Irene Wapnir

Surgical oncologist, Breast surgeon

Professor of Surgery (General Surgery) at the Stanford University Medical Center

Breast Cancer Program

  • 900 Blake Wilbur Drive
  • Palo Alto, CA 94304
  • Phone: 650-498-6004
Learn More About the Clinic Getting Here Make An Appointment

Women's Cancer Center

  • 900 Blake Wilbur Drive
  • Palo Alto, CA 94304
  • Phone: 650-498-6004
Learn More About the Clinic Getting Here Make An Appointment

Professional Education

Internship: Lincoln Med and Mental Hlth Ctr (1981) NY

Fellowship: Robert Wood Johnson University Hospital (1988) NJ

Board Certification: General Surgery, American Board of Surgery (1986)

Residency: New York Medical College (1985) NY

Medical Education: Universidad Autonoma Metropolitana (1980) Mexico

MD, Universidad A. Metropolitana, Medicine (1980)

BA, Goucher College, Biological Sciences (1975)

Honors & Awards

Visiting Scholar, Ben Gurion University of the Negev, Israel (2012)

Publications Committee, American Society of Breast Surgeons (2010-present)

Protocol Chair Breast Cancer Local Recurrence Trial, NSABP (2006)

Working Group Breast Committee, NSABP (2000)

Awards Committee, Assoc Women Surgeons (2004)

Administrative Appointments

Chief of Breast Surgery, Section of Surgical Oncology (2005 - Present)

Clinical Trials

Clinical trials are research studies that evaluate a new medical approach, device, drug, or other treatment. As a Stanford Health Care patient, you have access to the latest, advanced clinical trials.

Open trials refer to studies currently accepting participants. Closed trials are not currently enrolling, but may open in the future.

PREDICT: Instituting an Educational Time Out in the Operating Room.
Yang, R. L., Esquivel, M., Erdrich, J., Lau, J., Melcher, M. L., & Wapnir, I. L. (2014). PREDICT: Instituting an Educational Time Out in the Operating Room. Journal of graduate medical education, 6(2), 382-383.

Ex vivo Evans blue assessment of the blood brain barrier in three breast cancer brain metastasis models.
Do, J., Foster, D., Renier, C., Vogel, H., Rosenblum, S., & Wapnir, I. (2014). Ex vivo Evans blue assessment of the blood brain barrier in three breast cancer brain metastasis models. Breast cancer research and treatment, 144(1), 93-101.

Chemotherapy for isolated locoregional recurrence of breast cancer (CALOR): a randomised trial
Aebi, S., Gelber, S., Anderson, S. J., Lang, I., Robidoux, A., & Wapnir, I. L. (2014). Chemotherapy for isolated locoregional recurrence of breast cancer (CALOR): a randomised trial. LANCET ONCOLOGY, 15(2), 156-163.

Intraoperative imaging of nipple perfusion patterns and ischemic complications in nipple-sparing mastectomies.
Wapnir, I., Dua, M., Kieryn, A., Paro, J., Morrison, D., & Gurtner, G. (2014). Intraoperative imaging of nipple perfusion patterns and ischemic complications in nipple-sparing mastectomies. Annals of surgical oncology, 21(1), 100-106.

Patient-derived xenografts of triple-negative breast cancer reproduce molecular features of patient tumors and respond to mTOR inhibition
Zhang, H., Cohen, A. L., Krishnakumar, S., Wapnir, I. L., Veeriah, S., & Jeffrey, S. S. (2014). Patient-derived xenografts of triple-negative breast cancer reproduce molecular features of patient tumors and respond to mTOR inhibition. BREAST CANCER RESEARCH, 16(2).

Outcomes of Partial Mastectomy in Male Breast Cancer Patients: Analysis of SEER, 1983-2009
Cloyd, J. M., Hernandez-Boussard, T., & Wapnir, I. L. (2013). Outcomes of Partial Mastectomy in Male Breast Cancer Patients: Analysis of SEER, 1983-2009. ANNALS OF SURGICAL ONCOLOGY, 20(5), 1545-1550.

