Stephen J. Roth

Professor of Pediatrics (Cardiology) at the Lucile Salter Packard Children's Hospital

Professional Education

Medical Education: Yale University School of Medicine (1986) CT

Fellowship: Children's Hospital Boston (1992) MA

Residency: Children's Hospital Boston (1989) MA

Board Certification: Pediatric Cardiology, American Board of Pediatrics (1994)

Internship: Children's Hospital Boston (1987) MA

M.P.H., Harvard School of Public Health, Tropical Public Health (1986)

M.D., Yale University School of Medicine (1986)

Honors & Awards

Listed, Best Doctors in America (2001-present)

Faculty Teaching Award, Department of Cardiology, Children's Hospital Boston (1999)

Clinical Investigator Development Award, National Institutes of Health (1992-1997)

New England Pediatric Society Prize, New England Pediatric Society (1986)

Norma Bailey Berniker Prize, Yale University (1986)

M.D. cum laude, Yale University (1986)

A.B. magna cum laude with High Honors, Harvard University (1980)

Scholarship for Academic Achievement, Harvard University (1977-1979)

Administrative Appointments

James Baxter & Yvonne Craig Wood Medical Director, CVICU, Lucile Packard Children's Hospital, Stanford University (2005 - Present)

Chief, Division of Pediatric Cardiology, Lucile Packard Children's Hospital, Stanford University (2011 - Present)

Director, The Children's Heart Center, Lucile Packard Children's Hospital, Stanford University (2011 - Present)

Clinical Trials

Clinical trials are research studies that evaluate a new medical approach, device, drug, or other treatment. As a Stanford Health Care patient, you have access to the latest, advanced clinical trials.

Open trials refer to studies currently accepting participants. Closed trials are not currently enrolling, but may open in the future.

Sedative and analgesic use on night and day shifts in a pediatric cardiovascular intensive care unit.
Staveski, S. L., Tesoro, T. M., Cisco, M. J., Roth, S. J., & Shin, A. Y. (2014). Sedative and analgesic use on night and day shifts in a pediatric cardiovascular intensive care unit. AACN advanced critical care, 25(2), 114-118.

Variability of Characteristics and Outcomes Following Cardiopulmonary Resuscitation Events in Diverse ICU Settings in a Single, Tertiary Care Children's Hospital
Gupta, P., Yan, K., Chow, V., Dao, D. T., Gossett, J. M., & Nadkarni, V. M. (2014). Variability of Characteristics and Outcomes Following Cardiopulmonary Resuscitation Events in Diverse ICU Settings in a Single, Tertiary Care Children's Hospital. PEDIATRIC CRITICAL CARE MEDICINE, 15(3), E128-E141.

Initial Experience Using Aminophylline to Improve Renal Dysfunction in the Pediatric Cardiovascular ICU
Axelrod, D. M., Anglemyer, A. T., Sherman-Levine, S. F., Zhu, A., Grimm, P. C., & Sutherland, S. M. (2014). Initial Experience Using Aminophylline to Improve Renal Dysfunction in the Pediatric Cardiovascular ICU. PEDIATRIC CRITICAL CARE MEDICINE, 15(1), 21-27.

One Hundred Useful References in Pediatric Cardiac Intensive Care: The 2012 Update
Axelrod, D. M., Klugman, D., Wright, G. E., Chang, A., Bronicki, R., & Roth, S. J. (2013). One Hundred Useful References in Pediatric Cardiac Intensive Care: The 2012 Update. PEDIATRIC CRITICAL CARE MEDICINE, 14(8), 770-785.

Clinical outcome score predicts the need for neurodevelopmental intervention after infant heart surgery
Mackie, A. S., Alton, G. Y., Dinu, I. A., Joffe, A. R., Roth, S. J., & Robertson, C. Mt. (2013). Clinical outcome score predicts the need for neurodevelopmental intervention after infant heart surgery. JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY, 145(5), 1248-?.

