Kathleen M. Sakamoto

Shelagh Galligan Professor in the School of Medicine

Professional Education

Fellowship: Children's Hospital Los Angeles (1991) CA

Board Certification: Pediatrics, American Board of Pediatrics (1989)

Residency: Children's Hospital Los Angeles (1988) CA

Board Certification: Pediatric Hematology-Oncology, American Board of Pediatrics (1992)

Medical Education: University of Cincinnati College of Medicine (1985) OH

B.A., Williams College, Biology (1979)

M.D., University of Cincinnati College of Medicine, Medicine (1985)

Ph.D., California Institute of Technology, Biology (2004)

Internship and Residency, Children's Hospital Los Angeles, Pediatrics (1988)

Fellowship, Children's Hospital Los Angeles, Pediatric Hematology/Oncology (1991)

Postdoctoral Fellowship, UCLA School of Medicine, Hematopoietic growth factors and signal transduction (1992)

Honors & Awards

Standing Member, NIDDK-D Study Section for Training Grants and K awards (2011-present)

Chair, Myeloid Biology Subcommittee, American Society of Hematology (2011)

Brett Ely Visiting Professor in Pediatric Oncology, University of Colorado and Children's Hospital Denver (2011)

Outstanding advances in cancer research award, Mendiburu Magic Foundation (2010)

Fernbach Distinguished Visiting Professor Lectureship, Texas Children's Cancer Center (2009)

Gift of Hope Award, Pediatric Cancer Research Foundation (2008)

Junior Faculty Ross Research Award, Western Society for Pediatric Research (1996)

Young Investigator Award, American Society of Pediatric Hematology/Oncology (1994)

STOP Cancer Career Development award, UCLA Jonsson Comprehensive Cancer Center (1992)

Victor E. Stork Award, Children's Hospital of Los Angeles (1988)

Administrative Appointments

Chief, Division of Pediatric Hematology/Oncology/Stem Cell Transplantation/Cancer Biology, Bass Cancer Center, Lucile Packard Children's Hospital (2011 - Present)

Fellowship Program Director, Division of Pediatric Hematology-Oncology, Stanford University School of Medicine (2011 - 2013)

Clinical Trials

Clinical trials are research studies that evaluate a new medical approach, device, drug, or other treatment. As a Stanford Health Care patient, you may have access to the latest, advanced clinical trials.

Open trials refer to studies currently accepting participants. Closed trials are not currently enrolling, but may open in the future.

The Multitargeted Receptor Tyrosine Kinase Inhibitor Linifanib (ABT-869) Induces Apoptosis through an Akt and Glycogen Synthase Kinase 3 beta-Dependent Pathway
Hernandez-Davies, J. E., Zape, J. P., Landaw, E. M., Tan, X., Presnell, A., & Sakamoto, K. M. (2011). The Multitargeted Receptor Tyrosine Kinase Inhibitor Linifanib (ABT-869) Induces Apoptosis through an Akt and Glycogen Synthase Kinase 3 beta-Dependent Pathway. MOLECULAR CANCER THERAPEUTICS, 10(6), 949-959.

CREB and leukemogenesis.
Cho, E.-C., Mitton, B., & Sakamoto, K. M. (2011). CREB and leukemogenesis. Critical reviews in oncogenesis, 16(1-2), 37-46.

Ribosomal protein S19 deficiency in zebrafish leads to developmental abnormalities and defective erythropoiesis through activation of p53 protein family
Danilova, N., Sakamoto, K. M., & Lin, S. (2008). Ribosomal protein S19 deficiency in zebrafish leads to developmental abnormalities and defective erythropoiesis through activation of p53 protein family. BLOOD, 112(13), 5228-5237.

The role of CREB as a proto-oncogene in hematopoiesis and in acute myeloid leukemia
Shankar, D. B., Cheng, J. C., Kinjo, K., Federman, N., Moore, T. B., & Sakamoto, K. M. (2005). The role of CREB as a proto-oncogene in hematopoiesis and in acute myeloid leukemia. CANCER CELL, 7(4), 351-362.

