To analyze the risk of cognitive impairment among female Swedish Twins with regard to endogenous and exogenous hormone exposure.A cross-sectional analysis of data from the HARMONY Study, a population-based cohort study of cognitive impairment in the Swedish Twin Registry.Information regarding age at menarche and menopause, parity, and length and type of hormone therapy (HT) was collected via a telephone interview from 6604 women, aged 65-84. Cognitive impairment was assessed with the TELE, a brief telephone cognitive screen.Length of reproductive period was inversely associated with risk of cognitive impairment (p<0.01). The OR was 1.15 (CI 95% 0.96-1.36) for women with reproductive periods <35 years and 0.82 (CI 95% 0.66-1.00) for women with reproductive periods >39 years. Age at menopause was inversely associated with risk of cognitive impairment. Use of HT was associated with average 40% decline in the risk of cognitive impairment, independent of type and timing of treatment.Our results suggest that both increased length of reproductive period and HT are associated with reduced risk of cognitive impairment.
View details for DOI 10.1016/j.psyneuen.2005.01.004
View details for Web of Science ID 000228502700005
View details for PubMedID 15808925