Eric Sibley, M.D., Ph.D.

Associate Professor of Pediatrics (Gastroenterology)

Professional Education

Undergraduate Education, Harvard College, A.B., Biochemical Sciences (1982)

Medical Education: Johns Hopkins University School of Medicine (1990) MD

Graduate Education, The Johns Hopkins University, Ph.D., Biological Chemistry (1990)

Internship: Harbor-UCLA Medical Center (1991) CA

Residency: Harbor-UCLA Medical Center (1993) CA

Fellowship: Stanford University School of Medicine (1996) CA

Board Certification: Pediatric Gastroenterology, American Board of Pediatrics (1997)

Honors & Awards

Member, American Clinical and Climatological Association (2010-present)

Council, elected, American Gastroenterology Association (2007-2011)

Council, elected, Society for Pediatric Research (2005-2008)

Named Investigator Award, Stanford Digestive Disease Center (2002-2003)

Young Faculty Investigator Award, North American Society for Pediatric Gastroenterology and Nutrition (1998)

Administrative Appointments

Assistant Dean for Academic Advising, Stanford University School of Medicine (2012 - Present)

Senator, School of Medicine Faculty Senate (2009 - Present)

Associate Director (Research), Stanford Pediatric Gastroenterology Training Program (2004 - Present)

Chair/Vice-Chair, Growth, Development and Aging Section, American Gastroenterology Association (2007 - 2011)

Editor-In-Chief, Journal of Pediatric Gastroenterology and Nutrition (2006 - 2010)

Member, Clinical and Integrative Gastrointestinal Pathobiology Study Section, NIH (2004 - 2007)

Admissions Committee, Stanford University School of Medicine (1998 - 2001)

Intestinal Pdx1 mediates nutrient metabolism gene networks and maternal expression is essential for perinatal growth in mice
Chen, C., Leavitt, T., & Sibley, E. (2012). Intestinal Pdx1 mediates nutrient metabolism gene networks and maternal expression is essential for perinatal growth in mice. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 424(3), 549-553.

The human lactase persistence-associated SNP -13910*T enables in vivo functional persistence of lactase promoter-reporter transgene expression
Fang, L., Ahn, J. K., Wodziak, D., & Sibley, E. (2012). The human lactase persistence-associated SNP -13910*T enables in vivo functional persistence of lactase promoter-reporter transgene expression. HUMAN GENETICS, 131(7), 1153-1159.

PDX1 regulation of FABP1 and novel target genes in human intestinal epithelial Caco-2 cells
Chen, C., Fang, R., Chou, L.-C., Lowe, A. W., & Sibley, E. (2012). PDX1 regulation of FABP1 and novel target genes in human intestinal epithelial Caco-2 cells. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 423(1), 183-187.

Expression profiling identifies novel gene targets and functions for Pdx1 in the duodenum of mature mice
Chen, C., & Sibley, E. (2012). Expression profiling identifies novel gene targets and functions for Pdx1 in the duodenum of mature mice. AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, 302(4), G407-G419.

Theodore E. Woodward Award: lactase persistence SNPs in African populations regulate promoter activity in intestinal cell culture.
Sibley, E., & Ahn, J. K. (2011). Theodore E. Woodward Award: lactase persistence SNPs in African populations regulate promoter activity in intestinal cell culture. Transactions of the American Clinical and Climatological Association, 122, 155-165.

-13915*G DNA polymorphism associated with lactase persistence in Africa interacts with Oct-1
Olds, L. C., Ahn, J. K., & Sibley, E. (2011). -13915*G DNA polymorphism associated with lactase persistence in Africa interacts with Oct-1. HUMAN GENETICS, 129(1), 111-113.

Increased HLA-DR Expression on Tissue Eosinophils in Eosinophilic Esophagitis
Patel, A. J., Fuentebella, J., Gernez, Y., Nguyen, T., Bass, D., & Nadeau, K. (2010). Increased HLA-DR Expression on Tissue Eosinophils in Eosinophilic Esophagitis. JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION, 51(3), 290-294.

Three-dimensional optical method for integrated visualization of mouse islet microstructure and vascular network with subcellular-level resolution
Fu, Y.-Y., Lu, C.-H., Lin, C.-W., Juang, J.-H., Enikolopov, G., & Tang, S.-C. (2010). Three-dimensional optical method for integrated visualization of mouse islet microstructure and vascular network with subcellular-level resolution. JOURNAL OF BIOMEDICAL OPTICS, 15(4).

Eotaxin and FGF enhance signaling through an extracellular signal-related kinase (ERK)-dependent pathway in the pathogenesis of Eosinophilic esophagitis.
Huang, J. J., Joh, J. W., Fuentebella, J., Patel, A., Nguyen, T., & Nadeau, K. C. (2010). Eotaxin and FGF enhance signaling through an extracellular signal-related kinase (ERK)-dependent pathway in the pathogenesis of Eosinophilic esophagitis. Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology, 6(1), 25-?.

