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Biography
Karim Sallam, MD, is trained in Cardiovascular Medicine and Advanced Heart Failure.
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Professional Summary
Education & Certifications
- Fellowship: Stanford University Pain Management Fellowship (2015) CA
- Board Certification: American Board of Internal Medicine, Cardiovascular Disease (2013)
- Fellowship: Stanford Hospital and Clinics (2015) CA
- Residency: Stanford University Medical Center (2013) CA
- Medical Education: University of Pittsburgh Medical Center (2006) PA
Honors & Awards
- Compassion and Humanism, Jeffrey Alan Grey Memorial Prize (2006)
- Empathetic, Sensitive and Respectful Behavior, Leonard Tow Humanism in Medicine Student Award (2006)
- Exemplary Professionalism Award, Stanford Medicine Residency Program (2007/2008)
- Highest Performance in Medicine, James D. Heard Junior Prize (2006)
Publications
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Embryonic stem cell biology: insights from molecular imaging.
Sallam, K., & Wu, J. C. (2010). Embryonic stem cell biology: insights from molecular imaging. Methods in Molecular Biology (Clifton, N.J.), 660, 185–99. -
Prognostic Implications of Q Waves and T-Wave Inversion Associated With Early Repolarization
Uberoi, A., Sallam, K., Perez, M., Jain, N. A., Ashley, E., & Froelicher, V. (2012). Prognostic Implications of Q Waves and T-Wave Inversion Associated With Early Repolarization. MAYO CLINIC PROCEEDINGS, 87(7), 614–19. -
Natural History of Early Repolarization in the Inferior Leads
Stein, R., Sallam, K., Adhikarla, C., Boga, M., Wood, A. D., & Froelicher, V. F. (2012). Natural History of Early Repolarization in the Inferior Leads. ANNALS OF NONINVASIVE ELECTROCARDIOLOGY, 17(4), 331–39. -
Drug screening using a library of human induced pluripotent stem cell-derived cardiomyocytes reveals disease-specific patterns of cardiotoxicity.
Liang, P., Lan, F., Lee, A. S., Gong, T., Sanchez-Freire, V., Wang, Y., … Wu, J. C. (2013). Drug screening using a library of human induced pluripotent stem cell-derived cardiomyocytes reveals disease-specific patterns of cardiotoxicity. Circulation, 127(16), 1677–91. -
COMPARISON OF EARLY REPOLARIZATION IN INFERIOR AND LATERAL LEADS
Downing, N. L., Abhimanyu, Uberoi, M., Sallam, K., Sadik, J., Adhikarla, C., & Froelicher, V. (2012). COMPARISON OF EARLY REPOLARIZATION IN INFERIOR AND LATERAL LEADS. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 59(13), E1940–E1940. -
Concomitant ECG findings and J wave patterns.
Sallam, K., & Froelicher, V. (2013). Concomitant ECG findings and J wave patterns. Journal of Electrocardiology, 46(5), 399–403. -
Cardiac stem cell biology: glimpse of the past, present, and future.
Matsa, E., Sallam, K., & Wu, J. C. (2014). Cardiac stem cell biology: glimpse of the past, present, and future. Circulation Research, 114(1), 21–27. -
Modeling inherited cardiac disorders.
Sallam, K., Kodo, K., & Wu, J. C. (2014). Modeling inherited cardiac disorders. Circulation Journal , 78(4), 784–794. -
Human induced pluripotent stem cell-derived cardiomyocytes as an in vitro model for coxsackievirus B3-induced myocarditis and antiviral drug screening platform.
Sharma, A., Marceau, C., Hamaguchi, R., Burridge, P. W., Rajarajan, K., Churko, J. M., … Wu, J. C. (2014). Human induced pluripotent stem cell-derived cardiomyocytes as an in vitro model for coxsackievirus B3-induced myocarditis and antiviral drug screening platform. Circulation Research, 115(6), 556–66. -
Epigenetic Regulation of Phosphodiesterases 2A and 3A Underlies Compromised ß-Adrenergic Signaling in an iPSC Model of Dilated Cardiomyopathy.
