Professional Summary
Education & Certifications
- Board Certification: American Society for Microbiology, Medical Microbiology (2019)
- Residency: Stanford University Pathology Residency (2011) CA
- Medical Education: Harvard Medical School (2008) MA
- MD, Harvard Medical School, Medicine (2008)
- PhD, Harvard Medical School, Biophysics (2006)
- BA, Harvard University, Biochemical Sciences (2001)
Honors & Awards
- Career Award for Medical Scientists, Burroughs-Wellcome Fund (2012-2017)
- Early Career Independence Award (DP5), NIH (2012-2017)
- Medical Scientist Training Program (MSTP), NIH (2001-2008)
Publications
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Type II thioesterase restores activity of a NRPS module stalled with an aminoacyl-S-enzyme that cannot be elongated
Yeh, E., Kohli, R. M., Bruner, S. D., & Walsh, C. T. (2004). Type II thioesterase restores activity of a NRPS module stalled with an aminoacyl-S-enzyme that cannot be elongated. CHEMBIOCHEM, 5(9), 1290–1293. -
Enhanced macrocyclizing activity of the thioesterase from tyrocidine synthetase in presence of nonionic detergent
Yeh, E., Lin, H. N., Clugston, S. L., Kohli, R. M., & Walsh, C. T. (2004). Enhanced macrocyclizing activity of the thioesterase from tyrocidine synthetase in presence of nonionic detergent. CHEMISTRY & BIOLOGY, 11(11), 1573–1582. -
Robust in vitro activity of RebF and RebH, a two-component reductase/halogenase, generating 7-chlorotryptophan during rebeccamycin biosynthesis
Yeh, E., Garneau, S., & Walsh, C. T. (2005). Robust in vitro activity of RebF and RebH, a two-component reductase/halogenase, generating 7-chlorotryptophan during rebeccamycin biosynthesis. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 102(11), 3960–3965. -
Cryptic chlorination by a non-haem iron enzyme during cyclopropyl amino acid biosynthesis
Vaillancourt, F. H., Yeh, E., Vosburg, D. A., O'Connor, S. E., & Walsh, C. T. (2005). Cryptic chlorination by a non-haem iron enzyme during cyclopropyl amino acid biosynthesis. NATURE, 436(7054), 1191–1194. -
Dichlorination of a pyrrolyl-S-carrier protein by FADH(2)-dependent halogenase PltA during pyoluteorin biosynthesis
Dorrestein, P. C., Yeh, E., Garneau-Tsodikova, S., Kelleher, N. L., & Walsh, C. T. (2005). Dichlorination of a pyrrolyl-S-carrier protein by FADH(2)-dependent halogenase PltA during pyoluteorin biosynthesis. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 102(39), 13843–13848. -
Flavin redox chemistry precedes substrate chlorination during the reaction of the flavin-dependent halogenase RebH
Yeh, E., Cole, L. J., Barr, E. W., Bollinger, J. M., Ballou, D. P., & Walsh, C. T. (2006). Flavin redox chemistry precedes substrate chlorination during the reaction of the flavin-dependent halogenase RebH. BIOCHEMISTRY, 45(25), 7904–7912. -
Nature's inventory of halogenation catalysts: Oxidative strategies predominate
Vaillancourt, F. H., Yeh, E., Vosburg, D. A., Garneau-Tsodikova, S., & Walsh, C. T. (2006). Nature's inventory of halogenation catalysts: Oxidative strategies predominate. CHEMICAL REVIEWS, 106(8), 3364–3378. -
Enzymatic generation of the antimetabolite gamma,gamma-dichloroaminobutyrate by NRPS and mononuclear iron halogenase action in a streptomycete
Ueki, M., Galonic, D. P., Vaillancourt, F. H., Garneau-Tsodikova, S., Yeh, E., Vosburg, D. A., … Walsh, C. T. (2006). Enzymatic generation of the antimetabolite gamma,gamma-dichloroaminobutyrate by NRPS and mononuclear iron halogenase action in a streptomycete. CHEMISTRY & BIOLOGY, 13(11), 1183–1191. -
