Eric Sibley, M.D., Ph.D.

Professional Education

Undergraduate Education, Harvard College, A.B., Biochemical Sciences (1982)

Medical Education: Johns Hopkins University School of Medicine (1990) MD

Graduate Education, The Johns Hopkins University, Ph.D., Biological Chemistry (1990)

Internship: Harbor-UCLA Medical Center (1991) CA

Residency: Harbor-UCLA Medical Center (1993) CA

Fellowship: Stanford University School of Medicine (1996) CA

Board Certification: Pediatric Gastroenterology, American Board of Pediatrics (1997)

Honors & Awards

Member, American Clinical and Climatological Association (2010-present)

Council, elected, American Gastroenterology Association (2007-2011)

Council, elected, Society for Pediatric Research (2005-2008)

Named Investigator Award, Stanford Digestive Disease Center (2002-2003)

Young Faculty Investigator Award, North American Society for Pediatric Gastroenterology and Nutrition (1998)

Administrative Appointments

Assistant Dean for Academic Advising, Stanford University School of Medicine, 2012

Senator, School of Medicine Faculty Senate, 2009

Associate Director (Research), Stanford Pediatric Gastroenterology Training Program, 2004

Chair/Vice-Chair, Growth, Development and Aging Section, American Gastroenterology Association, 2007

Editor-In-Chief, Journal of Pediatric Gastroenterology and Nutrition, 2006

Member, Clinical and Integrative Gastrointestinal Pathobiology Study Section, NIH, 2004

Admissions Committee, Stanford University School of Medicine, 1998

Intestinal Pdx1 mediates nutrient metabolism gene networks and maternal expression is essential for perinatal growth in mice
Chen, C., Leavitt, T., & Sibley, E. (2012). Intestinal Pdx1 mediates nutrient metabolism gene networks and maternal expression is essential for perinatal growth in mice. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 424(3), 549-553.

The human lactase persistence-associated SNP -13910*T enables in vivo functional persistence of lactase promoter-reporter transgene expression
Fang, L., Ahn, J. K., Wodziak, D., & Sibley, E. (2012). The human lactase persistence-associated SNP -13910*T enables in vivo functional persistence of lactase promoter-reporter transgene expression. HUMAN GENETICS, 131(7), 1153-1159.

PDX1 regulation of FABP1 and novel target genes in human intestinal epithelial Caco-2 cells
Chen, C., Fang, R., Chou, L.-C., Lowe, A. W., & Sibley, E. (2012). PDX1 regulation of FABP1 and novel target genes in human intestinal epithelial Caco-2 cells. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 423(1), 183-187.

Expression profiling identifies novel gene targets and functions for Pdx1 in the duodenum of mature mice
Chen, C., & Sibley, E. (2012). Expression profiling identifies novel gene targets and functions for Pdx1 in the duodenum of mature mice. AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, 302(4), G407-G419.

Theodore E. Woodward Award: lactase persistence SNPs in African populations regulate promoter activity in intestinal cell culture.
Sibley, E., & Ahn, J. K. (2011). Theodore E. Woodward Award: lactase persistence SNPs in African populations regulate promoter activity in intestinal cell culture. Transactions of the American Clinical and Climatological Association, 122, 155-165.

-13915*G DNA polymorphism associated with lactase persistence in Africa interacts with Oct-1
Olds, L. C., Ahn, J. K., & Sibley, E. (2011). -13915*G DNA polymorphism associated with lactase persistence in Africa interacts with Oct-1. HUMAN GENETICS, 129(1), 111-113.

Increased HLA-DR Expression on Tissue Eosinophils in Eosinophilic Esophagitis
Patel, A. J., Fuentebella, J., Gernez, Y., Nguyen, T., Bass, D., & Nadeau, K. (2010). Increased HLA-DR Expression on Tissue Eosinophils in Eosinophilic Esophagitis. JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION, 51(3), 290-294.

Three-dimensional optical method for integrated visualization of mouse islet microstructure and vascular network with subcellular-level resolution
Fu, Y.-Y., Lu, C.-H., Lin, C.-W., Juang, J.-H., Enikolopov, G., & Tang, S.-C. (2010). Three-dimensional optical method for integrated visualization of mouse islet microstructure and vascular network with subcellular-level resolution. JOURNAL OF BIOMEDICAL OPTICS, 15(4).

Eotaxin and FGF enhance signaling through an extracellular signal-related kinase (ERK)-dependent pathway in the pathogenesis of Eosinophilic esophagitis.
Huang, J. J., Joh, J. W., Fuentebella, J., Patel, A., Nguyen, T., & Nadeau, K. C. (2010). Eotaxin and FGF enhance signaling through an extracellular signal-related kinase (ERK)-dependent pathway in the pathogenesis of Eosinophilic esophagitis. Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology, 6(1), 25-?.

