Joshua M. Spin

Cardiologist

Center for Marfan Syndrome

  • 300 Pasteur Drive
  • Stanford, CA 94305
  • Phone: 650-725-8246
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Professional Education

Fellowship: Stanford University School of Medicine (2003) CA

Internship: Stanford University School of Medicine (1998) CA

Residency: Stanford University School of Medicine (2000) CA

Board Certification: Cardiovascular Disease, American Board of Internal Medicine (2003)

Medical Education: Boston University School of Medicine (1997) MA

BA, Cornell University, Biophysics (1989)

MD, PhD, Boston University Med School, Biophysics (1997)

Hemodynamic regulation of reactive oxygen species: implications for vascular diseases.
Raaz, U., Toh, R., Maegdefessel, L., Adam, M., Nakagami, F., & Tsao, P. S. (2014). Hemodynamic regulation of reactive oxygen species: implications for vascular diseases. Antioxidants & redox signaling, 20(6), 914-928.

Micromanaging Abdominal Aortic Aneurysms
Maegdefessel, L., Spin, J. M., Adam, M., Raaz, U., Toh, R., & Tsao, P. S. (2013). Micromanaging Abdominal Aortic Aneurysms. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 14(7), 14374-14394.

MicroRNAs in Abdominal Aortic Aneurysm.
Adam, M., Raaz, U., Spin, J. M., & Tsao, P. S. (2013). MicroRNAs in Abdominal Aortic Aneurysm. Current vascular pharmacology.

Loss of CDKN2B Promotes p53-Dependent Smooth Muscle Cell Apoptosis and Aneurysm Formation
Leeper, N. J., Raiesdana, A., Kojima, Y., Kundu, R. K., Cheng, H., & Quertermous, T. (2013). Loss of CDKN2B Promotes p53-Dependent Smooth Muscle Cell Apoptosis and Aneurysm Formation. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 33(1), E1-?.

Vascular smooth muscle cell phenotypic plasticity: focus on chromatin remodelling
Spin, J. M., Maegdefessel, L., & Tsao, P. S. (2012). Vascular smooth muscle cell phenotypic plasticity: focus on chromatin remodelling. CARDIOVASCULAR RESEARCH, 95(2), 147-155.

MicroRNA-21 Blocks Abdominal Aortic Aneurysm Development and Nicotine-Augmented Expansion
Maegdefessel, L., Azuma, J., Toh, R., Deng, A., Merk, D. R., & Tsao, P. S. (2012). MicroRNA-21 Blocks Abdominal Aortic Aneurysm Development and Nicotine-Augmented Expansion. SCIENCE TRANSLATIONAL MEDICINE, 4(122).

Inhibition of microRNA-29b reduces murine abdominal aortic aneurysm development
Maegdefessel, L., Azuma, J., Toh, R., Merk, D. R., Deng, A., & Tsao, P. S. (2012). Inhibition of microRNA-29b reduces murine abdominal aortic aneurysm development. JOURNAL OF CLINICAL INVESTIGATION, 122(2), 497-506.

miR-29b Participates in Early Aneurysm Development in Marfan Syndrome
Merk, D. R., Chin, J. T., Dake, B. A., Maegdefessel, L., Miller, M. O., & Fischbein, M. P. (2012). miR-29b Participates in Early Aneurysm Development in Marfan Syndrome. CIRCULATION RESEARCH, 110(2), 312-?.

In Vivo Functional and Transcriptional Profiling of Bone Marrow Stem Cells After Transplantation Into Ischemic Myocardium
Sheikh, A. Y., Huber, B. C., Narsinh, K. H., Spin, J. M., van der Bogt, K., & Wu, J. C. (2012). In Vivo Functional and Transcriptional Profiling of Bone Marrow Stem Cells After Transplantation Into Ischemic Myocardium. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 32(1), 92-102.

Cardiac pressure overload hypertrophy is differentially regulated by beta-adrenergic receptor subtypes
Zhao, M., Fajardo, G., Urashima, T., Spin, J. M., Poorfarahani, S., & Bernstein, D. (2011). Cardiac pressure overload hypertrophy is differentially regulated by beta-adrenergic receptor subtypes. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 301(4), H1461-H1470.