Poor compliance with breast cancer treatment guidelines in men undergoing breast-conserving surgery
Cloyd, J. M., Hernandez-Boussard, T., & Wapnir, I. L. (2013). Poor compliance with breast cancer treatment guidelines in men undergoing breast-conserving surgery. BREAST CANCER RESEARCH AND TREATMENT, 139(1), 177-182.

The diagnostic value of nipple discharge cytology: Breast imaging complements predictive value of nipple discharge cytology
Kalu, O. N., Chow, C., Wheeler, A., Kong, C., & Wapnir, I. (2012). The diagnostic value of nipple discharge cytology: Breast imaging complements predictive value of nipple discharge cytology. JOURNAL OF SURGICAL ONCOLOGY, 106(4), 381-385.

MRI Enhancement Correlates With High Grade Desmoid Tumor of Breast
Kim, M. Jj., Wapnir, I. L., Ikeda, D. M., Chisholm, K. M., Do, Y., & Daniel, B. L. (2012). MRI Enhancement Correlates With High Grade Desmoid Tumor of Breast. BREAST JOURNAL, 18(4), 374-376.

Integration and safety of fertility preservation in a breast cancer program
Westphal, L. M., & Wapnir, I. L. (2012). Integration and safety of fertility preservation in a breast cancer program. GYNECOLOGIC ONCOLOGY, 124(3), 474-476.

Long-Term Outcomes of Invasive Ipsilateral Breast Tumor Recurrences After Lumpectomy in NSABP B-17 and B-24 Randomized Clinical Trials for DCIS
Wapnir, I. L., Dignam, J. J., Fisher, B., Mamounas, E. P., Anderson, S. J., & Wolmark, N. (2011). Long-Term Outcomes of Invasive Ipsilateral Breast Tumor Recurrences After Lumpectomy in NSABP B-17 and B-24 Randomized Clinical Trials for DCIS. JOURNAL OF THE NATIONAL CANCER INSTITUTE, 103(6), 478-488.

KT5823 Differentially Modulates Sodium Iodide Symporter Expression, Activity, and Glycosylation between Thyroid and Breast Cancer Cells
Beyer, S., Lakshmanan, A., Liu, Y.- yu, Zhang, X., Wapnir, I., & Jhiang, S. (2011). KT5823 Differentially Modulates Sodium Iodide Symporter Expression, Activity, and Glycosylation between Thyroid and Breast Cancer Cells. ENDOCRINOLOGY, 152(3), 782-792.

Eusorbents and Eusorption: A Review of Physiological Events to Therapeutic Concepts
Wapnir, R. A., Wapnir, I., & Lifshitz, F. (2011). Eusorbents and Eusorption: A Review of Physiological Events to Therapeutic Concepts. JOURNAL OF THE AMERICAN COLLEGE OF NUTRITION, 30(1), 1-10.

In Situ Vaccination With a TLR9 Agonist Induces Systemic Lymphoma Regression: A Phase I/II Study
Brody, J. D., Ai, W. Z., Czerwinski, D. K., Torchia, J. A., Levy, M., & Levy, R. (2010). In Situ Vaccination With a TLR9 Agonist Induces Systemic Lymphoma Regression: A Phase I/II Study. JOURNAL OF CLINICAL ONCOLOGY, 28(28), 4324-4332.

Breast cancer brain metastases express the sodium iodide symporter
Renier, C., Vogel, H., Offor, O., Yao, C., & Wapnir, I. (2010). Breast cancer brain metastases express the sodium iodide symporter. JOURNAL OF NEURO-ONCOLOGY, 96(3), 331-336.

Timing of Breast Cancer Treatments with Oocyte Retrieval and Embryo Cryopreservation
Baynosa, J., Westphal, L. M., Madrigrano, A., & Wapnir, I. (2009). Timing of Breast Cancer Treatments with Oocyte Retrieval and Embryo Cryopreservation. JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS, 209(5), 603-607.

