Emmanuel Mignot, MD, PhD

Sleep specialist

Craig Reynolds Professor of Sleep Medicine

Sleep Medicine Center

  • 450 Broadway Street
  • Redwood City, CA 94063
  • Phone: 650-723-6601
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Professional Education

Internship: Necker Enfants Malades Hospital (1984) France

Board Certification: Sleep Medicine, American Board of Sleep Medicine (1990)

Residency: Necker Enfants Malades Hospital (1989) France

Fellowship: Stanford University School of Medicine (1996) CA

Medical Education: University Of Paris (1985) France

Honors & Awards

Elected member, Institute of Medicine (2006)

Sleep Research Society, Outstanding Scientific Achievement Award (2006)

W. Alden Spencer Award, College of Physicians and Surgeons of Columbia University (2004)

Foster Elting Bennett Memorial Lecture Award, American Neurological Association (2004)

Investigator Award, Howard Hughes Medical Institute (2002-2010)

Neuroscience of Brain Disorders Award, McKnight Foundation (2002)

Jacobaeus Award, Sleep Research Society (2001)

American Academy of Sleep Medicine, William C Dement Academic Achievement Award (2000)

Javits Award, National Institute of Neurological Disease and Stroke (NINDS) (1999)

Administrative Appointments

Director, Center For Narcolepsy (1989 - 2015)

Director, Center For Sleep Sciences and Medicine (2010 - 2015)

Clinical Trials

Clinical trials are research studies that evaluate a new medical approach, device, drug, or other treatment. As a Stanford Health Care patient, you have access to the latest, advanced clinical trials.

Open trials refer to studies currently accepting participants. Closed trials are not currently enrolling, but may open in the future.

Sleep-spindle detection: crowdsourcing and evaluating performance of experts, non-experts and automated methods.
Warby, S. C., Wendt, S. L., Welinder, P., Munk, E. Gs., Carrillo, O., & Mignot, E. (2014). Sleep-spindle detection: crowdsourcing and evaluating performance of experts, non-experts and automated methods. Nature methods, 11(4), 385-392.

CD4+ T cell autoimmunity to hypocretin/orexin and cross-reactivity to a 2009 H1N1 influenza A epitope in narcolepsy.
De la Herrán-Arita, A. K., Kornum, B. R., Mahlios, J., Jiang, W., Lin, L., & Mignot, E. (2013). CD4+ T cell autoimmunity to hypocretin/orexin and cross-reactivity to a 2009 H1N1 influenza A epitope in narcolepsy. Science translational medicine, 5(216), 216ra176-?.

Genome wide analysis of narcolepsy in China implicates novel immune loci and reveals changes in association prior to versus after the 2009 H1N1 influenza pandemic.
Han, F., Faraco, J., Dong, X. S., Ollila, H. M., Lin, L., & Mignot, E. (2013). Genome wide analysis of narcolepsy in China implicates novel immune loci and reveals changes in association prior to versus after the 2009 H1N1 influenza pandemic. PLoS genetics, 9(10).

Nocturnal rapid eye movement sleep latency for identifying patients with narcolepsy/hypocretin deficiency.
Andlauer, O., Moore, H., Jouhier, L., Drake, C., Peppard, P. E., & Mignot, E. (2013). Nocturnal rapid eye movement sleep latency for identifying patients with narcolepsy/hypocretin deficiency. JAMA neurology, 70(7), 891-902.

ImmunoChip study implicates antigen presentation to T cells in narcolepsy.
Faraco, J., Lin, L., Kornum, B. R., Kenny, E. E., Trynka, G., & Mignot, E. (2013). ImmunoChip study implicates antigen presentation to T cells in narcolepsy. PLoS genetics, 9(2).

HLA-DQ association and allele competition in Chinese narcolepsy
Han, F., Lin, L., Li, J., Dong, S. X., An, P., & Mignot, E. (2012). HLA-DQ association and allele competition in Chinese narcolepsy. TISSUE ANTIGENS, 80(4), 328-335.

Predictors of Hypocretin (Orexin) Deficiency in Narcolepsy Without Cataplexy
Andlauer, O., Moore, H., Hong, S.-C., Dauvilliers, Y., Kanbayashi, T., & Mignot, E. (2012). Predictors of Hypocretin (Orexin) Deficiency in Narcolepsy Without Cataplexy. SLEEP, 35(9), 1247-1255.

Mutations in DNMT1 cause autosomal dominant cerebellar ataxia, deafness and narcolepsy
Winkelmann, J., Lin, L., Schormair, B., Kornum, B. R., Faraco, J., & Mignot, E. (2012). Mutations in DNMT1 cause autosomal dominant cerebellar ataxia, deafness and narcolepsy. HUMAN MOLECULAR GENETICS, 21(10), 2205-2210.

Narcolepsy Onset Is Seasonal and Increased following the 2009 H1N1 Pandemic in China
Han, F., Lin, L., Warby, S. C., Faraco, J., Li, J., & Mignot, E. (2011). Narcolepsy Onset Is Seasonal and Increased following the 2009 H1N1 Pandemic in China. ANNALS OF NEUROLOGY, 70(3), 410-417.

Genetics of Sleep and Sleep Disorders
Sehgal, A., & Mignot, E. (2011). Genetics of Sleep and Sleep Disorders. CELL, 146(2), 194-207.

Common variants in P2RY11 are associated with narcolepsy
Kornum, B. R., Kawashima, M., Faraco, J., Lin, L., Rico, T. J., & Mignot, E. (2011). Common variants in P2RY11 are associated with narcolepsy. NATURE GENETICS, 43(1), 66-U90.

Narcolepsy is strongly associated with the T-cell receptor alpha locus
Hallmayer, J., Faraco, J., Lin, L., Hesselson, S., Winkelmann, J., & Mignot, E. (2009). Narcolepsy is strongly associated with the T-cell receptor alpha locus. NATURE GENETICS, 41(6), 708-711.

IGFBP3 Colocalizes with and Regulates Hypocretin (Orexin)
Honda, M., Eriksson, K. S., Zhang, S., Tanaka, S., Lin, L., & Mignot, E. (2009). IGFBP3 Colocalizes with and Regulates Hypocretin (Orexin). PLOS ONE, 4(1).

Cataplexy features in childhood narcolepsy
Serra, L., Montagna, P., Mignot, E., Lugaresi, E., & Plazzi, G. (2008). Cataplexy features in childhood narcolepsy. MOVEMENT DISORDERS, 23(6), 858-865.

Kleine-Levin syndrome: A systematic study of 108 patients
Arnulf, I., Lin, L., Gadoth, N., File, J., Lecendreux, M., & Mignot, E. (2008). Kleine-Levin syndrome: A systematic study of 108 patients. ANNALS OF NEUROLOGY, 63(4), 482-493.

Why we sleep: The temporal organization of recovery
Mignot, E. (2008). Why we sleep: The temporal organization of recovery. PLOS BIOLOGY, 6(4), 661-669.

Correlates of sleep-onset REM periods during the Multiple Sleep Latency Test in community adults
Mignot, E., Lin, g L., Finn, L., Lopes, C., Pluff, K., & Young, T. (2006). Correlates of sleep-onset REM periods during the Multiple Sleep Latency Test in community adults. BRAIN, 129, 1609-1623.

Short sleep duration is associated with reduced leptin, elevated ghrelin, and increased body mass index
Taheri, S., Lin, L., Austin, D., Young, T., & Mignot, E. (2004). Short sleep duration is associated with reduced leptin, elevated ghrelin, and increased body mass index. PLOS MEDICINE, 1(3), 210-217.

The role of cerebrospinal fluid hypocretin measurement in the diagnosis of narcolepsy and other hypersomnias
Mignot, E., Lammers, G. J., Ripley, B., Okun, M., Nevsimalova, S., & Nishino, S. (2002). The role of cerebrospinal fluid hypocretin measurement in the diagnosis of narcolepsy and other hypersomnias. ARCHIVES OF NEUROLOGY, 59(10), 1553-1562.

Complex HLA-DR and -DQ interactions confer risk of narcolepsy-cataplexy in three ethnic groups
Mignot, E., Lin, L., Rogers, W., Honda, Y., Qiu, X. H., & Risch, N. (2001). Complex HLA-DR and -DQ interactions confer risk of narcolepsy-cataplexy in three ethnic groups. AMERICAN JOURNAL OF HUMAN GENETICS, 68(3), 686-699.

A mutation in a case of early onset narcolepsy and a generalized absence of hypocretin peptides in human narcoleptic brains
Peyron, C., Faraco, J., Rogers, W., Ripley, B., Overeem, S., & Mignot, E. (2000). A mutation in a case of early onset narcolepsy and a generalized absence of hypocretin peptides in human narcoleptic brains. NATURE MEDICINE, 6(9), 991-997.

The sleep disorder canine narcolepsy is caused by a mutation in the hypocretin (orexin) receptor 2 gene
Lin, L., Faraco, J., Li, R., KADOTANI, H., Rogers, W., & Mignot, E. (1999). The sleep disorder canine narcolepsy is caused by a mutation in the hypocretin (orexin) receptor 2 gene. CELL, 98(3), 365-376.

Validation of a cataplexy questionnaire in 983 sleep-disorders patients
Anic-Labat, S., Guilleminault, C., Kraemer, H. C., Meehan, J., Arrigoni, J., & Mignot, E. (1999). Validation of a cataplexy questionnaire in 983 sleep-disorders patients. SLEEP, 22(1), 77-87.

Pharmacological aspects of human and canine narcolepsy
Nishino, S., & Mignot, E. (1997). Pharmacological aspects of human and canine narcolepsy. PROGRESS IN NEUROBIOLOGY, 52(1), 27-78.

CANINE CATAPLEXY IS PREFERENTIALLY CONTROLLED BY ADRENERGIC-MECHANISMS - EVIDENCE USING MONOAMINE SELECTIVE UPTAKE INHIBITORS AND RELEASE ENHANCERS
Mignot, E., RENAUD, A., Nishino, S., Arrigoni, J., Guilleminault, C., & Dement, W. C. (1993). CANINE CATAPLEXY IS PREFERENTIALLY CONTROLLED BY ADRENERGIC-MECHANISMS - EVIDENCE USING MONOAMINE SELECTIVE UPTAKE INHIBITORS AND RELEASE ENHANCERS. PSYCHOPHARMACOLOGY, 113(1), 76-82.

HETEROZYGOSITY AT THE CANARC-1 LOCUS CAN CONFER SUSCEPTIBILITY FOR NARCOLEPSY - INDUCTION OF CATAPLEXY IN HETEROZYGOUS ASYMPTOMATIC DOGS AFTER ADMINISTRATION OF A COMBINATION OF DRUGS ACTING ON MONOAMINERGIC AND CHOLINERGIC SYSTEMS
Mignot, E., Nishino, S., Sharp, L. H., Arrigoni, J., Siegel, J. M., & Dement, W. C. (1993). HETEROZYGOSITY AT THE CANARC-1 LOCUS CAN CONFER SUSCEPTIBILITY FOR NARCOLEPSY - INDUCTION OF CATAPLEXY IN HETEROZYGOUS ASYMPTOMATIC DOGS AFTER ADMINISTRATION OF A COMBINATION OF DRUGS ACTING ON MONOAMINERGIC AND CHOLINERGIC SYSTEMS. JOURNAL OF NEUROSCIENCE, 13(3), 1057-1064.

The autoimmune basis of narcolepsy
Mahlios, J., De la Herran-Arita, A. K., & Mignot, E. (2013). The autoimmune basis of narcolepsy. CURRENT OPINION IN NEUROBIOLOGY, 23(5), 767-773.

Genetic association, seasonal infections and autoimmune basis of narcolepsy
Singh, A. K., Mahlios, J., & Mignot, E. (2013). Genetic association, seasonal infections and autoimmune basis of narcolepsy. JOURNAL OF AUTOIMMUNITY, 43, 26-31.

Physiology. The perfect hypnotic?
Mignot, E. (2013). Physiology. The perfect hypnotic?. Science , 340(6128), 36-38.

High Prevalence of Precocious Puberty and Obesity in Childhood Narcolepsy with Cataplexy
Poli, F., Pizza, F., Mignot, E., Ferri, R., Pagotto, U., & Plazzi, G. (2013). High Prevalence of Precocious Puberty and Obesity in Childhood Narcolepsy with Cataplexy. SLEEP, 36(2), 175-181.

