Beverly S. Mitchell, M.D.

Hematologist, Leukemia specialist, Medical oncologist

George E. Becker Professor in Medicine and Professor, by courtesy, of Chemical and Systems Biology

Hematology Program

  • 875 Blake Wilbur Drive
  • Palo Alto, CA 94304
  • Phone: 650-498-6000
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Professional Education

Medical Education: Harvard Medical School (1969) MA

Board Certification: Hematology, American Board of Internal Medicine (1978)

Fellowship: University Hospital Zurich (1973) Switzerland

Fellowship: University of Michigan Hospital (1977) MI

Board Certification: Internal Medicine, American Board of Internal Medicine (1973)

Residency: University of Washington (1973) WA

Internship: Harborview Medical Center (1970) WA

M.D., Harvard Medical School, Medicine (1969)

Honors & Awards

Walter Hewlitt Physician Scientist Award, Stanford Department of Medicine (2012)

Mentorship Award, American Society of Hematology (2012)

President, American Society of Hematology (2001)

Member, American Society for Clinical Investigation (to present)

Member, Association of American Professors (1991)

National Academy of Sciences, Institute of Medicine (Inducted 2001)

Administrative Appointments

Director, Stanford Cancer Institute (2008 - Present)

Deputy Director, Stanford Cancer Center (2005 - 2008)

Reduced rRNA expression and increased rDNA promoter methylation in CD34(+) cells of patients with myelodysplastic syndromes
Raval, A., Sridhar, K. J., Patel, S., Turnbull, B. B., Greenberg, P. L., & Mitchell, B. S. (2012). Reduced rRNA expression and increased rDNA promoter methylation in CD34(+) cells of patients with myelodysplastic syndromes. BLOOD, 120(24), 4812-4818.

Effect of nucleophosmin1 haploinsufficiency on hematopoietic stem cells
Raval, A., Kusler, B., Pang, W. W., Weissman, I. L., Mitchell, B. S., & Park, C. Y. (2012). Effect of nucleophosmin1 haploinsufficiency on hematopoietic stem cells. LEUKEMIA, 26(4), 853-855.

Cyclopentenyl Cytosine Induces Senescence in Breast Cancer Cells through the Nucleolar Stress Response and Activation of p53
Huang, M., Whang, P., Lewicki, P., & Mitchell, B. S. (2011). Cyclopentenyl Cytosine Induces Senescence in Breast Cancer Cells through the Nucleolar Stress Response and Activation of p53. MOLECULAR PHARMACOLOGY, 80(1), 40-48.

Reactive Oxygen Species Regulate Nucleostemin Oligomerization and Protein Degradation
Huang, M., Whang, P., Chodaparambil, J. V., Pollyea, D. A., Kusler, B., & Mitchell, B. S. (2011). Reactive Oxygen Species Regulate Nucleostemin Oligomerization and Protein Degradation. JOURNAL OF BIOLOGICAL CHEMISTRY, 286(13), 11035-11046.

Depletion of Guanine Nucleotides Leads to the Mdm2-Dependent Proteasomal Degradation of Nucleostemin
Huang, M., Itahana, K., Zhang, Y., & Mitchell, B. S. (2009). Depletion of Guanine Nucleotides Leads to the Mdm2-Dependent Proteasomal Degradation of Nucleostemin. CANCER RESEARCH, 69(7), 3004-3012.

Determinants of sensitivity of human T-cell leukemia CCRF-CEM cells to immucillin-H
Huang, M., Wang, Y., Gu, J., Yang, J., Noel, K., & Graves, L. M. (2008). Determinants of sensitivity of human T-cell leukemia CCRF-CEM cells to immucillin-H. LEUKEMIA RESEARCH, 32(8), 1268-1278.

Guanine nucleotide depletion inhibits pre-ribosomal RNA synthesis and causes nucleolar proteins
Huang M, Ji Y, Itahana K, Zhang Y, & Mitchell BS. (2008). Guanine nucleotide depletion inhibits pre-ribosomal RNA synthesis and causes nucleolar proteins. Leuk Res, 32(1).

The 5 '-nucleotidases as regulators of nucleotide and drug metabolism
Hunsucker, S. A., Mitchell, B. S., & Spychala, J. (2005). The 5 '-nucleotidases as regulators of nucleotide and drug metabolism. PHARMACOLOGY & THERAPEUTICS, 107(1), 1-30.

Phase I study of 506U78 administered on a consecutive 5-day schedule in children and adults with refractory hematologic malignancies
Kurtzberg, J., Ernst, T. J., Keating, M. J., Gandhi, V., Hodge, J. P., & Mitchell, B. S. (2005). Phase I study of 506U78 administered on a consecutive 5-day schedule in children and adults with refractory hematologic malignancies. JOURNAL OF CLINICAL ONCOLOGY, 23(15), 3396-3403.

Synergy between imatinib and mycophenolic acid in inducing apoptosis in cell lines expressing Bcr-Abl
Gu, J. J., Santiago, L., & Mitchell, B. S. (2005). Synergy between imatinib and mycophenolic acid in inducing apoptosis in cell lines expressing Bcr-Abl. BLOOD, 105(8), 3270-3277.

Phase 1 trial of the proteasome inhibitor bortezomib and pegylated liposomal doxorubicin in patients with advanced hematologic malignancies
Orlowski, R. Z., Voorhees, P. M., Garcia, R. A., Hall, M. D., Kudrik, F. J., & Dees, E. C. (2005). Phase 1 trial of the proteasome inhibitor bortezomib and pegylated liposomal doxorubicin in patients with advanced hematologic malignancies. BLOOD, 105(8), 3058-3065.

ACCO: ASCO core curriculum outline
Muss, H. B., Von Roenn, J., Damon, L. E., DeAngelis, L. M., Flaherty, L. E., & Sparano, J. (2005). ACCO: ASCO core curriculum outline. JOURNAL OF CLINICAL ONCOLOGY, 23(9), 2049-2077.

Effects of the IMP-dehydrogenase inhibitor, Tiazofurin, in bcr-abl positive acute myelogenous leukemia - Part I. In vivo studies
Malek, K., Boosalis, M. S., Waraska, K., Mitchell, B. S., & Wright, D. G. (2004). Effects of the IMP-dehydrogenase inhibitor, Tiazofurin, in bcr-abl positive acute myelogenous leukemia - Part I. In vivo studies. LEUKEMIA RESEARCH, 28(11), 1125-1136.

Role of estrogen receptor in the regulation of ecto-5 '-nucleotidase and adenosine in breast cancer
Spychala, J., Lazarowski, E., Ostapkowicz, A., Ayscue, L. H., Jin, A., & Mitchell, B. S. (2004). Role of estrogen receptor in the regulation of ecto-5 '-nucleotidase and adenosine in breast cancer. CLINICAL CANCER RESEARCH, 10(2), 708-717.

Role of human Pso4 in mammalian DNA repair and association with terminal deoxynucleotidyl transferase
Mahajan, K. N., & Mitchell, B. S. (2003). Role of human Pso4 in mammalian DNA repair and association with terminal deoxynucleotidyl transferase. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 100(19), 10746-10751.

Role of cysteine 288 in nucleophosmin cytoplasmic mutations: sensitization to toxicity induced by arsenic trioxide and bortezomib
Huang, M., Thomas, D., Li, M. X., Feng, W., Chan, S. M., & Mitchell, B. S. (2013). Role of cysteine 288 in nucleophosmin cytoplasmic mutations: sensitization to toxicity induced by arsenic trioxide and bortezomib. LEUKEMIA, 27(10), 1970-1980.