Prognosis After Ipsilateral Breast Tumor Recurrence and Locoregional Recurrences in Patients Treated by Breast-Conserving Therapy in Five National Surgical Adjuvant Breast and Bowel Project Protocols of Node-Negative Breast Cancer
Anderson, S. J., Wapnir, I., Dignam, J. J., Fisher, B., Mamounas, E. P., & Wolmark, N. (2009). Prognosis After Ipsilateral Breast Tumor Recurrence and Locoregional Recurrences in Patients Treated by Breast-Conserving Therapy in Five National Surgical Adjuvant Breast and Bowel Project Protocols of Node-Negative Breast Cancer. JOURNAL OF CLINICAL ONCOLOGY, 27(15), 2466-2473.

Association of reactive oxygen species levels and radioresistance in cancer stem cells
Diehn, M., Cho, R. W., Lobo, N. A., Kalisky, T., Dorie, M. J., & Clarke, M. F. (2009). Association of reactive oxygen species levels and radioresistance in cancer stem cells. NATURE, 458(7239), 780-U123.

Endogenous NIS Expression in Triple-Negative Breast Cancers
Renier, C., Yao, C., Goris, M., Ghosh, M., Katznelson, L., & Wapnir, I. (2009). Endogenous NIS Expression in Triple-Negative Breast Cancers. ANNALS OF SURGICAL ONCOLOGY, 16(4), 962-968.

Progress on BIG 1-02/IBCSG 27-02/NSABP B-37, a Prospective Randomized Trial Evaluating Chemotherapy after Local Therapy for Isolated Locoregional Recurrences of Breast Cancer
Wapnir, I. L., Aebi, S., Gelber, S., Anderson, S. J., Lang, I., & Wolmark, N. (2008). Progress on BIG 1-02/IBCSG 27-02/NSABP B-37, a Prospective Randomized Trial Evaluating Chemotherapy after Local Therapy for Isolated Locoregional Recurrences of Breast Cancer. ANNALS OF SURGICAL ONCOLOGY, 15(11), 3227-3231.

New models and online calculator for predicting non-sentinel lymph node status in sentinel lymph node positive breast cancer patients
Kohrt, H., Olshen, R., Bermas, H., GOODSON, W., Henry, S., & JEFFREY, S. (2008). New models and online calculator for predicting non-sentinel lymph node status in sentinel lymph node positive breast cancer patients. BREAST CANCER RESEARCH AND TREATMENT, 109(3), 588-588.

A randomized clinical trial of adjuvant chemotherapy for radically resected locoregional relapse of breast cancer: IBCSG 27-02, BIG 1-02, and NSABP B-37
Wapnir, I. L., Aebi, S., Geyer, C. E., Zahrieh, D., Gelber, R. D., & Wolmark, N. (2008). A randomized clinical trial of adjuvant chemotherapy for radically resected locoregional relapse of breast cancer: IBCSG 27-02, BIG 1-02, and NSABP B-37. CLINICAL BREAST CANCER, 8(3), 287-292.

New models and online calculator for predicting non-sentinel lymph node status in sentinel lymph node positive breast cancer patients
Kohrt, H. E., Olshen, R. A., Bermas, H. R., Goodson, W. H., Wood, D. J., & Jeffrey, S. S. (2008). New models and online calculator for predicting non-sentinel lymph node status in sentinel lymph node positive breast cancer patients. BMC CANCER, 8.

Metastases to the breast: Alveolar soft part sarcoma in adolescents
Madrigrano, A., Beach, B., Wheeler, A., & Wapnir, I. (2008). Metastases to the breast: Alveolar soft part sarcoma in adolescents. CLINICAL BREAST CANCER, 8(1), 92-93.