Daytime continuous polysomnography predicts MSLT results in hypersomnias of central origin
Pizza, F., Moghadam, K. K., Vandi, S., Detto, S., Poli, F., & Plazzi, G. (2013). Daytime continuous polysomnography predicts MSLT results in hypersomnias of central origin. JOURNAL OF SLEEP RESEARCH, 22(1), 32-40.

Genome-wide association study of HLA-DQB1*06:02 negative essential hypersomnia.
Khor, S.-S., Miyagawa, T., Toyoda, H., Yamasaki, M., Kawamura, Y., & Tokunaga, K. (2013). Genome-wide association study of HLA-DQB1*06:02 negative essential hypersomnia. PeerJ, 1.

Narcolepsy with cataplexy mimicry: the strange case of two sisters.
Pizza, F., Vandi, S., Poli, F., Moghadam, K. K., Franceschini, C., & Plazzi, G. (2013). Narcolepsy with cataplexy mimicry: the strange case of two sisters. Journal of clinical sleep medicine , 9(6), 611-612.

Association of Sleep Disordered Breathing and Cognitive Deficit in APOE e4 Carriers.
Nikodemova, M., Finn, L., Mignot, E., Salzieder, N., & Peppard, P. E. (2013). Association of Sleep Disordered Breathing and Cognitive Deficit in APOE e4 Carriers. Sleep, 36(6), 873-880.

Diagnosis, disease course, and management of patients with Kleine-Levin syndrome
Arnulf, I., Rico, T. J., & Mignot, E. (2012). Diagnosis, disease course, and management of patients with Kleine-Levin syndrome. LANCET NEUROLOGY, 11(10), 918-928.

A Practical Guide to the Therapy of Narcolepsy and Hypersomnia Syndromes
Mignot, E. Jm. (2012). A Practical Guide to the Therapy of Narcolepsy and Hypersomnia Syndromes. NEUROTHERAPEUTICS, 9(4), 739-752.

Treatment of Sleep Disorders
Pelayo, R., & Mignot, E. (2012). Treatment of Sleep Disorders. NEUROTHERAPEUTICS, 9(4), 685-686.

Clinical phenotype of patients with narcolepsy with cataplexy, cerebellar ataxia, deafness and neuropathy associated to DNMT1 gene mutation
Moghadam, K. K., Pizza, F., Poli, F., Franceschini, C., Tonon, C., & Plazzi, G. (2012). Clinical phenotype of patients with narcolepsy with cataplexy, cerebellar ataxia, deafness and neuropathy associated to DNMT1 gene mutation. JOURNAL OF SLEEP RESEARCH, 21, 311-311.

EARLY IVIg TREATMENT HAS NO EFFECT ON POST-H1N1 NARCOLEPSY PHENOTYPE OR HYPOCRETIN DEFICIENCY
Knudsen, S., Biering-Sorensen, B., Kornum, B. R., Petersen, E. R., Ibsen, J. D., & Jennum, P. J. (2012). EARLY IVIg TREATMENT HAS NO EFFECT ON POST-H1N1 NARCOLEPSY PHENOTYPE OR HYPOCRETIN DEFICIENCY. NEUROLOGY, 79(1), 102-103.

Time-course of cerebrospinal fluid histamine in the wake-consolidated squirrel monkey
Zeitzer, J. M., Kodama, T., Buckmaster, C. L., Honda, Y., Lyons, D. M., & Mignot, E. (2012). Time-course of cerebrospinal fluid histamine in the wake-consolidated squirrel monkey. JOURNAL OF SLEEP RESEARCH, 21(2), 189-194.

DQB1*06:02 allele-specific expression varies by allelic dosage, not narcolepsy status
Lachmi, K. W., Lin, L., Kornum, B. R., Rico, T., Lo, B., & Mignot, E. (2012). DQB1*06:02 allele-specific expression varies by allelic dosage, not narcolepsy status. HUMAN IMMUNOLOGY, 73(4), 405-410.

TCRA, P2RY11, and CPT1B/CHKB associations in Chinese narcolepsy
Han, F., Lin, L., Li, J., Aran, A., Dong, S. X., & Mignot, E. (2012). TCRA, P2RY11, and CPT1B/CHKB associations in Chinese narcolepsy. SLEEP MEDICINE, 13(3), 269-272.

CSF Levels of Hypocretin-1 (Orexin-A) Peak during Early Infancy in Humans
Aran, A., Shors, I., Lin, L., Mignot, E., & Schimmel, M. S. (2012). CSF Levels of Hypocretin-1 (Orexin-A) Peak during Early Infancy in Humans. SLEEP, 35(2), 187-191.

MUTATIONS IN DNMT1 CAUSE AUTOSOMAL DOMINANT CEREBELLAR ATAXIA, DEAFNESS AND NARCOLEPSY
Winkelmann, J., Lin, L., Schormair, B., Kornum, B. R., Faraco, J., & Mignot, E. (2012). MUTATIONS IN DNMT1 CAUSE AUTOSOMAL DOMINANT CEREBELLAR ATAXIA, DEAFNESS AND NARCOLEPSY. SLEEP, 35, A11-A11.

LEG MOVEMENT DETECTION SOFTWARE AND PERIODIC LEG MOVEMENT INDEX CALCULATOR
MOORE, H. E., Warby, S., Woodward, S. H., Peppard, P. E., Young, T., & Mignot, E. (2012). LEG MOVEMENT DETECTION SOFTWARE AND PERIODIC LEG MOVEMENT INDEX CALCULATOR. SLEEP, 35, A264-A264.

Complex movement disorders at disease onset in childhood narcolepsy with cataplexy.
Plazzi, G., Pizza, F., Palaia, V., Franceschini, C., Poli, F., & Bhatia, K. P. (2011). Complex movement disorders at disease onset in childhood narcolepsy with cataplexy. Brain , 134, 3480-3492.

Narcolepsy with hypocretin/orexin deficiency, infections and autoimmunity of the brain
Kornum, B. R., Faraco, J., & Mignot, E. (2011). Narcolepsy with hypocretin/orexin deficiency, infections and autoimmunity of the brain. CURRENT OPINION IN NEUROBIOLOGY, 21(6), 897-903.

Complex movement disorders at disease onset in childhood narcolepsy with cataplexy
Plazzi, G., Pizza, F., Palaia, V., Franceschini, C., Poli, F., & Bhatia, K. P. (2011). Complex movement disorders at disease onset in childhood narcolepsy with cataplexy. BRAIN, 134, 3477-3489.

Narcolepsy with Cataplexy Associated with Nocturnal Compulsive Behaviors: A Case-Control Study
Palaia, V., Poli, F., Pizza, F., Antelmi, E., Franceschini, C., & Plazzi, G. (2011). Narcolepsy with Cataplexy Associated with Nocturnal Compulsive Behaviors: A Case-Control Study. SLEEP, 34(10), 1365-U100.

Post-Streptococcal Antibodies Are Associated with Metabolic Syndrome in a Population-Based Cohort
Aran, A., Lin, L., Finn, L. A., Weiner, K., Peppard, P., & Mignot, E. (2011). Post-Streptococcal Antibodies Are Associated with Metabolic Syndrome in a Population-Based Cohort. PLOS ONE, 6(9).

Genome-Wide Association Study Identifies Novel Restless Legs Syndrome Susceptibility Loci on 2p14 and 16q12.1
Winkelmann, J., Czamara, D., Schormair, B., Knauf, F., Schulte, E. C., & Meitinger, T. (2011). Genome-Wide Association Study Identifies Novel Restless Legs Syndrome Susceptibility Loci on 2p14 and 16q12.1. PLOS GENETICS, 7(7).

Presentations of Primary Hypersomnia in Chinese Children
Han, F., Lin, L., Li, J., Aran, A., Dong, S. X., & Mignot, E. (2011). Presentations of Primary Hypersomnia in Chinese Children. SLEEP, 34(5), 627-632A.

beta 2 adrenergic receptor polymorphisms and nocturnal blood pressure dipping status in the Wisconsin Sleep Cohort Study
Vardeny, O., Peppard, P. E., Finn, L. A., Faraco, J. H., Mignot, E., & Hla, K. M. (2011). beta 2 adrenergic receptor polymorphisms and nocturnal blood pressure dipping status in the Wisconsin Sleep Cohort Study. JOURNAL OF THE AMERICAN SOCIETY OF HYPERTENSION, 5(2), 114-122.

POST-STREPTOCOCCAL ANTIBODIES ARE ASSOCIATED WITH METABOLIC SYNDROME IN A POPULATION-BASED SAMPLE OF HEALTHY ADULTS
Aran, A., Lin, L., Finn, L., Weiner, K., Peppard, P. E., & Mignot, E. (2011). POST-STREPTOCOCCAL ANTIBODIES ARE ASSOCIATED WITH METABOLIC SYNDROME IN A POPULATION-BASED SAMPLE OF HEALTHY ADULTS. SLEEP, 34, A222-A222.

Transcriptional regulation of the hypocretin/orexin gene by NR6A1
Tanaka, S., Kodama, T., Nonaka, T., Toyoda, H., Arai, M., & Mignot, E. (2010). Transcriptional regulation of the hypocretin/orexin gene by NR6A1. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 403(2), 178-183.

Clinical and Therapeutic Aspects of Childhood Narcolepsy-Cataplexy: A Retrospective Study of 51 Children
Aran, A., Einen, M., Lin, L., Plazzi, G., Nishino, S., & Mignot, E. (2010). Clinical and Therapeutic Aspects of Childhood Narcolepsy-Cataplexy: A Retrospective Study of 51 Children. SLEEP, 33(11), 1457-1464.

Post-H1N1 Narcolepsy-Cataplexy
Dauvilliers, Y., Montplaisir, J., Cochen, V., Desautels, A., Einen, M., & Mignot, E. (2010). Post-H1N1 Narcolepsy-Cataplexy. SLEEP, 33(11), 1428-1430.

DQB1*0602 predicts interindividual differences in physiologic sleep, sleepiness, and fatigue
Goel, N., Banks, S., Mignot, E., & Dinges, D. F. (2010). DQB1*0602 predicts interindividual differences in physiologic sleep, sleepiness, and fatigue. NEUROLOGY, 75(17), 1509-1519.

Circadian and Homeostatic Regulation of Structural Synaptic Plasticity in Hypocretin Neurons
Appelbaum, L., Wang, G., Yokogawa, T., Skariah, G. M., Smith, S. J., & Mignot, E. (2010). Circadian and Homeostatic Regulation of Structural Synaptic Plasticity in Hypocretin Neurons. NEURON, 68(1), 87-98.

Sleep Well and Stay Slim: Dream or Reality?
Taheri, S., & Mignot, E. (2010). Sleep Well and Stay Slim: Dream or Reality?. ANNALS OF INTERNAL MEDICINE, 153(7), 475-?.

Effects of sleep on the cardiovascular and thermoregulatory systems: a possible role for hypocretins
Schwimmer, H., Stauss, H. M., Abboud, F., Nishino, S., Mignot, E., & Zeitzer, J. M. (2010). Effects of sleep on the cardiovascular and thermoregulatory systems: a possible role for hypocretins. JOURNAL OF APPLIED PHYSIOLOGY, 109(4), 1053-1063.

Post-Streptococcal Auto-Antibodies Inhibit Protein Disulfide Isomerase and Are Associated with Insulin Resistance
Aran, A., Weiner, K., Lin, L., Finn, L. A., Greco, M. A., & Mignot, E. (2010). Post-Streptococcal Auto-Antibodies Inhibit Protein Disulfide Isomerase and Are Associated with Insulin Resistance. PLOS ONE, 5(9).

Anti-Tribbles Homo log 2 (TRIB2) Autoantibodies in Narcolepsy are Associated with Recent Onset of Cataplexy
Kawashima, M., Lin, L., Tanaka, S., Jennum, P., Knudsen, S., & Mignot, E. (2010). Anti-Tribbles Homo log 2 (TRIB2) Autoantibodies in Narcolepsy are Associated with Recent Onset of Cataplexy. SLEEP, 33(7), 869-874.