Sequential azacitidine plus lenalidomide combination for elderly patients with untreated acute myeloid leukemia
Pollyea, D. A., Zehnder, J., Coutre, S., Gotlib, J. R., Gallegos, L., & Medeiros, B. C. (2013). Sequential azacitidine plus lenalidomide combination for elderly patients with untreated acute myeloid leukemia. HAEMATOLOGICA, 98(4), 591-596.

Age and Genetics: How Do Prognostic Factors at Diagnosis Explain Disparities in Acute Myeloid Leukemia?
Patel, M. I., Ma, Y., Mitchell, B. S., & Rhoads, K. F. (2013). Age and Genetics: How Do Prognostic Factors at Diagnosis Explain Disparities in Acute Myeloid Leukemia?. American journal of clinical oncology.

Understanding disparities in leukemia: a national study
Patel, M. I., Ma, Y., Mitchell, B. S., & Rhoads, K. F. (2012). Understanding disparities in leukemia: a national study. CANCER CAUSES & CONTROL, 23(11), 1831-1837.

Safety, efficacy and biological predictors of response to sequential azacitidine and lenalidomide for elderly patients with acute myeloid leukemia
Pollyea, D. A., Kohrt, H. E., Gallegos, L., Figueroa, M. E., Abdel-Wahab, O., & Medeiros, B. C. (2012). Safety, efficacy and biological predictors of response to sequential azacitidine and lenalidomide for elderly patients with acute myeloid leukemia. LEUKEMIA, 26(5), 893-901.

Synthesis of 2 '-Deoxy-2 '-[F-18]Fluoro-9-beta-D-Arabinofuranosylguanine: a Novel Agent for Imaging T-Cell Activation with PET
Namavari, M., Chang, Y.-F., Kusler, B., Yaghoubi, S., Mitchell, B. S., & Gambhir, S. S. (2011). Synthesis of 2 '-Deoxy-2 '-[F-18]Fluoro-9-beta-D-Arabinofuranosylguanine: a Novel Agent for Imaging T-Cell Activation with PET. MOLECULAR IMAGING AND BIOLOGY, 13(5), 812-818.

Impact of TET2 mutations on mRNA expression and clinical outcomes in MDS patients treated with DNA methyltransferase inhibitors
Pollyea, D. A., Raval, A., Kusler, B., Gotlib, J. R., Alizadeh, A. A., & Mitchell, B. S. (2011). Impact of TET2 mutations on mRNA expression and clinical outcomes in MDS patients treated with DNA methyltransferase inhibitors. HEMATOLOGICAL ONCOLOGY, 29(3), 157-160.

Guanine nucleotide depletion mediates translocation of nucleolar proteins, including RNA helicase A (DHX-9).
Huang, M., & Mitchell, B. S. (2008). Guanine nucleotide depletion mediates translocation of nucleolar proteins, including RNA helicase A (DHX-9). Nucleosides, nucleotides & nucleic acids, 27(6), 704-711.

Tenascin C interacts with ecto-5'-nucleotidase (eN) and regulates adenosine generation in cancer cells
Sadej R, Inai K, Rajfur Z, Ostapkowicz A, Kohler J, & Spychala J. (2008). Tenascin C interacts with ecto-5'-nucleotidase (eN) and regulates adenosine generation in cancer cells. Biochem Biophys Acta, 1782(1).

Nelarabine induces complete remissions in adults with relapsed or refractory T-lineage acute lymphoblastic leukemia or lymphoblastic lymphoma: Cancer and Leukemia Group B study 19801
DeAngelo, D. J., Yu, D., Johnson, J. L., Coutre, S. E., Stone, R. M., & Larson, R. A. (2007). Nelarabine induces complete remissions in adults with relapsed or refractory T-lineage acute lymphoblastic leukemia or lymphoblastic lymphoma: Cancer and Leukemia Group B study 19801. BLOOD, 109(12), 5136-5142.

Nelarabing induces complete remissions in adults with relapsed or refractory t-lineage acute lymphoblastic leukemia or lymphoblastic lymphoma: cancer and leukemia group B study 19801
DeAngelo D, Yu D, Johnson J, Coutre S, Stone R, & Larson R. (2007). Nelarabing induces complete remissions in adults with relapsed or refractory t-lineage acute lymphoblastic leukemia or lymphoblastic lymphoma: cancer and leukemia group B study 19801. Blood, 109(12).

Effect of lysophosphatidic acid acyltransferase-beta inhibition in acute leukemia
Douvas, M. G., Hogan, K. N., Ji, Ys., Hollenback, D., Bonham, L., & Mitchell, B. S. (2006). Effect of lysophosphatidic acid acyltransferase-beta inhibition in acute leukemia. LEUKEMIA RESEARCH, 30(8), 1027-1036.

Regulation of the interaction of inosine monophosphate dehydrogenase with mycophenolic acid by GTP
Ji, Y. S., Gu, J. J., Makhov, A. M., Griffith, J. D., & Mitchell, B. S. (2006). Regulation of the interaction of inosine monophosphate dehydrogenase with mycophenolic acid by GTP. JOURNAL OF BIOLOGICAL CHEMISTRY, 281(1), 206-212.

Effect of lysosphatidic acid acyltransferase-B inhibition in acute luekemia
Douvas MG, Hogan KN, Ji Y, Holleneck D, Bonham L, & Mitchell BS. (2006). Effect of lysosphatidic acid acyltransferase-B inhibition in acute luekemia. Leu Res, 30(8).

Regulation of equilibrative nucleoside uptake by protein kinase inhibitors
Huang, M., Wang, Y. H., Mitchell, B. S., & Graves, L. M. (2004). Regulation of equilibrative nucleoside uptake by protein kinase inhibitors. NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS, 23(8-9), 1445-1450.

On the molecular pathology of neurodegeneration in IMPDH1-based retinitis pigmentosa
Aherne, A., Kennan, A., Kenna, P. F., McNally, N., Lloyd, D. G., & Humphries, P. (2004). On the molecular pathology of neurodegeneration in IMPDH1-based retinitis pigmentosa. HUMAN MOLECULAR GENETICS, 13(6), 641-650.

Targeted disruption of the inosine 5 '-monophosphate dehydrogenase type I gene in mice
Gu, J. J., Tolin, A. K., Jain, J., Huang, H., Santiago, L., & Mitchell, B. S. (2003). Targeted disruption of the inosine 5 '-monophosphate dehydrogenase type I gene in mice. MOLECULAR AND CELLULAR BIOLOGY, 23(18), 6702-6712.

The proteasome - An emerging therapeutic target in cancer
Mitchell, B. S. (2003). The proteasome - An emerging therapeutic target in cancer. NEW ENGLAND JOURNAL OF MEDICINE, 348(26), 2597-2598.

Induction of apoptosis in IL-3-dependent hematopoietic cell lines by guanine nucleotide depletion
Gu, J. J., Gathy, K., Santiago, L., Chen, E., Huang, M., & Mitchell, B. S. (2003). Induction of apoptosis in IL-3-dependent hematopoietic cell lines by guanine nucleotide depletion. BLOOD, 101(12), 4958-4965.

Inhibition of nucleoside transport by protein kinase inhibitors
Huang, M., Wang, Y. H., Cogut, S. B., Mitchell, B. S., & Graves, L. M. (2003). Inhibition of nucleoside transport by protein kinase inhibitors. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 304(2), 753-760.

Phase I trial of the proteasome inhibitor PS-341 in patients with refractory hematologic malignancies
Orlowski, R. Z., Stinchcombe, T. E., Mitchell, B. S., Shea, T. C., Baldwin, A. S., & Soignet, S. L. (2002). Phase I trial of the proteasome inhibitor PS-341 in patients with refractory hematologic malignancies. JOURNAL OF CLINICAL ONCOLOGY, 20(22), 4420-4427.