Characterization of the aminocarboxycyclopropane-forming enzyme CmaC
Kelly, W. L., Boyne, M. T., Yeh, E., Vosburg, D. A., Galonic, D. P., Kelleher, N. L., & Walsh, C. T. (2007). Characterization of the aminocarboxycyclopropane-forming enzyme CmaC. BIOCHEMISTRY, 46(2), 359–368. -
Chlorination by a long-lived intermediate in the mechanism of flavin-dependent halogenases
Yeh, E., Blasiak, L. C., Koglin, A., Drennan, C. L., & Walsh, C. T. (2007). Chlorination by a long-lived intermediate in the mechanism of flavin-dependent halogenases. BIOCHEMISTRY, 46(5), 1284–1292. -
Hair Sheep Blood, Citrated or Defibrinated, Fulfills All Requirements of Blood Agar for Diagnostic Microbiology Laboratory Tests
Yeh, E., Pinsky, B. A., Banaei, N., & Baron, E. J. (2009). Hair Sheep Blood, Citrated or Defibrinated, Fulfills All Requirements of Blood Agar for Diagnostic Microbiology Laboratory Tests. PLOS ONE, 4(7). -
Preferential Lower Respiratory Tract Infection in Swine-Origin 2009 A(H1N1) Influenza
Yeh, E., Luo, R. F., Dyner, L. L., Hong, D. K., Banaei, N., Baron, E. J., & Pinsky, B. A. (2010). Preferential Lower Respiratory Tract Infection in Swine-Origin 2009 A(H1N1) Influenza. CLINICAL INFECTIOUS DISEASES, 50(3), 391–94. -
Real-Time PCR Testing for mecA Reduces Vancomycin Usage and Length of Hospitalization for Patients Infected with Methicillin-Sensitive Staphylococci
Nguyen, D. T., Yeh, E., Perry, S., Luo, R. F., Pinsky, B. A., Lee, B. P., … Banaei, N. (2010). Real-Time PCR Testing for mecA Reduces Vancomycin Usage and Length of Hospitalization for Patients Infected with Methicillin-Sensitive Staphylococci. JOURNAL OF CLINICAL MICROBIOLOGY, 48(3), 785–90. -
Immediate Incubation Reduces Indeterminate Results for QuantiFERON-TB Gold In-Tube Assay
Herrera, V., Yeh, E., Murphy, K., Parsonnet, J., & Banaei, N. (2010). Immediate Incubation Reduces Indeterminate Results for QuantiFERON-TB Gold In-Tube Assay. JOURNAL OF CLINICAL MICROBIOLOGY, 48(8), 2672–76. -
Chemical Rescue of Malaria Parasites Lacking an Apicoplast Defines Organelle Function in Blood-Stage Plasmodium falciparum
Yeh, E., & DeRisi, J. L. (2011). Chemical Rescue of Malaria Parasites Lacking an Apicoplast Defines Organelle Function in Blood-Stage Plasmodium falciparum. PLOS BIOLOGY, 9(8). -
A Chemical Rescue Screen Identifies a Plasmodium falciparum Apicoplast Inhibitor Targeting MEP Isoprenoid Precursor Biosynthesis.
Wu, W., Herrera, Z., Ebert, D., Baska, K., Cho, S. H., DeRisi, J. L., & Yeh, E. (2015). A Chemical Rescue Screen Identifies a Plasmodium falciparum Apicoplast Inhibitor Targeting MEP Isoprenoid Precursor Biosynthesis. Antimicrobial Agents and Chemotherapy, 59(1), 356–364. -
The Prenylated Proteome of Plasmodium falciparum Reveals Pathogen-specific Prenylation Activity and Drug Mechanism-of-action
Gisselberg, J. E., Zhang, L., Elias, J. E., & Yeh, E. (2017). The Prenylated Proteome of Plasmodium falciparum Reveals Pathogen-specific Prenylation Activity and Drug Mechanism-of-action. MOLECULAR & CELLULAR PROTEOMICS, 16(4), S54–S64. -
The apicoplast: now you see it, now you don't
McFadden, G. I., & Yeh, E. (2017). The apicoplast: now you see it, now you don't. INTERNATIONAL JOURNAL FOR PARASITOLOGY, 47(2-3), 137–44. -
ATG8 Is Essential Specifically for an Autophagy-Independent Function in Apicoplast Biogenesis in Blood-Stage Malaria Parasites.