Postoperative Respiratory Failure in Children With Tetralogy of Fallot, Pulmonary Atresia, and Major Aortopulmonary Collaterals: A Pilot Study
Asija, R., Hanley, F. L., & Roth, S. J. (2013). Postoperative Respiratory Failure in Children With Tetralogy of Fallot, Pulmonary Atresia, and Major Aortopulmonary Collaterals: A Pilot Study. PEDIATRIC CRITICAL CARE MEDICINE, 14(4), 384-389.

Efficacy and Predictors of Success of Noninvasive Ventilation for Prevention of Extubation Failure in Critically Ill Children With Heart Disease
Gupta, P., Kuperstock, J. E., Hashmi, S., Arnolde, V., Gossett, J. M., & Roth, S. J. (2013). Efficacy and Predictors of Success of Noninvasive Ventilation for Prevention of Extubation Failure in Critically Ill Children With Heart Disease. PEDIATRIC CARDIOLOGY, 34(4), 964-977.

Pediatric plastic bronchitis: case report and retrospective comparative analysis of epidemiology and pathology.
Kunder, R., Kunder, C., Sun, H. Y., Berry, G., Messner, A., & Mark, J. (2013). Pediatric plastic bronchitis: case report and retrospective comparative analysis of epidemiology and pathology. Case reports in pulmonology, 2013, 649365-?.

Safety and efficacy of prolonged dexmedetomidine use in critically ill children with heart disease
Gupta, P., Whiteside, W., Sabati, A., Tesoro, T. M., Gossett, J. M., & Roth, S. J. (2012). Safety and efficacy of prolonged dexmedetomidine use in critically ill children with heart disease. PEDIATRIC CRITICAL CARE MEDICINE, 13(6), 660-666.

Early Outcomes After Extracardiac Conduit Fontan Operation Without Cardiopulmonary Bypass
McCammond, A. N., Kuo, K., Parikh, V. N., Abdullah, K., Balise, R., & Roth, S. J. (2012). Early Outcomes After Extracardiac Conduit Fontan Operation Without Cardiopulmonary Bypass. PEDIATRIC CARDIOLOGY, 33(7), 1078-1085.

Predictors for use of temporary epicardial pacing wires after pediatric cardiac surgery
Gupta, P., Jines, P., Gossett, J. M., Maurille, M., Hanley, F. L., & Roth, S. J. (2012). Predictors for use of temporary epicardial pacing wires after pediatric cardiac surgery. JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY, 144(3), 557-562.

Pulmonary reperfusion injury after the unifocalization procedure for tetralogy of Fallot, pulmonary atresia, and major aortopulmonary collateral arteries
Maskatia, S. A., Feinstein, J. A., Newman, B., Hanley, F. L., & Roth, S. J. (2012). Pulmonary reperfusion injury after the unifocalization procedure for tetralogy of Fallot, pulmonary atresia, and major aortopulmonary collateral arteries. JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY, 144(1), 184-189.

Nursing mortality and morbidity and journal club cycles: paving the way for nursing autonomy, patient safety, and evidence-based practice.
Staveski, S., Leong, K., Graham, K., Pu, L., & Roth, S. (2012). Nursing mortality and morbidity and journal club cycles: paving the way for nursing autonomy, patient safety, and evidence-based practice. AACN advanced critical care, 23(2), 133-141.

Rapid Response Team Implementation in a Children's Hospital
Sharek, P. J., Parast, L. M., & Roth, S. J. (2011). Rapid Response Team Implementation in a Children's Hospital. ARCHIVES OF PEDIATRICS & ADOLESCENT MEDICINE, 165(12), 1139-1139.

Hemodynamic correlates of serum cortisol in neonates after cardiopulmonary bypass
Mackie, A. S., Gauvreau, K., Booth, K. L., Newburger, J. W., Laussen, P. C., & Roth, S. J. (2011). Hemodynamic correlates of serum cortisol in neonates after cardiopulmonary bypass. PEDIATRIC CRITICAL CARE MEDICINE, 12(3), 297-303.

