Matthew Wheeler

Cardiologist

Heart Transplant Program

  • 300 Pasteur Drive
  • Stanford, CA 94305
  • Phone: 650-723-5468
Learn More About the Clinic Getting Here Make An Appointment

Professional Education

Fellowship: Stanford University School of Medicine (2013) CA

Fellowship: Stanford University School of Medicine (2012) CA

Medical Education: University of Chicago Pritzker School of Medicine (2005) IL

Residency: Stanford University Hospital -Internal Medicine Residency Training Program (2007) CA

Board Certification: Cardiovascular Disease, American Board of Internal Medicine (2012)

Board Certification: Internal Medicine, American Board of Internal Medicine (2008)

Bachelor of Arts, Williams College, History and Biology (1998)

Clinical assessment incorporating a personal genome
Ashley, E. A., Butte, A. J., Wheeler, M. T., Chen, R., Klein, T. E., & Altman, R. B. (2010). Clinical assessment incorporating a personal genome. LANCET, 375(9725), 1525-1535.

Cost-Effectiveness of Preparticipation Screening for Prevention of Sudden Cardiac Death in Young Athletes
Wheeler, M. T., Heidenreich, P. A., Froelicher, V. F., Hlatky, M. A., & Ashley, E. A. (2010). Cost-Effectiveness of Preparticipation Screening for Prevention of Sudden Cardiac Death in Young Athletes. ANNALS OF INTERNAL MEDICINE, 152(5), 276-W91.

Physical Activity and Other Health Behaviors in Adults With Hypertrophic Cardiomyopathy
Reineck, E., Rolston, B., Bragg-Gresham, J. L., Salberg, L., Baty, L., & Day, S. M. (2013). Physical Activity and Other Health Behaviors in Adults With Hypertrophic Cardiomyopathy. AMERICAN JOURNAL OF CARDIOLOGY, 111(7), 1034-1039.

Abnormal Calcium Handling Properties Underlie Familial Hypertrophic Cardiomyopathy Pathology in Patient-Specific Induced Pluripotent Stem Cells
Lan, F., Lee, A. S., Liang, P., Sanchez-Freire, V., Nguyen, P. K., & Wu, J. C. (2013). Abnormal Calcium Handling Properties Underlie Familial Hypertrophic Cardiomyopathy Pathology in Patient-Specific Induced Pluripotent Stem Cells. CELL STEM CELL, 12(1), 101-113.

A public resource facilitating clinical use of genomes
Ball, M. P., Thakuria, J. V., Zaranek, A. W., Clegg, T., Rosenbaum, A. M., & Church, G. M. (2012). A public resource facilitating clinical use of genomes. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 109(30), 11920-11927.

DNA Sequencing Clinical Applications of New DNA Sequencing Technologies
Dewey, F. E., Pan, S., Wheeler, M. T., Quake, S. R., & Ashley, E. A. (2012). DNA Sequencing Clinical Applications of New DNA Sequencing Technologies. CIRCULATION, 125(7), 931-944.

Phased Whole-Genome Genetic Risk in a Family Quartet Using a Major Allele Reference Sequence
Dewey, F. E., Chen, R., Cordero, S. P., Ormond, K. E., Caleshu, C., & Ashley, E. A. (2011). Phased Whole-Genome Genetic Risk in a Family Quartet Using a Major Allele Reference Sequence. PLOS GENETICS, 7(9).

Interpretation of the Electrocardiogram of Young Athletes
Uberoi, A., Stein, R., Perez, M. V., Freeman, J., Wheeler, M., & Froelicher, V. (2011). Interpretation of the Electrocardiogram of Young Athletes. CIRCULATION, 124(6), 746-757.

Systems biology of heart failure, challenges and hopes
Dewey, F. E., Wheeler, M. T., & Ashley, E. A. (2011). Systems biology of heart failure, challenges and hopes. CURRENT OPINION IN CARDIOLOGY, 26(4), 314-321.

Gene Coexpression Network Topology of Cardiac Development, Hypertrophy, and Failure
Dewey, F. E., Perez, M. V., Wheeler, M. T., Watt, C., Spin, J., & Ashley, E. A. (2011). Gene Coexpression Network Topology of Cardiac Development, Hypertrophy, and Failure. CIRCULATION-CARDIOVASCULAR GENETICS, 4(1), 26-U129.