Leiomyosarcoma of the breast in a patient with a 10-year-history of cyclophosphamide exposure: a case report.
De la Pena, J., & Wapnir, I. (2008). Leiomyosarcoma of the breast in a patient with a 10-year-history of cyclophosphamide exposure: a case report. Cases journal, 1(1), 301-?.

Progress on BIG 1-02/IBCSG 27-2/NSABP B-37, A prospective randomized trial of evaluating chemotherapy after local therapy for isolated locoregional recurrences of breast cancer
Wapnir IL, Aebi S, Gelber SAebi S, Gelber S, Robidoux A, & Wolmark N. (2008). Progress on BIG 1-02/IBCSG 27-2/NSABP B-37, A prospective randomized trial of evaluating chemotherapy after local therapy for isolated locoregional recurrences of breast cancer. Annals of Surgical Oncology, 15(11).

Egg retrieval with cryopreservation does not delay breast cancer treatment
Madrigrano, A., Westphal, L., & Wapnir, I. (2007). Egg retrieval with cryopreservation does not delay breast cancer treatment. AMERICAN JOURNAL OF SURGERY, 194(4), 477-481.

Expression of the Na+/I- symporter (NIS) is markedly decreased or absent in gastric cancer and intestinal metaplastic mucosa of Barrett esophagus
Altorjay, A., Dohan, O., Szilagyi, A., Paroder, M., Wapnir, I. L., & Carrasco, N. (2007). Expression of the Na+/I- symporter (NIS) is markedly decreased or absent in gastric cancer and intestinal metaplastic mucosa of Barrett esophagus. BMC CANCER, 7.

Expression of the Na+/I- symporter (NIS) is markedly decreased or absent in gastric cancer
Altorjay A, Dohan O, Szilagyi A, Paroder M, Wapnir IL, & Carrasco N. (2007). Expression of the Na+/I- symporter (NIS) is markedly decreased or absent in gastric cancer. BMC Cancer, 7.

Resolution of hypoalbuminemia after excision of malignant phyllodes tumor
Samiian, L., Daniel, B., & Wapnir, I. (2006). Resolution of hypoalbuminemia after excision of malignant phyllodes tumor. CLINICAL BREAST CANCER, 7(5), 411-412.

Prognosis after ipsilateral breast tumor recurrence and locoregional recurrences in five national surgical adjuvant breast and bowel project node-positive adjuvant breast cancer trials
Wapnir, I. L., Anderson, S. J., Mamounas, E. P., Geyer, C. E., Jeong, J. H., & Wolmark, N. (2006). Prognosis after ipsilateral breast tumor recurrence and locoregional recurrences in five national surgical adjuvant breast and bowel project node-positive adjuvant breast cancer trials. JOURNAL OF CLINICAL ONCOLOGY, 24(13), 2028-2037.

Bioluminescent-inescent monitoring of NIS-mediated I-131 ablative effects in MCF-7 Xenografts
Ghosh, M., Gambhir, S. S., De, A., Nowels, K., Goris, M., & Wapnir, I. (2006). Bioluminescent-inescent monitoring of NIS-mediated I-131 ablative effects in MCF-7 Xenografts. MOLECULAR IMAGING, 5(2), 76-84.

Magnetic resonance imaging of suspicious breast masses seen on one mammographic view.
Offodile, R. S., Daniel, B. L., Jeffrey, S. S., Wapnir, I., Dirbas, F. M., & Ikeda, D. M. (2004). Magnetic resonance imaging of suspicious breast masses seen on one mammographic view. breast journal, 10(5), 416-422.

The Na+/I- symporter mediates iodide uptake in breast cancer metastases and can be selectively down-regulated in the thyroid
Wapnir, I. L., Goris, M., Yudd, A., Dohan, O., Adelman, D., & Carrasco, N. (2004). The Na+/I- symporter mediates iodide uptake in breast cancer metastases and can be selectively down-regulated in the thyroid. CLINICAL CANCER RESEARCH, 10(13), 4294-4302.