Transcriptional profiling and network analysis of the murine angiotensin II-induced abdominal aortic aneurysm
Spin, J. M., Hsu, M., Azuma, J., Tedesco, M. M., Deng, A., & Tsao, P. S. (2011). Transcriptional profiling and network analysis of the murine angiotensin II-induced abdominal aortic aneurysm. PHYSIOLOGICAL GENOMICS, 43(17), 993-1003.

MicroRNA-26a Is a Novel Regulator of Vascular Smooth Muscle Cell Function
Leeper, N. J., Raiesdana, A., Kojima, Y., Chun, H. J., Azuma, J., & Spin, J. M. (2011). MicroRNA-26a Is a Novel Regulator of Vascular Smooth Muscle Cell Function. JOURNAL OF CELLULAR PHYSIOLOGY, 226(4), 1035-1043.

Gene Mutations and Familial Thoracic Aortic Aneurysms A Walk on the Mild Side
Spin, J. M. (2011). Gene Mutations and Familial Thoracic Aortic Aneurysms A Walk on the Mild Side. CIRCULATION-CARDIOVASCULAR GENETICS, 4(1), 4-6.

Chromatin Remodeling Pathways in Smooth Muscle Cell Differentiation, and Evidence for an Integral Role for p300
Spin, J. M., Quertermous, T., & Tsao, P. S. (2010). Chromatin Remodeling Pathways in Smooth Muscle Cell Differentiation, and Evidence for an Integral Role for p300. PLOS ONE, 5(12).

Nicotine Accelerates the Expansion of Abdominal Aortic Aneurysms in Mice; A Potential Role for miR-21 and miR-26a
Maegdefessel, L., Azuma, J., Spin, J. M., Deng, A., McConnell, M. V., & Tsao, P. S. (2010). Nicotine Accelerates the Expansion of Abdominal Aortic Aneurysms in Mice; A Potential Role for miR-21 and miR-26a. CIRCULATION, 122(21).

New options with dabigatran etexilate in anticoagulant therapy.
Maegdefessel, L., Spin, J. M., Azuma, J., & Tsao, P. S. (2010). New options with dabigatran etexilate in anticoagulant therapy. Vascular health and risk management, 6, 339-349.

Analysis of In Situ and Ex Vivo Vascular Endothelial Growth Factor Receptor Expression During Experimental Aortic Aneurysm Progression
Tedesco, M. M., Terashima, M., Blankenberg, F. G., Levashova, Z., Spin, J. M., & Dalman, R. L. (2009). Analysis of In Situ and Ex Vivo Vascular Endothelial Growth Factor Receptor Expression During Experimental Aortic Aneurysm Progression. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 29(10), 1452-?.

Frontiers in nephrology: Genomic approaches to understanding the molecular basis of atherosclerosis
Ashley, E. A., Spin, J. M., Tabibiazar, R., & Quertermous, T. (2007). Frontiers in nephrology: Genomic approaches to understanding the molecular basis of atherosclerosis. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 18(11), 2853-2862.

Network analysis of human in-stent restenosis
Ashley, E. A., Ferrara, R., King, J. Y., Vailaya, A., Kuchinsky, A., & Quertermous, T. (2006). Network analysis of human in-stent restenosis. CIRCULATION, 114(24), 2644-2654.

Molecular signatures determining coronary artery and saphenous vein smooth muscle cell phenotypes - Distinct responses to stimuli
Deng, D. Xf., Spin, J. M., Tsalenko, A., Vailaya, A., Ben-Dor, A., & Quertermous, T. (2006). Molecular signatures determining coronary artery and saphenous vein smooth muscle cell phenotypes - Distinct responses to stimuli. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 26(5), 1058-1065.