Pdx1 inactivation restricted to the intestinal epithelium in mice alters duodenal gene expression in enterocytes and enteroendocrine cells
Chen, C., Fang, R., Davis, C., Maravelias, C., & Sibley, E. (2009). Pdx1 inactivation restricted to the intestinal epithelium in mice alters duodenal gene expression in enterocytes and enteroendocrine cells. AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, 297(6), G1126-G1137.

Microtome-Free 3-Dimensional Confocal Imaging Method for Visualization of Mouse Intestine With Subcellular-Level Resolution
Fu, Y.-Y., Lin, C.-W., Enikolopov, G., Sibley, E., Chiang, A.-S., & Tang, S.-C. (2009). Microtome-Free 3-Dimensional Confocal Imaging Method for Visualization of Mouse Intestine With Subcellular-Level Resolution. GASTROENTEROLOGY, 137(2), 453-465.

Transient cytochalasin-D treatment induces apically administered rAAV2 across tight junctions for transduction of enterocytes
Fu, Y.-Y., Sibley, E., & Tang, S.-C. (2008). Transient cytochalasin-D treatment induces apically administered rAAV2 across tight junctions for transduction of enterocytes. JOURNAL OF GENERAL VIROLOGY, 89, 3004-3008.

Application of doxorubicin-induced rAAV2-p53 gene delivery in combined chemotherapy and gene therapy for hepatocellular carcinoma
Chen, C.-A., Lo, C.-K., Lin, B.-L., Sibley, E., & Tang, S.-C. (2008). Application of doxorubicin-induced rAAV2-p53 gene delivery in combined chemotherapy and gene therapy for hepatocellular carcinoma. CANCER BIOLOGY & THERAPY, 7(2), 303-U3.

Genetic modification of somatic gut mucosa: An adeno-associated virus approach
Tang, S.-C., & Sibley, E. (2006). Genetic modification of somatic gut mucosa: An adeno-associated virus approach. JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION, 43(2), 158-159.

Spatio-temporal patterns of intestine-specific transcription factor expression during postnatal mouse gut development
Fang, R. X., Olds, L. C., & Sibley, E. (2006). Spatio-temporal patterns of intestine-specific transcription factor expression during postnatal mouse gut development. GENE EXPRESSION PATTERNS, 6(4), 426-432.

Lactase gene promoter fragments mediate differential spatial and temporal expression patterns in transgenic mice
Wang, Z., Maravelias, C., & Sibley, E. (2006). Lactase gene promoter fragments mediate differential spatial and temporal expression patterns in transgenic mice. DNA AND CELL BIOLOGY, 25(4), 215-222.

Proteasome modulating agents induce rAAV2-mediated transgene expression in human intestinal epithelial cells
Tang, S. C., Sambanis, A., & Sibley, E. (2005). Proteasome modulating agents induce rAAV2-mediated transgene expression in human intestinal epithelial cells. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 331(4), 1392-1400.

Transcriptional regulation of the lactase-phlorizin hydrolase promoter by PDX-1
Wang, Z., Fang, R. X., Olds, L. C., & Sibley, E. (2004). Transcriptional regulation of the lactase-phlorizin hydrolase promoter by PDX-1. AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, 287(3), G555-G561.

PCR-RFLP genotyping assay for a lactase persistence polymorphism upstream of the lactase-phlorizin hydrolase gene
Chao, C. K., & Sibley, E. (2004). PCR-RFLP genotyping assay for a lactase persistence polymorphism upstream of the lactase-phlorizin hydrolase gene. GENETIC TESTING, 8(2), 190-193.

Carbohydrate intolerance
Sibley, E. (2004). Carbohydrate intolerance. CURRENT OPINION IN GASTROENTEROLOGY, 20(2), 162-167.

Genetic variation and lactose intolerance: detection methods and clinical implications.
Sibley, E. (2004). Genetic variation and lactose intolerance: detection methods and clinical implications. American journal of pharmacogenomics , 4(4), 239-245.

Lactase persistence DNA variant enhances lactase promoter activity in vitro: functional role as a cis regulatory element
Olds, L. C., & Sibley, E. (2003). Lactase persistence DNA variant enhances lactase promoter activity in vitro: functional role as a cis regulatory element. HUMAN MOLECULAR GENETICS, 12(18), 2333-2340.

Regulation of intestine-specific spatiotemporal expression by the rat lactase promoter
Lee, S. Y., Wang, Z., Lin, C. K., Contag, C. H., Olds, L. C., & Sibley, E. (2002). Regulation of intestine-specific spatiotemporal expression by the rat lactase promoter. JOURNAL OF BIOLOGICAL CHEMISTRY, 277(15), 13099-13105.

Subarachnoid hemorrhage and isolated atresia of the aortic arch
Sibley, E., Doroshow, R. W., Milliken, J. C., & Anand, S. K. (2002). Subarachnoid hemorrhage and isolated atresia of the aortic arch. JOURNAL OF EMERGENCY MEDICINE, 22(2), 179-183.