Clinical course of thrombocytopenia in patients treated with imatinib mesylate for accelerated phase chronic myelogenous leukemia
van Deventer, H. W., Hall, M. D., Orlowski, R. Z., Mitchell, B. S., Berkowitz, L. R., & Shea, T. C. (2002). Clinical course of thrombocytopenia in patients treated with imatinib mesylate for accelerated phase chronic myelogenous leukemia. AMERICAN JOURNAL OF HEMATOLOGY, 71(3), 184-190.

Alemtuzumab in previously treated chronic lymphocytic leukemia patients who also had received fludarabine
Rai, K. R., Freter, C. E., Mercier, R. J., Cooper, M. R., Mitchell, B. S., & Brettman, L. (2002). Alemtuzumab in previously treated chronic lymphocytic leukemia patients who also had received fludarabine. JOURNAL OF CLINICAL ONCOLOGY, 20(18), 3891-3897.

A77 1726 induces differentiation of human myeloid leukemia K562 cells by depletion of intracellular CTP pools
Huang, M., Wang, Y. H., Collins, M., Mitchell, B. S., & Graves, L. M. (2002). A77 1726 induces differentiation of human myeloid leukemia K562 cells by depletion of intracellular CTP pools. MOLECULAR PHARMACOLOGY, 62(3), 463-472.

Inhibition of nucleoside transport by p38 MAPK inhibitors
Huang, M., Wang, Y. H., Collins, M., Gu, J. J., Mitchell, B. S., & Graves, L. M. (2002). Inhibition of nucleoside transport by p38 MAPK inhibitors. JOURNAL OF BIOLOGICAL CHEMISTRY, 277(32), 28364-28367.

Cyclosporin A and FK506 decrease adenosine kinase activity and adenosine uptake in T-lymphocytes
Spychala, J., & Mitchell, B. S. (2002). Cyclosporin A and FK506 decrease adenosine kinase activity and adenosine uptake in T-lymphocytes. JOURNAL OF LABORATORY AND CLINICAL MEDICINE, 140(2), 84-91.

Association of DNA polymerase mu (pol mu) with Ku and ligase IV: Role for pol mu in end-joining double-strand break repair
Mahajan, K. N., McElhinny, S. An., Mitchell, B. S., & Ramsden, D. A. (2002). Association of DNA polymerase mu (pol mu) with Ku and ligase IV: Role for pol mu in end-joining double-strand break repair. MOLECULAR AND CELLULAR BIOLOGY, 22(14), 5194-5202.

Arabinosylguanine is phosphorylated by both cytoplasmic deoxycytidine kinase and mitochondrial deoxyguanosine kinase
Rodriguez, C. O., Mitchell, B. S., Ayres, M., Eriksson, S., & Gandhi, V. (2002). Arabinosylguanine is phosphorylated by both cytoplasmic deoxycytidine kinase and mitochondrial deoxyguanosine kinase. CANCER RESEARCH, 62(11), 3100-3105.

Tumor uptake and elimination of 2 ',2 '-difluoro-2 '-deoxycytidine (gemcitabine) after deoxycytidine kinase gene transfer: Correlation with in vivo tumor response
Blackstock, A. W., Lightfoot, H., Case, L. D., Tepper, J. E., Mukherji, S. K., & Hess, S. M. (2001). Tumor uptake and elimination of 2 ',2 '-difluoro-2 '-deoxycytidine (gemcitabine) after deoxycytidine kinase gene transfer: Correlation with in vivo tumor response. CLINICAL CANCER RESEARCH, 7(10), 3263-3268.

Human cytosolic 5 '-nucleotidase I - Characterization and role in nucleoside analog resistance
Hunsucker, S. A., Spychala, J., & Mitchell, B. S. (2001). Human cytosolic 5 '-nucleotidase I - Characterization and role in nucleoside analog resistance. JOURNAL OF BIOLOGICAL CHEMISTRY, 276(13), 10498-10504.

Inhibition of T lymphocyte activation in mice heterozygous for loss of the IMPDH II gene
Gu, J. J., Stegmann, S., Gathy, K., Murray, R., Laliberte, J., & Mitchell, B. S. (2000). Inhibition of T lymphocyte activation in mice heterozygous for loss of the IMPDH II gene. JOURNAL OF CLINICAL INVESTIGATION, 106(4), 599-606.

Association of terminal deoxynucleotidyl transferase with Ku
Mahajan, K. N., Gangi-Peterson, L., Sorscher, D. H., Wang, J. S., Gathy, K. N., & Mitchell, B. S. (1999). Association of terminal deoxynucleotidyl transferase with Ku. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 96(24), 13926-13931.

Tissue-specific regulation of the ecto-5 '-nucleotidase promoter - Role of the cAMP response element site in mediating repression by the upstream regulatory region
Spychala, J., Zimmermann, A. G., & Mitchell, B. S. (1999). Tissue-specific regulation of the ecto-5 '-nucleotidase promoter - Role of the cAMP response element site in mediating repression by the upstream regulatory region. JOURNAL OF BIOLOGICAL CHEMISTRY, 274(32), 22705-22712.

Nucleotide pool imbalance and adenosine deaminase deficiency induce alterations of N-region insertions during V(D)J recombination
Gangi-Peterson, L., Sorscher, D. H., Reynolds, J. W., Kepler, T. B., & Mitchell, B. S. (1999). Nucleotide pool imbalance and adenosine deaminase deficiency induce alterations of N-region insertions during V(D)J recombination. JOURNAL OF CLINICAL INVESTIGATION, 103(6), 833-841.

ATP and phosphate reciprocally affect subunit association of human recombinant High Km 5 '-nucleotidase - Role for the C-terminal polyglutamic acid tract in subunit association and catalytic activity
Spychala, J., Chen, V., Oka, J., & Mitchell, B. S. (1999). ATP and phosphate reciprocally affect subunit association of human recombinant High Km 5 '-nucleotidase - Role for the C-terminal polyglutamic acid tract in subunit association and catalytic activity. EUROPEAN JOURNAL OF BIOCHEMISTRY, 259(3), 851-858.

The use of the lectin Helix pomatia agglutinin (HPA) as a prognostic indicator and as a tool in cancer research
Mitchell, B. S., & Schumacher, U. (1999). The use of the lectin Helix pomatia agglutinin (HPA) as a prognostic indicator and as a tool in cancer research. HISTOLOGY AND HISTOPATHOLOGY, 14(1), 217-226.

Compound GW506U78 in refractory hematologic malignancies: Relationship between cellular pharmacokinetics and clinical response
Gandhi, V., Plunkett, W., Rodriguez, C. O., Nowak, B. J., Du, M., & Keating, M. J. (1998). Compound GW506U78 in refractory hematologic malignancies: Relationship between cellular pharmacokinetics and clinical response. JOURNAL OF CLINICAL ONCOLOGY, 16(11), 3607-3615.

Effects of guanine nucleotide depletion on cell cycle progression in human T lymphocytes
Laliberte, J., Yee, A., Xiong, Y., & Mitchell, B. S. (1998). Effects of guanine nucleotide depletion on cell cycle progression in human T lymphocytes. BLOOD, 91(8), 2896-2904.

Lectin histochemistry of human leukaemic mast cells (HMC-1) transplanted into severe combined immunodeficient (scid) mice
Schumacher, U., Van Damme, E. Jm., Peumans, W. J., Butterfield, J. H., & Mitchell, B. S. (1998). Lectin histochemistry of human leukaemic mast cells (HMC-1) transplanted into severe combined immunodeficient (scid) mice. ACTA HISTOCHEMICA, 100(1), 1-9.

Effects of guanine nucleotide depletion on cell cycle progression in human T lymphocytes
Laliberte J, Yee A, Xiong Y, & Mitchell BS. (1998). Effects of guanine nucleotide depletion on cell cycle progression in human T lymphocytes. Blood.

