Matthew Wheeler

Cardiologist

Instructor, Medicine - Cardiovascular Medicine

Heart Transplant Program

  • 300 Pasteur Drive
  • Stanford, CA 94305
  • Phone: 650-723-5468
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Center for Inherited Cardiovascular Disease

  • 300 Pasteur Drive
  • Stanford, CA 94305
  • Phone: 650-721-4363
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Hypertrophic Cardiomyopathy Center

  • 300 Pasteur Drive
  • Stanford, CA 94305
  • Phone: 650-723-6459
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Amyloid Center

  • 300 Pasteur Drive
  • Stanford, CA 94305
  • Phone: 650-725-6186
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Professional Education

Fellowship: Stanford University School of Medicine (2013) CA

Fellowship: Stanford University School of Medicine (2012) CA

Medical Education: University of Chicago Pritzker School of Medicine (2005) IL

Residency: Stanford University Hospital -Internal Medicine Residency Training Program (2007) CA

Board Certification: Cardiovascular Disease, American Board of Internal Medicine (2012)

Board Certification: Internal Medicine, American Board of Internal Medicine (2008)

Bachelor of Arts, Williams College, History and Biology (1998)

Clinical Trials

Clinical trials are research studies that evaluate a new medical approach, device, drug, or other treatment. As a Stanford Health Care patient, you have access to the latest, advanced clinical trials.

Open trials refer to studies currently accepting participants. Closed trials are not currently enrolling, but may open in the future.

Clinical assessment incorporating a personal genome
Ashley, E. A., Butte, A. J., Wheeler, M. T., Chen, R., Klein, T. E., & Altman, R. B. (2010). Clinical assessment incorporating a personal genome. LANCET, 375(9725), 1525-1535.

Cost-Effectiveness of Preparticipation Screening for Prevention of Sudden Cardiac Death in Young Athletes
Wheeler, M. T., Heidenreich, P. A., Froelicher, V. F., Hlatky, M. A., & Ashley, E. A. (2010). Cost-Effectiveness of Preparticipation Screening for Prevention of Sudden Cardiac Death in Young Athletes. ANNALS OF INTERNAL MEDICINE, 152(5), 276-W91.

Physical Activity and Other Health Behaviors in Adults With Hypertrophic Cardiomyopathy
Reineck, E., Rolston, B., Bragg-Gresham, J. L., Salberg, L., Baty, L., & Day, S. M. (2013). Physical Activity and Other Health Behaviors in Adults With Hypertrophic Cardiomyopathy. AMERICAN JOURNAL OF CARDIOLOGY, 111(7), 1034-1039.

Abnormal Calcium Handling Properties Underlie Familial Hypertrophic Cardiomyopathy Pathology in Patient-Specific Induced Pluripotent Stem Cells
Lan, F., Lee, A. S., Liang, P., Sanchez-Freire, V., Nguyen, P. K., & Wu, J. C. (2013). Abnormal Calcium Handling Properties Underlie Familial Hypertrophic Cardiomyopathy Pathology in Patient-Specific Induced Pluripotent Stem Cells. CELL STEM CELL, 12(1), 101-113.

A public resource facilitating clinical use of genomes
Ball, M. P., Thakuria, J. V., Zaranek, A. W., Clegg, T., Rosenbaum, A. M., & Church, G. M. (2012). A public resource facilitating clinical use of genomes. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 109(30), 11920-11927.

DNA Sequencing Clinical Applications of New DNA Sequencing Technologies
Dewey, F. E., Pan, S., Wheeler, M. T., Quake, S. R., & Ashley, E. A. (2012). DNA Sequencing Clinical Applications of New DNA Sequencing Technologies. CIRCULATION, 125(7), 931-944.

Phased Whole-Genome Genetic Risk in a Family Quartet Using a Major Allele Reference Sequence
Dewey, F. E., Chen, R., Cordero, S. P., Ormond, K. E., Caleshu, C., & Ashley, E. A. (2011). Phased Whole-Genome Genetic Risk in a Family Quartet Using a Major Allele Reference Sequence. PLOS GENETICS, 7(9).

Interpretation of the Electrocardiogram of Young Athletes
Uberoi, A., Stein, R., Perez, M. V., Freeman, J., Wheeler, M., & Froelicher, V. (2011). Interpretation of the Electrocardiogram of Young Athletes. CIRCULATION, 124(6), 746-757.

