Matthew Porteus

Associate Professor of Pediatrics (Cancer Biology)

Professional Education

Residency: Children's Hospital Boston (06/1996) MA

Fellowship: Children's Hospital Boston (06/1999) MA

Medical Education: Stanford University School of Medicine (06/1994) CA

Board Certification: Pediatric Hematology-Oncology, American Board of Pediatrics (2000)

Clinical Trials

Clinical trials are research studies that evaluate a new medical approach, device, drug, or other treatment. As a Stanford Health Care patient, you have access to the latest, advanced clinical trials.

Open trials refer to studies currently accepting participants. Closed trials are not currently enrolling, but may open in the future.

Quantifying Genome-Editing Outcomes at Endogenous Loci with SMRT Sequencing
Hendel, A., Kildebeck, E. J., Fine, E. J., Clark, J. T., Punjya, N., & Porteus, M. H. (2014). Quantifying Genome-Editing Outcomes at Endogenous Loci with SMRT Sequencing. CELL REPORTS, 7(1), 293-305.

SAPTA: a new design tool for improving TALE nuclease activity
Lin, Y., Fine, E. J., Zheng, Z., Antico, C. J., Voit, R. A., & Bao, G. (2014). SAPTA: a new design tool for improving TALE nuclease activity. NUCLEIC ACIDS RESEARCH, 42(6).

Nuclease-mediated gene editing by homologous recombination of the human globin locus
Voit, R. A., Hendel, A., Pruett-Miller, S. M., & Porteus, M. H. (2014). Nuclease-mediated gene editing by homologous recombination of the human globin locus. NUCLEIC ACIDS RESEARCH, 42(2), 1365-1378.

Phosphorylation of EXO1 by CDKs 1 and 2 regulates DNA end resection and repair pathway choice.
Tomimatsu, N., Mukherjee, B., Catherine Hardebeck, M., Ilcheva, M., Vanessa Camacho, C., & Burma, S. (2014). Phosphorylation of EXO1 by CDKs 1 and 2 regulates DNA end resection and repair pathway choice. Nature communications, 5, 3561-?.

An Erythroid Enhancer of BCL11A Subject to Genetic Variation Determines Fetal Hemoglobin Level
Bauer, D. E., Kamran, S. C., Lessard, S., Xu, J., Fujiwara, Y., & Orkin, S. H. (2013). An Erythroid Enhancer of BCL11A Subject to Genetic Variation Determines Fetal Hemoglobin Level. SCIENCE, 342(6155), 253-257.

Receptor-mediated delivery of engineered nucleases for genome modification
Chen, Z., Jaafar, L., Agyekum, D. G., Xiao, H., Wade, M. F., & Meiler, S. E. (2013). Receptor-mediated delivery of engineered nucleases for genome modification. NUCLEIC ACIDS RESEARCH, 41(19).

Newborn screening for severe combined immunodeficiency and T-cell lymphopenia in California: Results of the first 2 years
Kwan, A., Church, J. A., Cowan, M. J., Agarwal, R., Kapoor, N., & Puck, J. M. (2013). Newborn screening for severe combined immunodeficiency and T-cell lymphopenia in California: Results of the first 2 years. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 132(1), 140-U245.

Generation of an HIV Resistant T-cell Line by Targeted "Stacking" of Restriction Factors
Voit, R. A., McMahon, M. A., Sawyer, S. L., & Porteus, M. H. (2013). Generation of an HIV Resistant T-cell Line by Targeted "Stacking" of Restriction Factors. MOLECULAR THERAPY, 21(4), 786-795.

A Crisper Look at Genome Editing: RNA-guided Genome Modification
Damian, M., & Porteus, M. H. (2013). A Crisper Look at Genome Editing: RNA-guided Genome Modification. MOLECULAR THERAPY, 21(4), 719-721.

A crisper look at genome editing: RNA-guided genome modification.
Damian, M., & Porteus, M. H. (2013). A crisper look at genome editing: RNA-guided genome modification. Molecular therapy : the journal of the American Society of Gene Therapy, 21(4), 720-722.