Survival after extreme left atrial hypertension and pulmonary hemorrhage in an infant supported with extracorporeal membrane oxygenation for refractory atrial flutter
Cisco, M. J., Asija, R., Dubin, A. M., Perry, S. B., Hanley, F. L., & Roth, S. J. (2011). Survival after extreme left atrial hypertension and pulmonary hemorrhage in an infant supported with extracorporeal membrane oxygenation for refractory atrial flutter. PEDIATRIC CRITICAL CARE MEDICINE, 12(3), E149-E152.

Implementation of a Comprehensive Interdisciplinary Care Coordination of Infants and Young Children on Berlin Heart Ventricular Assist Devices
Staveski, S. L., Avery, S., Rosenthal, D. N., Roth, S. J., & Wright, G. E. (2011). Implementation of a Comprehensive Interdisciplinary Care Coordination of Infants and Young Children on Berlin Heart Ventricular Assist Devices. JOURNAL OF CARDIOVASCULAR NURSING, 26(3), 231-238.

Interagency Registry for Mechanically Assisted Circulatory Support (INTERMACS)-Defined Morbidity and Mortality Associated With Pediatric Ventricular Assist Device Support at a Single US Center The Stanford Experience
Stein, M. L., Robbins, R., Sabati, A. A., Reinhartz, O., Chin, C., & Rosenthal, D. (2010). Interagency Registry for Mechanically Assisted Circulatory Support (INTERMACS)-Defined Morbidity and Mortality Associated With Pediatric Ventricular Assist Device Support at a Single US Center The Stanford Experience. CIRCULATION-HEART FAILURE, 3(6), 682-688.

A continuous heparin infusion does not prevent catheter-related thrombosis in infants after cardiac surgery
Schroeder, A. R., Axelrod, D. M., Silverman, N. H., Rubesova, E., Merkel, E., & Roth, S. J. (2010). A continuous heparin infusion does not prevent catheter-related thrombosis in infants after cardiac surgery. PEDIATRIC CRITICAL CARE MEDICINE, 11(4), 489-495.

Host Factor Vulnerability and Development of Progressive Intraluminal Pulmonary Vein Stenosis after Congenital Heart Surgery
Goff, D. A., Gauvreau, K., del Nido, P. J., Kieran, M. W., Roth, S. J., & Jenkins, K. J. (2009). Host Factor Vulnerability and Development of Progressive Intraluminal Pulmonary Vein Stenosis after Congenital Heart Surgery. CONGENITAL HEART DISEASE, 4(2), 86-90.

Randomized trial of hematocrit 25% versus 35% during hypothermic cardiopulmonary bypass in infant heart surgery
Newburger, J. W., Jonas, R. A., Soul, J., Kussman, B. D., Bellinger, D. C., & Wypij, D. (2008). Randomized trial of hematocrit 25% versus 35% during hypothermic cardiopulmonary bypass in infant heart surgery. JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY, 135(2), 347-U97.

Response to Frost P and Wise MP: Cardiorespiratory Arrests and Rapid Response Teams in Pediatrics
Sharek PJ, & Roth SJ. (2008). Response to Frost P and Wise MP: Cardiorespiratory Arrests and Rapid Response Teams in Pediatrics. Journal of the American Medical Association, 299.

Effect of a rapid response team on hospital-wide mortality and code rates outside the ICU in a children's hospital
Sharek, P. J., Parast, L. M., Leong, K., Coombs, J., Earnest, K., & Roth, S. J. (2007). Effect of a rapid response team on hospital-wide mortality and code rates outside the ICU in a children's hospital. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 298(19), 2267-2274.

Determinants of early outcome after neonatal cardiac surgery in a developing country
Bakshi, K. D., Vaidyanathan, B., Sundaram, K. R., Roth, S. J., Shivaprakasha, K., & Kumar, R. K. (2007). Determinants of early outcome after neonatal cardiac surgery in a developing country. JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY, 134(3), 765-771.

Indication for initiation of mechanical circulatory support impacts survival of infants with shunted single-ventricle circulation supported with extracorporeal membrane oxygenation
Allan, C. K., Thiagarajan, R. R., del Nido, P. J., Roth, S. J., Almodovar, M. C., & Laussen, P. C. (2007). Indication for initiation of mechanical circulatory support impacts survival of infants with shunted single-ventricle circulation supported with extracorporeal membrane oxygenation. JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY, 133(3), 660-667.

