Ronald Witteles

Cardiologist

Assistant Professor of Medicine (Cardiovascular Medicine) at the Stanford University Medical Center

Amyloid Center

  • 300 Pasteur Drive
  • Stanford, CA 94305
  • Phone: 650-725-6186
Learn More About the Clinic Getting Here Make An Appointment

Heart Failure and Cardiomyopathy Clinic

  • 300 Pasteur Drive
  • Stanford, CA 94305
  • Phone: 650-723-5468
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Heart Transplant Program

  • 300 Pasteur Drive
  • Stanford, CA 94305
  • Phone: 650-723-5468
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Professional Education

Board Certification: Advanced Heart Failure and Transplant Cardiology, American Board of Internal Medicine (2006)

Fellowship: Stanford University School of Medicine (2007) CA

Residency: Stanford University School of Medicine (2004) CA

Residency: Stanford University School of Medicine (2003) CA

Board Certification: Cardiovascular Disease, American Board of Internal Medicine (2007)

Board Certification: Internal Medicine, American Board of Internal Medicine (2003)

Chief Resident, Stanford University, Internal Medicine (2004)

Internship: Stanford University School of Medicine (2001) CA

M.D. with Honors, University of Chicago, Medicine (2000)

B.A., Northwestern University, Biology/Neuroscience (1996)

F.A.C.P., American College of Physicians, Internal Medicine (2010)

F.A.C.C., American College of Cardiology, Cardiology (2008)

Chief Fellow, Stanford University, Cardiovascular Medicine (2007)

Medical Education: University of Chicago Pritzker (2000) IL

Honors & Awards

David W. Rytand Award for Excellence in Clinical Teaching by a Department of Medicine faculty member, Stanford University Department of Internal Medicine (2009, 2010)

First Author - Selected as one of 15 most important heart failure articles in 2007, Journal of the American College of Cardiology (2008)

Clinical Research Award, Stanford Univ. Division of Cardiovascular Medicine (2007)

Timothy F. Beckett, Jr. Award for Excellence in Teaching by a Medicine Fellow, Stanford Univ. Dept. of Internal Medicine (2006)

Clinical Excellence Award, Stanford University Division of Cardiovascular Medicine (2006)

National Research Fellowship Award, Heart Failure Society of America (2006)

First Author - Selected as one of 10 most important heart failure articles in 2004, Journal of the American College of Cardiology (2005)

National Associates' Research Award, American College of Physicians/American Society of Internal Medicine (2004)

Charles Dorsey Armstrong Clinical Excellence Award, Stanford University Dept. of Internal Medicine (2003)

Outstanding Clinical Teaching Award, Stanford University Dept. of Internal Medicine (2002, 2003)

Francis G. Ebaugh, Jr. Research Award, Stanford University Dept. of Internal Medicine (2001, 2002, 2003)

M.D. with Honors (highest distinction by U. of Chicago), University of Chicago Pritzker School of Medicine (2000)

Calvin Fentress Research Fellowship, University of Chicago Pritzker School of Medicine (1999)

Administrative Appointments

Program Director, Internal Medicine Residency Training Program (2011 - Present)

Co-Director, Stanford Amyloid Center (2008 - Present)

Sr. Associate Program Director, Internal Medicine Residency Training Program (2009 - 2011)

Associate Director, Coronary Care Unit (CCU) (2008 - 2009)

Clinical Trials

Clinical trials are research studies that evaluate a new medical approach, device, drug, or other treatment. As a Stanford Health Care patient, you have access to the latest, advanced clinical trials.

Open trials refer to studies currently accepting participants. Closed trials are not currently enrolling, but may open in the future.

Implantable cardioverter-defibrillator placement in patients with cardiac amyloidosis.
Varr, B. C., Zarafshar, S., Coakley, T., Liedtke, M., Lafayette, R. A., & Witteles, R. M. (2014). Implantable cardioverter-defibrillator placement in patients with cardiac amyloidosis. Heart rhythm , 11(1), 158-162.

Variation in Use of Left Ventriculography in the Veterans Affairs Health Care System
Heidenreich, P. A., Lin, S., Knowles, J. W., Perez, M., Maddox, T. M., & Witteles, R. M. (2013). Variation in Use of Left Ventriculography in the Veterans Affairs Health Care System. CIRCULATION-CARDIOVASCULAR QUALITY AND OUTCOMES, 6(6), 687-693.

Underestimating Cardiac Toxicity in Cancer Trials: Lessons Learned?
Witteles, R. M., & Telli, M. (2012). Underestimating Cardiac Toxicity in Cancer Trials: Lessons Learned?. JOURNAL OF CLINICAL ONCOLOGY, 30(16), 1916-1918.