Expanding the Repertoire of Target Sites for Zinc Finger Nuclease-mediated Genome Modification
Wilson, K. A., McEwen, A. E., Pruett-Miller, S. M., Zhang, J., Kildebeck, E. J., & Porteus, M. H. (2013). Expanding the Repertoire of Target Sites for Zinc Finger Nuclease-mediated Genome Modification. MOLECULAR THERAPY-NUCLEIC ACIDS, 2.

Design and Development of Artificial Zinc Finger Transcription Factors and Zinc Finger Nucleases to the hTERT Locus
Wilson, K. A., Chateau, M. L., & Porteus, M. H. (2013). Design and Development of Artificial Zinc Finger Transcription Factors and Zinc Finger Nucleases to the hTERT Locus. MOLECULAR THERAPY-NUCLEIC ACIDS, 2.

A survey of ex vivo/in vitro transduction efficiency of mammalian primary cells and cell lines with Nine natural adeno-associated virus (AAV1-9) and one engineered adeno-associated virus serotype
Ellis, B. L., Hirsch, M. L., Barker, J. C., Connelly, J. P., Steininger, R. J., & Porteus, M. H. (2013). A survey of ex vivo/in vitro transduction efficiency of mammalian primary cells and cell lines with Nine natural adeno-associated virus (AAV1-9) and one engineered adeno-associated virus serotype. VIROLOGY JOURNAL, 10.

Zinc-finger nuclease-mediated gene correction using single AAV vector transduction and enhancement by Food and Drug Administration-approved drugs
Ellis, B. L., HIRSCH, M. L., Porter, S. N., Samulski, R. J., & Porteus, M. H. (2013). Zinc-finger nuclease-mediated gene correction using single AAV vector transduction and enhancement by Food and Drug Administration-approved drugs. GENE THERAPY, 20(1), 35-42.

Gene therapy for primary immunodeficiencies
Kildebeck, E., Checketts, J., & Porteus, M. (2012). Gene therapy for primary immunodeficiencies. CURRENT OPINION IN PEDIATRICS, 24(6), 731-738.

Engineering the immune system to cure genetic diseases, HIV, and cancer Editorial overview
Porteus, M. H., & Fischer, A. (2012). Engineering the immune system to cure genetic diseases, HIV, and cancer Editorial overview. CURRENT OPINION IN IMMUNOLOGY, 24(5), 576-579.

Development of nuclease-mediated site-specific genome modification.
Wirt, S. E., & Porteus, M. H. (2012). Development of nuclease-mediated site-specific genome modification. Current opinion in immunology, 24(5), 609-616.

Gene editing: not just for translation anymore.
McMahon, M. A., Rahdar, M., & Porteus, M. (2012). Gene editing: not just for translation anymore. Nature methods, 9(1), 28-31.

Viral Single-Strand DNA Induces p53-Dependent Apoptosis in Human Embryonic Stem Cells
Hirsch, M. L., Fagan, B. M., Dumitru, R., Bower, J. J., Yadav, S., & Samulski, R. J. (2011). Viral Single-Strand DNA Induces p53-Dependent Apoptosis in Human Embryonic Stem Cells. PLOS ONE, 6(11).

Seeing the light: integrating genome engineering with double-strand break repair
Porteus, M. (2011). Seeing the light: integrating genome engineering with double-strand break repair. NATURE METHODS, 8(8), 628-630.

Translating the Lessons From Gene Therapy to the Development of Regenerative Medicine
Porteus, M. (2011). Translating the Lessons From Gene Therapy to the Development of Regenerative Medicine. MOLECULAR THERAPY, 19(3), 439-441.

Homologous recombination-based gene therapy for the primary immunodeficiencies
Porteus, M. (2011). Homologous recombination-based gene therapy for the primary immunodeficiencies. YEAR IN HUMAN AND MEDICAL GENETICS: INBORN ERRORS OF IMMUNITY II, 1246, 131-140.