Effect of Gender on Computerized Electrocardiogram Measurements in College Athletes
Mandic, S., Fonda, H., Dewey, F., Vy-van Le, Stein, R., & Froelicher, V. F. (2010). Effect of Gender on Computerized Electrocardiogram Measurements in College Athletes. PHYSICIAN AND SPORTSMEDICINE, 38(2), 156-164.

Challenges in the clinical application of whole-genome sequencing
Ormond, K. E., Wheeler, M. T., Hudgins, L., Klein, T. E., Butte, A. J., & Greely, H. T. (2010). Challenges in the clinical application of whole-genome sequencing. LANCET, 375(9727), 1749-1751.

Addition of the Electrocardiogram to the Preparticipation Examination of College Athletes
Le, V.-V., Wheeler, M. T., Mandic, S., Dewey, F., Fonda, H., & Froelicher, V. (2010). Addition of the Electrocardiogram to the Preparticipation Examination of College Athletes. CLINICAL JOURNAL OF SPORT MEDICINE, 20(2), 98-105.

A New Era in Clinical Genetic Testing for Hypertrophic Cardiomyopathy
Wheeler, M., Pavlovic, A., deGoma, E., Salisbury, H., Brown, C., & Ashley, E. A. (2009). A New Era in Clinical Genetic Testing for Hypertrophic Cardiomyopathy. JOURNAL OF CARDIOVASCULAR TRANSLATIONAL RESEARCH, 2(4), 381-391.

Mechanisms of exercise intolerance in patients with hypertrophic cardiomyopathy
Le, V.-V., Perez, M. V., Wheeler, M. T., Myers, J., Schnittger, I., & Ashley, E. A. (2009). Mechanisms of exercise intolerance in patients with hypertrophic cardiomyopathy. AMERICAN HEART JOURNAL, 158(3), E27-E34.

A New Era in Clinical Genetic Testing for Hypertrophic Cardiomyopathy
Wheeler M, Pavlovic A, DeGoma E, Salisbury H, Brown C, & Ashley EA. (2009). A New Era in Clinical Genetic Testing for Hypertrophic Cardiomyopathy. J Cardiovasc Translational Res, 2(4).

Genetics of Arrhythmia: Disease Pathways Beyond Ion Channels
Perez, M. V., Wheeler, M., Ho, M., Pavlovic, A., Wang, P., & Ashley, E. A. (2008). Genetics of Arrhythmia: Disease Pathways Beyond Ion Channels. JOURNAL OF CARDIOVASCULAR TRANSLATIONAL RESEARCH, 1(2), 155-165.

Pharmacogenetics of Heart Failure: Evidence, Opportunities, and Challenges for Cardiovascular Pharmacogenomics
Wheeler, M. T., Ho, M., Knowles, J. W., Pavlovic, A., & Ashley, E. A. (2008). Pharmacogenetics of Heart Failure: Evidence, Opportunities, and Challenges for Cardiovascular Pharmacogenomics. JOURNAL OF CARDIOVASCULAR TRANSLATIONAL RESEARCH, 1(1), 25-36.

Angiotensin-converting enzyme genotype predicts cardiac and autonomic responses to prolonged exercise
Ashley, E. A., Kardos, A., Jack, E. S., Habenbacher, W., Wheeler, M., & Douglas, P. (2006). Angiotensin-converting enzyme genotype predicts cardiac and autonomic responses to prolonged exercise. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 48(3), 523-531.

The interaction of coronary tone and cardiac fibrosis.
Wheeler, M. T., & McNally, E. M. (2005). The interaction of coronary tone and cardiac fibrosis. Current atherosclerosis reports, 7(3), 219-226.

Secondary coronary artery vasospasm promotes cardiomyopathy progression
Wheeler, M. T., Korcarz, C. E., Collins, K. A., Lapidos, K. A., Hack, A. A., & McNally, E. M. (2004). Secondary coronary artery vasospasm promotes cardiomyopathy progression. AMERICAN JOURNAL OF PATHOLOGY, 164(3), 1063-1071.