Use and overuse of left ventriculography
Witteles, R. M., Knowles, J. W., Perez, M., Morris, W. M., Spettell, C. M., & Heidenreich, P. A. (2012). Use and overuse of left ventriculography. AMERICAN HEART JOURNAL, 163(4), 617-?.

Heart transplantation and cardiac amyloidosis: Approach to screening and novel management strategies
Varr, B. C., Liedtke, M., Arai, S., Lafayette, R. A., Schrier, S. L., & Witteles, R. M. (2012). Heart transplantation and cardiac amyloidosis: Approach to screening and novel management strategies. JOURNAL OF HEART AND LUNG TRANSPLANTATION, 31(3), 325-331.

Chemotherapy-Associated Cardiotoxicity: How Often Does it Really Occur and How Can it Be Prevented?
Witteles, R. M., Fowler, M. B., & Telli, M. L. (2011). Chemotherapy-Associated Cardiotoxicity: How Often Does it Really Occur and How Can it Be Prevented?. HEART FAILURE CLINICS, 7(3), 333-?.

Radiation Therapy for Breast Cancer Buyer Beware
Witteles, R. M. (2011). Radiation Therapy for Breast Cancer Buyer Beware. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 57(4), 453-454.

Left Ventricular Dysfunction in Patients Receiving Cardiotoxic Cancer Therapies Are Clinicians Responding Optimally?
Yoon, G. J., Telli, M. L., Kao, D. P., Matsuda, K. Y., Carlson, R. W., & Witteles, R. M. (2010). Left Ventricular Dysfunction in Patients Receiving Cardiotoxic Cancer Therapies Are Clinicians Responding Optimally?. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 56(20), 1644-1650.

Heart Failure in Hispanics
Vivo, R. P., Krim, S. R., Cevik, C., & Witteles, R. M. (2009). Heart Failure in Hispanics. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 53(14), 1167-1175.

Clinical problem-solving. Fool's Gold.
Leeper, N. J., Dhaliwal, G., Saint, S., & Witteles, R. M. (2008). Clinical problem-solving. Fool's Gold. New England journal of medicine, 359(19), 2035-2041.

Insulin-resistant cardiomyopathy
Witteles, R. M., & Fowler, M. B. (2008). Insulin-resistant cardiomyopathy. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 51(2), 93-102.

Impact of nesiritide on renal function in patients with acute decompensated failure an pre-existing renal dysfunction - A randomized, double-blind, placebo-controlled clinical trial
Witteles, R. M., Kao, D., Christopherson, D., Matsuda, K., Vagelos, R. H., & Fowler, M. B. (2007). Impact of nesiritide on renal function in patients with acute decompensated failure an pre-existing renal dysfunction - A randomized, double-blind, placebo-controlled clinical trial. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 50(19), 1835-1840.

Cardiomyopathy of insulin resistance.
Witteles, R. M., & Fowler, M. B. (2006). Cardiomyopathy of insulin resistance. Heart failure clinics, 2(1), 13-23.

Insulin resistance in idiopathic dilated cardiomyopathy - A possible etiologic link
Witteles, R. M., Tang, W. Hw., Jamali, A. H., Chu, J. W., Reaven, G. M., & Fowler, M. B. (2004). Insulin resistance in idiopathic dilated cardiomyopathy - A possible etiologic link. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 44(1), 78-81.

Radiation-induced heart disease: an under-recognized entity?
Davis, M., & Witteles, R. M. (2014). Radiation-induced heart disease: an under-recognized entity?. Current treatment options in cardiovascular medicine, 16(6), 317-?.

Cancer Therapy-Induced Left Ventricular Dysfunction: Interventions and Prognosis
Thakur, A., & Witteles, R. M. (2014). Cancer Therapy-Induced Left Ventricular Dysfunction: Interventions and Prognosis. JOURNAL OF CARDIAC FAILURE, 20(3), 155-158.

Lenalidomide, melphalan and dexamethasone in a population of patients with immunoglobulin light chain amyloidosis with high rates of advanced cardiac involvement.
Dinner, S., Witteles, W., Afghahi, A., Witteles, R., Arai, S., & Liedtke, M. (2013). Lenalidomide, melphalan and dexamethasone in a population of patients with immunoglobulin light chain amyloidosis with high rates of advanced cardiac involvement. Haematologica, 98(10), 1593-1599.