COCCIDIOIDAL ANTIGEN-REACTIVE CD4(+) T-LYMPHOCYTES IN THE CEREBROSPINAL-FLUID IN COCCIDIOIDES-IMMITIS MENINGITIS
Vollmer, T. L., Gaiser, C., DELLOCA, R. L., Porteus, M., Steinman, L., & Stevens, D. A. (1995). COCCIDIOIDAL ANTIGEN-REACTIVE CD4(+) T-LYMPHOCYTES IN THE CEREBROSPINAL-FLUID IN COCCIDIOIDES-IMMITIS MENINGITIS. JOURNAL OF MEDICAL AND VETERINARY MYCOLOGY, 33(1), 43-48.

DLX-P, MASH-1, AND MAP-5 EXPRESSION AND BROMODEOXYURIDINE INCORPORATION DEFINE MOLECULARLY DISTINCT CELL-POPULATIONS IN THE EMBRYONIC MOUSE FOREBRAIN
Porteus, M. H., Bulfone, A., Liu, J. K., Puelles, L., Lo, L. C., & Rubenstein, J. Lr. (1994). DLX-P, MASH-1, AND MAP-5 EXPRESSION AND BROMODEOXYURIDINE INCORPORATION DEFINE MOLECULARLY DISTINCT CELL-POPULATIONS IN THE EMBRYONIC MOUSE FOREBRAIN. JOURNAL OF NEUROSCIENCE, 14(11), 6370-6383.

DLX2 (TES1), A HOMEOBOX GENE OF THE DISTAL-LESS FAMILY, ASSIGNED TO CONSERVED REGIONS ON HUMAN AND MOUSE CHROMOSOMES-2
Ozcelik, T., Porteus, M. H., Rubenstein, J. Lr., & FRANCKE, U. (1992). DLX2 (TES1), A HOMEOBOX GENE OF THE DISTAL-LESS FAMILY, ASSIGNED TO CONSERVED REGIONS ON HUMAN AND MOUSE CHROMOSOMES-2. GENOMICS, 13(4), 1157-1161.

ISOLATION AND CHARACTERIZATION OF A LIBRARY OF CDNA CLONES THAT ARE PREFERENTIALLY EXPRESSED IN THE EMBRYONIC TELENCEPHALON
Porteus, M. H., BRICE, A. Ej., Bulfone, A., Usdin, T. B., CIARANELLO, R. D., & Rubenstein, J. Lr. (1992). ISOLATION AND CHARACTERIZATION OF A LIBRARY OF CDNA CLONES THAT ARE PREFERENTIALLY EXPRESSED IN THE EMBRYONIC TELENCEPHALON. MOLECULAR BRAIN RESEARCH, 12(1-3), 7-22.

ISOLATION AND CHARACTERIZATION OF A NOVEL CDNA CLONE ENCODING A HOMEODOMAIN THAT IS DEVELOPMENTALLY REGULATED IN THE VENTRAL FOREBRAIN
Porteus, M. H., Bulfone, A., CIARANELLO, R. D., & Rubenstein, J. Lr. (1991). ISOLATION AND CHARACTERIZATION OF A NOVEL CDNA CLONE ENCODING A HOMEODOMAIN THAT IS DEVELOPMENTALLY REGULATED IN THE VENTRAL FOREBRAIN. NEURON, 7(2), 221-229.

SUBTRACTIVE HYBRIDIZATION SYSTEM USING SINGLE-STRANDED PHAGEMIDS WITH DIRECTIONAL INSERTS
Rubenstein, J. Lr., BRICE, A. Ej., CIARANELLO, R. D., Denney, D., Porteus, M. H., & Usdin, T. B. (1990). SUBTRACTIVE HYBRIDIZATION SYSTEM USING SINGLE-STRANDED PHAGEMIDS WITH DIRECTIONAL INSERTS. NUCLEIC ACIDS RESEARCH, 18(16), 4833-4842.

VALIDATION OF A MODEL OF NON-RHEGMATOGENOUS RETINAL-DETACHMENT
Marmor, M. F., Porteus, M., Negi, A., & Immel, J. (1984). VALIDATION OF A MODEL OF NON-RHEGMATOGENOUS RETINAL-DETACHMENT. CURRENT EYE RESEARCH, 3(3), 515-518.