Elephantiasic prefibial myxedema
Cohen, J. B., Balzer, B., Wapnir, I., & McDougall, I. R. (2004). Elephantiasic prefibial myxedema. THYROID, 14(3), 237-238.

Immunohistochemical profile of the sodium/iodide symporter in thyroid, breast, and other carcinomas using high density tissue microarrays and conventional sections
Wapnir, I. L., van de Rijn, M., Nowels, K., Amenta, P. S., Walton, K., & Carrasco, N. (2003). Immunohistochemical profile of the sodium/iodide symporter in thyroid, breast, and other carcinomas using high density tissue microarrays and conventional sections. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 88(4), 1880-1888.

The inverse relationship between microvessel counts and tumor volume in breast cancer.
Wapnir, I. L., Barnard, N., Wartenberg, D., & Greco, R. S. (2001). The inverse relationship between microvessel counts and tumor volume in breast cancer. breast journal, 7(3), 184-188.

The mammary gland iodide transporter is expressed during lactation and in breast cancer
Tazebay, U. H., Wapnir, I. L., Levy, O., Dohan, O., Zuckier, L. S., & Carrasco, N. (2000). The mammary gland iodide transporter is expressed during lactation and in breast cancer. NATURE MEDICINE, 6(8), 871-878.

Subtle differences in quality of life after breast cancer surgery
Wapnir, I. L., Cody, R. P., & Greco, R. S. (1999). Subtle differences in quality of life after breast cancer surgery. ANNALS OF SURGICAL ONCOLOGY, 6(4), 359-366.

The verbal abuse of resident physicians
Wapnir IL, Cody RP, & Greco RS. (1999). The verbal abuse of resident physicians. Disease Management and Clinical Outcomes, 1(6).

Collagen gene expression in the neomatrix of carcinoma of the breast
Wapnir, I. L., Southard, H., Chen, G. H., Friedman, J., BOYD, C. D., & Amenta, P. S. (1996). Collagen gene expression in the neomatrix of carcinoma of the breast. INVASION & METASTASIS, 16(6), 308-316.

Three dimensional staging of breast cancer
Wapnir, I. L., WARTENBERG, D. E., & Greco, R. S. (1996). Three dimensional staging of breast cancer. BREAST CANCER RESEARCH AND TREATMENT, 41(1), 15-19.

Pathologic differences in nonpalpable breast cancers detected by xeromammography and film screen mammography
Wapnir IL, Fang M, Zicherman B, & Greco RS. (1996). Pathologic differences in nonpalpable breast cancers detected by xeromammography and film screen mammography. Breast Disease, 9(4).

Superior quality of life following lumpectomy-axillary dissection in patients with stage I and stage II beast cancer
Wapnir IL, Cody RP, & Greco RS. (1996). Superior quality of life following lumpectomy-axillary dissection in patients with stage I and stage II beast cancer. Surgical Forum, XLVII.

Local recurrence after breast conservation
Wapnir IL. (1996). Local recurrence after breast conservation. Current Surgery, 53(161).

Stage II ductal carcinoma arising in a fibroadenoma
Wapnir, Il., & Barnard N. (1995). Stage II ductal carcinoma arising in a fibroadenoma. Breast Disease, 8.

COLLAGEN-INDUCED MMP-2 ACTIVATION IN HUMAN BREAST-CANCER
Thompson, E. W., Yu, M., Bueno, J., Jin, L., Maiti, S. N., & Azzam, H. (1994). COLLAGEN-INDUCED MMP-2 ACTIVATION IN HUMAN BREAST-CANCER. BREAST CANCER RESEARCH AND TREATMENT, 31(2-3), 357-370.

Mammographic changes following biopsy and lumpectomy-breast irradiation.
Wapnir, I. L., Alden-Corbett, S., Zicherman, B., & Greco, R. S. (1993). Mammographic changes following biopsy and lumpectomy-breast irradiation. New Jersey medicine : the journal of the Medical Society of New Jersey, 90(1), 55-59.