Inosine-5 '-monophosphate dehydrogenase: Regulation of expression and role in cellular proliferation and T lymphocyte activation
Zimmermann, A. G., Gu, J. J., Laliberte, J., & Mitchell, B. S. (1998). Inosine-5 '-monophosphate dehydrogenase: Regulation of expression and role in cellular proliferation and T lymphocyte activation. PROGRESS IN NUCLEIC ACID RESEARCH AND MOLECULAR BIOLOGY, VOL 61, 61, 181-209.

Regulation of inosine-5'-monophosphate dehydrogenase type II gene expression in human T cells - Role for a novel 5' palindromic octamer sequence
Zimmermann, A. G., Wright, K. L., Ting, J. Py., & Mitchell, B. S. (1997). Regulation of inosine-5'-monophosphate dehydrogenase type II gene expression in human T cells - Role for a novel 5' palindromic octamer sequence. JOURNAL OF BIOLOGICAL CHEMISTRY, 272(36), 22913-22923.

Cellular delivery of nucleoside diphosphates: A prodrug approach
Kang, S. H., Sinhababu, A. K., Cory, J. G., Mitchell, B. S., Thakker, D. R., & Cho, M. J. (1997). Cellular delivery of nucleoside diphosphates: A prodrug approach. PHARMACEUTICAL RESEARCH, 14(6), 706-712.

Adenosine metabolism during phorbol myristate acetate-mediated induction of HL-60 cell difference - Changes in expression pattern of adenosine kinase, adenosine deaminase, and 5'-nucleotidase
Spychala, J., Mitchell, B. S., & BARANKIEWICZ, J. (1997). Adenosine metabolism during phorbol myristate acetate-mediated induction of HL-60 cell difference - Changes in expression pattern of adenosine kinase, adenosine deaminase, and 5'-nucleotidase. JOURNAL OF IMMUNOLOGY, 158(10), 4947-4952.

Regulation of the human inosine monophosphate dehydrogenase type I gene - Utilization of alternative promoters
Gu, J. J., Spychala, J., & Mitchell, B. S. (1997). Regulation of the human inosine monophosphate dehydrogenase type I gene - Utilization of alternative promoters. JOURNAL OF BIOLOGICAL CHEMISTRY, 272(7), 4458-4466.

Retroviral transfer of deoxycytidine kinase into tumor cell lines enhances nucleoside toxicity
Hapke, D. M., Stegmann, A. Pa., & Mitchell, B. S. (1996). Retroviral transfer of deoxycytidine kinase into tumor cell lines enhances nucleoside toxicity. CANCER RESEARCH, 56(10), 2343-2347.

Viral vector transduction of the human deoxycytidine kinase cDNA sensitizes glioma cells to the cytotoxic effects of cytosine arabinoside in vitro and in vivo
Manome, Y., Wen, P. Y., Dong, Y. H., Tanaka, T., Mitchell, B. S., & Fine, H. A. (1996). Viral vector transduction of the human deoxycytidine kinase cDNA sensitizes glioma cells to the cytotoxic effects of cytosine arabinoside in vitro and in vivo. NATURE MEDICINE, 2(5), 567-573.

Cloning of human adenosine kinase cDNA: Sequence similarity to microbial ribokinases and fructokinases
Spychala, J., Datta, N. S., Takabayashi, K., Datta, M., Fox, I. H., & Mitchell, B. S. (1996). Cloning of human adenosine kinase cDNA: Sequence similarity to microbial ribokinases and fructokinases. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 93(3), 1232-1237.

Inosine monophosphate dehydrogenase expression: Transcriptional regulation of the type I and type II genes
Zimmermann, A., Gu, J. J., Spychala, J., & Mitchell, B. S. (1996). Inosine monophosphate dehydrogenase expression: Transcriptional regulation of the type I and type II genes. ADVANCES IN ENZYME REGULATION, VOL 36, 36, 75-84.

Transcriptional regulationof the IMPDH type I and II genes
Zimmermann A, Gu JJ, Spychala j, & Mitchell BS. (1996). Transcriptional regulationof the IMPDH type I and II genes. Adv Enzyme Regul, (36).

A 73 year-old woman with anemia and thrombocytopenia
Mitchell B, & Brecher M. (1996). A 73 year-old woman with anemia and thrombocytopenia. J Am Ger Soc, (44).

RECOMBINANT HUMAN INOSINE MONOPHOSPHATE DEHYDROGENASE TYPE-I AND TYPE-II PROTEINS - PURIFICATION AND CHARACTERIZATION OF INHIBITOR BINDING
Hager, P. W., COLLART, F. R., HUBERMAN, E., & Mitchell, B. S. (1995). RECOMBINANT HUMAN INOSINE MONOPHOSPHATE DEHYDROGENASE TYPE-I AND TYPE-II PROTEINS - PURIFICATION AND CHARACTERIZATION OF INHIBITOR BINDING. BIOCHEMICAL PHARMACOLOGY, 49(9), 1323-1329.

GTP DEPLETION INDUCED BY IMP DEHYDROGENASE INHIBITORS BLOCKS RNA-PRIMED DNA-SYNTHESIS
Catapano, C. V., DAYTON, J. S., Mitchell, B. S., & Fernandes, D. J. (1995). GTP DEPLETION INDUCED BY IMP DEHYDROGENASE INHIBITORS BLOCKS RNA-PRIMED DNA-SYNTHESIS. MOLECULAR PHARMACOLOGY, 47(5), 948-955.

CHARACTERIZATION OF THE DEOXYCYTIDINE KINASE PROMOTER IN HUMAN LYMPHOBLAST CELL-LINES
Chen, E. H., Johnson, E. E., Vetter, S. M., & Mitchell, B. S. (1995). CHARACTERIZATION OF THE DEOXYCYTIDINE KINASE PROMOTER IN HUMAN LYMPHOBLAST CELL-LINES. JOURNAL OF CLINICAL INVESTIGATION, 95(4), 1660-1668.

CHARACTERIZATION OF THE HUMAN INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE TYPE-II GENES
Zimmermann, A. G., Spychala, J., & Mitchell, B. S. (1995). CHARACTERIZATION OF THE HUMAN INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE TYPE-II GENES. JOURNAL OF BIOLOGICAL CHEMISTRY, 270(12), 6808-6814.

ASSIGNMENT OF THE HUMAN TYPE-I IMP DEHYDROGENASE GENE (IMPDH1) TO CHROMOSOME 7Q31.3-Q32
Gu, J. J., KAISERROGERS, K., Rao, K., & Mitchell, B. S. (1994). ASSIGNMENT OF THE HUMAN TYPE-I IMP DEHYDROGENASE GENE (IMPDH1) TO CHROMOSOME 7Q31.3-Q32. GENOMICS, 24(1), 179-181.

HEREDITARY OVEREXPRESSION OF ADENOSINE-DEAMINASE IN ERYTHROCYTES - STUDIES IN ERYTHROID CELL-LINES AND TRANSGENIC MICE
Chen, E. H., & Mitchell, B. S. (1994). HEREDITARY OVEREXPRESSION OF ADENOSINE-DEAMINASE IN ERYTHROCYTES - STUDIES IN ERYTHROID CELL-LINES AND TRANSGENIC MICE. BLOOD, 84(7), 2346-2353.

STRUCTURAL-ANALYSIS OF THE DEOXYCYTIDINE KINASE GENE IN PATIENTS WITH ACUTE MYELOID-LEUKEMIA AND RESISTANCE TO CYTOSINE-ARABINOSIDE
Flasshove, M., Strumberg, D., Ayscue, L., Mitchell, B. S., Tirier, C., & Schutte, J. (1994). STRUCTURAL-ANALYSIS OF THE DEOXYCYTIDINE KINASE GENE IN PATIENTS WITH ACUTE MYELOID-LEUKEMIA AND RESISTANCE TO CYTOSINE-ARABINOSIDE. LEUKEMIA, 8(5), 780-785.