Cerebral perfusion and oxygenation after the Norwood procedure: Comparison of right ventricle-pulmonary artery conduit with modified Blalock-Taussig shunt
Kussman, B. D., Gauvreau, K., DiNardo, J. A., Newburger, J. W., Mackie, A. S., & Laussen, P. C. (2007). Cerebral perfusion and oxygenation after the Norwood procedure: Comparison of right ventricle-pulmonary artery conduit with modified Blalock-Taussig shunt. JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY, 133(3), 648-655.

Design of a large cross-sectional study to facilitate future clinical trials in children with the Fontan palliation
Sleeper, L. A., Anderson, P., Hsu, D. T., Mahony, L., McCrindle, B. W., & Clark, B. J. (2006). Design of a large cross-sectional study to facilitate future clinical trials in children with the Fontan palliation. AMERICAN HEART JOURNAL, 152(3), 427-433.

Somatic growth after ventricular septal defect in malnourished infants
Vaidyanathan, B., Roth, S. J., Gauvreau, K., Shvaprakasha, K., Rao, S. G., & Kumar, R. K. (2006). Somatic growth after ventricular septal defect in malnourished infants. JOURNAL OF PEDIATRICS, 149(2), 205-209.

Homograft valved right ventricle to pulmonary artery conduit as a modification of the Norwood procedure
Reinhartz, O., Reddy, V. M., Petrossian, E., Macdonald, M., Lamberti, J. J., & Hanley, F. L. (2006). Homograft valved right ventricle to pulmonary artery conduit as a modification of the Norwood procedure. CIRCULATION, 114, I594-I599.

Summary proceedings from the cardiology group on postoperative cardiac dysfunction
Roth, S. J., Adatia, I., & Pearson, G. D. (2006). Summary proceedings from the cardiology group on postoperative cardiac dysfunction. PEDIATRICS, 117(3), S40-S46.

Response to Haas NA and Camphausen CK: Triiodothyronine in Neonatal Heart Surgery - Looking for an Answer
Mackie AS, Newburger JW, & Roth SJ. (2006). Response to Haas NA and Camphausen CK: Triiodothyronine in Neonatal Heart Surgery - Looking for an Answer. Journal of Thoracic and Cardiovascular Surgery, 131(2).

A randomized, double-blind, placebo-controlled pilot trial of triiodothyronine in neonatal heart surgery
Mackie, A. S., Booth, K. L., Newburger, J. W., Gauvreau, K., Huang, S. A., & Roth, S. J. (2005). A randomized, double-blind, placebo-controlled pilot trial of triiodothyronine in neonatal heart surgery. JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY, 130(3), 810-816.

Management of infants with large, unrepaired ventricular septal defects and respiratory infection requiring mechanical ventilation
Bhatt, M., Roth, S. J., Kumar, R. K., Gauvreau, K., Nair, S. G., & Rao, S. G. (2004). Management of infants with large, unrepaired ventricular septal defects and respiratory infection requiring mechanical ventilation. JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY, 127(5), 1466-1473.

Extracorporeal membrane oxygenation support of the Fontan and bidirectional Glenn circulations
Booth, K. L., Roth, S. J., Thiagarajan, R. R., Almodovar, M. C., Del Nido, P. J., & Laussen, P. C. (2004). Extracorporeal membrane oxygenation support of the Fontan and bidirectional Glenn circulations. ANNALS OF THORACIC SURGERY, 77(4), 1341-1348.

The influence of hemodilution on outcome after hypothermic cardiopulmonary bypass: Results of a randomized trial in infants
Jonas, R. A., Wypij, D., Roth, S. J., Bellinger, D. C., Visconti, K. J., & Newburger, J. W. (2003). The influence of hemodilution on outcome after hypothermic cardiopulmonary bypass: Results of a randomized trial in infants. JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY, 126(6), 1765-1774.