Wu, H., Lee, J., Vincent, L. G., Wang, Q., Gu, M., Lan, F., … Wu, J. C. (2015). Epigenetic Regulation of Phosphodiesterases 2A and 3A Underlies Compromised ß-Adrenergic Signaling in an iPSC Model of Dilated Cardiomyopathy. Cell Stem Cell, 17(1), 89–100. -
Finding the rhythm of sudden cardiac death: new opportunities using induced pluripotent stem cell-derived cardiomyocytes.
Sallam, K., Li, Y., Sager, P. T., Houser, S. R., & Wu, J. C. (2015). Finding the rhythm of sudden cardiac death: new opportunities using induced pluripotent stem cell-derived cardiomyocytes. Circulation Research, 116(12), 1989–2004. -
A Rapid, High-Quality, Cost-Effective, Comprehensive and Expandable Targeted Next-Generation Sequencing Assay for Inherited Heart Diseases.
Wilson, K. D., Shen, P., Fung, E., Karakikes, I., Zhang, A., Inanloorahatloo, K., … Wu, J. C. (2015). A Rapid, High-Quality, Cost-Effective, Comprehensive and Expandable Targeted Next-Generation Sequencing Assay for Inherited Heart Diseases. Circulation Research, 117(7), 603–11. -
Establishing disease causality for a novel gene variant in familial dilated cardiomyopathy using a functional in-vitro assay of regulated thin filaments and human cardiac myosin.
Pan, S., Sommese, R. F., Sallam, K. I., Nag, S., Sutton, S., Miller, S. M., … Ashley, E. A. (2015). Establishing disease causality for a novel gene variant in familial dilated cardiomyopathy using a functional in-vitro assay of regulated thin filaments and human cardiac myosin. BMC Medical Genetics, 16(1), 97-? -
Patient-Specific and Genome-Edited Induced Pluripotent Stem Cell-Derived Cardiomyocytes Elucidate Single-Cell Phenotype of Brugada Syndrome.
Liang, P., Sallam, K., Wu, H., Li, Y., Itzhaki, I., Garg, P., … Wu, J. C. (2016). Patient-Specific and Genome-Edited Induced Pluripotent Stem Cell-Derived Cardiomyocytes Elucidate Single-Cell Phenotype of Brugada Syndrome. Journal of the American College of Cardiology, 68(19), 2086–96. -
Simultaneous ramp right heart catheterization and echocardiography in a ReliantHeart left ventricular assist device.
Banerjee, D., Dutt, D., Duclos, S., Sallam, K., Wheeler, M., & Ha, R. (2017). Simultaneous ramp right heart catheterization and echocardiography in a ReliantHeart left ventricular assist device. World Journal of Cardiology, 9(1), 55–59. -
Patient-Specific Induced Pluripotent Stem Cell-Based Disease Model for Pathogenesis Studies and Clinical Pharmacotherapy.
Li, Y., Sallam, K., Schwartz, P. J., & Wu, J. C. (2017). Patient-Specific Induced Pluripotent Stem Cell-Based Disease Model for Pathogenesis Studies and Clinical Pharmacotherapy. Circulation. Arrhythmia and Electrophysiology, 10(6). -
Transcriptomic and epigenomic differences in human induced pluripotent stem cells generated from six reprogramming methods
Churko, J. M., Lee, J., Ameen, M., Gu, M., Venkatasubramanian, M., Diecke, S., … Wu, J. C. (2017). Transcriptomic and epigenomic differences in human induced pluripotent stem cells generated from six reprogramming methods. NATURE BIOMEDICAL ENGINEERING, 1(10), 826–37. -
RIGHT HEART MALADAPTIVE PHENOTYPES AND PREDICTION OF RIGHT HEART FAILURE FOLLOWING CONTINUOUS-FLOW LEFT VENTRICULAR ASSIST DEVICE IMPLANTATION
Aymami, M., Haddad, F., Amsallem, M., Wheeler, M., Moneghetti, K., Adams, J., … Banerjee, D. (2018). RIGHT HEART MALADAPTIVE PHENOTYPES AND PREDICTION OF RIGHT HEART FAILURE FOLLOWING CONTINUOUS-FLOW LEFT VENTRICULAR ASSIST DEVICE IMPLANTATION. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 71(11), 652. -
Genome Editing of Induced PluripotentStem Cells to Decipher CardiacChannelopathy Variant.