EFFECTS OF HUMAN T-LYMPHOCYTE ACTIVATION ON INOSINE MONOPHOSPHATE DEHYDROGENASE EXPRESSION
DAYTON, J. S., LINDSTEN, T., Thompson, C. B., & Mitchell, B. S. (1994). EFFECTS OF HUMAN T-LYMPHOCYTE ACTIVATION ON INOSINE MONOPHOSPHATE DEHYDROGENASE EXPRESSION. JOURNAL OF IMMUNOLOGY, 152(3), 984-991.

Regulation of low Km (Ecto-) 5'-nucleotidase gene expression in leukemic cells
Spychala, J., & Mitchell, B. S. (1994). Regulation of low Km (Ecto-) 5'-nucleotidase gene expression in leukemic cells. PURINE AND PYRIMIDINE METABOLISM IN MAN VIII, 370, 683-687.

HEREDITARY OVEREXPRESSION OF ADENOSINE-DEAMINASE IN ERYTHROCYTES - EVIDENCE FOR A CIS-ACTING MUTATION
Chen, E. H., TARTAGLIA, A. P., & Mitchell, B. S. (1993). HEREDITARY OVEREXPRESSION OF ADENOSINE-DEAMINASE IN ERYTHROCYTES - EVIDENCE FOR A CIS-ACTING MUTATION. AMERICAN JOURNAL OF HUMAN GENETICS, 53(4), 889-893.

TYPE-I INOSINE MONOPHOSPHATE DEHYDROGENASE - EVIDENCE FOR A SINGLE FUNCTIONAL GENE IN MAMMALIAN-SPECIES
DAYTON, J. S., & Mitchell, B. S. (1993). TYPE-I INOSINE MONOPHOSPHATE DEHYDROGENASE - EVIDENCE FOR A SINGLE FUNCTIONAL GENE IN MAMMALIAN-SPECIES. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 195(2), 897-901.

GENOMIC STRUCTURE AND CHROMOSOMAL LOCALIZATION OF THE HUMAN DEOXYCYTIDINE KINASE GENE
Song, J. J., Walker, S., Chen, E., Johnson, E. E., Spychala, J., & Mitchell, B. S. (1993). GENOMIC STRUCTURE AND CHROMOSOMAL LOCALIZATION OF THE HUMAN DEOXYCYTIDINE KINASE GENE. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 90(2), 431-434.

REGULATION OF HUMAN DEOXYCYTIDINE KINASE EXPRESSION
Mitchell, B. S., Song, J. J., Johnson, E. E., Chen, E., & DAYTON, J. S. (1993). REGULATION OF HUMAN DEOXYCYTIDINE KINASE EXPRESSION. PERGAMON PRESS LTD.

IMP DEHYDROGENASE INHIBITORS AS IMMUNOMODULATORS
Mitchell, B. S., DAYTON, J. S., Turka, L. A., & Thompson, C. B. (1993). IMP DEHYDROGENASE INHIBITORS AS IMMUNOMODULATORS. IMMUNOMODULATING DRUGS, 685, 217-224.

RESISTANCE TO 1-BETA-D-ARABINOFURANOSYLCYTOSINE IN HUMAN T-LYMPHOBLASTS MEDIATED BY MUTATIONS WITHIN THE DEOXYCYTIDINE KINASE GENE
Owens, J. K., Shewach, D. S., Ullman, B., & Mitchell, B. S. (1992). RESISTANCE TO 1-BETA-D-ARABINOFURANOSYLCYTOSINE IN HUMAN T-LYMPHOBLASTS MEDIATED BY MUTATIONS WITHIN THE DEOXYCYTIDINE KINASE GENE. CANCER RESEARCH, 52(9), 2389-2393.

COMPARISON OF THE EFFECTS OF MIZORIBINE WITH THOSE OF AZATHIOPRINE, 6-MERCAPTOPURINE, AND MYCOPHENOLIC-ACID ON LYMPHOCYTE-T PROLIFERATION AND PURINE RIBONUCLEOTIDE METABOLISM
DAYTON, J. S., Turka, L. A., Thompson, C. B., & Mitchell, B. S. (1992). COMPARISON OF THE EFFECTS OF MIZORIBINE WITH THOSE OF AZATHIOPRINE, 6-MERCAPTOPURINE, AND MYCOPHENOLIC-ACID ON LYMPHOCYTE-T PROLIFERATION AND PURINE RIBONUCLEOTIDE METABOLISM. MOLECULAR PHARMACOLOGY, 41(4), 671-676.

GUANINE RIBONUCLEOTIDE DEPLETION INHIBITS T-CELL ACTIVATION - MECHANISM OF ACTION OF THE IMMUNOSUPPRESSIVE DRUG MIZORIBINE
Turka, L. A., Dayton, J., Sinclair, G., Thompson, C. B., & Mitchell, B. S. (1991). GUANINE RIBONUCLEOTIDE DEPLETION INHIBITS T-CELL ACTIVATION - MECHANISM OF ACTION OF THE IMMUNOSUPPRESSIVE DRUG MIZORIBINE. JOURNAL OF CLINICAL INVESTIGATION, 87(3), 940-948.

CLONING AND EXPRESSION OF HUMAN DEOXYCYTIDINE KINASE CDNA
CHOTTINER, E. G., Shewach, D. S., Datta, N. S., Ashcraft, E., GRIBBIN, D., & Mitchell, B. S. (1991). CLONING AND EXPRESSION OF HUMAN DEOXYCYTIDINE KINASE CDNA. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 88(4), 1531-1535.

Guanine ribonucleotide depletion inhibits T cell activation.
DAYTON, J. S., Turka, L. A., Thompson, C. B., & Mitchell, B. S. (1991). Guanine ribonucleotide depletion inhibits T cell activation. Advances in experimental medicine and biology, 309B, 293-296.

Development of an in vitro model system to study the physiologic effects and toxicities of immunosuppressants
Thompson CB, Jackson KM, Turka LA, Mitchell BS, & June CH. (1991). Development of an in vitro model system to study the physiologic effects and toxicities of immunosuppressants. Alternative Methods in Toxicology, 8.

CD11C (LEU-M5) EXPRESSION CHARACTERIZES A B-CELL CHRONIC LYMPHOPROLIFERATIVE DISORDER WITH FEATURES OF BOTH CHRONIC LYMPHOCYTIC-LEUKEMIA AND HAIRY-CELL LEUKEMIA
Hanson, C. A., Gribbin, T. E., SCHNITZER, B., SCHLEGELMILCH, J. A., Mitchell, B. S., & Stoolman, L. M. (1990). CD11C (LEU-M5) EXPRESSION CHARACTERIZES A B-CELL CHRONIC LYMPHOPROLIFERATIVE DISORDER WITH FEATURES OF BOTH CHRONIC LYMPHOCYTIC-LEUKEMIA AND HAIRY-CELL LEUKEMIA. BLOOD, 76(11), 2360-2367.

MUTATIONS INDUCED AT THE HYPOXANTHINE-GUANINE PHOSPHORIBOSYLTRANSFERASE LOCUS OF HUMAN T-LYMPHOBLASTS BY PERTURBATIONS OF PURINE DEOXYRIBONUCLEOSIDE TRIPHOSPHATE POOLS
Mattano, S. S., PALELLA, T. D., & Mitchell, B. S. (1990). MUTATIONS INDUCED AT THE HYPOXANTHINE-GUANINE PHOSPHORIBOSYLTRANSFERASE LOCUS OF HUMAN T-LYMPHOBLASTS BY PERTURBATIONS OF PURINE DEOXYRIBONUCLEOSIDE TRIPHOSPHATE POOLS. CANCER RESEARCH, 50(15), 4566-4571.

