxon, J. V., Cunningham, M. A., McDermott, M. M., & Golledge, J. (2014). Association of lower extremity performance with cardiovascular and all-cause mortality in patients with peripheral artery disease: a systematic review and meta-analysis. Journal of the American Heart Association, 3(4).

Disease-Related Growth Factor and Embryonic Signaling Pathways Modulate an Enhancer of TCF21 Expression at the 6q23.2 Coronary Heart Disease Locus
Miller, C. L., Anderson, D. R., Kundu, R. K., Raiesdana, A., Nuernberg, S. T., & Quertermous, T. (2013). Disease-Related Growth Factor and Embryonic Signaling Pathways Modulate an Enhancer of TCF21 Expression at the 6q23.2 Coronary Heart Disease Locus. PLOS GENETICS, 9(7).

Walking Impairment Questionnaire Improves Mortality Risk Prediction Models in a High-Risk Cohort Independent of Peripheral Arterial Disease Status
Nead, K. T., Zhou, M., Caceres, R. D., Olin, J. W., Cooke, J. P., & Leeper, N. J. (2013). Walking Impairment Questionnaire Improves Mortality Risk Prediction Models in a High-Risk Cohort Independent of Peripheral Arterial Disease Status. CIRCULATION-CARDIOVASCULAR QUALITY AND OUTCOMES, 6(3), 255-261.

Usefulness of the Addition of Beta-2-Microglobulin, Cystatin C and C-Reactive Protein to an Established Risk Factors Model to Improve Mortality Risk Prediction in Patients Undergoing Coronary Angiography
Nead, K. T., Zhou, M. J., Caceres, R. D., Sharp, S. J., Wehner, M. R., & Leeper, N. J. (2013). Usefulness of the Addition of Beta-2-Microglobulin, Cystatin C and C-Reactive Protein to an Established Risk Factors Model to Improve Mortality Risk Prediction in Patients Undergoing Coronary Angiography. AMERICAN JOURNAL OF CARDIOLOGY, 111(6), 851-856.

Exercise capacity is the strongest predictor of mortality in patients with peripheral arterial disease
Leeper, N. J., Myers, J., Zhou, M., Nead, K. T., Syed, A., & Cooke, J. P. (2013). Exercise capacity is the strongest predictor of mortality in patients with peripheral arterial disease. JOURNAL OF VASCULAR SURGERY, 57(3), 728-733.

Network analysis of unstructured EHR data for clinical research.
Bauer-Mehren, A., LePendu, P., Iyer, S. V., Harpaz, R., Leeper, N. J., & Shah, N. H. (2013). Network analysis of unstructured EHR data for clinical research. AMIA Summits on Translational Science proceedings AMIA Summit on Translational Science, 2013, 14-18.

Practice-based evidence: profiling the safety of cilostazol by text-mining of clinical notes.
Leeper, N. J., Bauer-Mehren, A., Iyer, S. V., LePendu, P., Olson, C., & Shah, N. H. (2013). Practice-based evidence: profiling the safety of cilostazol by text-mining of clinical notes. PloS one, 8(5).

Disease-related growth factor and embryonic signaling pathways modulate an enhancer of TCF21 expression at the 6q23.2 coronary heart disease locus.
Miller, C. L., Anderson, D. R., Kundu, R. K., Raiesdana, A., Nürnberg, S. T., & Quertermous, T. (2013). Disease-related growth factor and embryonic signaling pathways modulate an enhancer of TCF21 expression at the 6q23.2 coronary heart disease locus. PLoS genetics, 9(7).

Loss of CDKN2B Promotes p53-Dependent Smooth Muscle Cell Apoptosis and Aneurysm Formation
Leeper, N. J., Raiesdana, A., Kojima, Y., Kundu, R. K., Cheng, H., & Quertermous, T. (2013). Loss of CDKN2B Promotes p53-Dependent Smooth Muscle Cell Apoptosis and Aneurysm Formation. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 33(1), E1-?.

The Effect of Angiotensin-Converting Enzyme Inhibitors and Statins on the Progression of Aortic Sclerosis and Mortality
Ardehali, R., Leeper, N. J., Wilson, A. M., & Heidenreich, P. A. (2012). The Effect of Angiotensin-Converting Enzyme Inhibitors and Statins on the Progression of Aortic Sclerosis and Mortality. JOURNAL OF HEART VALVE DISEASE, 21(3), 337-343.

Two Decades of Progress in Vascular Medicine
Leeper, N. J., Lee, J. T., & Cooke, J. P. (2011). Two Decades of Progress in Vascular Medicine. AMERICAN JOURNAL OF MEDICINE, 124(9), 791-792.

Endogenous regulation of cardiovascular function by apelin-APJ
Charo, D. N., Ho, M., Fajardo, G., Kawana, M., Kundu, R. K., & Quertermous, T. (2009). Endogenous regulation of cardiovascular function by apelin-APJ. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 297(5), H1904-H1913.

Response to letter regarding article, "Statin use in patients with extremely low low-density lipoprotein levels is associated with improved survival"
Leeper, N. J., Ardehali, R., DeGoma, E. M., & Heidenreich, P. A. (2008). Response to letter regarding article, "Statin use in patients with extremely low low-density lipoprotein levels is associated with improved survival". CIRCULATION, 117(9), E175-E175.

Clinical significance of high-density lipoprotein cholesterol in patients with low low-density lipoprotein cholesterol
deGoma, E. M., Leeper, N. J., & Heidenreich, P. A. (2008). Clinical significance of high-density lipoprotein cholesterol in patients with low low-density lipoprotein cholesterol. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 51(1), 49-55.

Clinical dilemmas in treating left ventricular thrombus.
Leeper, N. J., Gupta, A., Schnittger, I., & Wu, J. C. (2007). Clinical dilemmas in treating left ventricular thrombus. International journal of cardiology, 114(3), e118-9.

Right coronary cameral fistula resulting from surgery of double chamber right ventricle.
Leeper, N. J., Gupta, A., Murphy, D. J., & Wu, J. C. (2006). Right coronary cameral fistula resulting from surgery of double chamber right ventricle. Journal of the American Society of Echocardiography , 19(9), 1191 e9-11.

The effect of preoperative statin therapy on cardiovascular outcomes in patients undergoing infrainguinal vascular surgery
Ward, R. P., Leeper, N. J., Kirkpatrick, J. N., Lang, R. M., Sorrentino, M. J., & Williams, K. A. (2005). The effect of preoperative statin therapy on cardiovascular outcomes in patients undergoing infrainguinal vascular surgery. INTERNATIONAL JOURNAL OF CARDIOLOGY, 104(3), 264-268.

Interleukin-6 causes endothelial barrier dysfunction via the protein kinase C pathway
Desai, T. R., Leeper, N. J., Hynes, K. L., & Gewertz, B. L. (2002). Interleukin-6 causes endothelial barrier dysfunction via the protein kinase C pathway. JOURNAL OF SURGICAL RESEARCH, 104(2), 118-123.

Gender does not influence outcomes after iliac angioplasty
Orr, J. D., Leeper, N. J., Funaki, B., Leef, J., Gewertz, B. L., & Desai, T. R. (2002). Gender does not influence outcomes after iliac angioplasty. ANNALS OF VASCULAR SURGERY, 16(1), 55-60.

Tetracycline-regulatable expression vectors tightly regulate in vitro gene expression of secreted proteins
Sturtz, F. G., Cioffi, L., Wittmer, S., Sonk, M. J., Shafer, A., & Platika, D. (1998). Tetracycline-regulatable expression vectors tightly regulate in vitro gene expression of secreted proteins. GENE, 221(2), 279-285.