Lactase gene transcription is activated in response to hypoxia in intestinal epithelial cells
Lee, S. Y., Madan, A., Furuta, G. T., Colgan, S. P., & Sibley, E. (2002). Lactase gene transcription is activated in response to hypoxia in intestinal epithelial cells. MOLECULAR GENETICS AND METABOLISM, 75(1), 65-69.

Thyroid hormone and the D-type cyclins interact in regulating enterocyte gene transcription
Meng, S. F., Badrinarain, J., Sibley, E., Fang, R. X., & Hodin, R. (2001). Thyroid hormone and the D-type cyclins interact in regulating enterocyte gene transcription. JOURNAL OF GASTROINTESTINAL SURGERY, 5(1), 49-55.

GATA family transcription factors activate lactase gene promoter in intestinal Caco-2 cells
Fang, R. X., Olds, L. C., Santiago, N. A., & Sibley, E. (2001). GATA family transcription factors activate lactase gene promoter in intestinal Caco-2 cells. AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, 280(1), G58-G67.

The homeodomain protein Cdx2 regulates lactase gene promoter activity during enterocyte differentiation
Fang, R. X., Santiago, N. A., Olds, L. C., & Sibley, E. (2000). The homeodomain protein Cdx2 regulates lactase gene promoter activity during enterocyte differentiation. GASTROENTEROLOGY, 118(1), 115-127.

EVOLVING ASYMMETRIC HYPERTROPHIC PYLORIC-STENOSIS ASSOCIATED WITH HISTOLOGIC EVIDENCE OF EOSINOPHILIC GASTROENTERITIS
Blankenberg, F. G., Parker, B. R., Sibley, E., & Kerner, J. A. (1995). EVOLVING ASYMMETRIC HYPERTROPHIC PYLORIC-STENOSIS ASSOCIATED WITH HISTOLOGIC EVIDENCE OF EOSINOPHILIC GASTROENTERITIS. PEDIATRIC RADIOLOGY, 25(4), 310-311.

SUBSTRATE PHOSPHORYLATION CATALYZED BY THE INSULIN-RECEPTOR TYROSINE KINASE - KINETIC CORRELATION TO AUTOPHOSPHORYLATION OF SPECIFIC SITES IN THE BETA-SUBUNIT
FLORESRIVEROS, J. R., Sibley, E., Kastelic, T., & Lane, M. D. (1989). SUBSTRATE PHOSPHORYLATION CATALYZED BY THE INSULIN-RECEPTOR TYROSINE KINASE - KINETIC CORRELATION TO AUTOPHOSPHORYLATION OF SPECIFIC SITES IN THE BETA-SUBUNIT. JOURNAL OF BIOLOGICAL CHEMISTRY, 264(36), 21557-21572.

CHARACTERIZATION OF THE MOUSE INSULIN-RECEPTOR GENE PROMOTER
Sibley, E., Kastelic, T., Kelly, T. J., & Lane, M. D. (1989). CHARACTERIZATION OF THE MOUSE INSULIN-RECEPTOR GENE PROMOTER. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 86(24), 9732-9736.

DIFFERENTIATION-INDUCED GENE-EXPRESSION IN 3T3-L1 PREADIPOCYTES - CHARACTERIZATION OF A DIFFERENTIALLY EXPRESSED GENE ENCODING STEAROYL-COA DESATURASE
Ntambi, J. M., BUHROW, S. A., Kaestner, K. H., Christy, R. J., Sibley, E., & Lane, M. D. (1988). DIFFERENTIATION-INDUCED GENE-EXPRESSION IN 3T3-L1 PREADIPOCYTES - CHARACTERIZATION OF A DIFFERENTIALLY EXPRESSED GENE ENCODING STEAROYL-COA DESATURASE. JOURNAL OF BIOLOGICAL CHEMISTRY, 263(33), 17291-17300.

EXPRESSION OF THE DIFFERENTIATION-INDUCED GENE FOR FATTY ACID-BINDING PROTEIN IS ACTIVATED BY GLUCOCORTICOID AND CAMP
Cook, J. S., Lucas, J. J., Sibley, E., BOLANOWSKI, M. A., Christy, R. J., & Lane, M. D. (1988). EXPRESSION OF THE DIFFERENTIATION-INDUCED GENE FOR FATTY ACID-BINDING PROTEIN IS ACTIVATED BY GLUCOCORTICOID AND CAMP. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 85(9), 2949-2953.

HIGH-LEVEL EXPRESSION OF A CLONED HLA HEAVY-CHAIN GENE INTRODUCED INTO MOUSE CELLS ON A BOVINE PAPILLOMAVIRUS VECTOR
DiMaio, D., Corbin, V., Sibley, E., & Maniatis, T. (1984). HIGH-LEVEL EXPRESSION OF A CLONED HLA HEAVY-CHAIN GENE INTRODUCED INTO MOUSE CELLS ON A BOVINE PAPILLOMAVIRUS VECTOR. MOLECULAR AND CELLULAR BIOLOGY, 4(2), 340-350.