DIFFERENTIAL METABOLISM OF 9-BETA-D-ARABINOFURANOSYLGUANINE IN HUMAN-LEUKEMIC CELLS
Shewach, D. S., & Mitchell, B. S. (1989). DIFFERENTIAL METABOLISM OF 9-BETA-D-ARABINOFURANOSYLGUANINE IN HUMAN-LEUKEMIC CELLS. CANCER RESEARCH, 49(23), 6498-6502.

ASSOCIATION OF A MATURE B-CELL LEUKEMIA WITH A 4P+ CHROMOSOMAL ABNORMALITY - DERIVATION AND CHARACTERIZATION OF A CELL-LINE
Gribbin, T. E., Stein, C. K., Harrison, J. S., Glover, T. W., Hanson, C. A., & Mitchell, B. S. (1989). ASSOCIATION OF A MATURE B-CELL LEUKEMIA WITH A 4P+ CHROMOSOMAL ABNORMALITY - DERIVATION AND CHARACTERIZATION OF A CELL-LINE. LEUKEMIA, 3(9), 643-647.

ERYTHROCYTE ADENOSINE-DEAMINASE OVERPRODUCTION IN HEREDITARY HEMOLYTIC-ANEMIA
CHOTTINER, E. G., Ginsburg, D., TARTAGLIA, A. P., & Mitchell, B. S. (1989). ERYTHROCYTE ADENOSINE-DEAMINASE OVERPRODUCTION IN HEREDITARY HEMOLYTIC-ANEMIA. BLOOD, 74(1), 448-453.

KINETIC-PROPERTIES AND INHIBITION OF HUMAN LYMPHOBLAST-T DEOXYCYTIDINE KINASE
Datta, N. S., Shewach, D. S., Mitchell, B. S., & Fox, I. H. (1989). KINETIC-PROPERTIES AND INHIBITION OF HUMAN LYMPHOBLAST-T DEOXYCYTIDINE KINASE. JOURNAL OF BIOLOGICAL CHEMISTRY, 264(16), 9359-9364.

HUMAN T-LYMPHOBLAST DEOXYCYTIDINE KINASE - PURIFICATION AND PROPERTIES
Datta, N. S., Shewach, D. S., Hurley, M. C., Mitchell, B. S., & Fox, I. H. (1989). HUMAN T-LYMPHOBLAST DEOXYCYTIDINE KINASE - PURIFICATION AND PROPERTIES. BIOCHEMISTRY, 28(1), 114-123.

Properties of highly purified human T lymphoblast (MOLT-4) deoxycytidine kinase.
Datta, N. S., Shewach, D. S., Hurley, M. C., Mitchell, B. S., & Fox, I. H. (1989). Properties of highly purified human T lymphoblast (MOLT-4) deoxycytidine kinase. Advances in experimental medicine and biology, 253B, 87-92.

Identification of an Apa I polymorphism within the human adenosine deaminase gene
Gribbin TE, Chottiner E, Ginsburg D, & Mitchell BS. (1989). Identification of an Apa I polymorphism within the human adenosine deaminase gene. Nucl Acids Res, (17).

Erythrocyte-specific overproduction of adenosine deaminase: molecular genetic studies.
CHOTTINER, E. G., Gribbin, T. E., Ginsburg, D., & Mitchell, B. S. (1989). Erythrocyte-specific overproduction of adenosine deaminase: molecular genetic studies. Progress in clinical and biological research, 319, 55-64.

Autosomal dominant hemolytic anemia and adenosine deaminase overproduction.
CHOTTINER, E. G., Ginsburg, D., & Mitchell, B. S. (1989). Autosomal dominant hemolytic anemia and adenosine deaminase overproduction. Advances in experimental medicine and biology, 253A, 493-497.

GENETIC EXPRESSION OF ADENOSINE-DEAMINASE IN HUMAN LYMPHOID MALIGNANCIES
Gan, T. E., DADONNA, P. E., & Mitchell, B. S. (1987). GENETIC EXPRESSION OF ADENOSINE-DEAMINASE IN HUMAN LYMPHOID MALIGNANCIES. BLOOD, 69(5), 1376-1380.

TRANSCRIPTIONAL REGULATION OF THE C-MYC PROTOONCOGENE BY 1,25-DIHYDROXYVITAMIN-D3 IN HL-60 PROMYELOCYTIC LEUKEMIA-CELLS
Simpson, R. U., Hsu, T., Begley, D. A., Mitchell, B. S., & ALIZADEH, B. N. (1987). TRANSCRIPTIONAL REGULATION OF THE C-MYC PROTOONCOGENE BY 1,25-DIHYDROXYVITAMIN-D3 IN HL-60 PROMYELOCYTIC LEUKEMIA-CELLS. JOURNAL OF BIOLOGICAL CHEMISTRY, 262(9), 4104-4108.

ELEVATED ADENOSINE-DEAMINASE ACTIVITY AND HEREDITARY HEMOLYTIC-ANEMIA - EVIDENCE FOR ABNORMAL TRANSLATIONAL CONTROL OF PROTEIN-SYNTHESIS
CHOTTINER, E. G., Cloft, H. J., TARTAGLIA, A. P., & Mitchell, B. S. (1987). ELEVATED ADENOSINE-DEAMINASE ACTIVITY AND HEREDITARY HEMOLYTIC-ANEMIA - EVIDENCE FOR ABNORMAL TRANSLATIONAL CONTROL OF PROTEIN-SYNTHESIS. JOURNAL OF CLINICAL INVESTIGATION, 79(3), 1001-1005.

Molecular basis for elevated adenosine deaminase activity in a kindred with hemolytic anemia
Chottiner EG, Cloft H, Tartaglia A, & Mitchell BS. (1987). Molecular basis for elevated adenosine deaminase activity in a kindred with hemolytic anemia. J Clin Invest.

Characterization of arabinosylguanine resistance in a lymphoblastoid cell line.
Shewach, D. S., & Mitchell, B. S. (1986). Characterization of arabinosylguanine resistance in a lymphoblastoid cell line. Advances in experimental medicine and biology, 195, 605-609.

Z-NUCLEOTIDE ACCUMULATION IN ERYTHROCYTES FROM LESCH-NYHAN PATIENTS
Sidi, Y., & Mitchell, B. S. (1985). Z-NUCLEOTIDE ACCUMULATION IN ERYTHROCYTES FROM LESCH-NYHAN PATIENTS. JOURNAL OF CLINICAL INVESTIGATION, 76(6), 2416-2419.

BIOCHEMICAL CONSEQUENCES OF ADENOSINE-DEAMINASE INHIBITION INVIVO - DIFFERENTIAL-EFFECTS IN ACUTE AND CHRONIC T-CELL LEUKEMIA
Mitchell, B. S., Sidi, Y., Hershfield, M., & Koller, C. A. (1985). BIOCHEMICAL CONSEQUENCES OF ADENOSINE-DEAMINASE INHIBITION INVIVO - DIFFERENTIAL-EFFECTS IN ACUTE AND CHRONIC T-CELL LEUKEMIA. ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, 451(OCT), 129-137.

DIFFERENTIAL METABOLISM OF DEOXYRIBONUCLEOSIDES BY LEUKEMIC T-CELLS OF IMMATURE AND MATURE PHENOTYPE
Sidi, Y., Edwards, N. L., Winkler, C., Bunn, P., & Mitchell, B. S. (1985). DIFFERENTIAL METABOLISM OF DEOXYRIBONUCLEOSIDES BY LEUKEMIC T-CELLS OF IMMATURE AND MATURE PHENOTYPE. BRITISH JOURNAL OF HAEMATOLOGY, 61(1), 125-134.