Systems biology of heart failure, challenges and hopes
Dewey, F. E., Wheeler, M. T., & Ashley, E. A. (2011). Systems biology of heart failure, challenges and hopes. CURRENT OPINION IN CARDIOLOGY, 26(4), 314-321.

Gene Coexpression Network Topology of Cardiac Development, Hypertrophy, and Failure
Dewey, F. E., Perez, M. V., Wheeler, M. T., Watt, C., Spin, J., & Ashley, E. A. (2011). Gene Coexpression Network Topology of Cardiac Development, Hypertrophy, and Failure. CIRCULATION-CARDIOVASCULAR GENETICS, 4(1), 26-U129.

Effect of Gender on Computerized Electrocardiogram Measurements in College Athletes
Mandic, S., Fonda, H., Dewey, F., Vy-van Le, Stein, R., & Froelicher, V. F. (2010). Effect of Gender on Computerized Electrocardiogram Measurements in College Athletes. PHYSICIAN AND SPORTSMEDICINE, 38(2), 156-164.

Challenges in the clinical application of whole-genome sequencing
Ormond, K. E., Wheeler, M. T., Hudgins, L., Klein, T. E., Butte, A. J., & Greely, H. T. (2010). Challenges in the clinical application of whole-genome sequencing. LANCET, 375(9727), 1749-1751.

Addition of the Electrocardiogram to the Preparticipation Examination of College Athletes
Le, V.-V., Wheeler, M. T., Mandic, S., Dewey, F., Fonda, H., & Froelicher, V. (2010). Addition of the Electrocardiogram to the Preparticipation Examination of College Athletes. CLINICAL JOURNAL OF SPORT MEDICINE, 20(2), 98-105.

A New Era in Clinical Genetic Testing for Hypertrophic Cardiomyopathy
Wheeler, M., Pavlovic, A., deGoma, E., Salisbury, H., Brown, C., & Ashley, E. A. (2009). A New Era in Clinical Genetic Testing for Hypertrophic Cardiomyopathy. JOURNAL OF CARDIOVASCULAR TRANSLATIONAL RESEARCH, 2(4), 381-391.

Mechanisms of exercise intolerance in patients with hypertrophic cardiomyopathy
Le, V.-V., Perez, M. V., Wheeler, M. T., Myers, J., Schnittger, I., & Ashley, E. A. (2009). Mechanisms of exercise intolerance in patients with hypertrophic cardiomyopathy. AMERICAN HEART JOURNAL, 158(3), E27-E34.

A New Era in Clinical Genetic Testing for Hypertrophic Cardiomyopathy
Wheeler M, Pavlovic A, DeGoma E, Salisbury H, Brown C, & Ashley EA. (2009). A New Era in Clinical Genetic Testing for Hypertrophic Cardiomyopathy. J Cardiovasc Translational Res, 2(4).

Genetics of Arrhythmia: Disease Pathways Beyond Ion Channels
Perez, M. V., Wheeler, M., Ho, M., Pavlovic, A., Wang, P., & Ashley, E. A. (2008). Genetics of Arrhythmia: Disease Pathways Beyond Ion Channels. JOURNAL OF CARDIOVASCULAR TRANSLATIONAL RESEARCH, 1(2), 155-165.

Pharmacogenetics of Heart Failure: Evidence, Opportunities, and Challenges for Cardiovascular Pharmacogenomics
Wheeler, M. T., Ho, M., Knowles, J. W., Pavlovic, A., & Ashley, E. A. (2008). Pharmacogenetics of Heart Failure: Evidence, Opportunities, and Challenges for Cardiovascular Pharmacogenomics. JOURNAL OF CARDIOVASCULAR TRANSLATIONAL RESEARCH, 1(1), 25-36.

Angiotensin-converting enzyme genotype predicts cardiac and autonomic responses to prolonged exercise
Ashley, E. A., Kardos, A., Jack, E. S., Habenbacher, W., Wheeler, M., & Douglas, P. (2006). Angiotensin-converting enzyme genotype predicts cardiac and autonomic responses to prolonged exercise. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 48(3), 523-531.

The interaction of coronary tone and cardiac fibrosis.
Wheeler, M. T., & McNally, E. M. (2005). The interaction of coronary tone and cardiac fibrosis. Current atherosclerosis reports, 7(3), 219-226.