Narcolepsy with Cataplexy Associated with Holoprosencephaly Misdiagnosed as Epileptic Drop Attacks
Plazzi, G., Tonon, C., Rubboli, G., Franceschini, C., Pizza, F., & Lodi, R. (2010). Narcolepsy with Cataplexy Associated with Holoprosencephaly Misdiagnosed as Epileptic Drop Attacks. MOVEMENT DISORDERS, 25(6), 788-790.

Behavioural and neurophysiological correlates of human cataplexy: A video-polygraphic study
Vetrugno, R., D'Angelo, R., Moghadam, K. K., Vandi, S., Franceschini, C., & Plazzi, G. (2010). Behavioural and neurophysiological correlates of human cataplexy: A video-polygraphic study. CLINICAL NEUROPHYSIOLOGY, 121(2), 153-162.

Sodium oxybate is an effective and safe treatment for narcolepsy
Lammers, G. J., Bassetti, C., Billiard, M., Black, J., Broughton, R., & Thorpy, M. (2010). Sodium oxybate is an effective and safe treatment for narcolepsy. SLEEP MEDICINE, 11(1), 105-106.

Sleep-wake regulation and hypocretin-melatonin interaction in zebrafish
Appelbaum, L., Wang, G. X., Maro, G. S., Mori, R., Tovin, A., & Mourrain, P. (2009). Sleep-wake regulation and hypocretin-melatonin interaction in zebrafish. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 106(51), 21942-21947.

Characterization of Two Melanin-Concentrating Hormone Genes in Zebrafish Reveals Evolutionary and Physiological Links with the Mammalian MCH System
Berman, J. R., Skariah, G., Maro, G. S., Mignot, E., & Mourrain, P. (2009). Characterization of Two Melanin-Concentrating Hormone Genes in Zebrafish Reveals Evolutionary and Physiological Links with the Mammalian MCH System. JOURNAL OF COMPARATIVE NEUROLOGY, 517(5), 695-710.

T-box 3 is expressed in the adult mouse hypothalamus and medulla
Eriksson, K. S., & Mignot, E. (2009). T-box 3 is expressed in the adult mouse hypothalamus and medulla. BRAIN RESEARCH, 1302, 233-239.

Body Mass Index-Independent Metabolic Alterations in Narcolepsy with Cataplexy
Poli, F., Plazzi, G., Di Dalmazi, G., Ribichini, D., Vicennati, V., & Pagotto, U. (2009). Body Mass Index-Independent Metabolic Alterations in Narcolepsy with Cataplexy. SLEEP, 32(11), 1491-1497.

Modafinil and gamma-hydroxybutyrate have sleep state-specific pharmacological actions on hypocretin-1 physiology in a primate model of human sleep
Zeitzer, J. M., Buckmaster, C. L., Landoltd, H.-P., Lyons, D. M., & Mignot, E. (2009). Modafinil and gamma-hydroxybutyrate have sleep state-specific pharmacological actions on hypocretin-1 physiology in a primate model of human sleep. BEHAVIOURAL PHARMACOLOGY, 20(7), 643-652.

Distribution of neurochemical abnormalities in patients with narcolepsy with cataplexy: An in vivo brain proton MR spectroscopy study
Tonon, C., Franceschini, C., Testa, C., Manners, D. N., Poli, F., & Plazzi, G. (2009). Distribution of neurochemical abnormalities in patients with narcolepsy with cataplexy: An in vivo brain proton MR spectroscopy study. BRAIN RESEARCH BULLETIN, 80(3), 147-150.

Resting Our Cortices by Going DOWN to Sleep
Mignot, E., & Huguenard, J. R. (2009). Resting Our Cortices by Going DOWN to Sleep. NEURON, 63(6), 719-721.

Absence of ubiquitinated inclusions in hypocretin neurons of patients with narcolepsy
Honda, M., Arai, T., Fukazawa, M., Honda, Y., Tsuchiya, K., & Mignot, E. (2009). Absence of ubiquitinated inclusions in hypocretin neurons of patients with narcolepsy. NEUROLOGY, 73(7), 511-517.

Elevated Anti-Streptococcal Antibodies in Patients with Recent Narcolepsy Onset
Aran, A., Lin, L., Nevsimalova, S., Plazzi, G., Hong, S. C., & Mignot, E. (2009). Elevated Anti-Streptococcal Antibodies in Patients with Recent Narcolepsy Onset. SLEEP, 32(8), 979-983.

Decreased CSF Histamine in Narcolepsy With and Without Low CSF Hypocretin-1 in Comparison to Healthy Controls
Nishino, S., Sakurai, E., Nevsimalova, S., Yoshida, Y., Watanabe, T., & Mignot, E. (2009). Decreased CSF Histamine in Narcolepsy With and Without Low CSF Hypocretin-1 in Comparison to Healthy Controls. SLEEP, 32(2), 175-180.

HLA DQB1*0602 IS ASSOCIATED WITH SLEEP PERCEPTION IN OLDER INDIVIDUALS WITH INSOMNIA
Zeitzer, J., Grove, M. E., Mignot, E., Yesavage, J. A., & Friedman, L. (2009). HLA DQB1*0602 IS ASSOCIATED WITH SLEEP PERCEPTION IN OLDER INDIVIDUALS WITH INSOMNIA. SLEEP, 32, A262-A262.

Sympathetic and cardiovascular activity during cataplexy in narcolepsy.
Donadio, V., Plazzi, G., Vandi, S., Franceschini, C., Karlsson, T., & Liguori, R. (2008). Sympathetic and cardiovascular activity during cataplexy in narcolepsy. Journal of sleep research, 17(4), 458-463.

Variant between CPT1B and CHKB associated with susceptibility to narcolepsy
Miyagawa, T., Kawashima, M., Nishida, N., Ohashi, J., Kimura, R., & Tokunaga, K. (2008). Variant between CPT1B and CHKB associated with susceptibility to narcolepsy. NATURE GENETICS, 40(11), 1324-1328.

Intravenous high-dose immunoglobulin treatment in recent onset childhood narcolepsy with cataplexy
Plazzi, G., Poli, F., Franceschini, C., Parmeggiani, A., Pirazzoli, P., & Montagna, P. (2008). Intravenous high-dose immunoglobulin treatment in recent onset childhood narcolepsy with cataplexy. JOURNAL OF NEUROLOGY, 255(10), 1549-1554.

Hypocretin receptor expression in canine and murine narcolepsy models and in hypocretin-ligand deficient human narcolepsy
Mishima, K., Fujiki, N., Yoshida, Y., Sakurai, T., Honda, M., & Nishino, S. (2008). Hypocretin receptor expression in canine and murine narcolepsy models and in hypocretin-ligand deficient human narcolepsy. SLEEP, 31(8), 1119-1126.

CSF hypocretin-1 assessment in sleep and neurological disorders
Bourgin, P., Zeitzer, J. M., & Mignot, E. (2008). CSF hypocretin-1 assessment in sleep and neurological disorders. LANCET NEUROLOGY, 7(7), 649-662.

Anomalous Hypothalamic Responses to Humor in Cataplexy
Reiss, A. L., Hoeft, F., Tenforde, A. S., Chen, W., Mobbs, D., & Mignot, E. J. (2008). Anomalous Hypothalamic Responses to Humor in Cataplexy. PLOS ONE, 3(5).

Sleep and EEG features in genetic models of Down syndrome
Colas, D., Valletta, J. S., Takimoto-Kimura, R., Nishino, S., Fujiki, N., & Mignot, E. (2008). Sleep and EEG features in genetic models of Down syndrome. NEUROBIOLOGY OF DISEASE, 30(1), 1-7.

Excessive daytime sleepiness: Population and etiology versus nosology
Mignot, E. (2008). Excessive daytime sleepiness: Population and etiology versus nosology. SLEEP MEDICINE REVIEWS, 12(2), 87-94.

The type III neurofilament peripherin is expressed in the tuberomammillary neurons of the mouse
Eriksson, K. S., Zhang, S., Lin, L., Lariviere, R. C., Julien, J.-P., & Mignot, E. (2008). The type III neurofilament peripherin is expressed in the tuberomammillary neurons of the mouse. BMC NEUROSCIENCE, 9.

The hypocretin neurotransmission system in myotonic dystrophy type 1
Ciafaloni, E., Mignot, E., Sansone, V., Hilbert, J. E., Lin, L., & Thornton, C. A. (2008). The hypocretin neurotransmission system in myotonic dystrophy type 1. NEUROLOGY, 70(3), 226-230.

Hypocretin neuron morphology and neurotransmitter identity in zebrafish
Appelbaum, L., Wang, G., Marin, W., Mignot, E., & Mourrain, P. (2008). Hypocretin neuron morphology and neurotransmitter identity in zebrafish. SLEEP, 31, A5-A5.

REM behavior disorder (RBD) can be one of the first symptoms of childhood narcolepsy
Nevsimalova, S., Prihodova, I., Kemlink, D., Lin, L., & Mignot, E. (2007). REM behavior disorder (RBD) can be one of the first symptoms of childhood narcolepsy. SLEEP MEDICINE, 8(7-8), 784-786.

Comparative expression of p2x receptors and ecto-nucleoside triphosphate diphosphohydrolase 3 in hypocretin and sensory neurons in zebrafish
Appelbaum, L., Skariah, G., Mourrain, P., & Mignot, E. (2007). Comparative expression of p2x receptors and ecto-nucleoside triphosphate diphosphohydrolase 3 in hypocretin and sensory neurons in zebrafish. BRAIN RESEARCH, 1174, 66-75.

Increasing length of wakefulness and modulation of hypocretin-1 in the wake-consolidated squirrel monkey
Zeitzer, J. M., Buckmaster, C. L., Lyons, D. M., & Mignot, E. (2007). Increasing length of wakefulness and modulation of hypocretin-1 in the wake-consolidated squirrel monkey. AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY, 293(4), R1736-R1742.

Characterization of sleep in zebrafish and insomnia in hypocretin receptor mutants
Yokogawa, T., Marin, W., Faraco, J., Pezeron, G., Appelbaum, L., & Mignot, E. (2007). Characterization of sleep in zebrafish and insomnia in hypocretin receptor mutants. PLOS BIOLOGY, 5(10), 2379-2397.

Depression: relationships to sleep paralysis and other sleep disturbances in a community sample
Szklo-Coxe, M., Young, T., Finn, L., & Mignot, E. (2007). Depression: relationships to sleep paralysis and other sleep disturbances in a community sample. JOURNAL OF SLEEP RESEARCH, 16(3), 297-312.

The development of hypocretin (orexin) deficiency in hypocretin/ataxin-3 transgenic rats
Zhang, S., Lin, L., Kaur, S., Thankachan, S., Blanco-Centurion, C., & Shiromani, P. J. (2007). The development of hypocretin (orexin) deficiency in hypocretin/ataxin-3 transgenic rats. NEUROSCIENCE, 148(1), 34-43.

Correlates of serum C-reactive protein (CRP) - No association with sleep duration or sleep disordered breathing
Taheri, S., Austin, D., Lin, L., Nieto, F. J., Young, T., & Mignot, E. (2007). Correlates of serum C-reactive protein (CRP) - No association with sleep duration or sleep disordered breathing. SLEEP, 30(8), 991-996.

A step forward for restless legs syndrome
Mignot, E. (2007). A step forward for restless legs syndrome. NATURE GENETICS, 39(8), 938-939.

Sleep/wake fragmentation disrupts metabolism in a mouse model of narcolepsy
Zhang, S., Zeitzer, J. M., Sakurai, T., Nishino, S., & Mignot, E. (2007). Sleep/wake fragmentation disrupts metabolism in a mouse model of narcolepsy. JOURNAL OF PHYSIOLOGY-LONDON, 581(2), 649-663.

Reduced expression of TACI, PENK and SOCS2 in Hcrtr-2 mutated narcoleptic dog brain
Lindberg, J., Saetre, P., Nishino, S., Mignot, E., & Jazin, E. (2007). Reduced expression of TACI, PENK and SOCS2 in Hcrtr-2 mutated narcoleptic dog brain. BMC NEUROSCIENCE, 8.