Walczak, M., Ganesan, S. M., Niles, J. C., & Yeh, E. (2018). ATG8 Is Essential Specifically for an Autophagy-Independent Function in Apicoplast Biogenesis in Blood-Stage Malaria Parasites. MBio, 9(1). -
Specific Inhibition of the Bifunctional Farnesyl/Geranylgeranyl Diphosphate Synthase in Malaria Parasites via a New Small-Molecule Binding Site
Gisselberg, J. E., Herrera, Z., Orchard, L. M., Llinas, M., & Yeh, E. (2018). Specific Inhibition of the Bifunctional Farnesyl/Geranylgeranyl Diphosphate Synthase in Malaria Parasites via a New Small-Molecule Binding Site. CELL CHEMICAL BIOLOGY, 25(2), 185-+. -
Small molecule inhibition of apicomplexan FtsH1 disrupts plastid biogenesis in human pathogens
Amberg-Johnson, K., Hari, S. B., Ganesan, S. M., Lorenzi, H. A., Sauer, R. T., Niles, J. C., & Yeh, E. (2017). Small molecule inhibition of apicomplexan FtsH1 disrupts plastid biogenesis in human pathogens. ELIFE, 6. -
Integrative proteomics and bioinformatic prediction enable a high-confidence apicoplast proteome in malaria parasites.
Boucher, M. J., Ghosh, S., Zhang, L., Lal, A., Jang, S. W., Ju, A., … Yeh, E. (2018). Integrative proteomics and bioinformatic prediction enable a high-confidence apicoplast proteome in malaria parasites. PLoS Biology, 16(9), e2005895. -
The Toxoplasma gondii Active Serine Hydrolase 4 Regulates Parasite Division and Intravacuolar Parasite Architecture.
Foe, I. T., Onguka, O., Amberg-Johnson, K., Garner, R. M., Amara, N., Beatty, W., … Bogyo, M. (2018). The Toxoplasma gondii Active Serine Hydrolase 4 Regulates Parasite Division and Intravacuolar Parasite Architecture. MSphere, 3(5). -
The Toxoplasma gondii Active Serine Hydrolase 4 Regulates Parasite Division and Intravacuolar Parasite Architecture (vol 3, e00393-18, 2018)
Foe, I. T., Onguka, O., Amberg-Johnson, K., Garner, R. M., Amara, N., Beatty, W., … Bogyo, M. (2018). The Toxoplasma gondii Active Serine Hydrolase 4 Regulates Parasite Division and Intravacuolar Parasite Architecture (vol 3, e00393-18, 2018). MSPHERE, 3(5). -
The Toxoplasma gondii Active Serine Hydrolase 4 Regulates Parasite Division and Intravacuolar Parasite Architecture (vol 3, e00393-18, 2018)
Foe, I. T., Onguka, O., Amberg-Johnson, K., Garner, R. M., Amara, N., Beatty, W., … Bogyo, M. (2018). The Toxoplasma gondii Active Serine Hydrolase 4 Regulates Parasite Division and Intravacuolar Parasite Architecture (vol 3, e00393-18, 2018). MSPHERE, 3(5). -
Host cell metabolism contributes to delayed-death kinetics of apicoplast inhibitors in Toxoplasma gondii.
Amberg-Johnson, K., & Yeh, E. (2018). Host cell metabolism contributes to delayed-death kinetics of apicoplast inhibitors in Toxoplasma gondii. Antimicrobial Agents and Chemotherapy. -
Disruption of Apicoplast Biogenesis by Chemical Stabilization of an Imported Protein Evades the Delayed-Death Phenotype in Malaria Parasites.
Boucher, M. J., & Yeh, E. (2019). Disruption of Apicoplast Biogenesis by Chemical Stabilization of an Imported Protein Evades the Delayed-Death Phenotype in Malaria Parasites. MSphere, 4(1). -
A mutagenesis screen for essential plastid biogenesis genes in human malaria parasites.
Tang, Y., Meister, T. R., Walczak, M., Pulkoski-Gross, M. J., Hari, S. B., Sauer, R. T., … Yeh, E. (2019). A mutagenesis screen for essential plastid biogenesis genes in human malaria parasites. PLoS Biology, 17(2), e3000136. -
Plastid-endomembrane connections in apicomplexan parasites.