A REAPPRAISAL OF PROPHYLACTIC MASTECTOMY
Wapnir, I. L., Rabinowitz, B., & Greco, R. S. (1990). A REAPPRAISAL OF PROPHYLACTIC MASTECTOMY. SURGERY GYNECOLOGY & OBSTETRICS, 171(2), 171-184.

COMPARTMENT SYNDROME IN COMBINED ARTERIAL AND VENOUS INJURIES OF THE LOWER-EXTREMITY
Shah, P. M., Wapnir, I., Babu, S., Stahl, W. M., & CLAUSS, R. H. (1989). COMPARTMENT SYNDROME IN COMBINED ARTERIAL AND VENOUS INJURIES OF THE LOWER-EXTREMITY. AMERICAN JOURNAL OF SURGERY, 158(2), 136-141.

Residual tumor and breast biopsy margins
Wapnir, Il., Bancila E, Devereux DF, & Grecor RS. (1989). Residual tumor and breast biopsy margins. Breast Disease, 2.

ASYMMETRICAL BREASTS IN AN ADOLESCENT
Wapnir, I., Rabinowitz, B., & Snyderman, R. (1988). ASYMMETRICAL BREASTS IN AN ADOLESCENT. PLASTIC AND RECONSTRUCTIVE SURGERY, 81(5), 813-813.

NONOPERATIVE MANAGEMENT VERSUS EARLY OPERATION FOR BLUNT SPLENIC TRAUMA IN ADULTS
NALLATHAMBI, M. N., Ivatury, R. R., Wapnir, I., Rohman, M., & Stahl, W. M. (1988). NONOPERATIVE MANAGEMENT VERSUS EARLY OPERATION FOR BLUNT SPLENIC TRAUMA IN ADULTS. SURGERY GYNECOLOGY & OBSTETRICS, 166(3), 252-258.

PORTAL-VEIN INJURIES - NONINVASIVE FOLLOW-UP OF VENORRHAPHY
Ivatury, R. R., NALLATHAMBI, M., LANKIN, D. H., Wapnir, I., Rohman, M., & Stahl, W. M. (1987). PORTAL-VEIN INJURIES - NONINVASIVE FOLLOW-UP OF VENORRHAPHY. ANNALS OF SURGERY, 206(6), 733-737.

PYOGENIC SPLENIC ABSCESS IN INTRAVENOUS DRUG-ADDICTION
NALLATHAMBI, M. N., Ivatury, R. R., LANKIN, D. H., Wapnir, I. L., & Stahl, W. M. (1987). PYOGENIC SPLENIC ABSCESS IN INTRAVENOUS DRUG-ADDICTION. AMERICAN SURGEON, 53(6), 342-346.

[Gastroesophageal reflux in children. Experience in 100 cases treated by Nissen's fundoplication].
Pérez-Fernández, L., Peña-Rodríguez, A., & Wapnir, I. (1985). [Gastroesophageal reflux in children. Experience in 100 cases treated by Nissen's fundoplication]. Boletín médico del Hospital Infantil de México, 42(4), 256-265.

LATENT MAMMARY TUBERCULOSIS - A CASE-REPORT
Wapnir, I. L., PALLAN, T. M., Gaudino, J., & Stahl, W. M. (1985). LATENT MAMMARY TUBERCULOSIS - A CASE-REPORT. SURGERY, 98(5), 976-978.

Muerte inesperada y sindrome de muerte subita en la infancia
Ridaura-Sanz C, Wapnir-Michalewicz IL, Lopez-Corella E, & Mendoza-Lopez E. (1980). Muerte inesperada y sindrome de muerte subita en la infancia. PAtologia (Mexico), 18.

MAGNESIUM-METABOLISM IN EXPERIMENTAL DIABETES-MELLITUS
Fort, P., Lifshitz, F., Wapnir, I. L., & Wapnir, R. A. (1977). MAGNESIUM-METABOLISM IN EXPERIMENTAL DIABETES-MELLITUS. DIABETES, 26(9), 882-886.