English translations of the first clinical reports on narcolepsy and cataplexy by Westphal and Gélineau in the late 19th century, with commentary.
Schenck, C. H., Bassetti, C. L., Arnulf, I., & Mignot, E. (2007). English translations of the first clinical reports on narcolepsy and cataplexy by Westphal and Gélineau in the late 19th century, with commentary. Journal of clinical sleep medicine , 3(3), 301-311.

Normal cerebrospinal fluid levels of hypocretin-1 (orexin A) in patients with fibromyalgia syndrome
Taiwo, O. B., Russell, I. J., Mignot, E., Lin, L., Michalek, J. E., & Larson, A. A. (2007). Normal cerebrospinal fluid levels of hypocretin-1 (orexin A) in patients with fibromyalgia syndrome. SLEEP MEDICINE, 8(3), 260-265.

Genomic and functional conservation of sedative-hypnotic targets in the zebrafish
Renier, C., Faraco, J. H., Bourgin, P., Motley, T., Bonaventure, P., & Mignot, E. (2007). Genomic and functional conservation of sedative-hypnotic targets in the zebrafish. PHARMACOGENETICS AND GENOMICS, 17(4), 237-253.

Analysis of extended HLA haplotypes in multiple sclerosis and narcolepsy families confirms a predisposing effect for the class I region in Tasmanian MS patients
Rubio, J. P., Bahlo, M., Stankovich, J., Burfoot, R. K., Johnson, L. J., & Foote, S. J. (2007). Analysis of extended HLA haplotypes in multiple sclerosis and narcolepsy families confirms a predisposing effect for the class I region in Tasmanian MS patients. IMMUNOGENETICS, 59(3), 177-186.

Narcolepsy with cataplexy
Dauvilliers, Y., Amulf, I., & Mignot, E. (2007). Narcolepsy with cataplexy. LANCET, 369(9560), 499-511.

A circadian sleep disorder reveals a complex clock
Mignot, E., & Takahashi, J. S. (2007). A circadian sleep disorder reveals a complex clock. CELL, 128(1), 22-23.

A novel candidate gene for narcolepsy colocalized in human and mouse hypocretin/orexin neurons
Honda, M., Eriksson, K., Lin, L., Salehi, A., Tanaka, S., & Mignot, E. (2007). A novel candidate gene for narcolepsy colocalized in human and mouse hypocretin/orexin neurons. SLEEP, 30, A218-A218.

DQB1*0301 and DQB1*0601 modulate narcolepsy susceptibility in Koreans
Hong, S.-C., Lin, L., Lo, B., Jeong, J.-H., Shin, Y.-K., & Mignot, E. (2007). DQB1*0301 and DQB1*0601 modulate narcolepsy susceptibility in Koreans. HUMAN IMMUNOLOGY, 68(1), 59-68.

Hypocretin-1 is inversely associated with wake fragmentation in Alzheimer's disease
Zeitzer, J., Friedman, L., Lin, L., Mignot, E., Peskind, E., & Yesavage, J. (2007). Hypocretin-1 is inversely associated with wake fragmentation in Alzheimer's disease. SLEEP, 30, A302-A302.

Identification of novel transcripts expressed in hypocretin-containing neurons
Bourgin, P., Lin, L., Priest, M., Renier, C., Sakurai, T., & Mignot, E. (2007). Identification of novel transcripts expressed in hypocretin-containing neurons. SLEEP, 30, A223-A223.

Different periodicity and time structure of leg movements during sleep in narcolepsy/cataplexy and restless legs syndrome
Ferri, R., Zucconi, M., Manconi, M., Bruni, O., Ferini-Strambi, L., & Plazzi, G. (2006). Different periodicity and time structure of leg movements during sleep in narcolepsy/cataplexy and restless legs syndrome. SLEEP, 29(12), 1587-1594.

A study of the diagnostic utility of HLA typing, CSF hypocretin-1 measurements, and MSLT testing for the diagnosis of narcolepsy in 163 Korean patients with unexplained excessive daytime sleepiness
Hong, S.-C., Lin, L., Jeong, J.-H., Shin, Y.-K., Han, J.-H., & Mignot, E. (2006). A study of the diagnostic utility of HLA typing, CSF hypocretin-1 measurements, and MSLT testing for the diagnosis of narcolepsy in 163 Korean patients with unexplained excessive daytime sleepiness. SLEEP, 29(11), 1429-1438.

Regulation of hypocretin (orexin) expression in embryonic zebrafish
Faraco, J. H., Appelbaum, L., Marin, W., Gaus, S. E., Mourrain, P., & Mignot, E. (2006). Regulation of hypocretin (orexin) expression in embryonic zebrafish. JOURNAL OF BIOLOGICAL CHEMISTRY, 281(40), 29753-29761.

CSF versus serum leptin in narcolepsy: Is there an effect of hypocretin deficiency?
Arnulf, I., Lin, L., Zhang, J., Russell, I. J., Ripley, B., & Mignot, E. (2006). CSF versus serum leptin in narcolepsy: Is there an effect of hypocretin deficiency?. SLEEP, 29(8), 1017-1024.

The neurobiology of hypocretins (orexins), narcolepsy and related therapeutic interventions
Zeitzer, J. M., Nishin, S., & Mignot, E. (2006). The neurobiology of hypocretins (orexins), narcolepsy and related therapeutic interventions. TRENDS IN PHARMACOLOGICAL SCIENCES, 27(7), 368-374.

Narcolepsy-cataplexy associated with precocious puberty
Plazzi, G., Parmeggiani, A., Mignot, E., Lin, L., Scano, M. C., & Cicognani, A. (2006). Narcolepsy-cataplexy associated with precocious puberty. NEUROLOGY, 66(10), 1577-1579.

Gene expression profiling in postmortem posterior hypothalamic tissue reveals narcolepsy specific genes
Honda, M., Eriksson, K., Salehi, A., Hesla, P., Maehlen, J., & Mignot, E. (2006). Gene expression profiling in postmortem posterior hypothalamic tissue reveals narcolepsy specific genes. SLEEP, 29, A219-A219.

CSF hypocretin levels are normal in Huntington's disease patients
Gaus, S. E., Lin, L., & Mignot, E. (2005). CSF hypocretin levels are normal in Huntington's disease patients. SLEEP, 28(12), 1607-1608.

Kleine-Levin syndrome: a systematic review of 186 cases in the literature
Arnulf, I., Zeitzer, J. M., File, J., Farber, N., & Mignot, E. (2005). Kleine-Levin syndrome: a systematic review of 186 cases in the literature. BRAIN, 128, 2763-2776.

Concomitant loss of dynorphin, NARP, and orexin in narcolepsy
Crocker, A., Espana, R. A., Papadopoulou, M., SAPER, C. B., Faraco, J., & Scammell, T. E. (2005). Concomitant loss of dynorphin, NARP, and orexin in narcolepsy. NEUROLOGY, 65(8), 1184-1188.

A link between short sleep and obesity: Building the evidence for causation
Cizza, G., Skarulis, M., & Mignot, E. (2005). A link between short sleep and obesity: Building the evidence for causation. SLEEP, 28(10), 1217-1220.

Late-onset narcolepsy presenting as rapidly progressing muscle weakness: Response to plasmapheresis
Chen, W., Black, J., Call, P., & Mignot, E. (2005). Late-onset narcolepsy presenting as rapidly progressing muscle weakness: Response to plasmapheresis. ANNALS OF NEUROLOGY, 58(3), 489-490.

Hypocretin-1 (orexin A) deficiency in acute traumatic brain injury
Baumann, C. R., Stocker, R., Imhof, H. G., Trentz, O., Hersberger, M., & Bassetti, C. L. (2005). Hypocretin-1 (orexin A) deficiency in acute traumatic brain injury. NEUROLOGY, 65(1), 147-149.

Polymorphisms within the canine MLPH gene are associated with dilute coat color in dogs
Philipp, U., Hamann, H., Mecklenburg, L., Nishino, S., Mignot, E., & Leeb, T. (2005). Polymorphisms within the canine MLPH gene are associated with dilute coat color in dogs. BMC GENETICS, 6.

Emerging therapies in narcolepsy-cataplexy
Mignot, E., & Nishino, S. (2005). Emerging therapies in narcolepsy-cataplexy. SLEEP, 28(6), 754-763.

History of the development of sleep medicine in the United States.
Shepard, J. W., Buysse, D. J., Chesson, A. L., Dement, W. C., Goldberg, R., & White, D. P. (2005). History of the development of sleep medicine in the United States. Journal of clinical sleep medicine , 1(1), 61-82.

HLA expression in narcoleptic hypothalamus
Honda, M., Salehi, A., Hesla, P., Maehlen, J., Gaus, S., & Mignot, E. (2005). HLA expression in narcoleptic hypothalamus. SLEEP, 28, A220-A220.

Hypocretin deficiency in Prader-Willi syndrome
Nevsimalova, S., Vankova, J., Stepanova, I., Seemanova, E., Mignot, E., & Nishino, S. (2005). Hypocretin deficiency in Prader-Willi syndrome. EUROPEAN JOURNAL OF NEUROLOGY, 12(1), 70-72.

Angiotensin-converting enzyme, sleep-disordered breathing, and hypertension
Lin, L., Finn, L., Zhang, J., Young, T., & Mignot, E. (2004). Angiotensin-converting enzyme, sleep-disordered breathing, and hypertension. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 170(12), 1349-1353.

Sodium oxybate for excessive daytime sleepiness in narcolepsy-cataplexy
Arnulf, I., & Mignot, E. (2004). Sodium oxybate for excessive daytime sleepiness in narcolepsy-cataplexy. SLEEP, 27(7), 1242-1243.

APOE epsilon 4 is associated with obstructive sleep apnea/hypopnea - The Sleep Heart Health Study
Gottlieb, D. J., DeStefano, A. L., Foley, D. J., Mignot, E., Redline, S., & Young, T. (2004). APOE epsilon 4 is associated with obstructive sleep apnea/hypopnea - The Sleep Heart Health Study. NEUROLOGY, 63(4), 664-668.

The diurnal rhythm of hypocretin in young and old F344 rats
Desarnaud, F., Murillo-Rodriguez, E., Lin, L., Xu, M., Gerashchenko, D., & Shiromani, P. J. (2004). The diurnal rhythm of hypocretin in young and old F344 rats. SLEEP, 27(5), 851-856.

The effect of hypocretin replacement therapy in a 3-year-old Weimaraner with narcolepsy
Schatzberg, S. J., Cutter-Schatzberg, K., Nydam, D., Barrett, J., Penn, R., & Mignot, E. (2004). The effect of hypocretin replacement therapy in a 3-year-old Weimaraner with narcolepsy. JOURNAL OF VETERINARY INTERNAL MEDICINE, 18(4), 586-588.

Lesions of the suprachiasmatic nucleus eliminate the daily rhythm of hypocretin-1 release
Zhang, S. W., Zeitzer, J. M., Yoshida, Y., Wisor, J. P., Nishino, S., & Mignot, E. (2004). Lesions of the suprachiasmatic nucleus eliminate the daily rhythm of hypocretin-1 release. SLEEP, 27(4), 619-627.

Locomotor-dependent and -independent components to hypocretin-1 (orexinA) regulation in sleep-wake consolidating monkeys
Zeitzer, J. M., Buckmaster, C. L., Lyons, D. M., & Mignot, E. (2004). Locomotor-dependent and -independent components to hypocretin-1 (orexinA) regulation in sleep-wake consolidating monkeys. JOURNAL OF PHYSIOLOGY-LONDON, 557(3), 1045-1053.

Sleep, sleep disorders and hypocretin (orexin)
Mignot, E. (2004). Sleep, sleep disorders and hypocretin (orexin). SLEEP MEDICINE, 5, S2-S8.

The roles of midbrain and diencephalic dopamine cell groups in the regulation of cataplexy in narcoleptic Dobermans
Okura, M., Fujiki, N., Kita, L., Honda, K., Yoshida, Y., & Nishino, S. (2004). The roles of midbrain and diencephalic dopamine cell groups in the regulation of cataplexy in narcoleptic Dobermans. NEUROBIOLOGY OF DISEASE, 16(1), 274-282.

Undetectable CSF hypocretin-1 in "Hashimoto's encephalopathy" associated with coma
Castillo, P. R., Mignot, E., Woodruff, B. K., & Boeve, B. F. (2004). Undetectable CSF hypocretin-1 in "Hashimoto's encephalopathy" associated with coma. NEUROLOGY, 62(10), 1909-1909.