Pdx1 inactivation restricted to the intestinal epithelium in mice alters duodenal gene expression in enterocytes and enteroendocrine cells
Chen, C., Fang, R., Davis, C., Maravelias, C., & Sibley, E. (2009). Pdx1 inactivation restricted to the intestinal epithelium in mice alters duodenal gene expression in enterocytes and enteroendocrine cells. AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, 297(6), G1126-G1137.

Microtome-Free 3-Dimensional Confocal Imaging Method for Visualization of Mouse Intestine With Subcellular-Level Resolution
Fu, Y.-Y., Lin, C.-W., Enikolopov, G., Sibley, E., Chiang, A.-S., & Tang, S.-C. (2009). Microtome-Free 3-Dimensional Confocal Imaging Method for Visualization of Mouse Intestine With Subcellular-Level Resolution. GASTROENTEROLOGY, 137(2), 453-465.

Transient cytochalasin-D treatment induces apically administered rAAV2 across tight junctions for transduction of enterocytes
Fu, Y.-Y., Sibley, E., & Tang, S.-C. (2008). Transient cytochalasin-D treatment induces apically administered rAAV2 across tight junctions for transduction of enterocytes. JOURNAL OF GENERAL VIROLOGY, 89, 3004-3008.

Application of doxorubicin-induced rAAV2-p53 gene delivery in combined chemotherapy and gene therapy for hepatocellular carcinoma
Chen, C.-A., Lo, C.-K., Lin, B.-L., Sibley, E., & Tang, S.-C. (2008). Application of doxorubicin-induced rAAV2-p53 gene delivery in combined chemotherapy and gene therapy for hepatocellular carcinoma. CANCER BIOLOGY & THERAPY, 7(2), 303-U3.

Genetic modification of somatic gut mucosa: An adeno-associated virus approach
Tang, S.-C., & Sibley, E. (2006). Genetic modification of somatic gut mucosa: An adeno-associated virus approach. JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION, 43(2), 158-159.

Spatio-temporal patterns of intestine-specific transcription factor expression during postnatal mouse gut development
Fang, R. X., Olds, L. C., & Sibley, E. (2006). Spatio-temporal patterns of intestine-specific transcription factor expression during postnatal mouse gut development. GENE EXPRESSION PATTERNS, 6(4), 426-432.

Lactase gene promoter fragments mediate differential spatial and temporal expression patterns in transgenic mice
Wang, Z., Maravelias, C., & Sibley, E. (2006). Lactase gene promoter fragments mediate differential spatial and temporal expression patterns in transgenic mice. DNA AND CELL BIOLOGY, 25(4), 215-222.

Proteasome modulating agents induce rAAV2-mediated transgene expression in human intestinal epithelial cells
Tang, S. C., Sambanis, A., & Sibley, E. (2005). Proteasome modulating agents induce rAAV2-mediated transgene expression in human intestinal epithelial cells. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 331(4), 1392-1400.

Transcriptional regulation of the lactase-phlorizin hydrolase promoter by PDX-1
Wang, Z., Fang, R. X., Olds, L. C., & Sibley, E. (2004). Transcriptional regulation of the lactase-phlorizin hydrolase promoter by PDX-1. AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, 287(3), G555-G561.

PCR-RFLP genotyping assay for a lactase persistence polymorphism upstream of the lactase-phlorizin hydrolase gene
Chao, C. K., & Sibley, E. (2004). PCR-RFLP genotyping assay for a lactase persistence polymorphism upstream of the lactase-phlorizin hydrolase gene. GENETIC TESTING, 8(2), 190-193.

Carbohydrate intolerance
Sibley, E. (2004). Carbohydrate intolerance. CURRENT OPINION IN GASTROENTEROLOGY, 20(2), 162-167.

Genetic variation and lactose intolerance: detection methods and clinical implications.
Sibley, E. (2004). Genetic variation and lactose intolerance: detection methods and clinical implications. American journal of pharmacogenomics , 4(4), 239-245.

Lactase persistence DNA variant enhances lactase promoter activity in vitro: functional role as a cis regulatory element
Olds, L. C., & Sibley, E. (2003). Lactase persistence DNA variant enhances lactase promoter activity in vitro: functional role as a cis regulatory element. HUMAN MOLECULAR GENETICS, 12(18), 2333-2340.

Regulation of intestine-specific spatiotemporal expression by the rat lactase promoter
Lee, S. Y., Wang, Z., Lin, C. K., Contag, C. H., Olds, L. C., & Sibley, E. (2002). Regulation of intestine-specific spatiotemporal expression by the rat lactase promoter. JOURNAL OF BIOLOGICAL CHEMISTRY, 277(15), 13099-13105.

Subarachnoid hemorrhage and isolated atresia of the aortic arch
Sibley, E., Doroshow, R. W., Milliken, J. C., & Anand, S. K. (2002). Subarachnoid hemorrhage and isolated atresia of the aortic arch. JOURNAL OF EMERGENCY MEDICINE, 22(2), 179-183.