EFFECTS OF GUANINE RIBONUCLEOTIDE ACCUMULATION ON THE METABOLISM AND CELL-CYCLE OF HUMAN LYMPHOID-CELLS
Sidi, Y., Hudson, J. L., & Mitchell, B. S. (1985). EFFECTS OF GUANINE RIBONUCLEOTIDE ACCUMULATION ON THE METABOLISM AND CELL-CYCLE OF HUMAN LYMPHOID-CELLS. CANCER RESEARCH, 45(10), 4940-4945.

Differential metabolism of deoxyribonucleosides by leukaemic T cells of immature and mature phenotype
Sidi Y, Edwards N, Winkler C, Bunn P, & Mitchell B. (1985). Differential metabolism of deoxyribonucleosides by leukaemic T cells of immature and mature phenotype. Br J Haemat, (61).

DIFFERENTIAL METABOLISM OF GUANINE NUCLEOSIDES BY HUMAN LYMPHOID-CELL LINES
Mitchell, B. S., & Sidi, Y. (1985). DIFFERENTIAL METABOLISM OF GUANINE NUCLEOSIDES BY HUMAN LYMPHOID-CELL LINES. PROCEEDINGS OF THE SOCIETY FOR EXPERIMENTAL BIOLOGY AND MEDICINE, 179(4), 427-431.

METABOLISM AND SELECTIVE CYTO-TOXICITY OF 9-BETA-D-ARABINOFURANOSYLGUANINE IN HUMAN-LYMPHOBLASTS
Shewach, D. S., Daddona, P. E., Ashcraft, E., & Mitchell, B. S. (1985). METABOLISM AND SELECTIVE CYTO-TOXICITY OF 9-BETA-D-ARABINOFURANOSYLGUANINE IN HUMAN-LYMPHOBLASTS. CANCER RESEARCH, 45(3), 1008-1014.

PLASMA-MEMBRANE 5'-NUCLEOTIDASE AND OTHER PURINE ENZYMES IN MURINE LYMPHOCYTES
Edwards, N. L., Mitchell, B. S., Fox, I. H., & Mond, J. J. (1984). PLASMA-MEMBRANE 5'-NUCLEOTIDASE AND OTHER PURINE ENZYMES IN MURINE LYMPHOCYTES. ADVANCES IN EXPERIMENTAL MEDICINE AND BIOLOGY, 165, 129-132.

Erythrocyte ATP a dATP measurements predict toxicity following 2'-deoxycoformycin therapy
Koller C, & Mitchell B. (1984). Erythrocyte ATP a dATP measurements predict toxicity following 2'-deoxycoformycin therapy. Cancer Treat Symp.

2'-DEOXYGUANOSINE TOXICITY FOR B-LYMPHOID AND MATURE T-LYMPHOID CELL-LINES IS MEDIATED BY GUANINE RIBONUCLEOTIDE ACCUMULATION
Sidi, Y., & Mitchell, B. S. (1984). 2'-DEOXYGUANOSINE TOXICITY FOR B-LYMPHOID AND MATURE T-LYMPHOID CELL-LINES IS MEDIATED BY GUANINE RIBONUCLEOTIDE ACCUMULATION. JOURNAL OF CLINICAL INVESTIGATION, 74(5), 1640-1648.

PURINE METABOLIZING ENZYMES AS PREDICTORS OF LYMPHOBLAST SENSITIVITY TO DEOXYADENOSINE
Mitchell, B. S., & Edwards, N. L. (1984). PURINE METABOLIZING ENZYMES AS PREDICTORS OF LYMPHOBLAST SENSITIVITY TO DEOXYADENOSINE. JOURNAL OF LABORATORY AND CLINICAL MEDICINE, 104(3), 414-424.

ALTERATIONS IN ERYTHROCYTE ADENINE-NUCLEOTIDE POOLS RESULTING FROM 2'-DEOXYCOFORMYCIN THERAPY
Koller, C. A., & Mitchell, B. S. (1983). ALTERATIONS IN ERYTHROCYTE ADENINE-NUCLEOTIDE POOLS RESULTING FROM 2'-DEOXYCOFORMYCIN THERAPY. CANCER RESEARCH, 43(3), 1409-1414.

DEOXYRIBONUCLEOSIDE TRIPHOSPHATE ACCUMULATION BY LEUKEMIC-CELLS
Mitchell, B. S., Edwards, N. L., & Koller, C. A. (1983). DEOXYRIBONUCLEOSIDE TRIPHOSPHATE ACCUMULATION BY LEUKEMIC-CELLS. BLOOD, 62(2), 419-424.

S-ADENOSYLHOMOCYSTEINE CATABOLISM AND BASIS FOR ACQUIRED-RESISTANCE DURING TREATMENT OF T-CELL ACUTE LYMPHOBLASTIC-LEUKEMIA WITH 2'-DEOXYCOFORMYCIN ALONE AND IN COMBINATION WITH 9-BETA-D-ARABINOFURANOSYLADENINE
Hershfield, M. S., Kredich, N. M., Koller, C. A., Mitchell, B. S., Kurtzberg, J., & FALLETTA, J. M. (1983). S-ADENOSYLHOMOCYSTEINE CATABOLISM AND BASIS FOR ACQUIRED-RESISTANCE DURING TREATMENT OF T-CELL ACUTE LYMPHOBLASTIC-LEUKEMIA WITH 2'-DEOXYCOFORMYCIN ALONE AND IN COMBINATION WITH 9-BETA-D-ARABINOFURANOSYLADENINE. CANCER RESEARCH, 43(7), 3451-3458.

ADENOSINE-DEAMINASE DEFICIENCY WITH NORMAL IMMUNE FUNCTION - AN ACIDIC ENZYME MUTATION
Daddona, P. E., Mitchell, B. S., Meuwissen, H. J., Davidson, B. L., Wilson, J. M., & Koller, C. A. (1983). ADENOSINE-DEAMINASE DEFICIENCY WITH NORMAL IMMUNE FUNCTION - AN ACIDIC ENZYME MUTATION. JOURNAL OF CLINICAL INVESTIGATION, 72(2), 483-492.

Deficiencies of adenosine deaminase and purine nucleoside phosphorylase: Implimcations for immunopharmacology
Mitchell BS. (1982). Deficiencies of adenosine deaminase and purine nucleoside phosphorylase: Implimcations for immunopharmacology. Med Gr Rounds.

Adult T-cell leukaemia-lymphoma with unusual phenotype
Schnitzer B, Lovett E, Hudson J, McClatchey K, Keren D, & Mitchell B. (1982). Adult T-cell leukaemia-lymphoma with unusual phenotype. The Lancet (Letter).

INHIBITION OF PURINE NUCLEOSIDE PHOSPHORYLASE BY 8-AMINOGUANOSINE - SELECTIVE TOXICITY FOR T-LYMPHOBLASTS
Kazmers, I. S., Mitchell, B. S., DADONNA, P. E., Wotring, L. L., Townsend, L. B., & Kelley, W. N. (1981). INHIBITION OF PURINE NUCLEOSIDE PHOSPHORYLASE BY 8-AMINOGUANOSINE - SELECTIVE TOXICITY FOR T-LYMPHOBLASTS. SCIENCE, 214(4525), 1137-1139.

INHIBITION OF ADENOSINE-DEAMINASE ACTIVITY RESULTS IN CYTO-TOXICITY TO T-LYMPHOBLASTS INVIVO
Mitchell, B. S., Koller, C. A., & Heyn, R. (1980). INHIBITION OF ADENOSINE-DEAMINASE ACTIVITY RESULTS IN CYTO-TOXICITY TO T-LYMPHOBLASTS INVIVO. BLOOD, 56(3), 556-559.