Ubistatins inhibit proteasome-dependent degradation by binding the ubiquitin chain
Verma, R., Peters, N. R., D'onofrio, M., Tochtrop, G. P., Sakamoto, K. M., & King, R. W. (2004). Ubistatins inhibit proteasome-dependent degradation by binding the ubiquitin chain. SCIENCE, 306(5693), 117-120.

Development of protacs to target cancer-promoting proteins for ubiquitination and degradation
Sakamoto, K. M., Kim, K. B., Verma, R., Ransick, A., Stein, B., & Deshaies, R. J. (2003). Development of protacs to target cancer-promoting proteins for ubiquitination and degradation. MOLECULAR & CELLULAR PROTEOMICS, 2(12), 1350-1358.

Protacs: Chimeric molecules that target proteins to the Skp1-Cullin-F box complex for ubiquitination and degradation
Sakamoto, K. M., Kim, K. B., Kumagai, A., Mercurio, F., Crews, C. M., & Deshaies, R. J. (2001). Protacs: Chimeric molecules that target proteins to the Skp1-Cullin-F box complex for ubiquitination and degradation. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 98(15), 8554-8559.

Net1 stimulates RNA polymerase I transcription and regulates nucleolar structure independently of controlling mitotic exit
Shou, W. Y., Sakamoto, K. M., Keener, J., Morimoto, K. W., Traverso, E. E., & Deshaies, R. J. (2001). Net1 stimulates RNA polymerase I transcription and regulates nucleolar structure independently of controlling mitotic exit. MOLECULAR CELL, 8(1), 45-55.

MicroRNA-34b promoter hypermethylation induces CREB overexpression and contributes to myeloid transformation.
Pigazzi, M., Manara, E., Bresolin, S., Tregnago, C., Beghin, A., & Basso, G. (2013). MicroRNA-34b promoter hypermethylation induces CREB overexpression and contributes to myeloid transformation. Haematologica, 98(4), 602-610.

Increased Abscess Formation and Defective Chemokine Regulation in CREB Transgenic Mice
Wen, A. Y., Landaw, E. M., Ochoa, R., Cho, M., Chao, A., & Sakamoto, K. M. (2013). Increased Abscess Formation and Defective Chemokine Regulation in CREB Transgenic Mice. PLOS ONE, 8(2).

Identification of somatic and germline mutations using whole exome sequencing of congenital acute lymphoblastic leukemia
Chang, V. Y., Basso, G., Sakamoto, K. M., & Nelson, S. F. (2013). Identification of somatic and germline mutations using whole exome sequencing of congenital acute lymphoblastic leukemia. BMC CANCER, 13.

Sox4 cooperates with CREB in myeloid transformation
Sandoval, S., Kraus, C., Cho, E.-C., Cho, M., Bies, J., & Sakamoto, K. M. (2012). Sox4 cooperates with CREB in myeloid transformation. BLOOD, 120(1), 155-165.

The neutropenic diet... still ageless?
Aftandilian, C. C., Milotich, C., & Sakamoto, K. M. (2012). The neutropenic diet... still ageless?. Oncology (Williston Park, N.Y.), 26(6), 586-?.

Editorial: Granulopoiesis versus monopoiesis: a consequence of transcription factors dancing with the right partners
Sakamoto, K. M. (2011). Editorial: Granulopoiesis versus monopoiesis: a consequence of transcription factors dancing with the right partners. JOURNAL OF LEUKOCYTE BIOLOGY, 90(4), 637-638.

Tubacin suppresses proliferation and induces apoptosis of acute lymphoblastic leukemia cells
Aldana-Masangkay, G. I., Rodriguez-Gonzalez, A., Lin, T., Ikeda, A. K., Hsieh, Y.-T., & Sakamoto, K. M. (2011). Tubacin suppresses proliferation and induces apoptosis of acute lymphoblastic leukemia cells. LEUKEMIA & LYMPHOMA, 52(8), 1544-1555.