Transcriptional profiling of reporter genes used for molecular imaging of embryonic stem cell transplantation
Wu, J. C., Spin, J. M., Cao, F., Lin, S. A., Xie, X. Y., & Quertermous, T. (2006). Transcriptional profiling of reporter genes used for molecular imaging of embryonic stem cell transplantation. PHYSIOLOGICAL GENOMICS, 25(1), 29-38.

Pathway analysis of coronary atherosclerosis
King, J. Y., Ferrara, R., Tabibiazar, R., Spin, J. M., Chen, M. M., & Ashley, E. A. (2005). Pathway analysis of coronary atherosclerosis. PHYSIOLOGICAL GENOMICS, 23(1), 103-118.

Signature patterns of gene expression in mouse atherosclerosis and their correlation to human coronary disease
Tabibiazar, R., Wagner, R. A., Ashley, E. A., King, J. Y., Ferrara, R., & Quertermous, T. (2005). Signature patterns of gene expression in mouse atherosclerosis and their correlation to human coronary disease. PHYSIOLOGICAL GENOMICS, 22(2), 213-226.

Mouse strain-specific differences in vascular wall gene expression and their relationship to vascular disease
Tabibiazar, R., Wagner, R. A., Spin, J. M., Ashley, E. A., Narasimhan, B., & Quertermous, T. (2005). Mouse strain-specific differences in vascular wall gene expression and their relationship to vascular disease. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 25(2), 302-308.

Transcriptional profiling of in vitro smooth muscle cell differentiation identifies specific patterns of gene and pathway activation
Spin, J. M., Nallamshetty, S., Tabibiazar, R., Ashley, E. A., King, J. Y., & Quertermous, T. (2004). Transcriptional profiling of in vitro smooth muscle cell differentiation identifies specific patterns of gene and pathway activation. PHYSIOLOGICAL GENOMICS, 19(3), 292-302.

Endothelial lipase modulates susceptibility to atherosclerosis in apolipoprotein-E-deficient mice
Ishida, T., Choi, S. Sy., Kundu, R. K., Spin, J., Yamashita, T., & Quertermous, T. (2004). Endothelial lipase modulates susceptibility to atherosclerosis in apolipoprotein-E-deficient mice. JOURNAL OF BIOLOGICAL CHEMISTRY, 279(43), 45085-45092.

Treadmill scores in elderly men
Lai, S., Kaykha, A., Yamazaki, T., Goldstein, M., Spin, J. M., & Froelicher, V. F. (2004). Treadmill scores in elderly men. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 43(4), 606-615.

Retinal evaluation of patients on chronic amiodarone therapy
Shaikh, S., Shaikh, N., Chun, S. H., Spin, J. M., Blumenkranz, M. S., & Marmor, M. F. (2003). Retinal evaluation of patients on chronic amiodarone therapy. RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES, 23(3), 354-359.

Early use of statins in acute coronary syndromes.
Spin, J. M., & Vagelos, R. H. (2003). Early use of statins in acute coronary syndromes. Current atherosclerosis reports, 5(1), 44-51.

Early use of statins in acute coronary syndromes.
Spin, J. M., & Vagelos, R. H. (2002). Early use of statins in acute coronary syndromes. Current cardiology reports, 4(4), 289-297.

The prognostic value of exercise testing in elderly men
Spin, J. M., PRAKASH, M., Froelicher, V. F., Partington, S., Marcus, R., & Myers, J. (2002). The prognostic value of exercise testing in elderly men. AMERICAN JOURNAL OF MEDICINE, 112(6), 453-459.

Abnormal ECG after extensive maxillofacial surgery
Spin, J., & Hancock, E. W. (1999). Abnormal ECG after extensive maxillofacial surgery. HOSPITAL PRACTICE, 34(11), 27-28.

CRYOELECTRON MICROSCOPY OF LOW-DENSITY-LIPOPROTEIN IN VITREOUS ICE
Spin, J. M., & Atkinson, D. (1995). CRYOELECTRON MICROSCOPY OF LOW-DENSITY-LIPOPROTEIN IN VITREOUS ICE. BIOPHYSICAL JOURNAL, 68(5), 2115-2123.