Hypocretin-1 CSF levels in anti-Ma2 associated encephalitis
Overeem, S., Dalmau, J., Bataller, L., Nishino, S., Mignot, E., & Lammers, G. J. (2004). Hypocretin-1 CSF levels in anti-Ma2 associated encephalitis. NEUROLOGY, 62(1), 138-140.

Increased hypocretin-1 levels in cerebrospinal fluid after REM sleep deprivation
Pedrazzoli, M., D'Almeida, V., Martins, P. Jf., Machado, R. B., Ling, L., & Mignot, E. (2004). Increased hypocretin-1 levels in cerebrospinal fluid after REM sleep deprivation. BRAIN RESEARCH, 995(1), 1-6.

Diurnal variations of CSF hypocretin (HCRT) and changes in gene expression as detected by microarrays in young and old rats
Desarnaud, F., Murillo-Rodriguez, E., Xu, M., Gerashenko, D., Lu, J., & Shiromani, P. (2004). Diurnal variations of CSF hypocretin (HCRT) and changes in gene expression as detected by microarrays in young and old rats. SLEEP, 27, 382-382.

Normal CSF hypocretin-1 (orexin A) levels in dementia with Lewy bodies associated with excessive daytime sleepiness
Baumann, C. R., Dauvilliers, Y., Mignot, E., & Bassetti, C. L. (2004). Normal CSF hypocretin-1 (orexin A) levels in dementia with Lewy bodies associated with excessive daytime sleepiness. EUROPEAN NEUROLOGY, 52(2), 73-76.

Mapping multiple sclerosis susceptibility to the HLA-DR locus in African Americans
Oksenberg, J. R., Barcellos, L. F., Cree, B. Ac., Baranzini, S. E., Bugawan, T. L., & Hauser, S. L. (2004). Mapping multiple sclerosis susceptibility to the HLA-DR locus in African Americans. AMERICAN JOURNAL OF HUMAN GENETICS, 74(1), 160-167.

Genes transcripts relating to the immune response are up-regulated in narcoleptic postmortem hypothalamus using microarray
Honda, M., Salehi, A., Hesla, P., Maehlen, J., Gaus, S., & Mignot, E. (2004). Genes transcripts relating to the immune response are up-regulated in narcoleptic postmortem hypothalamus using microarray. SLEEP, 27, 250-251.

Effects of IV and ICV hypocretin-1 (Orexin A) in hypocretin receptor-2 gene mutated narcoleptic dogs and IV hypocretin-1 replacement therapy in a hypocretin-ligand-deficient narcoleptic dog
Fujiki, N., Yoshida, Y., Ripley, B., Mignot, E., & Nishino, S. (2003). Effects of IV and ICV hypocretin-1 (Orexin A) in hypocretin receptor-2 gene mutated narcoleptic dogs and IV hypocretin-1 replacement therapy in a hypocretin-ligand-deficient narcoleptic dog. SLEEP, 26(8), 953-959.

Normal hypocretin-1 levels in the cerebrospinal fluid of patients with fatal familial insomnia
Martinez-Rodriguez, J. E., Sanchez-Valle, R., Saiz, A., Lin, L., Iranzo, A., & Santamaria, J. (2003). Normal hypocretin-1 levels in the cerebrospinal fluid of patients with fatal familial insomnia. SLEEP, 26(8), 1068-1068.

Relationship between CSF hypocretin levels and hypocretin neuronal loss
Gerashchenko, D., Munillo-Rodriguez, E., Lin, L., Xu, M., Hallett, L., & Shiromani, P. J. (2003). Relationship between CSF hypocretin levels and hypocretin neuronal loss. EXPERIMENTAL NEUROLOGY, 184(2), 1010-1016.

CSF hypocretin-1 levels in restless legs syndrome
Stiasny-Kolster, K., Mignot, E., Ling, L., Moller, J. C., Cassel, W., & Oertel, W. H. (2003). CSF hypocretin-1 levels in restless legs syndrome. NEUROLOGY, 61(10), 1426-1429.

Narcolepsy: involvement of imprinted, differentially-methylated promotor haplotypes of vesicular monoamine transporter 2 (VMAT2).
Drgon, T., Takahashi, M., Walther, D., Lin, Z., Lin, L., & Uhl, G. R. (2003). Narcolepsy: involvement of imprinted, differentially-methylated promotor haplotypes of vesicular monoamine transporter 2 (VMAT2). AMERICAN JOURNAL OF HUMAN GENETICS, 73(5), 332-332.

Report of a case of immunosuppression with prednisone in an 8-year-old boy with an acute onset of hypocretin-deficiency narcolepsy
Hecht, M., Lin, L., Kushida, C. A., Umetsu, D. T., Taheri, S., & Mignot, E. (2003). Report of a case of immunosuppression with prednisone in an 8-year-old boy with an acute onset of hypocretin-deficiency narcolepsy. SLEEP, 26(7), 809-810.

CSF hypocretin levels in Guillain-Barre syndrome and other inflammatory neuropathies
Nishino, S., Kanbayashi, T., Fujiki, N., Uchino, M., Ripley, B., & Mignot, E. (2003). CSF hypocretin levels in Guillain-Barre syndrome and other inflammatory neuropathies. NEUROLOGY, 61(6), 823-825.

On the value of measuring CSF hypocretin-1 in diagnosing narcolepsy
Mignot, E., Chen, W., & Black, J. (2003). On the value of measuring CSF hypocretin-1 in diagnosing narcolepsy. SLEEP, 26(6), 646-649.

Diurnal variation of cerebrospinal fluid hypocretin-1 (orexin-A) levels in control and depressed subjects
Salomon, R. M., Ripley, B., Kennedy, J. S., Johnson, B., Schmidt, D., & Mignot, E. (2003). Diurnal variation of cerebrospinal fluid hypocretin-1 (orexin-A) levels in control and depressed subjects. BIOLOGICAL PSYCHIATRY, 54(2), 96-104.

Sleep disturbances and hypocretin deficiency in Niemann-Pick disease type C
Vankova, J., Stepanova, I., Jech, R., Elleder, M., Ling, L., & Nevsimalova, S. (2003). Sleep disturbances and hypocretin deficiency in Niemann-Pick disease type C. SLEEP, 26(4), 427-430.

Circadian and homeostatic regulation of hypocretin in a primate model: Implications for the consolidation of wakefulness
Zeitzer, J. M., Buckmaster, C. L., Parker, K. J., Hauck, C. M., Lyons, D. M., & Mignot, E. (2003). Circadian and homeostatic regulation of hypocretin in a primate model: Implications for the consolidation of wakefulness. JOURNAL OF NEUROSCIENCE, 23(8), 3555-3560.

Voxel-based morphometry in hypocretin-deficient narcolepsy
Overeem, S., Steens, S. Ca., Good, C. D., Ferrari, M. D., Mignot, E., & Lammers, G. J. (2003). Voxel-based morphometry in hypocretin-deficient narcolepsy. SLEEP, 26(1), 44-46.

Sleeping with the hypothalamus: emerging therapeutic targets for sleep disorders
Mignot, E., Taheri, S., & Nishino, S. (2002). Sleeping with the hypothalamus: emerging therapeutic targets for sleep disorders. NATURE NEUROSCIENCE, 5, 1071-1075.

Increased CSF hypocretin-1 (orexin-A) in restless legs syndrome
Allen, R. P., Mignot, E., Ripley, B., Nishino, S., & Earley, C. J. (2002). Increased CSF hypocretin-1 (orexin-A) in restless legs syndrome. NEUROLOGY, 59(4), 639-641.

HLA and hypocretin studies in Korean patients with narcolepsy
Hong, S. C., Leen-Kim, Park, S. A., Han, J. H., Lee, S. P., & Mignot, E. (2002). HLA and hypocretin studies in Korean patients with narcolepsy. SLEEP, 25(4), 440-444.

Hypocretin stimulates [(35)]GTP gamma S binding in Hcrtr 2-transfected cell lines and in brain homogenate
Shiba, T., Ozu, M., Yoshida, Y., Mignot, E., & Nishino, S. (2002). Hypocretin stimulates [(35)]GTP gamma S binding in Hcrtr 2-transfected cell lines and in brain homogenate. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 294(3), 615-620.

CSF hypocretin-1 levels in schizophrenics and controls: relationship to sleep architecture
Nishino, S., Ripley, B., Mignot, E., Benson, K. L., & Zarcone, V. P. (2002). CSF hypocretin-1 levels in schizophrenics and controls: relationship to sleep architecture. PSYCHIATRY RESEARCH, 110(1), 1-7.

Diurnal variation of CSF hypocretin-1 (orexin A) levels in control and depressed subjects
Salomon, R. M., Ripley, B., Kennedy, J. S., Schmidt, D., Zeitzer, J., & Mignot, E. (2002). Diurnal variation of CSF hypocretin-1 (orexin A) levels in control and depressed subjects. SLEEP, 25, A12-A13.

Stimulant medication usage in a large cohort of narcoleptic subjects
Okun, M. L., Lopez, A., Colrain, I., Ginney, C., Brooks, S., & Black, J. (2002). Stimulant medication usage in a large cohort of narcoleptic subjects. SLEEP, 25, A474-A474.

Clinical aspects of narcolepsy-cataplexy across ethnic groups
Okun, M. L., Lin, L., Pelin, Z., Hong, S. C., & Mignot, E. (2002). Clinical aspects of narcolepsy-cataplexy across ethnic groups. SLEEP, 25(1), 27-35.

The role of hypocretins (orexins) in sleep regulation and narcolepsy
Taheri, S., Zeitzer, J. M., & Mignot, E. (2002). The role of hypocretins (orexins) in sleep regulation and narcolepsy. ANNUAL REVIEW OF NEUROSCIENCE, 25, 283-313.

CSF hypocretin/orexin levels in narcolepsy and other neurological conditions
Ripley, B., Overeem, S., Fujiki, N., Nevsimalova, S., Uchino, M., & Nishino, S. (2001). CSF hypocretin/orexin levels in narcolepsy and other neurological conditions. NEUROLOGY, 57(12), 2253-2258.

Polymorphisms in the vicinity of the hypocretin/orexin are not associated with human narcolepsy
Hungs, M., Lin, L., Okun, M., & Mignot, E. (2001). Polymorphisms in the vicinity of the hypocretin/orexin are not associated with human narcolepsy. NEUROLOGY, 57(10), 1893-1895.

Decreased brain histamine content in hypocretin/orexin receptor-2 mutated narcoleptics dogs
Nishino, S., Fujiki, N., Ripley, B., SAKURAI, E., Kato, M., & Yanai, K. (2001). Decreased brain histamine content in hypocretin/orexin receptor-2 mutated narcoleptics dogs. NEUROSCIENCE LETTERS, 313(3), 125-128.

A commentary on the neurobiology of the hypocretin/orexin system
Mignot, E. (2001). A commentary on the neurobiology of the hypocretin/orexin system. NEUROPSYCHOPHARMACOLOGY, 25, S5-S13.

Fluctuation of extracellular hypocretin-1 (orexin A) levels in the rat in relation to the light-dark cycle and sleep-wake activities
Yoshida, Y., Fujiki, N., Nakajima, T., Ripley, B., Matsumura, H., & Nishino, S. (2001). Fluctuation of extracellular hypocretin-1 (orexin A) levels in the rat in relation to the light-dark cycle and sleep-wake activities. EUROPEAN JOURNAL OF NEUROSCIENCE, 14(7), 1075-1081.

Narcolepsy and the HLA region
Lin, L., Hungs, M., & Mignot, E. (2001). Narcolepsy and the HLA region. JOURNAL OF NEUROIMMUNOLOGY, 117(1-2), 9-20.

Narcolepsy and low CSF orexin (hypocretin) concentration after a diencephalic stroke
Scammell, T. E., Nishino, S., Mignot, E., & SAPER, C. B. (2001). Narcolepsy and low CSF orexin (hypocretin) concentration after a diencephalic stroke. NEUROLOGY, 56(12), 1751-1753.