Human pulmonary valve endothelial cells express functional adhesion molecules for leukocytes
Dvorin, E. L., Jacobson, J., Roth, S. J., & Bischoff, J. (2003). Human pulmonary valve endothelial cells express functional adhesion molecules for leukocytes. JOURNAL OF HEART VALVE DISEASE, 12(5), 617-624.

Extracorporeal membrane oxygenation as a bridge to cardiac transplantation in a patient with cardiomyopathy and hemophilia A
Thiagarajan, R. R., Roth, S. J., Margossian, S., Mackie, A. S., Neufeld, E. J., & Blume, E. D. (2003). Extracorporeal membrane oxygenation as a bridge to cardiac transplantation in a patient with cardiomyopathy and hemophilia A. INTENSIVE CARE MEDICINE, 29(6), 985-988.

Cardiovascular tissue engineering: constructing living tissue cardiac valves and blood vessels using bone marrow, umbilical cord blood, and peripheral blood cells.
Perry, T. E., & Roth, S. J. (2003). Cardiovascular tissue engineering: constructing living tissue cardiac valves and blood vessels using bone marrow, umbilical cord blood, and peripheral blood cells. journal of cardiovascular nursing, 18(1), 30-37.

Cardiac catheterization of patients supported by extracorporeal membrane oxygenation
Booth, K. L., Roth, S. J., Perry, S. B., Del Nido, P. J., Wessel, D. L., & Laussen, P. C. (2002). Cardiac catheterization of patients supported by extracorporeal membrane oxygenation. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 40(9), 1681-1686.

Anticipatory use of venoarterial extracorporeal membrane oxygenation for a high-risk interventional cardiac procedure.
Carmichael, T. B., Walsh, E. P., & Roth, S. J. (2002). Anticipatory use of venoarterial extracorporeal membrane oxygenation for a high-risk interventional cardiac procedure. Respiratory care, 47(9), 1002-1006.

Outcome of ventricular septal defect repair in a developing country
Vaidyanathan, B., Roth, S. J., Rao, S. G., Gauvreau, K., Shivaprakasha, K., & Kumar, R. K. (2002). Outcome of ventricular septal defect repair in a developing country. JOURNAL OF PEDIATRICS, 140(6), 736-741.

Aortic valve endothelial cells undergo transforming growth factor-beta-mediated and non-transforming growth factor-beta-mediated transdifferentiation in vitro
Paranya, G., Vineberg, S., Dvorin, E., Kaushal, S., Roth, S. J., & Bischoff, J. (2001). Aortic valve endothelial cells undergo transforming growth factor-beta-mediated and non-transforming growth factor-beta-mediated transdifferentiation in vitro. AMERICAN JOURNAL OF PATHOLOGY, 159(4), 1335-1343.

Synchronized independent lung ventilation in palliated congenital heart disease with variable sources of pulmonary blood flow.
Almodovar, M. C., Laussen, P. C., & Roth, S. J. (2000). Synchronized independent lung ventilation in palliated congenital heart disease with variable sources of pulmonary blood flow. Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies, 1(1), 79-83.

Effects of a monoclonal antibody to P-selectin on recovery of neonatal lamb hearts after cold cardioplegic ischemia
Nagashima, M., Shin'oka, T., Nollert, G., Shum-Tim, D., Hickey, P. R., & Mayer, J. E. (1998). Effects of a monoclonal antibody to P-selectin on recovery of neonatal lamb hearts after cold cardioplegic ischemia. CIRCULATION, 98(19), II391-II397.

Transendothelial chemotaxis of human alpha/beta and gamma/delta T lymphocytes to chemokines
Roth, S. J., Diacovo, T. G., Brenner, M. B., Rosat, J. P., Buccola, J., & Springer, T. A. (1998). Transendothelial chemotaxis of human alpha/beta and gamma/delta T lymphocytes to chemokines. EUROPEAN JOURNAL OF IMMUNOLOGY, 28(1), 104-113.

Perioperative effects of alpha-stat versus pH-stat strategies for deep hypothermic cardiopulmonary bypass in infants
du Plessis, A. J., Jonas, R. A., Wypij, D., Hickey, P. R., Riviello, J., & Newburger, J. W. (1997). Perioperative effects of alpha-stat versus pH-stat strategies for deep hypothermic cardiopulmonary bypass in infants. JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY, 114(6), 991-1000.