Increasing Diversity in Pediatric Hematology/Oncology
Fruge, E., Lakoski, J. M., Luban, N., Lipton, J. M., Poplack, D. G., & Sakamoto, K. M. (2011). Increasing Diversity in Pediatric Hematology/Oncology. PEDIATRIC BLOOD & CANCER, 57(1), 147-152.

The Role of HDAC6 in Cancer
Aldana-Masangkay, G. I., & Sakamoto, K. M. (2011). The Role of HDAC6 in Cancer. JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY.

Self-Renewal of Acute Lymphocytic Leukemia Cells Is Limited by the Hedgehog Pathway Inhibitors Cyclopamine and IPI-926
Lin, T. L., Wang, Q. H., Brown, P., Peacock, C., Merchant, A. A., & Matsui, W. (2010). Self-Renewal of Acute Lymphocytic Leukemia Cells Is Limited by the Hedgehog Pathway Inhibitors Cyclopamine and IPI-926. PLOS ONE, 5(12).

The Role of the Transcription Factor CREB in Immune Function
Wen, A. Y., Sakamoto, K. M., & Miller, L. S. (2010). The Role of the Transcription Factor CREB in Immune Function. JOURNAL OF IMMUNOLOGY, 185(11), 6413-6419.

Germline CBL mutations cause developmental abnormalities and predispose to juvenile myelomonocytic leukemia
Niemeyer, C. M., Kang, M. W., Shin, D. H., Furlan, I., Erlacher, M., & Loh, M. L. (2010). Germline CBL mutations cause developmental abnormalities and predispose to juvenile myelomonocytic leukemia. NATURE GENETICS, 42(9), 794-U93.

Targeting CREB for Cancer Therapy: Friend or Foe
Xiao, X., Li, B. X., Mitton, B., Ikeda, A., & Sakamoto, K. M. (2010). Targeting CREB for Cancer Therapy: Friend or Foe. CURRENT CANCER DRUG TARGETS, 10(4), 384-391.

Macroautophagy modulates cellular response to proteasome inhibitors in cancer therapy
Wu, W. Kk., Sakamoto, K. M., Milani, M., Aldana-Masankgay, G., Fan, D., & Sung, J. Jy. (2010). Macroautophagy modulates cellular response to proteasome inhibitors in cancer therapy. DRUG RESISTANCE UPDATES, 13(3), 87-92.

Targeting steroid hormone receptors for ubiquitination and degradation in breast and prostate cancer
Rodriguez-Gonzalez, A., Cyrus, K., Salcius, M., Kim, K., Crews, C. M., & Sakamoto, K. M. (2008). Targeting steroid hormone receptors for ubiquitination and degradation in breast and prostate cancer. ONCOGENE, 27(57), 7201-7211.

CREB is a critical regulator of normal hematopoiesis and leukemogenesis
Cheng, J. C., Kinjo, K., Judelson, D. R., Chang, J., Wu, W. S., & Sakamoto, K. M. (2008). CREB is a critical regulator of normal hematopoiesis and leukemogenesis. BLOOD, 111(3), 1182-1192.

Expression profile of CREB knockdown in myeloid leukemia cells.
Pellegrini, M., Cheng, J. C., Voutila, J., Judelson, D., Taylor, J., & Sakamoto, K. M. (2008). Expression profile of CREB knockdown in myeloid leukemia cells. BMC cancer, 8, 264-?.

Expression of cyclic adenosine monophosphate response-element binding protein in acute leukemia
Crans-Vargas, H. N., Landaw, E. M., Bhatia, S., Sandusky, G., Moore, T. B., & Sakamoto, K. M. (2002). Expression of cyclic adenosine monophosphate response-element binding protein in acute leukemia. BLOOD, 99(7), 2617-2619.