Karl Sylvester

Professional Education

Board Certification: Pediatric Surgery, American Board of Surgery (2002)

Fellowship: The Children's Hospital of Philadelphia (1997) PA

Fellowship: Yale - New Haven Hospital (2001) CT

Residency: University of Pennsylvania (1999) PA

Internship: Hospital of the University of Pennsylvania (1993) PA

Medical Education: Jefferson Medical College (1992) PA

Clinical Trials

Clinical trials are research studies that evaluate a new medical approach, device, drug, or other treatment. As a Stanford Hospital & Clinics patient, you have access to the latest, advanced clinical trials.

Open trials refer to studies currently accepting participants. Closed trials are not currently enrolling, but may open in the future.

Heterotaxy syndromes and abnormal bowel rotation.
Newman, B., Koppolu, R., Murphy, D., & Sylvester, K. (2014). Heterotaxy syndromes and abnormal bowel rotation. Pediatric radiology, 44(5), 542-551.

Urine protein biomarkers for the diagnosis and prognosis of necrotizing enterocolitis in infants.
Sylvester, K. G., Ling, X. B., Liu, G. Yg., Kastenberg, Z. J., Ji, J., & Moss, R. L. (2014). Urine protein biomarkers for the diagnosis and prognosis of necrotizing enterocolitis in infants. journal of pediatrics, 164(3), 607-612 e7.

A data-driven algorithm integrating clinical and laboratory features for the diagnosis and prognosis of necrotizing enterocolitis.
Ji, J., Ling, X. B., Zhao, Y., Hu, Z., Zheng, X., & Sylvester, K. G. (2014). A data-driven algorithm integrating clinical and laboratory features for the diagnosis and prognosis of necrotizing enterocolitis. PloS one, 9(2).

Wnt/ß-Catenin Signaling Protects Mouse Liver against Oxidative Stress-induced Apoptosis through the Inhibition of Forkhead Transcription Factor FoxO3.
Tao, G.-Z., Lehwald, N., Jang, K. Y., Baek, J., Xu, B., & Sylvester, K. G. (2013). Wnt/ß-Catenin Signaling Protects Mouse Liver against Oxidative Stress-induced Apoptosis through the Inhibition of Forkhead Transcription Factor FoxO3. journal of biological chemistry, 288(24), 17214-17224.

Heme oxygenase-1 deficiency promotes the development of necrotizing enterocolitis-like intestinal injury in a newborn mouse model.
Schulz, S., Wong, R. J., Jang, K. Y., Kalish, F., Chisholm, K. M., & Stevenson, D. K. (2013). Heme oxygenase-1 deficiency promotes the development of necrotizing enterocolitis-like intestinal injury in a newborn mouse model. American journal of physiology. Gastrointestinal and liver physiology, 304(11), G991-G1001.

The surgical management of necrotizing enterocolitis.
Kastenberg, Z. J., & Sylvester, K. G. (2013). The surgical management of necrotizing enterocolitis. Clinics in perinatology, 40(1), 135-148.

SIRT1 and c-Myc Promote Liver Tumor Cell Survival and Predict Poor Survival of Human Hepatocellular Carcinomas
Jang, K. Y., Noh, S. J., Lehwald, N., Tao, G.-Z., Bellovin, D. I., & Sylvester, K. G. (2012). SIRT1 and c-Myc Promote Liver Tumor Cell Survival and Predict Poor Survival of Human Hepatocellular Carcinomas. PLOS ONE, 7(9).

beta-Catenin Regulates Hepatic Mitochondrial Function and Energy Balance in Mice
Lehwald, N., Tao, G.-Z., Jang, K. Y., Papandreou, I., Liu, B., & Sylvester, K. G. (2012). beta-Catenin Regulates Hepatic Mitochondrial Function and Energy Balance in Mice. GASTROENTEROLOGY, 143(3), 754-764.

Notch signaling inhibits hepatocellular carcinoma following inactivation of the RB pathway
Viatour, P., Ehmer, U., Saddic, L. A., Dorrell, C., Andersen, J. B., & Sage, J. (2011). Notch signaling inhibits hepatocellular carcinoma following inactivation of the RB pathway. JOURNAL OF EXPERIMENTAL MEDICINE, 208(10), 1963-1976.

Intestinal involvement during 3,5-diethoxycarbonyl-1,4-dihydrocollidine-induced chronic liver injury in a mouse model
Sukhotnik, I., Kuscuoglu, U., Altindag, B., Tao, G.-Z., Lehwald, N., & Sylvester, K. G. (2011). Intestinal involvement during 3,5-diethoxycarbonyl-1,4-dihydrocollidine-induced chronic liver injury in a mouse model. JOURNAL OF PEDIATRIC SURGERY, 46(8), 1495-1502.

Wnt-beta-catenin Signaling Protects Against Hepatic Ischemia and Reperfusion Injury in Mice
Lehwald, N., Tao, G.-Z., Jang, K. Y., Sorkin, M., Knoefel, W. T., & Sylvester, K. G. (2011). Wnt-beta-catenin Signaling Protects Against Hepatic Ischemia and Reperfusion Injury in Mice. GASTROENTEROLOGY, 141(2), 707-U417.

Risk Factors for Parenteral Nutrition-associated Liver Disease Following Surgical Therapy for Necrotizing Enterocolitis
Duro, D., Mitchell, P. D., Kalish, L. A., Martin, C., Mccarthy, M., & Duggan, C. (2011). Risk Factors for Parenteral Nutrition-associated Liver Disease Following Surgical Therapy for Necrotizing Enterocolitis. JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION, 52(5), 595-600.