AG10 inhibits amyloidogenesis and cellular toxicity of the familial amyloid cardiomyopathy-associated V122I transthyretin
Penchala, S. C., Connelly, S., Wang, Y., Park, M. S., Zhao, L., & Alhamadsheh, M. M. (2013). AG10 inhibits amyloidogenesis and cellular toxicity of the familial amyloid cardiomyopathy-associated V122I transthyretin. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 110(24), 9992-9997.

The prognostic value of diagnosing concurrent multiple myeloma in immunoglobulin light chain amyloidosis
Dinner, S., Witteles, W., Witteles, R., Lam, A., Arai, S., & Liedtke, M. (2013). The prognostic value of diagnosing concurrent multiple myeloma in immunoglobulin light chain amyloidosis. BRITISH JOURNAL OF HAEMATOLOGY, 161(3), 367-372.

Cardiac testing to manage cardiovascular risk in cancer patients.
Davis, M., & Witteles, R. M. (2013). Cardiac testing to manage cardiovascular risk in cancer patients. Seminars in oncology, 40(2), 147-155.

The Frequency and Severity of Cardiovascular Toxicity From Targeted Therapy in Advanced Renal Cell Carcinoma Patients.
Hall, P. S., Harshman, L. C., Srinivas, S., & Witteles, R. M. (2013). The Frequency and Severity of Cardiovascular Toxicity From Targeted Therapy in Advanced Renal Cell Carcinoma Patients. JACC. Heart failure, 1(1), 72-78.

Broken Heart Syndrome (Takotsubo Cardiomyopathy) Triggered by Acute Mania: A Review and Case Report
Maldonado, J. R., Pajouhi, P., & Witteles, R. (2013). Broken Heart Syndrome (Takotsubo Cardiomyopathy) Triggered by Acute Mania: A Review and Case Report. PSYCHOSOMATICS, 54(1), 74-79.

Capecitabine-Induced Chest Pain Relieved by Diltiazem
Ambrosy, A. P., Kunz, P. L., Fisher, G. A., & Witteles, R. M. (2012). Capecitabine-Induced Chest Pain Relieved by Diltiazem. AMERICAN JOURNAL OF CARDIOLOGY, 110(11), 1623-1626.

Dipeptidyl Peptidase 4 Inhibition Increases Myocardial Glucose Uptake in Nonischemic Cardiomyopathy
Witteles, R. M., Keu, K. V., Quon, A., Tavana, H., & Fowler, M. B. (2012). Dipeptidyl Peptidase 4 Inhibition Increases Myocardial Glucose Uptake in Nonischemic Cardiomyopathy. JOURNAL OF CARDIAC FAILURE, 18(10), 804-809.

More Than a Frog in the Throat A Case Series and Review of Localized Laryngeal Amyloidosis
Stevenson, R., Witteles, R., Damrose, E., Arai, S., Lafayette, R. A., & Liedtke, M. (2012). More Than a Frog in the Throat A Case Series and Review of Localized Laryngeal Amyloidosis. ARCHIVES OF OTOLARYNGOLOGY-HEAD & NECK SURGERY, 138(5), 509-511.

OVERUSE OF LEFT VENTRICULOGRAPHY
Witteles, R., Knowles, J. W., Perez, M., Morris, W. H., Spettell, C. M., & Heidenreich, P. A. (2011). OVERUSE OF LEFT VENTRICULOGRAPHY. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 57(14), E1289-E1289.

Trastuzumab-Related Cardiac Dysfunction
Telli, M. L., & Witteles, R. M. (2011). Trastuzumab-Related Cardiac Dysfunction. JOURNAL OF THE NATIONAL COMPREHENSIVE CANCER NETWORK, 9(2), 243-249.

Renal sympathetic denervation in patients with treatment-resistant hypertension (The Symplicity HTN-2 Trial): a randomised controlled trial
Esler, M. D., Krum, H., Sobotka, P. A., Schlaich, M. P., Schmieder, R. E., & Massaro, J. M. (2010). Renal sympathetic denervation in patients with treatment-resistant hypertension (The Symplicity HTN-2 Trial): a randomised controlled trial. LANCET, 376(9756), 1903-1909.

Measurement Precision in the Optimization of Cardiac Resynchronization Therapy
Turcott, R. G., Witteles, R. M., Wang, P. J., Vagelos, R. H., Fowler, M. B., & Ashley, E. A. (2010). Measurement Precision in the Optimization of Cardiac Resynchronization Therapy. CIRCULATION-HEART FAILURE, 3(3), 395-404.