Smooth muscle cell-extrinsic vascular spasm arises from cardiomyocyte degeneration in sarcoglycan-deficient cardiomyopathy
Wheeler, M. T., Allikian, M. J., Heydemann, A., Hadhazy, M., Zarnegar, S., & McNally, E. M. (2004). Smooth muscle cell-extrinsic vascular spasm arises from cardiomyocyte degeneration in sarcoglycan-deficient cardiomyopathy. JOURNAL OF CLINICAL INVESTIGATION, 113(5), 668-675.

Functional nitric oxide synthase mislocalization in cardiomyopathy
Heydemann, A., Huber, J. M., Kakkar, R., Wheeler, M. T., & McNally, E. M. (2004). Functional nitric oxide synthase mislocalization in cardiomyopathy. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, 36(2), 213-223.

Sarcoglycans in vascular smooth and striated muscle
Wheeler, M. T., & McNally, E. M. (2003). Sarcoglycans in vascular smooth and striated muscle. TRENDS IN CARDIOVASCULAR MEDICINE, 13(6), 238-243.

Cytoskeletal defects in cardiomyopathy
McNally, E., Allikian, M., Wheeler, M. T., Mislow, J. M., & Heydemann, A. (2003). Cytoskeletal defects in cardiomyopathy. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, 35(3), 231-241.

zeta-Sarcoglycan, a novel component of the sarcoglycan complex, is reduced in muscular dystrophy
Wheeler, M. T., Zarnegar, S., & McNally, E. M. (2002). zeta-Sarcoglycan, a novel component of the sarcoglycan complex, is reduced in muscular dystrophy. HUMAN MOLECULAR GENETICS, 11(18), 2147-2154.

Episodic coronary artery vasospasm and hypertension develop in the absence of Sur2 K-ATP channels
Chutkow, W. A., Pu, J. L., Wheeler, M. T., Wada, T., Makielski, J. C., & McNally, E. M. (2002). Episodic coronary artery vasospasm and hypertension develop in the absence of Sur2 K-ATP channels. JOURNAL OF CLINICAL INVESTIGATION, 110(2), 203-208.

Cardiomyopathy is independent of skeletal muscle disease in muscular dystrophy.
Zhu, X., Wheeler, M. T., Hadhazy, M., Lam, M.-Y. J., & McNally, E. M. (2002). Cardiomyopathy is independent of skeletal muscle disease in muscular dystrophy. FASEB journal , 16(9), 1096-1098.

Cardiomyopathy is independent of skeletal muscle disease in muscular dystrophy
Zhu, X. L., Wheeler, M. T., Hadhazy, M., Lam, M. Yj., & McNally, E. M. (2002). Cardiomyopathy is independent of skeletal muscle disease in muscular dystrophy. FASEB JOURNAL, 16(7), 1096-?.

The sarcoglycan complex in striated and vascular smooth muscle
Wheeler, M. T., Allikian, M. J., Heydemann, A., & McNally, E. M. (2002). The sarcoglycan complex in striated and vascular smooth muscle. COLD SPRING HARBOR SYMPOSIA ON QUANTITATIVE BIOLOGY, 67, 389-397.

Overexpression of gamma-sarcoglycan induces severe muscular dystrophy - Implications for the regulation of sarcoglycan assembly
Zhu, X. L., Hadhazy, M., Groh, M. E., Wheeler, M. T., Wollmann, R., & McNally, E. M. (2001). Overexpression of gamma-sarcoglycan induces severe muscular dystrophy - Implications for the regulation of sarcoglycan assembly. JOURNAL OF BIOLOGICAL CHEMISTRY, 276(24), 21785-21790.

Cardiomyopathy in animal models of muscular dystrophy
Heydemann, A., Wheeler, M. T., & McNally, E. M. (2001). Cardiomyopathy in animal models of muscular dystrophy. CURRENT OPINION IN CARDIOLOGY, 16(3), 211-217.

An E-box within the MHC IIB gene is bound by MyoD and is required for gene expression in fast muscle
Wheeler, M. T., Snyder, E. C., Patterson, M. N., & Swoap, S. J. (1999). An E-box within the MHC IIB gene is bound by MyoD and is required for gene expression in fast muscle. AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY, 276(5), C1069-C1078.