Glenn Rosen

Pulmonologist

Associate Professor of Medicine (Pulmonary and Critical Care Medicine)

Chest Clinic

  • 300 Pasteur Drive
  • Stanford, CA 94305
  • Phone: 650-725-7061
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Center for Advanced Lung Disease

  • 300 Pasteur Drive
  • Stanford, CA 94305
  • Phone: 650-723-3633
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Center for Advanced Lung Disease in Fresno

  • 1377 E Herndon Avenue
  • Fresno, CA 93720
  • Phone: 650-723-3633
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Center for Advanced Lung Disease in Monterey

  • 5 Lower Ragsdale Drive
  • Monterey, CA 93940
  • Phone: 650-736-5400
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Professional Education

Fellowship: Washington University School Of Medicine (1992) MO

Residency: Graduate Hospital (1986) PA

Board Certification: Pulmonary Disease, American Board of Internal Medicine (1990)

Medical Education: University of Pennsylvania (1983) PA

Fellowship: UCSF Medical Center (1987) CA

Board Certification: Internal Medicine, American Board of Internal Medicine (1986)

Internship: Graduate Hospital (1984) PA

MD, University of Pennsylvania, Medicine (1983)

B.A., University of Pennsylvania, History (1979)

Honors & Awards

Award for Lung Cancer Research, Jack Elway Memorial Fund (2002-2003)

Institutional American Cancer Society Award, Stanford University (1994-1995)

Research Fellowship Award, American Lung Association (1990)

Magna Cum Laude, University of Pennsylvania (1979)

Phi Betta Kappa, University of Pennsylvania (1979)

Administrative Appointments

Clinical Director Interstitial Lung Disease Program, Advanced Lung Disease Center, Stanford University Medical Center (2011 - Present)

Director, Fellowship Program, Pulmonary and Critical Care Medicine (2004 - 2010)

Division Co-Chief, Pulmonary and Critical Care Medicine (2004 - 2010)

Connective Tissue Disease-associated Interstitial Lung Disease: A review.
Gutsche, M., Rosen, G. D., & Swigris, J. J. (2012). Connective Tissue Disease-associated Interstitial Lung Disease: A review. Current respiratory care reports, 1, 224-232.

An Analysis of Connective Tissue Disease-associated Interstitial Lung Disease at a US Tertiary Care Center: Better Survival in Patients with Systemic Sclerosis
Su, R., Bennett, M., Jacobs, S., Hunter, T., Bailey, C., & Chung, L. (2011). An Analysis of Connective Tissue Disease-associated Interstitial Lung Disease at a US Tertiary Care Center: Better Survival in Patients with Systemic Sclerosis. JOURNAL OF RHEUMATOLOGY, 38(4), 693-701.

The HLA Class II Allele DRB1*1501 Is Over-Represented in Patients with Idiopathic Pulmonary Fibrosis
Xue, J., Gochuico, B. R., Alawad, A. S., Feghali-Bostwick, C. A., Noth, I., & Duncan, S. R. (2011). The HLA Class II Allele DRB1*1501 Is Over-Represented in Patients with Idiopathic Pulmonary Fibrosis. PLOS ONE, 6(2).

SPARC Suppresses Apoptosis of Idiopathic Pulmonary Fibrosis Fibroblasts through Constitutive Activation of beta-Catenin
Chang, W., Wei, K., Jacobs, S. S., Upadhyay, D., Weill, D., & Rosen, G. D. (2010). SPARC Suppresses Apoptosis of Idiopathic Pulmonary Fibrosis Fibroblasts through Constitutive Activation of beta-Catenin. JOURNAL OF BIOLOGICAL CHEMISTRY, 285(11), 8196-8206.

Nicotine Induces Resistance to Chemotherapy by Modulating Mitochondrial Signaling in Lung Cancer
Zhang, J., Kamdar, O., Le, W., Rosen, G. D., & Upadhyay, D. (2009). Nicotine Induces Resistance to Chemotherapy by Modulating Mitochondrial Signaling in Lung Cancer. AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, 40(2), 135-146.