Garg, P., Oikonomopoulos, A., Chen, H., Li, Y., Lam, C. K., Sallam, K., … Wu, J. C. (2018). Genome Editing of Induced PluripotentStem Cells to Decipher CardiacChannelopathy Variant. Journal of the American College of Cardiology, 72(1), 62–75. -
The Incremental Value of Right Ventricular Size and Strain in the Risk Assessment of Right Heart Failure Post - Left Ventricular Assist Device Implantation.
Aymami, M., Amsallem, M., Adams, J., Sallam, K., Moneghetti, K., Wheeler, M., … Banerjee, D. (2018). The Incremental Value of Right Ventricular Size and Strain in the Risk Assessment of Right Heart Failure Post - Left Ventricular Assist Device Implantation. Journal of Cardiac Failure, 24(12), 823–32. -
Transcriptomic and epigenomic differences in human induced pluripotent stem cells generated from six reprogramming methods.
Churko, J. M., Lee, J., Ameen, M., Gu, M., Venkatasubramanian, M., Diecke, S., … Wu, J. C. (2017). Transcriptomic and epigenomic differences in human induced pluripotent stem cells generated from six reprogramming methods. Nature Biomedical Engineering, 1(10), 826–837. -
Targeted and Selective Treatment of Pluripotent Stem Cell-derived Teratomas Using External Beam Radiation in a Small-animal Model.
Sallam, K., Rhee, J.-W., Chour, T., D'addabbo, J., Lee, A. S., Graves, E., & Nguyen, P. K. (2019). Targeted and Selective Treatment of Pluripotent Stem Cell-derived Teratomas Using External Beam Radiation in a Small-animal Model. Journal of Visualized Experiments : JoVE, (144). -
Targeted and Selective Treatment of Pluripotent Stem Cell-derived Teratomas Using External Beam Radiation in a Small-animal Model
Sallam, K., Rhee, J.-W., Chour, T., D'addabbo, J., Lee, A. S., Graves, E., & Nguyen, P. K. (2019). Targeted and Selective Treatment of Pluripotent Stem Cell-derived Teratomas Using External Beam Radiation in a Small-animal Model. JOVE-JOURNAL OF VISUALIZED EXPERIMENTS, (144). -
Modelling diastolic dysfunction in induced pluripotent stem cell-derived cardiomyocytes from hypertrophic cardiomyopathy patients.
Wu, H., Yang, H., Rhee, J.-W. W., Zhang, J. Z., Lam, C. K., Sallam, K., … Wu, J. C. (2019). Modelling diastolic dysfunction in induced pluripotent stem cell-derived cardiomyocytes from hypertrophic cardiomyopathy patients. European Heart Journal. -
Activation of PDGF pathway links LMNA mutation to dilated cardiomyopathy.
Lee, J., Termglinchan, V., Diecke, S., Itzhaki, I., Lam, C. K., Garg, P., … Wu, J. C. (2019). Activation of PDGF pathway links LMNA mutation to dilated cardiomyopathy. Nature. -
Electronic Cigarettes: Where There Is Smoke There Is Disease.