Association between apolipoprotein E epsilon 4 and sleep-disordered breathing in adults
KADOTANI, H., Kadotani, T., Young, T., Peppard, P. E., Finn, L., & Mignot, E. (2001). Association between apolipoprotein E epsilon 4 and sleep-disordered breathing in adults. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 285(22), 2888-2890.

Hypocretin levels in sporadic and familial cases of canine narcolepsy
Ripley, B., Fujiki, N., Okura, M., Mignot, E., & Nishino, S. (2001). Hypocretin levels in sporadic and familial cases of canine narcolepsy. NEUROBIOLOGY OF DISEASE, 8(3), 525-534.

Narcoleptic canines display periodic leg movements during sleep
Okura, M., Fujiki, N., Ripley, B., Takahashi, S., Amitai, N., & Nishino, S. (2001). Narcoleptic canines display periodic leg movements during sleep. PSYCHIATRY AND CLINICAL NEUROSCIENCES, 55(3), 243-244.

Hypocretin/orexin, sleep and narcolepsy
Hungs, M., & Mignot, E. (2001). Hypocretin/orexin, sleep and narcolepsy. BIOESSAYS, 23(5), 397-408.

Physical and radiation hybrid mapping of canine chromosome 12, in a region corresponding to human chromosome 6p12-q12
Li, R., Faraco, J. H., Lin, L., Lin, X. Y., Hinton, L., & Mignot, E. (2001). Physical and radiation hybrid mapping of canine chromosome 12, in a region corresponding to human chromosome 6p12-q12. GENOMICS, 73(3), 299-315.

Changes in CSF hypocretin-1 (orexin A) levels in rats across 24 hours and in response to food deprivation
Fujiki, N., Yoshida, Y., Ripley, B., Honda, K., Mignot, E., & Nishino, S. (2001). Changes in CSF hypocretin-1 (orexin A) levels in rats across 24 hours and in response to food deprivation. NEUROREPORT, 12(5), 993-997.

Diagnostic value of low CSF hypocretin/orexin levels in human narcolepsy
Nishino, S., Ripley, B., Overeem, S., Nevsimalova, S., Lammers, G. J., & Mignot, E. (2001). Diagnostic value of low CSF hypocretin/orexin levels in human narcolepsy. SLEEP, 24, A95-A96.

A hundred years of narcolepsy research
Mignot, E. (2001). A hundred years of narcolepsy research. ARCHIVES ITALIENNES DE BIOLOGIE, 139(3), 207-220.

Identification and functional analysis of mutations in the Hypocretin (Orexin) genes of narcoleptic canines
Hungs, M., Fan, J., Lin, L., Lin, X. Y., Maki, R. A., & Mignot, E. (2001). Identification and functional analysis of mutations in the Hypocretin (Orexin) genes of narcoleptic canines. GENOME RESEARCH, 11(4), 531-539.

Narcolepsy: Clinical features, new pathophysiologic insights, and future perspectives
Overeem, S., Mignot, E., van Dijk, J. G., & Lammers, G. J. (2001). Narcolepsy: Clinical features, new pathophysiologic insights, and future perspectives. JOURNAL OF CLINICAL NEUROPHYSIOLOGY, 18(2), 78-105.

Dopaminergic role in stimulant-induced wakefulness
Wisor, J. P., Nishino, S., Sora, I., Uhl, G. H., Mignot, E., & Edgar, D. M. (2001). Dopaminergic role in stimulant-induced wakefulness. JOURNAL OF NEUROSCIENCE, 21(5), 1787-1794.

The role of histamine in a hypocretin (orexin)-deficient sleep disorder, narcolepsy
Nishino, S., Honda, K., Fujiki, N., Wurts, S. W., SAKURAI, E., & Yanai, K. (2001). The role of histamine in a hypocretin (orexin)-deficient sleep disorder, narcolepsy. HISTAMINE RESEARCH IN THE NEW MILLENNIUM, 1224, 247-251.

Is narcolepsy a REM sleep disorder? Analysis of sleep abnormalities in narcoleptic Dobermans
Nishino, S., Riehl, J., Hong, J., Kwan, M., REID, M., & Mignot, E. (2000). Is narcolepsy a REM sleep disorder? Analysis of sleep abnormalities in narcoleptic Dobermans. NEUROSCIENCE RESEARCH, 38(4), 437-446.

Sulpiride, a D2/D3 blocker, reduces cataplexy but not REM sleep in canine narcolepsy
Okura, M., Riehl, J., Mignot, E., & Nishino, S. (2000). Sulpiride, a D2/D3 blocker, reduces cataplexy but not REM sleep in canine narcolepsy. NEUROPSYCHOPHARMACOLOGY, 23(5), 528-538.

Chronic oral administration of CG-3703, a thyrotropin releasing hormone analog, increases wake and decreases cataplexy in canine narcolepsy
Riehl, J., Honda, K., Kwan, M., Hong, J., Mignot, E., & Nishino, S. (2000). Chronic oral administration of CG-3703, a thyrotropin releasing hormone analog, increases wake and decreases cataplexy in canine narcolepsy. NEUROPSYCHOPHARMACOLOGY, 23(1), 34-45.

Clinical and polysomnographic features in DQB1*0602 positive and negative narcolepsy patients: results from the modafinil clinical trial
Hong, S. C., Hayduk, R., Lim, J., & Mignot, E. (2000). Clinical and polysomnographic features in DQB1*0602 positive and negative narcolepsy patients: results from the modafinil clinical trial. SLEEP MEDICINE, 1(1), 33-39.

Narcolepsy: genetic predisposition and neuropharmacological mechanisms
Nishino, S., Okura, M., & Mignot, E. (2000). Narcolepsy: genetic predisposition and neuropharmacological mechanisms. SLEEP MEDICINE REVIEWS, 4(1), 57-99.

Hypocretin (orexin) deficiency in human narcolepsy
Nishino, S., Ripley, B., Overeem, S., Lammers, G. J., & Mignot, E. (2000). Hypocretin (orexin) deficiency in human narcolepsy. LANCET, 355(9197), 39-40.

Perspectives in narcolepsy and hypocretin (orexin) research.
Mignot, E. (2000). Perspectives in narcolepsy and hypocretin (orexin) research. Sleep medicine, 1(2), 87-90.

[Hypocretin (orexin) deficiency in narcolepsy-cataplexy].
Nevsímalová, S., Vanková, J., Sonka, K., Faraco, J., Rogers, W., & Mignot, E. (2000). [Hypocretin (orexin) deficiency in narcolepsy-cataplexy]. Sborník lékar?ský, 101(4), 381-386.

Implication of dopaminergic mechanisms in the wake-promoting effects of amphetamine: A study of D- and L-derivatives in canine narcolepsy
Kanbayashi, T., Honda, K., Kodama, T., Mignot, E., & Nishino, S. (2000). Implication of dopaminergic mechanisms in the wake-promoting effects of amphetamine: A study of D- and L-derivatives in canine narcolepsy. NEUROSCIENCE, 99(4), 651-659.

Narcolepsy: genetic predisposition and neuropharmacological mechanisms. REVIEW ARTICLE.
Nishino, S., Okura, M., & Mignot, E. (2000). Narcolepsy: genetic predisposition and neuropharmacological mechanisms. REVIEW ARTICLE. Sleep medicine reviews, 4(1), 57-99.

A polymorphism in the human timeless gene is not associated with diurnal preferences in normal adults.
Pedrazzoli, M., Ling, L., Finn, L., Kubin, L., Young, T., & Mignot, E. (2000). A polymorphism in the human timeless gene is not associated with diurnal preferences in normal adults. Sleep research online : SRO, 3(2), 73-76.

Dopamine D3 agonists into the substantia nigra aggravate cataplexy but do not modify sleep (vol 10, pg 3111, 1999)
Honda, K., Riehl, J., Mignot, E., & Nishino, S. (1999). Dopamine D3 agonists into the substantia nigra aggravate cataplexy but do not modify sleep (vol 10, pg 3111, 1999). NEUROREPORT, 10(17), 3717-3724.

Dopamine D-3 agonists into the substratia nigra aggravates cataplexy but does not modify sleep
Honda, K., Riehl, J., Mignot, E., & Nishino, S. (1999). Dopamine D-3 agonists into the substratia nigra aggravates cataplexy but does not modify sleep. NEUROREPORT, 10(14), 3111-3118.

A human period gene (HPER1) polymorphism is not associated with diurnal preference in normal adults
Katzenberg, D., Young, T., Lin, L., Finn, L., & Mignot, E. (1999). A human period gene (HPER1) polymorphism is not associated with diurnal preference in normal adults. PSYCHIATRIC GENETICS, 9(2), 107-109.

Construction and characterization of an eightfold redundant dog genomic bacterial artificial chromosome library
Li, R., Mignot, E., Faraco, J., KADOTANI, H., Cantanese, J., & de Jong, P. J. (1999). Construction and characterization of an eightfold redundant dog genomic bacterial artificial chromosome library. GENOMICS, 58(1), 9-17.

Nocturnal sleep and daytime sleepiness in normal subjects with HLA-DQB1*0602
Mignot, E., Young, T., Lin, L., & Finn, L. (1999). Nocturnal sleep and daytime sleepiness in normal subjects with HLA-DQB1*0602. SLEEP, 22(3), 347-352.

Genetic studies in narcolepsy, a disorder affecting REM sleep
Faraco, J., Lin, X., Li, R., Hinton, L., Lin, L., & Mignot, E. (1999). Genetic studies in narcolepsy, a disorder affecting REM sleep. JOURNAL OF HEREDITY, 90(1), 129-132.

Neuronal activity in the cholinoceptive basal forebrain of freely moving narcoleptic dobermans
Nishino, S., Honda, K., Riehl, J., Okura, M., & Mignot, E. (1998). Neuronal activity in the cholinoceptive basal forebrain of freely moving narcoleptic dobermans. NEUROREPORT, 9(16), 3653-3661.

A CLOCK polymorphism associated with human diurnal preference
Katzenberg, D., Young, T., Finn, L., Lin, L., King, D. P., & Mignot, E. (1998). A CLOCK polymorphism associated with human diurnal preference. SLEEP, 21(6), 569-576.

Development of cataplexy in genetically narcoleptic Dobermans
Riehl, J., Nishino, S., Cederberg, R., Dement, W. C., & Mignot, E. (1998). Development of cataplexy in genetically narcoleptic Dobermans. EXPERIMENTAL NEUROLOGY, 152(2), 292-302.

Microsatellite single nucleotide polymorphisms in the HLA-DQ region
Lin, L., Jin, L., Lin, X., Voros, A., Underhill, P., & Mignot, E. (1998). Microsatellite single nucleotide polymorphisms in the HLA-DQ region. TISSUE ANTIGENS, 52(1), 9-18.

Cerebrospinal fluid prostaglandins and corticotropin releasing factor in schizophrenics and controls: relationship to sleep architecture
Nishino, S., Mignot, E., Benson, K. L., & Zarcone, V. P. (1998). Cerebrospinal fluid prostaglandins and corticotropin releasing factor in schizophrenics and controls: relationship to sleep architecture. PSYCHIATRY RESEARCH, 78(3), 141-150.

Neuropharmacological characterization of basal forebrain cholinergic stimulated cataplexy in narcoleptic canines
Reid, M. S., Nishino, S., Tafti, M., Siegel, J. M., Dement, W. C., & Mignot, E. (1998). Neuropharmacological characterization of basal forebrain cholinergic stimulated cataplexy in narcoleptic canines. EXPERIMENTAL NEUROLOGY, 151(1), 89-104.

Neurobiology of narcolepsy
Nishino, S., & Mignot, E. (1998). Neurobiology of narcolepsy. NEUROSCIENTIST, 4(2), 133-143.

Genetic and familial aspects of narcolepsy
Mignot, E. (1998). Genetic and familial aspects of narcolepsy. NEUROLOGY, 50(2), S16-S22.

Breeding history of the Stanford colony of narcoleptic dogs
Cederberg, R., Nishino, S., Dement, W. C., & Mignot, E. (1998). Breeding history of the Stanford colony of narcoleptic dogs. VETERINARY RECORD, 142(2), 31-36.

The role of genetic factors in the development of narcolepsy and hypersomnia in childhood
Nevsimalova, S., & Mignot, E. (1998). The role of genetic factors in the development of narcolepsy and hypersomnia in childhood. 9TH EUROPEAN CONGRESS OF CLINICAL NEUROPHYSIOLOGY, 63-68.