Contrasting responses to multiple chemotactic stimuli in transendothelial migration - Heterologous desensitization in neutrophils and augmentation of migration in eosinophils
Kitayama, J., Carr, M. W., Roth, S. J., Buccola, J., & Springer, T. A. (1997). Contrasting responses to multiple chemotactic stimuli in transendothelial migration - Heterologous desensitization in neutrophils and augmentation of migration in eosinophils. JOURNAL OF IMMUNOLOGY, 158(5), 2340-2349.

Neutrophil rolling, arrest, and transmigration across activated, surface-adherent platelets via sequential action of P-selectin and the beta(2)-integrin CD11b/CD18
Diacovo, T. G., Roth, S. J., Buccola, J. M., Bainton, D. F., & Springer, T. A. (1996). Neutrophil rolling, arrest, and transmigration across activated, surface-adherent platelets via sequential action of P-selectin and the beta(2)-integrin CD11b/CD18. BLOOD, 88(1), 146-157.

Interactions of human alpha/beta and gamma/delta T lymphocyte subsets in shear flow with E-selectin and P-selectin
Diacovo, T. G., Roth, S. J., Morita, C. T., Rosat, J. P., Brenner, M. B., & Springer, T. A. (1996). Interactions of human alpha/beta and gamma/delta T lymphocyte subsets in shear flow with E-selectin and P-selectin. JOURNAL OF EXPERIMENTAL MEDICINE, 183(3), 1193-1203.

Effects of endothelin-1 and L-arginine after cold ischemia in lamb hearts
Hiramatsu, T., Forbess, J. M., Miura, T., Roth, S. J., CIOFFI, M. A., & Mayer, J. E. (1996). Effects of endothelin-1 and L-arginine after cold ischemia in lamb hearts. ANNALS OF THORACIC SURGERY, 61(1), 36-40.

Characterization of transendothelial chemotaxis of T lymphocytes
Roth, S. J., Carr, M. W., Rose, S. S., & Springer, T. A. (1995). Characterization of transendothelial chemotaxis of T lymphocytes. JOURNAL OF IMMUNOLOGICAL METHODS, 188(1), 97-116.

C-C chemokines, but not the C-X-C chemokines interleukin-8 and interferon-gamma inducible protein-10, stimulate transendothelial chemotaxis of T lymphocytes
Roth, S. J., Carr, M. W., & Springer, T. A. (1995). C-C chemokines, but not the C-X-C chemokines interleukin-8 and interferon-gamma inducible protein-10, stimulate transendothelial chemotaxis of T lymphocytes. EUROPEAN JOURNAL OF IMMUNOLOGY, 25(12), 3482-3488.

Ten-year institutional experience with palliative surgery for hypoplastic left heart syndrome. Risk factors related to stage I mortality.
Forbess, J. M., Cook, N., Roth, S. J., Serraf, A., Mayer, J. E., & Jonas, R. A. (1995). Ten-year institutional experience with palliative surgery for hypoplastic left heart syndrome. Risk factors related to stage I mortality. Circulation, 92(9), II262-6.

Effects of endothelin-1 and endothelin-A receptor antagonist on recovery after hypothermic cardioplegic ischemia in neonatal lamb hearts.
Hiramatsu, T., Forbess, J., Miura, T., Roth, S. J., CIOFFI, M. A., & Mayer, J. E. (1995). Effects of endothelin-1 and endothelin-A receptor antagonist on recovery after hypothermic cardioplegic ischemia in neonatal lamb hearts. Circulation, 92(9), II400-4.

MONOCYTE CHEMOATTRACTANT PROTEIN-1 ACTS AS A T-LYMPHOCYTE CHEMOATTRACTANT
Carr, M. W., Roth, S. J., Luther, E., Rose, S. S., & Springer, T. A. (1994). MONOCYTE CHEMOATTRACTANT PROTEIN-1 ACTS AS A T-LYMPHOCYTE CHEMOATTRACTANT. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 91(9), 3652-3656.