Rosiglitazone Increases Myocardial Glucose Metabolism in Insulin-Resistant Cardiomyopathy
Kao, D. P., Witteles, R. M., Quon, A., Wu, J. C., Gambhir, S. S., & Fowler, M. B. (2010). Rosiglitazone Increases Myocardial Glucose Metabolism in Insulin-Resistant Cardiomyopathy. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 55(9), 926-927.

Nesiritide, Heart Failure, and Renal Dysfunction: Irrational Exuberance or Throwing the Baby out with the Bathwater Editorial to: "Impact of Nesiritide on Renal Function and Mortality in Patients Suffering from Heart Failure" by Dontas et al.
Witteles, R. M. (2009). Nesiritide, Heart Failure, and Renal Dysfunction: Irrational Exuberance or Throwing the Baby out with the Bathwater Editorial to: "Impact of Nesiritide on Renal Function and Mortality in Patients Suffering from Heart Failure" by Dontas et al. CARDIOVASCULAR DRUGS AND THERAPY, 23(3), 183-186.

Cardiotoxicity associated with the cancer therapeutic agent sunitinib malate
Telli, M. L., Witteles, R. M., Fisher, G. A., & Srinivas, S. (2008). Cardiotoxicity associated with the cancer therapeutic agent sunitinib malate. ANNALS OF ONCOLOGY, 19(9), 1613-1618.

Trastuzumab cardiotoxicity: Clinical management of asymptomatic declines in left ventricular function
Telli ML, Witteles RM, Hunt SA, Carlson RW, & Guardino AE. (2008). Trastuzumab cardiotoxicity: Clinical management of asymptomatic declines in left ventricular function. The American Journal of Hematology/Oncology, 7(1).

Reversible high-output cardiac failure, an unusual marker of disease status in multiple myeloma
Kohrt H, Logan A, Temmins C, Witteles R, Liedtke M, & Medeiros B. (2008). Reversible high-output cardiac failure, an unusual marker of disease status in multiple myeloma. Leukemia and Lymphoma, 49.

Reversibility of trastuzumab cardiotoxicity: Is the concept alive and well?
Telli ML, Carlson RW, Guardino AE, Hunt SA, & Witteles RM. (2007). Reversibility of trastuzumab cardiotoxicity: Is the concept alive and well?. Journal of Clinical Oncology, 25(34).

Premature ventricular contractions causing pacemaker-mediated tachycardia: A failure of postventricular atrial refractory period after premature ventricular contraction extension?
Witteles, R., Engel, G., Wang, P. J., & Al-Ahmad, A. (2005). Premature ventricular contractions causing pacemaker-mediated tachycardia: A failure of postventricular atrial refractory period after premature ventricular contraction extension?. HEART RHYTHM, 2(12), 1389-1390.

B-type natriuretic peptide is effective therapy before cardiac transplantation
Witteles R, Matsuda K, & Fowler MB. (2004). B-type natriuretic peptide is effective therapy before cardiac transplantation. Annals of Internal Medicine, 141(11).

Parathyroid carcinoma
Witteles RM, Straus FH, Koka MLR, & Kaplan EL. (2002). Parathyroid carcinoma. Surgery of the thyroid and parathyroid glands.

Neuroendocrine tumors of the pancreas
Buell J, Witteles RM, Koka MLR, Sugg SL, & Kaplan EL. (2002). Neuroendocrine tumors of the pancreas. The Practice of General Surgery.

Adult-onset nesidioblastosis causing hypoglycemia: An important clinical entity and continuing treatment dilemma
Witteles RM, Straus II FH, Sugg SL, Koka MR, Costa EA, & Kaplan EL. (2001). Adult-onset nesidioblastosis causing hypoglycemia: An important clinical entity and continuing treatment dilemma. Archives of Surgery, 136(6).

Episodic hypertension associated with sitting on hard surfaces
Witteles RM. (2001). Episodic hypertension associated with sitting on hard surfaces. Journal of General Internal Medicine, 16.

A new provocative test for the diagnosis of pheochromocytoma?
Witteles R, & Roizen MF. (2001). A new provocative test for the diagnosis of pheochromocytoma?. American Journal of Anesthesiology, 28.

Sensitivity of diagnostic and localization tests for pheochromocytoma in clinical practice
Witteles RM, Kaplan EL, & Roizen MF. (2000). Sensitivity of diagnostic and localization tests for pheochromocytoma in clinical practice. Archives of Internal Medicine, 160(16).

Safe and cost-effective preoperative preparation of patients with pheochromocytoma
Witteles RM, Kaplan EL, & Roizen MF. (2000). Safe and cost-effective preoperative preparation of patients with pheochromocytoma. Anesthesia and Analgesia, 91(2).