Wu, J. C., Rhee, J.-W. W., & Sallam, K. (2019). Electronic Cigarettes: Where There Is Smoke There Is Disease. Journal of the American College of Cardiology, 74(25), 3121–23. -
HIF1a Regulates Early Metabolic Changes due to Activation of Innate Immunity in Nuclear Reprogramming.
Liu, C., Ruan, H., Himmati, F., Zhao, M.-T. T., Chen, C. C., Makar, M., … Sayed, N. (2020). HIF1a Regulates Early Metabolic Changes due to Activation of Innate Immunity in Nuclear Reprogramming. Stem Cell Reports, 14(2), 192–200. -
Modeling Secondary Iron Overload Cardiomyopathy with Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes.
Rhee, J.-W. W., Yi, H., Thomas, D., Lam, C. K., Belbachir, N., Tian, L., … Wu, J. C. (2020). Modeling Secondary Iron Overload Cardiomyopathy with Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes. Cell Reports, 32(2), 107886. -
Clinical trial in a dish using iPSCs shows lovastatin improves endothelial dysfunction and cellular cross-talk in LMNA cardiomyopathy.
Sayed, N., Liu, C., Ameen, M., Himmati, F., Zhang, J. Z., Khanamiri, S., … Wu, J. C. (2020). Clinical trial in a dish using iPSCs shows lovastatin improves endothelial dysfunction and cellular cross-talk in LMNA cardiomyopathy. Science Translational Medicine, 12(554). -
Sirolimus Adverse Event Profile in a Non-Clinical Trial Cohort of Heart Transplantation Patients.
Sallam, K., Bhumireddy, G. P., Evuri, V. D., Abella, J. P., Haddad, F., Valentine, H. A., … Pham, M. X. (2021). Sirolimus Adverse Event Profile in a Non-Clinical Trial Cohort of Heart Transplantation Patients. Annals of Transplantation, 26, e923536. -
Generation of three induced pluripotent stem cell lines, SCVIi003-A, SCVIi004-A, SCVIi005-A, from patients with ARVD/C caused by heterozygous mutations in the PKP2 gene.
Jahng, J. W., Black, K. E., Liu, L., Bae, H. R., Perez, M., Ashley, E. A., … Wu, J. C. (2021). Generation of three induced pluripotent stem cell lines, SCVIi003-A, SCVIi004-A, SCVIi005-A, from patients with ARVD/C caused by heterozygous mutations in the PKP2 gene. Stem Cell Research, 53, 102284. -
The Unfolded Protein Response as a Compensatory Mechanism and Potential Therapeutic Target in PLN R14del Cardiomyopathy.
Feyen, D. A., Perea-Gil, I., Maas, R. G., Harakalova, M., Gavidia, A. A., Arthur Ataam, J., … Karakikes, I. (2021). The Unfolded Protein Response as a Compensatory Mechanism and Potential Therapeutic Target in PLN R14del Cardiomyopathy. Circulation. -
A protocol for transdifferentiation of human cardiac fibroblasts into endothelial cells via activation of innate immunity.
Liu, C., Medina, P., Thomas, D., Chen, I. Y., Sallam, K., Sayed, D., & Sayed, N. (2021). A protocol for transdifferentiation of human cardiac fibroblasts into endothelial cells via activation of innate immunity. STAR Protocols, 2(2), 100556. -
Generation of three induced pluripotent stem cell lines from hypertrophic cardiomyopathy patients carrying MYH7 mutations.
Cao, X., Jahng, J. W., Lee, C., Zha, Y., Wheeler, M. T., Sallam, K., & Wu, J. C. (2021). Generation of three induced pluripotent stem cell lines from hypertrophic cardiomyopathy patients carrying MYH7 mutations. Stem Cell Research, 55, 102455. -
Coronary Artery Vasospasm Requiring Cardiac Autotransplantation Yet Controlled With Tobacco.