PURINOGENIC IMMUNODEFICIENCY DISEASES - CLINICAL-FEATURES AND MOLECULAR MECHANISMS
Mitchell, B. S., & Kelley, W. N. (1980). PURINOGENIC IMMUNODEFICIENCY DISEASES - CLINICAL-FEATURES AND MOLECULAR MECHANISMS. ANNALS OF INTERNAL MEDICINE, 92(6), 826-831.

AN ASSAY OF DEOXYADENOSINE AND ADENOSINE IN HUMAN-PLASMA BY HPLC
Koller, C. A., Stetson, P. L., Nichamin, L. D., & Mitchell, B. S. (1980). AN ASSAY OF DEOXYADENOSINE AND ADENOSINE IN HUMAN-PLASMA BY HPLC. BIOCHEMICAL MEDICINE, 24(2), 179-184.

MULTIPLE-MYELOMA - CURRENT CONCEPTS IN DIAGNOSIS AND MANAGEMENT
Paredes, J. M., & Mitchell, B. S. (1980). MULTIPLE-MYELOMA - CURRENT CONCEPTS IN DIAGNOSIS AND MANAGEMENT. MEDICAL CLINICS OF NORTH AMERICA, 64(4), 729-742.

ATP DEPLETION AS A CONSEQUENCE OF ADENOSINE-DEAMINASE INHIBITION IN MAN
SIAW, M. Fe., Mitchell, B. S., Koller, C. A., Coleman, M. S., & HUTTON, J. J. (1980). ATP DEPLETION AS A CONSEQUENCE OF ADENOSINE-DEAMINASE INHIBITION IN MAN. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 77(10), 6157-6161.

Treatment of acute lymphoblastic leukemia with the adenosine deaminase inhibitor 2'-deoxycoformycin.
Mitchell, B. S., Koller, C. A., & Kelley, W. N. (1979). Treatment of acute lymphoblastic leukemia with the adenosine deaminase inhibitor 2'-deoxycoformycin. Advances in experimental medicine and biology, 122B, 347-350.

Molecular mechanism(s) of deoxyribonucleoside toxicity in T-lymphoblasts.
Wilson, J. M., Mitchell, B. S., & Kelley, W. N. (1979). Molecular mechanism(s) of deoxyribonucleoside toxicity in T-lymphoblasts. Advances in experimental medicine and biology, 122B, 265-270.

TREATMENT OF ACUTE LYMPHOBLASTIC-LEUKEMIA WITH 2'-DEOXYCOFORMYCIN - CLINICAL AND BIOCHEMICAL CONSEQUENCES OF ADENOSINE-DEAMINASE INHIBITION
Koller, C. A., Mitchell, B. S., Grever, M. R., MEJIAS, E., Malspeis, L., & METZ, E. N. (1979). TREATMENT OF ACUTE LYMPHOBLASTIC-LEUKEMIA WITH 2'-DEOXYCOFORMYCIN - CLINICAL AND BIOCHEMICAL CONSEQUENCES OF ADENOSINE-DEAMINASE INHIBITION. CANCER TREATMENT REPORTS, 63(11-1), 1949-1952.

Possible role for 5'-nucleotidase in deoxyadenosine selective toxicity to cultured human lymphoblasts.
Wortmann, R. L., Mitchell, B. S., Edwards, N. L., & Fox, I. H. (1979). Possible role for 5'-nucleotidase in deoxyadenosine selective toxicity to cultured human lymphoblasts. Advances in experimental medicine and biology, 122B, 243-259.

BIOCHEMICAL BASIS FOR DIFFERENTIAL DEOXYADENOSINE TOXICITY TO LYMPHOBLAST-T AND LYMPHOBLAST-B - ROLE FOR 5'-NUCLEOTIDASE
Wortmann, R. L., Mitchell, B. S., Edwards, N. L., & Fox, I. H. (1979). BIOCHEMICAL BASIS FOR DIFFERENTIAL DEOXYADENOSINE TOXICITY TO LYMPHOBLAST-T AND LYMPHOBLAST-B - ROLE FOR 5'-NUCLEOTIDASE. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 76(5), 2434-2437.

PURINOGENIC IMMUNODEFICIENCY DISEASES - DIFFERENTIAL EFFECTS OF DEOXYADENOSINE AND DEOXYGUANOSINE ON DNA-SYNTHESIS IN HUMAN T-LYMPHOBLASTS
Wilson, J. M., Mitchell, B. S., Daddona, P. E., & Kelley, W. N. (1979). PURINOGENIC IMMUNODEFICIENCY DISEASES - DIFFERENTIAL EFFECTS OF DEOXYADENOSINE AND DEOXYGUANOSINE ON DNA-SYNTHESIS IN HUMAN T-LYMPHOBLASTS. JOURNAL OF CLINICAL INVESTIGATION, 64(5), 1475-1484.

PURINOGENIC IMMUNODEFICIENCY DISEASES - SELECTIVE TOXICITY OF DEOXYRIBONUCLEOSIDES FOR T-CELLS
Mitchell, B. S., MEJIAS, E., Daddona, P. E., & Kelley, W. N. (1978). PURINOGENIC IMMUNODEFICIENCY DISEASES - SELECTIVE TOXICITY OF DEOXYRIBONUCLEOSIDES FOR T-CELLS. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 75(10), 5011-5014.

Uridine diphosphate galactose 4'-epimerase deficiency
Gitzelmann R, Steinmann B, Mitchell B, & Haigis E. (1976). Uridine diphosphate galactose 4'-epimerase deficiency. Helv Paediat Acta, IV(31).

Granulocyte and erythroid colony forming cells from rat marrow: Studies of physical and cell cycle characteristics and competition for expression
Mitchell B, & Adamson J. (1975). Granulocyte and erythroid colony forming cells from rat marrow: Studies of physical and cell cycle characteristics and competition for expression. In Erythropoiesis, Nakao K, Fisher J, Pakaku F (Eds) University Park Press.

Reversal of UDP-galactose 4-epimerase deficiency of human leukocytes in culture
Mitchell B, Haigis E, Steinmann B, & Gitzelmann R. (1975). Reversal of UDP-galactose 4-epimerase deficiency of human leukocytes in culture. Proc Nat Acad Sci (USA), (72).

EPIDEMIOLOGICAL ASPECTS OF NEOPLASTIC DISORDERS IN ISRAELI MIGRANT POPULATION .V. LYMPHOMAS
Modan, B., Goldman, B., Shani, M., Meytes, D., & Mitchell, B. S. (1969). EPIDEMIOLOGICAL ASPECTS OF NEOPLASTIC DISORDERS IN ISRAELI MIGRANT POPULATION .V. LYMPHOMAS. JOURNAL OF THE NATIONAL CANCER INSTITUTE, 42(3), 375-?.

The effect of phenylthiourea on melanogenesis of Fundulus Heteroclitus
Bamford S, Cassin C, & Mitchell B. (1966). The effect of phenylthiourea on melanogenesis of Fundulus Heteroclitus. Biological Bulletin, (131).

SEX CHROMATIN DETERMINATIONS IN SELECTED CASES OF DEVELOPMENTAL SEX ABNORMALITIES WITH AN ASSESSMENT OF RESULTS
BAMFORD, S. B., CASSIN, C. M., & Mitchell, B. S. (1963). SEX CHROMATIN DETERMINATIONS IN SELECTED CASES OF DEVELOPMENTAL SEX ABNORMALITIES WITH AN ASSESSMENT OF RESULTS. ACTA CYTOLOGICA, 7(3), 151-?.