Secondary coronary artery vasospasm promotes cardiomyopathy progression
Wheeler, M. T., Korcarz, C. E., Collins, K. A., Lapidos, K. A., Hack, A. A., & McNally, E. M. (2004). Secondary coronary artery vasospasm promotes cardiomyopathy progression. AMERICAN JOURNAL OF PATHOLOGY, 164(3), 1063-1071.

Smooth muscle cell-extrinsic vascular spasm arises from cardiomyocyte degeneration in sarcoglycan-deficient cardiomyopathy
Wheeler, M. T., Allikian, M. J., Heydemann, A., Hadhazy, M., Zarnegar, S., & McNally, E. M. (2004). Smooth muscle cell-extrinsic vascular spasm arises from cardiomyocyte degeneration in sarcoglycan-deficient cardiomyopathy. JOURNAL OF CLINICAL INVESTIGATION, 113(5), 668-675.

Functional nitric oxide synthase mislocalization in cardiomyopathy
Heydemann, A., Huber, J. M., Kakkar, R., Wheeler, M. T., & McNally, E. M. (2004). Functional nitric oxide synthase mislocalization in cardiomyopathy. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, 36(2), 213-223.

Sarcoglycans in vascular smooth and striated muscle
Wheeler, M. T., & McNally, E. M. (2003). Sarcoglycans in vascular smooth and striated muscle. TRENDS IN CARDIOVASCULAR MEDICINE, 13(6), 238-243.

Cytoskeletal defects in cardiomyopathy
McNally, E., Allikian, M., Wheeler, M. T., Mislow, J. M., & Heydemann, A. (2003). Cytoskeletal defects in cardiomyopathy. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, 35(3), 231-241.

zeta-Sarcoglycan, a novel component of the sarcoglycan complex, is reduced in muscular dystrophy
Wheeler, M. T., Zarnegar, S., & McNally, E. M. (2002). zeta-Sarcoglycan, a novel component of the sarcoglycan complex, is reduced in muscular dystrophy. HUMAN MOLECULAR GENETICS, 11(18), 2147-2154.

Episodic coronary artery vasospasm and hypertension develop in the absence of Sur2 K-ATP channels
Chutkow, W. A., Pu, J. L., Wheeler, M. T., Wada, T., Makielski, J. C., & McNally, E. M. (2002). Episodic coronary artery vasospasm and hypertension develop in the absence of Sur2 K-ATP channels. JOURNAL OF CLINICAL INVESTIGATION, 110(2), 203-208.

Cardiomyopathy is independent of skeletal muscle disease in muscular dystrophy.
Zhu, X., Wheeler, M. T., Hadhazy, M., Lam, M.-Y. J., & McNally, E. M. (2002). Cardiomyopathy is independent of skeletal muscle disease in muscular dystrophy. FASEB journal , 16(9), 1096-1098.

Cardiomyopathy is independent of skeletal muscle disease in muscular dystrophy
Zhu, X. L., Wheeler, M. T., Hadhazy, M., Lam, M. Yj., & McNally, E. M. (2002). Cardiomyopathy is independent of skeletal muscle disease in muscular dystrophy. FASEB JOURNAL, 16(7), 1096-?.

The sarcoglycan complex in striated and vascular smooth muscle
Wheeler, M. T., Allikian, M. J., Heydemann, A., & McNally, E. M. (2002). The sarcoglycan complex in striated and vascular smooth muscle. COLD SPRING HARBOR SYMPOSIA ON QUANTITATIVE BIOLOGY, 67, 389-397.

Overexpression of gamma-sarcoglycan induces severe muscular dystrophy - Implications for the regulation of sarcoglycan assembly
Zhu, X. L., Hadhazy, M., Groh, M. E., Wheeler, M. T., Wollmann, R., & McNally, E. M. (2001). Overexpression of gamma-sarcoglycan induces severe muscular dystrophy - Implications for the regulation of sarcoglycan assembly. JOURNAL OF BIOLOGICAL CHEMISTRY, 276(24), 21785-21790.

Cardiomyopathy in animal models of muscular dystrophy
Heydemann, A., Wheeler, M. T., & McNally, E. M. (2001). Cardiomyopathy in animal models of muscular dystrophy. CURRENT OPINION IN CARDIOLOGY, 16(3), 211-217.

An E-box within the MHC IIB gene is bound by MyoD and is required for gene expression in fast muscle
Wheeler, M. T., Snyder, E. C., Patterson, M. N., & Swoap, S. J. (1999). An E-box within the MHC IIB gene is bound by MyoD and is required for gene expression in fast muscle. AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY, 276(5), C1069-C1078.