Air pollution induces enhanced mitochondrial oxidative stress in cystic fibrosis airway epithelium
Kamdar, O., Le, W., Zhang, J., Ghio, A. J., Rosen, G. D., & Upadhyay, D. (2008). Air pollution induces enhanced mitochondrial oxidative stress in cystic fibrosis airway epithelium. FEBS LETTERS, 582(25-26), 3601-3606.

Ambient particulate matter induces alveolar epithelial cell cycle arrest: Role of G1 cyclins
Zhang, J., Ghio, A. J., Gao, M., Wei, K., Rosen, G. D., & Upadhyay, D. (2007). Ambient particulate matter induces alveolar epithelial cell cycle arrest: Role of G1 cyclins. FEBS LETTERS, 581(27), 5315-5320.

Bim mediates mitochondria-regulated particulate matter-induced apoptosis in alveolar epithelial cells
Zhang, J., Ghio, A. J., Chang, W., Kamdar, O., Rosen, G. D., & Upadhyay, D. (2007). Bim mediates mitochondria-regulated particulate matter-induced apoptosis in alveolar epithelial cells. FEBS LETTERS, 581(22), 4148-4152.

Fibroblast growth factor-10 prevents H2O2-induced cell cycle arrest by regulation of GI cyclins and cyclin dependent kinases
Upadhyay, D., Chang, W., Wei, K., Gao, M., & Rosen, G. D. (2007). Fibroblast growth factor-10 prevents H2O2-induced cell cycle arrest by regulation of GI cyclins and cyclin dependent kinases. FEBS LETTERS, 581(2), 248-252.

Recurrence of pulmonary intravascular bronchoalveolar tumor with mediastinal metastasis 20 years later
Chen, T. M., Donington, J., Mak, G., Berry, G. J., Ruoss, S. J., & Upadhyay, D. (2006). Recurrence of pulmonary intravascular bronchoalveolar tumor with mediastinal metastasis 20 years later. RESPIRATORY MEDICINE, 100(2), 367-370.

A 35-year-old man, with fever, dyspnea, and diffuse reticular opacities
Katikireddy, C. K., Krishna, G., Keifer, T., Kuschner, W., & Rosen, G. (2006). A 35-year-old man, with fever, dyspnea, and diffuse reticular opacities. CHEST, 129(2), 482-487.

A placebo-controlled trial of interferon gamma-1b in patients with idiopathic pulmonary fibrosis
Raghu, G., Brown, K. K., Bradford, W. Z., Starko, K., Noble, P. W., & Riley, D. (2004). A placebo-controlled trial of interferon gamma-1b in patients with idiopathic pulmonary fibrosis. NEW ENGLAND JOURNAL OF MEDICINE, 350(2), 125-133.

PG490-88, a derivative of triptolide, causes tumor regression and sensitizes tumors to chemotherapy
Fidler, J. M., Li, K., Chung, C., Wei, K., Ross, J. A., & Rosen, G. D. (2003). PG490-88, a derivative of triptolide, causes tumor regression and sensitizes tumors to chemotherapy. MOLECULAR CANCER THERAPEUTICS, 2(9), 855-862.

Triptolide sensitizes lung cancer cells to TNF-related apoptosis-inducing ligand (TRAIL)-induced apoptosis by inhibition of NF-kappa B activation
Lee, K. Y., Park, J. S., Jee, Y. K., & Rosen, G. D. (2002). Triptolide sensitizes lung cancer cells to TNF-related apoptosis-inducing ligand (TRAIL)-induced apoptosis by inhibition of NF-kappa B activation. EXPERIMENTAL AND MOLECULAR MEDICINE, 34(6), 462-468.

PG490-88, a derivative of triptolide, attenuates obliterative airway disease in a mouse heterotopic tracheal allograft model
Leonard, C. T., Soccal, P. M., Berry, G. J., Doyle, R. L., Theodore, J., & Rosen, G. D. (2002). PG490-88, a derivative of triptolide, attenuates obliterative airway disease in a mouse heterotopic tracheal allograft model. JOURNAL OF HEART AND LUNG TRANSPLANTATION, 21(12), 1314-1318.