HLA-DQB1*0602 homozygosity increases relative risk for narcolepsy but not disease severity in two ethnic groups
Pelin, Z., Guilleminault, C., Risch, N., GRUMET, F. C., & Mignot, E. (1998). HLA-DQB1*0602 homozygosity increases relative risk for narcolepsy but not disease severity in two ethnic groups. TISSUE ANTIGENS, 51(1), 96-100.

DQ microsatellite association studies in three ethnic groups
Lin, L., Jin, L., Kimura, A., Carrington, M., & Mignot, E. (1997). DQ microsatellite association studies in three ethnic groups. TISSUE ANTIGENS, 50(5), 507-520.

Effects of thyrotropin-releasing hormone and its analogs on daytime sleepiness and cataplexy in canine narcolepsy
Nishino, S., Arrigoni, J., Shelton, J., Kanbayashi, T., Dement, W. C., & Mignot, E. (1997). Effects of thyrotropin-releasing hormone and its analogs on daytime sleepiness and cataplexy in canine narcolepsy. JOURNAL OF NEUROSCIENCE, 17(16), 6401-6408.

Genetics of narcolepsy and other sleep disorders
Mignot, E. (1997). Genetics of narcolepsy and other sleep disorders. AMERICAN JOURNAL OF HUMAN GENETICS, 60(6), 1289-1302.

HLA DR15 (DR2) and DQB1*0602 typing studies in 188 narcoleptic patients with cataplexy
Rogers, A. E., Meehan, J., Guilleminault, C., GRUMET, F. C., & Mignot, E. (1997). HLA DR15 (DR2) and DQB1*0602 typing studies in 188 narcoleptic patients with cataplexy. NEUROLOGY, 48(6), 1550-1556.

Extensive HLA class II studies in 58 non-DRB1*15 (DR2) narcoleptic patients with cataplexy
Mignot, E., Kimura, A., Lattermann, A., Lin, X., Yasunaga, S., & Underhill, P. (1997). Extensive HLA class II studies in 58 non-DRB1*15 (DR2) narcoleptic patients with cataplexy. TISSUE ANTIGENS, 49(4), 329-341.

Mesopontine organization of cholinergic and catecholaminergic cell groups in the normal and narcoleptic dog
Tafti, M., Nishino, S., Liao, W., Dement, W. C., & Mignot, E. (1997). Mesopontine organization of cholinergic and catecholaminergic cell groups in the normal and narcoleptic dog. JOURNAL OF COMPARATIVE NEUROLOGY, 379(2), 185-197.

HLA class II studies in non DRB1*1501 patients with narcolepsy-cataplexy
Mignot, E., Kimura, A., Lattermann, A., GRUMET, F. C., Mayer, G., & Mueller-Eckhardt, G. (1997). HLA class II studies in non DRB1*1501 patients with narcolepsy-cataplexy. HLA - GENETIC DIVERSITY OF HLA FUNCTIONAL AND MEDICAL IMPLICATION, PROCEEDINGS OF THE TWELFTH INTERNATIONAL HISTOCOMPATIBILITY WORKSHOP AND CONFERENCE (12TH IHWC), VOL I: WORKSHOP, 436-441.

Familial aspects of narcolepsy-cataplexy in the Czech Republic
Nevsimalova, S., Mignot, E., Sonka, K., & Arrigoni, J. L. (1997). Familial aspects of narcolepsy-cataplexy in the Czech Republic. SLEEP, 20(11), 1021-1026.

HLA DQB1*0602 is associated with cataplexy in 509 narcoleptic patients
Mignot, E., Hayduk, R., Black, J., GRUMET, F. C., & Guilleminault, C. (1997). HLA DQB1*0602 is associated with cataplexy in 509 narcoleptic patients. SLEEP, 20(11), 1012-1020.

The natural history of a microsatellite located in the HLA DQ region
Mignot, E., Macaubas, C., Jin, L., Hallmayer, J., Kimura, A., & GRUMET, F. C. (1997). The natural history of a microsatellite located in the HLA DQ region. HLA - GENETIC DIVERSITY OF HLA FUNCTIONAL AND MEDICAL IMPLICATION, PROCEEDINGS OF THE TWELFTH INTERNATIONAL HISTOCOMPATIBILITY WORKSHOP AND CONFERENCE (12TH IHWC), VOL II: CONFERENCE, 121-124.

Mutation rate varies among alleles at a microsatellite locus: Phylogenetic evidence
Jin, L., Macaubas, C., Hallmayer, J., Kimura, A., & Mignot, E. (1996). Mutation rate varies among alleles at a microsatellite locus: Phylogenetic evidence. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 93(26), 15285-15288.

Local administration of dopaminergic drugs into the ventral tegmental area modulates cataplexy in the narcoleptic canine
Reid, M. S., Tafti, M., Nishino, S., Sampathkumaran, R., Siegel, J. M., & Mignot, E. (1996). Local administration of dopaminergic drugs into the ventral tegmental area modulates cataplexy in the narcoleptic canine. BRAIN RESEARCH, 733(1), 83-100.

Thalidomide, a hypnotic with immune modulating properties, increases cataplexy in canine narcolepsy
Kanbayashi, T., Nishino, S., Tafti, M., Hishikawa, Y., Dement, W. C., & Mignot, E. (1996). Thalidomide, a hypnotic with immune modulating properties, increases cataplexy in canine narcolepsy. NEUROREPORT, 7(12), 1881-1886.

Major histocompatibility class II molecules in the CNS: Increased microglial expression at the onset of narcolepsy in a canine model
Tafti, M., Nishino, S., Aldrich, M. S., Liao, W. N., Dement, W. C., & Mignot, E. (1996). Major histocompatibility class II molecules in the CNS: Increased microglial expression at the onset of narcolepsy in a canine model. JOURNAL OF NEUROSCIENCE, 16(15), 4588-4595.

IgH (mu-switch and gamma-1) region restriction fragment length polymorphism in human narcolepsy
Singh, S. M., George, C. Fp., OTT, R. N., Rattazzi, C., Guilleminault, C., & Mignot, E. (1996). IgH (mu-switch and gamma-1) region restriction fragment length polymorphism in human narcolepsy. JOURNAL OF CLINICAL IMMUNOLOGY, 16(4), 208-215.

The natural history of a microsatellite located in the HLA DQ region
Mignot, E., Macaubas, C., Jin, L., Hallmayer, J., Kimura, A., & GRUMET, F. C. (1996). The natural history of a microsatellite located in the HLA DQ region. HUMAN IMMUNOLOGY, 47(1-2), O09-O09.

Thalidomide, immune modulation and narcolepsy
Kanbayashi, T., Nishino, S., Tafti, M., Hishikawa, Y., Dement, W. C., & Mignot, E. (1996). Thalidomide, immune modulation and narcolepsy. SLEEP, 19(2), 116-116.

Some genetic aspects of narcolepsy
Nevsimalova, S., Mignot, E., Sonka, K., & Arrigoni, J. L. (1996). Some genetic aspects of narcolepsy. CESKA A SLOVENSKA NEUROLOGIE A NEUROCHIRURGIE, 59(4), 210-215.

Comparative effects of modafinil and amphetamine on daytime sleepiness and cataplexy of narcoleptic dogs
Shelton, J., Nishino, S., Vaught, J., Dement, W. C., & Mignot, E. (1995). Comparative effects of modafinil and amphetamine on daytime sleepiness and cataplexy of narcoleptic dogs. SLEEP, 18(10), 817-826.

DQCAR MICROSATELLITE POLYMORPHISMS IN 3 SELECTED HLA CLASS II-ASSOCIATED DISEASES
Mignot, E., Kimura, A., Abbal, M., Thorsby, E., Lin, X., & GRUMET, F. C. (1995). DQCAR MICROSATELLITE POLYMORPHISMS IN 3 SELECTED HLA CLASS II-ASSOCIATED DISEASES. TISSUE ANTIGENS, 46(4), 299-304.

TRACKING THE EVOLUTION OF A MICROSATELLITE LOCUS LOCATED IN THE HLA-DQA1/DQB1 CLASS-II REGION
Macaubas, C., Jin, L., Hallmayer, J., Kimura, A., & Mignot, E. (1995). TRACKING THE EVOLUTION OF A MICROSATELLITE LOCUS LOCATED IN THE HLA-DQA1/DQB1 CLASS-II REGION. AMERICAN JOURNAL OF HUMAN GENETICS, 57(4), 953-953.

MUSCLE ATONIA IS TRIGGERED BY CHOLINERGIC STIMULATION OF THE BASAL FOREBRAIN - IMPLICATION FOR THE PATHOPHYSIOLOGY OF CANINE NARCOLEPSY
Nishino, S., Tafti, M., Reid, M. S., Shelton, J., Siegel, J. M., & Mignot, E. (1995). MUSCLE ATONIA IS TRIGGERED BY CHOLINERGIC STIMULATION OF THE BASAL FOREBRAIN - IMPLICATION FOR THE PATHOPHYSIOLOGY OF CANINE NARCOLEPSY. JOURNAL OF NEUROSCIENCE, 15(7), 4806-4814.

EXTENSIVE POLYMORPHISM OF A (CA)(N) MICROSATELLITE LOCATED IN THE HLA-DQA1/DQB1 CLASS-II REGION
Macaubas, C., Hallmayer, J., Kalil, J., Kimura, A., Yasunaga, S., & Mignot, E. (1995). EXTENSIVE POLYMORPHISM OF A (CA)(N) MICROSATELLITE LOCATED IN THE HLA-DQA1/DQB1 CLASS-II REGION. HUMAN IMMUNOLOGY, 42(3), 209-220.

EFFECT OF 5-HT1A RECEPTOR AGONISTS AND ANTAGONISTS ON CANINE CATAPLEXY
Nishino, S., Shelton, J., RENAUD, A., Dement, W. C., & Mignot, E. (1995). EFFECT OF 5-HT1A RECEPTOR AGONISTS AND ANTAGONISTS ON CANINE CATAPLEXY. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 272(3), 1170-1175.

A NEW DRB1(ASTERISK)1202 ALLELE (DRB1(ASTERISK)12022) FOUND IN ASSOCIATION WITH DQA1(ASTERISK)0102 AND DQB1(ASTERISK)0602 IN 2 BLACK NARCOLEPTIC SUBJECTS
Behar, E., Lin, X. Y., GRUMET, F. C., & Mignot, E. (1995). A NEW DRB1(ASTERISK)1202 ALLELE (DRB1(ASTERISK)12022) FOUND IN ASSOCIATION WITH DQA1(ASTERISK)0102 AND DQB1(ASTERISK)0602 IN 2 BLACK NARCOLEPTIC SUBJECTS. IMMUNOGENETICS, 41(1), 52-52.

NARCOLEPSY AND IMMUNITY
Mignot, E., Tafti, M., Dement, W. C., & GRUMET, F. C. (1995). NARCOLEPSY AND IMMUNITY. ADVANCES IN NEUROIMMUNOLOGY, 5(1), 23-37.

CONTROVERSIES IN THE DIAGNOSIS OF NARCOLEPSY
Guilleminault, C., Mignot, E., & Partinen, M. (1994). CONTROVERSIES IN THE DIAGNOSIS OF NARCOLEPSY. SLEEP, 17(8), S1-S6.

NEUROPHARMACOLOGY AND NEUROCHEMISTRY OF CANINE NARCOLEPSY
Nishino, S., Reid, M. S., Dement, W. C., & Mignot, E. (1994). NEUROPHARMACOLOGY AND NEUROCHEMISTRY OF CANINE NARCOLEPSY. SLEEP, 17(8), S84-S92.

AN IMMUNOGLOBULIN SWITCHLIKE SEQUENCE IS LINKED WITH CANINE NARCOLEPSY
Mignot, E., Bell, R. A., Rattazzi, C., LOVETT, M., GRUMET, F. C., & Dement, W. C. (1994). AN IMMUNOGLOBULIN SWITCHLIKE SEQUENCE IS LINKED WITH CANINE NARCOLEPSY. SLEEP, 17(8), S68-S76.