Risk Factors for Intestinal Failure in Infants with Necrotizing Enterocolitis: A Glaser Pediatric Research Network Study
Duro, D., Kalish, L. A., Johnston, P., Jaksic, T., Mccarthy, M., & Duggan, C. (2010). Risk Factors for Intestinal Failure in Infants with Necrotizing Enterocolitis: A Glaser Pediatric Research Network Study. JOURNAL OF PEDIATRICS, 157(2), 203-U50.

URINE PEPTIDOMICS FOR CLINICAL BIOMARKER DISCOVERY
Ling, X. B., Mellins, E. D., Sylvester, K. G., & Cohen, H. J. (2010). URINE PEPTIDOMICS FOR CLINICAL BIOMARKER DISCOVERY. ADVANCES IN CLINICAL CHEMISTRY, VOL 51, 51, 181-213.

Clinical parameters do not adequately predict outcome in necrotizing enterocolitis: a multi-institutional study
Moss, R. L., Kalish, L. A., Duggan, C., Johnston, P., Brandt, M. L., & Sylvester, K. G. (2008). Clinical parameters do not adequately predict outcome in necrotizing enterocolitis: a multi-institutional study. JOURNAL OF PERINATOLOGY, 28(10), 665-674.

Hepatotoxin-Induced Changes in the Adult Murine Liver Promote MYC-Induced Tumorigenesis
Beer, S., Komatsubara, K., Bellovin, D. I., Kurobe, M., Sylvester, K., & Felsher, D. W. (2008). Hepatotoxin-Induced Changes in the Adult Murine Liver Promote MYC-Induced Tumorigenesis. PLOS ONE, 3(6).

Doxycycline sclerotherapy as primary treatment of head and neck lymphatic malformations in children
Nehra, D., Jacobson, L., Barnes, P., Mallory, B., Albanese, C. T., & Sylvester, K. G. (2008). Doxycycline sclerotherapy as primary treatment of head and neck lymphatic malformations in children. JOURNAL OF PEDIATRIC SURGERY, 43(3), 451-460.

Hepatic parenchymal replacement in mice by transplanted allogeneic hepatocytes is facilitated by bone marrow transplantation and mediated by CD4 cells
Streetz, K. L., Doyonnas, R., Grimm, D., Jenkins, D. D., Fuess, S., & Kay, M. A. (2008). Hepatic parenchymal replacement in mice by transplanted allogeneic hepatocytes is facilitated by bone marrow transplantation and mediated by CD4 cells. HEPATOLOGY, 47(2), 706-718.

Wnt/beta-catenin signaling in murine hepatic transit amplifying progenitor cells
Hu, M., Kurobe, M., Jeong, Y. J., Fuerer, C., Ghole, S., & Sylvester, K. G. (2007). Wnt/beta-catenin signaling in murine hepatic transit amplifying progenitor cells. GASTROENTEROLOGY, 133(5), 1579-1591.

Risk factors for the development of abdominal abscess following operation for perforated appendicitis in children - A multicenter case-control study
Henry, M. Cw., Walker, A., Silverman, B. L., Gollin, G., Islam, S., & Moss, R. L. (2007). Risk factors for the development of abdominal abscess following operation for perforated appendicitis in children - A multicenter case-control study. ARCHIVES OF SURGERY, 142(3), 236-241.

Matched analysis of nonoperative management vs immediate appendectomy for perforated appendicitis
Henry, M. Cw., Gollin, G., Islam, S., Sylvester, K., Walker, A., & Moss, R. L. (2007). Matched analysis of nonoperative management vs immediate appendectomy for perforated appendicitis. JOURNAL OF PEDIATRIC SURGERY, 42(1), 19-24.

Stem cells: tissue regeneration and cancer.
Tataria, M., Perryman, S. V., & Sylvester, K. G. (2006). Stem cells: tissue regeneration and cancer. Seminars in pediatric surgery, 15(4), 284-292.

Laparotomy versus peritoneal drainage for necrotizing enterocolitis and perforation
Moss, R. L., Dimmitt, R. A., Barnhart, D. C., Sylvester, K. G., Brown, R. L., & Silverman, B. L. (2006). Laparotomy versus peritoneal drainage for necrotizing enterocolitis and perforation. NEW ENGLAND JOURNAL OF MEDICINE, 354(21), 2225-2234.

Absence of the p53 tumor suppressor gene promotes osteogenesis in mesenchymal stem cells
Tataria, M., Quarto, N., Longaker, M. T., & Sylvester, K. G. (2006). Absence of the p53 tumor suppressor gene promotes osteogenesis in mesenchymal stem cells. JOURNAL OF PEDIATRIC SURGERY, 41(4), 624-632.

Repair and regeneration: opportunities for carcinogenesis from tissue stem cells
Perryman, S. V., & Sylvester, K. G. (2006). Repair and regeneration: opportunities for carcinogenesis from tissue stem cells. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE, 10(2), 292-308.

In vivo selection of primary and bone-marrow-derived hepatocytes after allogeneic transplantation in mice
Streetz, K. L., Doyonnas, R., Jenkins, D., Perryman, S., Fuess, S., & Kay, M. A. (2006). In vivo selection of primary and bone-marrow-derived hepatocytes after allogeneic transplantation in mice. JOURNAL OF HEPATOLOGY, 44, S33-S33.

Donor-derived, liver-specific protein expression after bone marrow transplantation
Jenkins, D. D., Streetz, K., Tataria, M., Sahar, D., Kurobe, M., & Sylvester, K. G. (2004). Donor-derived, liver-specific protein expression after bone marrow transplantation. TRANSPLANTATION, 78(4), 530-536.

Hepatocyte targeting for quantifiable and functional cellular transplantation
Jenkins, D. D., Streetz, K., Kay, M., Longaker, M., & Sylvester, K. (2003). Hepatocyte targeting for quantifiable and functional cellular transplantation. JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS, 197(3), S15-S15.