The molecular biology of lung cancer
Ross, J. A., & Rosen, G. D. (2002). The molecular biology of lung cancer. CURRENT OPINION IN PULMONARY MEDICINE, 8(4), 265-269.

Oligoclonal CD4(+) T cell expansions in lung transplant recipients with obliterative bronchiolitis
Duncan, S. R., Leonard, C., Theodore, J., Lega, M., Girgis, R. E., & Theofilopoulos, A. N. (2002). Oligoclonal CD4(+) T cell expansions in lung transplant recipients with obliterative bronchiolitis. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 165(10), 1439-1444.

Pharmacogenomics and the challenge to privacy.
Vaszar, L. T., Rosen, G. D., & Raffin, T. A. (2002). Pharmacogenomics and the challenge to privacy. pharmacogenomics journal, 2(3), 144-147.

Diversity of gene expression in adenocarcinoma of the lung
Garber, M. E., Troyanskaya, O. G., Schluens, K., Petersen, S., Thaesler, Z., & Petersen, I. (2001). Diversity of gene expression in adenocarcinoma of the lung. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 98(24), 13784-13789.

Tumor necrosis factor-related apoptosis-inducing ligand and chemotherapy cooperate to induce apoptosis in mesothelioma cell lines
Liu, W. H., Bodle, E., Chen, J. Y., Gao, M. X., Rosen, G. D., & Broaddus, V. C. (2001). Tumor necrosis factor-related apoptosis-inducing ligand and chemotherapy cooperate to induce apoptosis in mesothelioma cell lines. AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, 25(1), 111-118.

PG490-88, a derivative of triptolide, blocks bleomycin-induced lung fibrosis
Krishna, G., Liu, K. L., Shigemitsu, H., Gao, M. X., Raffin, T. A., & Rosen, G. D. (2001). PG490-88, a derivative of triptolide, blocks bleomycin-induced lung fibrosis. AMERICAN JOURNAL OF PATHOLOGY, 158(3), 997-1004.

Triptolide and chemotherapy cooperate in tumor cell apoptosis - A role for the p53 pathway
Chang, W. T., Kang, J. J., Lee, K. Y., Wei, K., Anderson, E., & Rosen, G. D. (2001). Triptolide and chemotherapy cooperate in tumor cell apoptosis - A role for the p53 pathway. JOURNAL OF BIOLOGICAL CHEMISTRY, 276(3), 2221-2227.

Dendritic cells and macrophages in lung allografts a role in chronic rejection?
Leonard, C. T., Soccal, P. M., Singer, L., Berry, G. J., Theodore, J., & Rosen, G. D. (2000). Dendritic cells and macrophages in lung allografts a role in chronic rejection?. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 161(4), 1349-1354.

Thoracic lymphangiomas, lymphangiectasis, lymphangiomatosis, and lymphatic dysplasia syndrome
Faul, J. L., Berry, G. J., Colby, T. V., Ruoss, S. J., Walter, M. B., & Raffin, T. A. (2000). Thoracic lymphangiomas, lymphangiectasis, lymphangiomatosis, and lymphatic dysplasia syndrome. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 161(3), 1037-1046.

Loss of STAT1 expression confers resistance to IFN-gamma-induced apoptosis in ME180 cells
Lee, K. Y., Anderson, E., Madani, K., & Rosen, G. D. (1999). Loss of STAT1 expression confers resistance to IFN-gamma-induced apoptosis in ME180 cells. FEBS LETTERS, 459(3), 323-326.

PG490 (triptolide) cooperates with tumor necrosis factor-alpha to induce apoptosis in tumor cells
Lee, K. Y., Chang, W. T., Qiu, D. M., Kao, P. N., & Rosen, G. D. (1999). PG490 (triptolide) cooperates with tumor necrosis factor-alpha to induce apoptosis in tumor cells. JOURNAL OF BIOLOGICAL CHEMISTRY, 274(19), 13451-13455.