DQB1-ASTERISK-0602 AND DQA1-ASTERISK-0102 (DQ1) ARE BETTER MARKERS THAN DR2 FOR NARCOLEPSY IN CAUCASIAN AND BLACK-AMERICANS
Mignot, E., Lin, X., Arrigoni, J., Macaubas, C., Olive, F., & GRUMET, F. C. (1994). DQB1-ASTERISK-0602 AND DQA1-ASTERISK-0102 (DQ1) ARE BETTER MARKERS THAN DR2 FOR NARCOLEPSY IN CAUCASIAN AND BLACK-AMERICANS. SLEEP, 17(8), S60-S67.

CHOLINERGIC REGULATION OF CATAPLEXY IN CANINE NARCOLEPSY IN THE PONTINE RETICULAR-FORMATION IS MEDIATED BY M2 MUSCARINIC RECEPTORS
Reid, M. S., Tafti, M., Nishino, S., Siegel, J. M., Dement, W. C., & Mignot, E. (1994). CHOLINERGIC REGULATION OF CATAPLEXY IN CANINE NARCOLEPSY IN THE PONTINE RETICULAR-FORMATION IS MEDIATED BY M2 MUSCARINIC RECEPTORS. SLEEP, 17(5), 424-435.

MODAFINIL BINDS TO THE DOPAMINE UPTAKE CARRIER SITE WITH LOW-AFFINITY
Mignot, E., Nishino, S., Guilleminault, C., & Dement, W. C. (1994). MODAFINIL BINDS TO THE DOPAMINE UPTAKE CARRIER SITE WITH LOW-AFFINITY. SLEEP, 17(5), 436-437.

CHOLINERGIC MECHANISMS IN CANINE NARCOLEPSY .1. MODULATION OF CATAPLEXY VIA LOCAL-DRUG ADMINISTRATION INTO THE PONTINE RETICULAR-FORMATION
Reid, M. S., Tafti, M., GEARY, J. N., Nishino, S., Siegel, J. M., & Mignot, E. (1994). CHOLINERGIC MECHANISMS IN CANINE NARCOLEPSY .1. MODULATION OF CATAPLEXY VIA LOCAL-DRUG ADMINISTRATION INTO THE PONTINE RETICULAR-FORMATION. NEUROSCIENCE, 59(3), 511-522.

STABILITY OF CATAPLEXY OVER SEVERAL MONTHS - INFORMATION FOR THE DESIGN OF THERAPEUTIC TRIALS
Gelb, M., Guilleminault, C., Kraemer, H., Lin, S., Moon, S., & Mignot, E. (1994). STABILITY OF CATAPLEXY OVER SEVERAL MONTHS - INFORMATION FOR THE DESIGN OF THERAPEUTIC TRIALS. SLEEP, 17(3), 265-273.

CHOLINERGIC MECHANISMS IN CANINE NARCOLEPSY .2. ACETYLCHOLINE-RELEASE IN THE PONTINE RETICULAR-FORMATION IS ENHANCED DURING CATAPLEXY
Reid, M. S., Siegel, J. M., Dement, W. C., & Mignot, E. (1994). CHOLINERGIC MECHANISMS IN CANINE NARCOLEPSY .2. ACETYLCHOLINE-RELEASE IN THE PONTINE RETICULAR-FORMATION IS ENHANCED DURING CATAPLEXY. NEUROSCIENCE, 59(3), 523-530.

DESMETHYL METABOLITES OF SEROTONERGIC UPTAKE INHIBITORS ARE MORE POTENT FOR SUPPRESSING CANINE CATAPLEXY THAN THEIR PARENT COMPOUNDS
Nishino, S., Arrigoni, J., Shelton, J., Dement, W. C., & Mignot, E. (1993). DESMETHYL METABOLITES OF SEROTONERGIC UPTAKE INHIBITORS ARE MORE POTENT FOR SUPPRESSING CANINE CATAPLEXY THAN THEIR PARENT COMPOUNDS. SLEEP, 16(8), 706-712.

FURTHER CHARACTERIZATION OF THE ALPHA-1 RECEPTOR SUBTYPE INVOLVED IN THE CONTROL OF CATAPLEXY IN CANINE NARCOLEPSY
Nishino, S., Fruhstorfer, B., Arrigoni, J., Guilleminault, C., Dement, W. C., & Mignot, E. (1993). FURTHER CHARACTERIZATION OF THE ALPHA-1 RECEPTOR SUBTYPE INVOLVED IN THE CONTROL OF CATAPLEXY IN CANINE NARCOLEPSY. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 264(3), 1079-1084.

PHARMACOLOGICAL CONTROL OF NARCOLEPSY AND REM-SLEEP
Mignot, E., & Guilleminault, C. (1993). PHARMACOLOGICAL CONTROL OF NARCOLEPSY AND REM-SLEEP. ENDOCRINE AND NUTRITIONAL CONTROL OF BASIC BIOLOGICAL FUNCTIONS, 7, 307-314.

DQB1-0602 (DQW1) IS NOT PRESENT IN MOST NONDR2 CAUCASIAN NARCOLEPTICS
Mignot, E., Lin, X., Kalil, J., George, C., Singh, S., & GRUMET, F. C. (1992). DQB1-0602 (DQW1) IS NOT PRESENT IN MOST NONDR2 CAUCASIAN NARCOLEPTICS. SLEEP, 15(5), 415-422.

MONOAMINERGIC UPTAKE IN SYNAPTOSOMES PREPARED FROM FROZEN BRAIN-TISSUE SAMPLES OF NORMAL AND NARCOLEPTIC CANINES
VALTIER, D., Dement, W. C., & Mignot, E. (1992). MONOAMINERGIC UPTAKE IN SYNAPTOSOMES PREPARED FROM FROZEN BRAIN-TISSUE SAMPLES OF NORMAL AND NARCOLEPTIC CANINES. BRAIN RESEARCH, 588(1), 115-119.

ACTIVITY OF MEDIAL MESOPONTINE UNITS DURING CATAPLEXY AND SLEEP-WAKING STATES IN THE NARCOLEPTIC DOG
Siegel, J. M., Nienhuis, R., Fahringer, H. M., Chiu, C., Dement, W. C., & Lufkin, R. (1992). ACTIVITY OF MEDIAL MESOPONTINE UNITS DURING CATAPLEXY AND SLEEP-WAKING STATES IN THE NARCOLEPTIC DOG. JOURNAL OF NEUROSCIENCE, 12(5), 1640-1646.

STRATEGIES FOR THE DEVELOPMENT OF NEW TREATMENTS IN SLEEP DISORDER MEDICINE
Mignot, E., Edgar, D. M., Miller, J. D., Prosser, R. A., VANGELDER, R. N., & Dement, W. C. (1992). STRATEGIES FOR THE DEVELOPMENT OF NEW TREATMENTS IN SLEEP DISORDER MEDICINE. TARGET RECEPTORS FOR ANXIOLYTICS AND HYPNOTICS : FROM MOLECULAR PHARMACOLOGY TO THERAPEUTICS, 3, 129-150.

DOPAMINE-D2 MECHANISMS IN CANINE NARCOLEPSY
Nishino, S., Arrigoni, J., VALTIER, D., Miller, J. D., Guilleminault, C., & Mignot, E. (1991). DOPAMINE-D2 MECHANISMS IN CANINE NARCOLEPSY. JOURNAL OF NEUROSCIENCE, 11(9), 2666-2671.

NEURONAL-ACTIVITY IN NARCOLEPSY - IDENTIFICATION OF CATAPLEXY-RELATED CELLS IN THE MEDIAL MEDULLA
Siegel, J. M., Nienhuis, R., Fahringer, H. M., Paul, R., Shiromani, P., & Chiu, C. (1991). NEURONAL-ACTIVITY IN NARCOLEPSY - IDENTIFICATION OF CATAPLEXY-RELATED CELLS IN THE MEDIAL MEDULLA. SCIENCE, 252(5010), 1315-1318.

GENETIC-LINKAGE OF AUTOSOMAL RECESSIVE CANINE NARCOLEPSY WITH A MU-IMMUNOGLOBULIN HEAVY-CHAIN SWITCH-LIKE SEGMENT
Mignot, E., Wang, C., Rattazzi, C., Gaiser, C., LOVETT, M., & GRUMET, F. C. (1991). GENETIC-LINKAGE OF AUTOSOMAL RECESSIVE CANINE NARCOLEPSY WITH A MU-IMMUNOGLOBULIN HEAVY-CHAIN SWITCH-LIKE SEGMENT. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 88(8), 3475-3478.

RADIOLIGAND BINDING TO ADENOSINE RECEPTORS AND ADENOSINE UPTAKE SITES IN DIFFERENT BRAIN-REGIONS OF NORMAL AND NARCOLEPTIC DOGS
Hawkins, M., OCONNOR, S., Radulovacki, M., Bowersox, S., Mignot, E., & Dement, W. (1991). RADIOLIGAND BINDING TO ADENOSINE RECEPTORS AND ADENOSINE UPTAKE SITES IN DIFFERENT BRAIN-REGIONS OF NORMAL AND NARCOLEPTIC DOGS. PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, 38(1), 1-6.

EFFECTS OF CENTRAL ALPHA-2 ADRENERGIC COMPOUNDS ON CANINE NARCOLEPSY, A DISORDER OF RAPID EYE-MOVEMENT SLEEP
Nishino, S., Haak, L., Shepherd, H., Guilleminault, C., Sakai, T., & Mignot, E. (1990). EFFECTS OF CENTRAL ALPHA-2 ADRENERGIC COMPOUNDS ON CANINE NARCOLEPSY, A DISORDER OF RAPID EYE-MOVEMENT SLEEP. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 253(3), 1145-1152.

RECEPTOLOGY IN NARCOLEPSY
Mignot, E., & Guilleminault, C. (1990). RECEPTOLOGY IN NARCOLEPSY. NEUROLOGY IN EUROPE 1, 521-530.

EFFECTS OF INTRAVENOUS ADMINISTRATION OF PROSTAGLANDINS ON CANINE NARCOLEPSY
Nishino, S., Mignot, E., Fruhstorfer, B., Kilduff, T. S., Ueno, R., & Dement, W. C. (1990). EFFECTS OF INTRAVENOUS ADMINISTRATION OF PROSTAGLANDINS ON CANINE NARCOLEPSY. ENDOGENOUS SLEEP FACTORS, 77-83.

NORADRENERGIC AND CHOLINERGIC CONTROL OF CATAPLEXY - PHARMACOLOGICAL EVIDENCE
Mignot, E., Nishino, S., Guilleminault, C., & Dement, W. C. (1990). NORADRENERGIC AND CHOLINERGIC CONTROL OF CATAPLEXY - PHARMACOLOGICAL EVIDENCE. ENDOGENOUS SLEEP FACTORS, 203-215.

FAMILIAL PATTERNS OF NARCOLEPSY
Guilleminault, C., Mignot, E., & GRUMET, F. C. (1989). FAMILIAL PATTERNS OF NARCOLEPSY. LANCET, 2(8676), 1376-1379.

EVIDENCE FOR MULTIPLE [H-3] PRAZOSIN BINDING-SITES IN CANINE BRAIN MEMBRANES
Mignot, E., Bowersox, S. S., Maddaluno, J., Dement, W., & CIARANELLO, R. (1989). EVIDENCE FOR MULTIPLE [H-3] PRAZOSIN BINDING-SITES IN CANINE BRAIN MEMBRANES. BRAIN RESEARCH, 486(1), 56-66.

PROSTAGLANDIN-E2 AND ITS METHYL-ESTER REDUCE CATAPLEXY IN CANINE NARCOLEPSY
Nishino, S., Mignot, E., Fruhstorfer, B., Dement, W. C., & Hayaishi, O. (1989). PROSTAGLANDIN-E2 AND ITS METHYL-ESTER REDUCE CATAPLEXY IN CANINE NARCOLEPSY. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 86(7), 2483-2487.

ROLE OF CENTRAL ALPHA-1 ADRENOCEPTORS IN CANINE NARCOLEPSY
Mignot, E., Guilleminault, C., Bowersox, S., Rappaport, A., & Dement, W. C. (1988). ROLE OF CENTRAL ALPHA-1 ADRENOCEPTORS IN CANINE NARCOLEPSY. JOURNAL OF CLINICAL INVESTIGATION, 82(3), 885-894.