Tran, M. V., Marceau, E., Liu, Y., Sallam, K., Medina, P., Liu, C., … Chen, I. Y. (2021). Coronary Artery Vasospasm Requiring Cardiac Autotransplantation Yet Controlled With Tobacco. JACC. Case Reports, 3(9), 1177–1181. -
Generation of two induced pluripotent stem cell lines from Brugada syndrome affected patients carrying SCN5A mutations.
Belbachir, N., Lai, C., Rhee, J.-W., Zhuge, Y., Perez, M. V., Sallam, K., & Wu, J. C. (2021). Generation of two induced pluripotent stem cell lines from Brugada syndrome affected patients carrying SCN5A mutations. Stem Cell Research, 57, 102605. -
Heterozygous LMNA mutation-carrying iPSC lines from three cardiac laminopathy patients.
Cho, S., Lee, C., Lai, C., Zhuge, Y., Haddad, F., Fowler, M., … Wu, J. C. (1800). Heterozygous LMNA mutation-carrying iPSC lines from three cardiac laminopathy patients. Stem Cell Research, 59, 102657. -
Modeling Effects of Immunosuppressive Drugs on Human Hearts Using Induced Pluripotent Stem Cell-Derived Cardiac Organoids and Single-Cell RNA Sequencing.
Sallam, K., Thomas, D., Gaddam, S., Lopez, N., Beck, A., Beach, L., … Wu, J. C. (2022). Modeling Effects of Immunosuppressive Drugs on Human Hearts Using Induced Pluripotent Stem Cell-Derived Cardiac Organoids and Single-Cell RNA Sequencing. Circulation, 145(17), 1367–1369. -
Generation of two induced pluripotent stem cell lines carrying the phospholamban R14del mutation for modeling ARVD/C.
Vera, C. D., Manhas, A., Shenoy, S. P., Wheeler, M. T., Sallam, K., & Wu, J. C. (2022). Generation of two induced pluripotent stem cell lines carrying the phospholamban R14del mutation for modeling ARVD/C. Stem Cell Research, 63, 102834. -
Generation of two induced pluripotent stem cell lines from dilated cardiomyopathy patients carrying heterozygous FLNC mutations.
Kojic, A., Kim, H., Guevara, J. V., Ravada, S., Sallam, K., & Wu, J. C. (2022). Generation of two induced pluripotent stem cell lines from dilated cardiomyopathy patients carrying heterozygous FLNC mutations. Stem Cell Research, 64, 102928. -
Cardiovascular effects of immunosuppression agents.
Elezaby, A., Dexheimer, R., & Sallam, K. (2022). Cardiovascular effects of immunosuppression agents. Frontiers in Cardiovascular Medicine, 9, 981838. -
Continuous Wearable Monitoring Analytics To Improve Outcomes In Heart Failure: Vanguard Phase Results And Study Design Of The Randomized Phase Of Link-HF2 Multicenter Study
Sideris, K., Weir, C., Schmalfuss, C., Bozkurt, B., Lewis, N., Sallam, K., … Stehlik, J. (2023). Continuous Wearable Monitoring Analytics To Improve Outcomes In Heart Failure: Vanguard Phase Results And Study Design Of The Randomized Phase Of Link-HF2 Multicenter Study. JOURNAL OF CARDIAC FAILURE. CHURCHILL LIVINGSTONE INC MEDICAL PUBLISHERS. -
Generation of two induced pluripotent stem cell lines from patients with cardiac amyloidosis carrying heterozygous transthyretin (TTR) mutation
Bonilauri, B., Shin, H. S., Htet, M., Yan, C. D., Witteles, R. M., Sallam, K., & Wu, J. C. (2023). Generation of two induced pluripotent stem cell lines from patients with cardiac amyloidosis carrying heterozygous transthyretin (TTR) mutation. STEM CELL RESEARCH, 72. -
Generation of two induced pluripotent stem cell lines from hereditary amyloidosis patients with polyneuropathy carrying heterozygous transthyretin (TTR) mutation.