Proteolytic cleavage of Ras GTPase-activating protein during apoptosis
Wen, L. P., Madani, K., Martin, G. A., & Rosen, G. D. (1998). Proteolytic cleavage of Ras GTPase-activating protein during apoptosis. CELL DEATH AND DIFFERENTIATION, 5(9), 729-734.

Dexamethasone inhibits lung epithelial cell apoptosis induced by IFN-gamma and Fas
Wen, L. P., Madani, K., Fahrni, J. A., Duncan, S. R., & Rosen, G. D. (1997). Dexamethasone inhibits lung epithelial cell apoptosis induced by IFN-gamma and Fas. AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY, 273(5), L921-L929.

Cleavage of focal adhesion kinase by caspases during apoptosis
Wen, L. P., Fahrni, J. A., Troie, S., Guan, J. L., Orth, K., & Rosen, G. D. (1997). Cleavage of focal adhesion kinase by caspases during apoptosis. JOURNAL OF BIOLOGICAL CHEMISTRY, 272(41), 26056-26061.

Rapamycin inhibits development of obliterative airway disease in a murine heterotopic airway transplant model
Fahrni, J. A., Berry, G. J., Morris, R. E., & Rosen, G. D. (1997). Rapamycin inhibits development of obliterative airway disease in a murine heterotopic airway transplant model. TRANSPLANTATION, 63(4), 533-537.

Airway epithelial cells produce stem cell factor
Wen, L. P., Fahrni, J. A., Matsui, S., & Rosen, G. D. (1996). Airway epithelial cells produce stem cell factor. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH, 1314(3), 183-186.

Acid aspiration induced lung injury - New insights and therapeutic options
Matthay, M. A., & Rosen, G. D. (1996). Acid aspiration induced lung injury - New insights and therapeutic options. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 154(2), 277-278.

MULTIPLE REGULATORY ELEMENTS CONTROL THE BASAL PROMOTER ACTIVITY OF THE HUMAN ALPHA-4 INTEGRIN GENE
Audet, J. F., Masson, J. Y., Rosen, G. D., Salesse, C., & Guerin, S. L. (1994). MULTIPLE REGULATORY ELEMENTS CONTROL THE BASAL PROMOTER ACTIVITY OF THE HUMAN ALPHA-4 INTEGRIN GENE. DNA AND CELL BIOLOGY, 13(11), 1071-1085.

AN INTRICATE ARRANGEMENT OF BINDING-SITES FOR THE ETS FAMILY OF TRANSCRIPTION FACTORS REGULATES ACTIVITY OF THE ALPHA-4 INTEGRIN GENE PROMOTER
Rosen, G. D., Barks, J. L., Iademarco, M. F., Fisher, R. J., & Dean, D. C. (1994). AN INTRICATE ARRANGEMENT OF BINDING-SITES FOR THE ETS FAMILY OF TRANSCRIPTION FACTORS REGULATES ACTIVITY OF THE ALPHA-4 INTEGRIN GENE PROMOTER. JOURNAL OF BIOLOGICAL CHEMISTRY, 269(22), 15652-15660.

EXPANDING ROLES FOR ALPHA-4 INTEGRIN AND ITS LIGANDS IN DEVELOPMENT
Sheppard, A. M., Onken, M. D., Rosen, G. D., Noakes, P. G., & Dean, D. C. (1994). EXPANDING ROLES FOR ALPHA-4 INTEGRIN AND ITS LIGANDS IN DEVELOPMENT. CELL ADHESION AND COMMUNICATION, 2(1), 27-43.

THE INTEGRIN ALPHA-4-BETA-1 AND ITS COUNTER-RECEPTOR VCAM-1 IN DEVELOPMENT AND IMMUNE FUNCTION
Dean, D. C., Iademarco, M. F., Rosen, G. D., & Sheppard, A. M. (1993). THE INTEGRIN ALPHA-4-BETA-1 AND ITS COUNTER-RECEPTOR VCAM-1 IN DEVELOPMENT AND IMMUNE FUNCTION. AMERICAN REVIEW OF RESPIRATORY DISEASE, 148(6), S43-S46.