Lactase gene transcription is activated in response to hypoxia in intestinal epithelial cells
Lee, S. Y., Madan, A., Furuta, G. T., Colgan, S. P., & Sibley, E. (2002). Lactase gene transcription is activated in response to hypoxia in intestinal epithelial cells. MOLECULAR GENETICS AND METABOLISM, 75(1), 65-69.

Thyroid hormone and the D-type cyclins interact in regulating enterocyte gene transcription
Meng, S. F., Badrinarain, J., Sibley, E., Fang, R. X., & Hodin, R. (2001). Thyroid hormone and the D-type cyclins interact in regulating enterocyte gene transcription. JOURNAL OF GASTROINTESTINAL SURGERY, 5(1), 49-55.

GATA family transcription factors activate lactase gene promoter in intestinal Caco-2 cells
Fang, R. X., Olds, L. C., Santiago, N. A., & Sibley, E. (2001). GATA family transcription factors activate lactase gene promoter in intestinal Caco-2 cells. AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, 280(1), G58-G67.

The homeodomain protein Cdx2 regulates lactase gene promoter activity during enterocyte differentiation
Fang, R. X., Santiago, N. A., Olds, L. C., & Sibley, E. (2000). The homeodomain protein Cdx2 regulates lactase gene promoter activity during enterocyte differentiation. GASTROENTEROLOGY, 118(1), 115-127.

EVOLVING ASYMMETRIC HYPERTROPHIC PYLORIC-STENOSIS ASSOCIATED WITH HISTOLOGIC EVIDENCE OF EOSINOPHILIC GASTROENTERITIS
Blankenberg, F. G., Parker, B. R., Sibley, E., & Kerner, J. A. (1995). EVOLVING ASYMMETRIC HYPERTROPHIC PYLORIC-STENOSIS ASSOCIATED WITH HISTOLOGIC EVIDENCE OF EOSINOPHILIC GASTROENTERITIS. PEDIATRIC RADIOLOGY, 25(4), 310-311.

SUBSTRATE PHOSPHORYLATION CATALYZED BY THE INSULIN-RECEPTOR TYROSINE KINASE - KINETIC CORRELATION TO AUTOPHOSPHORYLATION OF SPECIFIC SITES IN THE BETA-SUBUNIT
FLORESRIVEROS, J. R., Sibley, E., Kastelic, T., & Lane, M. D. (1989). SUBSTRATE PHOSPHORYLATION CATALYZED BY THE INSULIN-RECEPTOR TYROSINE KINASE - KINETIC CORRELATION TO AUTOPHOSPHORYLATION OF SPECIFIC SITES IN THE BETA-SUBUNIT. JOURNAL OF BIOLOGICAL CHEMISTRY, 264(36), 21557-21572.

CHARACTERIZATION OF THE MOUSE INSULIN-RECEPTOR GENE PROMOTER
Sibley, E., Kastelic, T., Kelly, T. J., & Lane, M. D. (1989). CHARACTERIZATION OF THE MOUSE INSULIN-RECEPTOR GENE PROMOTER. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 86(24), 9732-9736.

DIFFERENTIATION-INDUCED GENE-EXPRESSION IN 3T3-L1 PREADIPOCYTES - CHARACTERIZATION OF A DIFFERENTIALLY EXPRESSED GENE ENCODING STEAROYL-COA DESATURASE
Ntambi, J. M., BUHROW, S. A., Kaestner, K. H., Christy, R. J., Sibley, E., & Lane, M. D. (1988). DIFFERENTIATION-INDUCED GENE-EXPRESSION IN 3T3-L1 PREADIPOCYTES - CHARACTERIZATION OF A DIFFERENTIALLY EXPRESSED GENE ENCODING STEAROYL-COA DESATURASE. JOURNAL OF BIOLOGICAL CHEMISTRY, 263(33), 17291-17300.

EXPRESSION OF THE DIFFERENTIATION-INDUCED GENE FOR FATTY ACID-BINDING PROTEIN IS ACTIVATED BY GLUCOCORTICOID AND CAMP
Cook, J. S., Lucas, J. J., Sibley, E., BOLANOWSKI, M. A., Christy, R. J., & Lane, M. D. (1988). EXPRESSION OF THE DIFFERENTIATION-INDUCED GENE FOR FATTY ACID-BINDING PROTEIN IS ACTIVATED BY GLUCOCORTICOID AND CAMP. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 85(9), 2949-2953.

HIGH-LEVEL EXPRESSION OF A CLONED HLA HEAVY-CHAIN GENE INTRODUCED INTO MOUSE CELLS ON A BOVINE PAPILLOMAVIRUS VECTOR
DiMaio, D., Corbin, V., Sibley, E., & Maniatis, T. (1984). HIGH-LEVEL EXPRESSION OF A CLONED HLA HEAVY-CHAIN GENE INTRODUCED INTO MOUSE CELLS ON A BOVINE PAPILLOMAVIRUS VECTOR. MOLECULAR AND CELLULAR BIOLOGY, 4(2), 340-350.