Melesio, J., Bonilauri, B., Li, A., Pang, P. D., Liao, R., Witteles, R. M., … Sallam, K. (2023). Generation of two induced pluripotent stem cell lines from hereditary amyloidosis patients with polyneuropathy carrying heterozygous transthyretin (TTR) mutation. Stem Cell Research, 74, 103265. -
Generation of induced pluripotent stem cell line from a patient suffering from arterial calcification due to deficiency of CD73 (ACDC).
Tripathi, D., Manhas, A., Noishiki, C., Wu, D., Adkar, S., Sallam, K., … Sayed, N. (2023). Generation of induced pluripotent stem cell line from a patient suffering from arterial calcification due to deficiency of CD73 (ACDC). Stem Cell Research, 75, 103285. -
Uptake of sodium-glucose cotransporter-2 inhibitors in hospitalized patients with heart failure: insights from the veterans affairs healthcare system.
Varshney, A. S., Calma, J., Kalwani, N. M., Hsiao, S., Sallam, K., Cao, F., … Sandhu, A. T. (2024). Uptake of sodium-glucose cotransporter-2 inhibitors in hospitalized patients with heart failure: insights from the veterans affairs healthcare system. Journal of Cardiac Failure.
Practice Locations
Mechanical Circulatory Support Program Stanford, CA
Stanford, CA
Mechanical Circulatory Support Program
300 Pasteur Drive , 2nd Floor, Room A260
Stanford , CA 94305
Make An Appointment More Clinic Information » Getting Here »Heart Transplant Program Stanford, CA
Stanford, CA
Heart Transplant Program
300 Pasteur Drive , 2nd Floor, Room A21
Stanford , CA 94305
Make An Appointment More Clinic Information » Getting Here »Center for Inherited Cardiovascular Disease at Stanford Stanford, CA
Stanford, CA
Center for Inherited Cardiovascular Disease at Stanford
300 Pasteur Drive, Heart Clinic 1, Clinic A21
Stanford , CA 94305
Make An Appointment More Clinic Information » Getting Here »Advanced Heart Failure Clinic at Stanford Stanford, CA
Stanford, CA
Advanced Heart Failure Clinic at Stanford
300 Pasteur Drive , 2nd Floor, Room A260
Stanford , CA 94305
Make An Appointment More Clinic Information » Getting Here »Important Information about Our Organizations and Physician Affiliation
Stanford Health Care, Stanford Health Care Tri-Valley, and Stanford Medicine Partners are each independent nonprofit organizations that are affiliated with but separate from each other and from Stanford University. The physicians who provide care at facilities operated by Stanford Health Care, Stanford Health Care Tri-Valley, and Stanford Medicine Partners are faculty, foundation, or community physicians who are not employees, representatives, or agents of Stanford Health Care, Stanford Health Care Tri- Valley, or Stanford Medicine Partners. Stanford Health Care, Stanford Health Care Tri-Valley, and Stanford Medicine Partners do not exercise control over the care provided by such faculty, foundation, and community physicians and are not responsible for their actions.
Patient Reviews
(12 reviews)
I am SO grateful for the expert medical care I received at your facility. MY life is very much improved because of it. Thank you.
Very happy!
Dr. Sallam was excellent!
Very good.
Very good person.
Dr. Sallam explains everything in detail to me regarding my health. He is also a good listener and makes sure that I am well cared for.
Between MD and patient build up a good relationship and then cooperation well with each other. That is the most important for patient. The MD does well.
Dr. was very thorough - spent nearly 60 minutes discussing medical condition.
Dr. Sallam is an excellent, patient, knowledgeable, cardiologist. He spent a great deal of time with me & my family & answered each concern clearly & concisely.
Dr. Sallam is great!! We love him.
Was very pleased with doctors explanation of my condition, etc. treatment and options.
Terrific group of providers!
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Referring Physicians
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