CHARACTERIZATION OF THE PROMOTER FOR VASCULAR CELL-ADHESION MOLECULE-1 (VCAM-1)
Iademarco, M. F., McQuillan, J. J., Rosen, G. D., & Dean, D. C. (1992). CHARACTERIZATION OF THE PROMOTER FOR VASCULAR CELL-ADHESION MOLECULE-1 (VCAM-1). JOURNAL OF BIOLOGICAL CHEMISTRY, 267(23), 16323-16329.

ROLES FOR THE INTEGRIN VLA-4 AND ITS COUNTER RECEPTOR VCAM-1 IN MYOGENESIS
Rosen, G. D., Sanes, J. R., Lachance, R., Cunningham, J. M., Roman, J., & Dean, D. C. (1992). ROLES FOR THE INTEGRIN VLA-4 AND ITS COUNTER RECEPTOR VCAM-1 IN MYOGENESIS. CELL, 69(7), 1107-1119.

IDENTIFICATION OF A PROTEIN THAT INTERACTS WITH THE NUCLEAR FACTOR-I (NF-1) BINDING-SITE IN CELLS THAT DO NOT EXPRESS NF-1 - COMPARISON TO NF-1, CELLULAR-DISTRIBUTION, AND EFFECT ON TRANSCRIPTION
McQuillan, J. J., Rosen, G. D., BIRKENMEIER, T. M., & Dean, D. C. (1991). IDENTIFICATION OF A PROTEIN THAT INTERACTS WITH THE NUCLEAR FACTOR-I (NF-1) BINDING-SITE IN CELLS THAT DO NOT EXPRESS NF-1 - COMPARISON TO NF-1, CELLULAR-DISTRIBUTION, AND EFFECT ON TRANSCRIPTION. NUCLEIC ACIDS RESEARCH, 19(23), 6627-6631.

EXPRESSION OF FIBRONECTIN AND ITS CELL-SURFACE RECEPTORS
Dean, D. C., BIRKENMEIER, T. M., Rosen, G. D., & Weintraub, S. J. (1991). EXPRESSION OF FIBRONECTIN AND ITS CELL-SURFACE RECEPTORS. AMERICAN REVIEW OF RESPIRATORY DISEASE, 144(3), S25-S28.

Glycoprotein synthesis and secretion. Expression of fibronectin and its cell surface receptors.
Dean, D. C., BIRKENMEIER, T. M., Rosen, G. D., & Weintraub, S. J. (1991). Glycoprotein synthesis and secretion. Expression of fibronectin and its cell surface receptors. American review of respiratory disease, 144(3), S25-8.

CHARACTERIZATION OF THE ALPHA-4 INTEGRIN GENE PROMOTER
Rosen, G. D., BIRKENMEIER, T. M., & Dean, D. C. (1991). CHARACTERIZATION OF THE ALPHA-4 INTEGRIN GENE PROMOTER. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 88(10), 4094-4098.

IDENTIFICATION OF A CYCLOOXYGENASE-RELATED GENE AND ITS POTENTIAL ROLE IN PROSTAGLANDIN FORMATION
Rosen, G. D., BIRKENMEIER, T. M., Raz, A., & Holtzman, M. J. (1989). IDENTIFICATION OF A CYCLOOXYGENASE-RELATED GENE AND ITS POTENTIAL ROLE IN PROSTAGLANDIN FORMATION. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 164(3), 1358-1365.

UPTAKE, RELEASE AND NOVEL SPECIES-DEPENDENT OXYGENATION OF ARACHIDONIC-ACID IN HUMAN AND ANIMAL AIRWAY EPITHELIAL-CELLS
Holtzman, M. J., Hansbrough, J. R., Rosen, G. D., & Turk, J. (1988). UPTAKE, RELEASE AND NOVEL SPECIES-DEPENDENT OXYGENATION OF ARACHIDONIC-ACID IN HUMAN AND ANIMAL AIRWAY EPITHELIAL-CELLS. BIOCHIMICA ET BIOPHYSICA ACTA, 963(3), 401-413.