Boucher, M. J., & Yeh, E. (2019). Plastid-endomembrane connections in apicomplexan parasites. PLoS Pathogens, 15(6), e1007661. -
Host Cell Metabolism Contributes to Delayed-Death Kinetics of Apicoplast Inhibitors in Toxoplasma gondii
Amberg-Johnson, K., & Yeh, E. (2019). Host Cell Metabolism Contributes to Delayed-Death Kinetics of Apicoplast Inhibitors in Toxoplasma gondii. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 63(2). -
Erratum for Foe et al., "The Toxoplasma gondii Active Serine Hydrolase 4 Regulates Parasite Division and Intravacuolar Parasite Architecture".
Foe, I. T., Onguka, O., Amberg-Johnson, K., Garner, R. M., Amara, N., Beatty, W., … Bogyo, M. (2018). Erratum for Foe et al., "The Toxoplasma gondii Active Serine Hydrolase 4 Regulates Parasite Division and Intravacuolar Parasite Architecture". MSphere, 3(5). -
The Toxoplasma gondii Active Serine Hydrolase 4 Regulates Parasite Division and Intravacuolar Parasite Architecture
Foe, I. T., Onguka, O., Amberg-Johnson, K., Garner, R. M., Amara, N., Beatty, W., … Bogyo, M. (2018). The Toxoplasma gondii Active Serine Hydrolase 4 Regulates Parasite Division and Intravacuolar Parasite Architecture. MSPHERE, 3(5). -
A mutagenesis screen for essential plastid biogenesis genes in human malaria parasites
Tang, Y., Meister, T. R., Walczak, M., Pulkoski-Gross, M. J., Hari, S. B., Sauer, R. T., … Yeh, E. (2019). A mutagenesis screen for essential plastid biogenesis genes in human malaria parasites. PLOS BIOLOGY, 17(2). -
Disruption of Apicoplast Biogenesis by Chemical Stabilization of an Imported Protein Evades the Delayed-Death Phenotype in Malaria Parasites
Etoucher, M. J., & Yeh, E. (2019). Disruption of Apicoplast Biogenesis by Chemical Stabilization of an Imported Protein Evades the Delayed-Death Phenotype in Malaria Parasites. MSPHERE, 4(1). -
Identification of anisomycin, prodigiosin and obatoclax as compounds with broad-spectrum anti-parasitic activity.
Ehrenkaufer, G., Li, P., Stebbins, E. E., Kangussu-Marcolino, M. M., Debnath, A., White, C. V., … Singh, U. (2020). Identification of anisomycin, prodigiosin and obatoclax as compounds with broad-spectrum anti-parasitic activity. PLoS Neglected Tropical Diseases, 14(3), e0008150. -
Identification of anisomycin, prodigiosin and obatoclax as compounds with broad-spectrum anti-parasitic activity
Ehrenkaufer, G., Li, P., Stebbins, E. E., Kangussu-Marcolino, M. M., Debnath, A., White, C., … Singh, U. (2020). Identification of anisomycin, prodigiosin and obatoclax as compounds with broad-spectrum anti-parasitic activity. PLOS NEGLECTED TROPICAL DISEASES, 14(3). -
CaaX-Like Protease of Cyanobacterial Origin Is Required for Complex Plastid Biogenesis in Malaria Parasites.
Meister, T. R., Tang, Y., Pulkoski-Gross, M. J., & Yeh, E. (2020). CaaX-Like Protease of Cyanobacterial Origin Is Required for Complex Plastid Biogenesis in Malaria Parasites. MBio, 11(5). -
Nonbisphosphonate inhibitors of Plasmodium falciparum FPPS/GGPPS.
Kabeche, S., Aida, J., Akther, T., Ichikawa, T., Ochida, A., Pulkoski-Gross, M. J., … Yeh, E. (2021). Nonbisphosphonate inhibitors of Plasmodium falciparum FPPS/GGPPS. Bioorganic & Medicinal Chemistry Letters, 127978. -
Structure-Function Relationship for a Divergent Atg8 Protein Required for a Nonautophagic Function in Apicomplexan Parasites.
Walczak, M., Meister, T. R., Nguyen, H. M., Zhu, Y., Besteiro, S., & Yeh, E. (2023). Structure-Function Relationship for a Divergent Atg8 Protein Required for a Nonautophagic Function in Apicomplexan Parasites. MBio, e0364221. -
Covalent Macrocyclic Proteasome Inhibitors Mitigate Resistance in Plasmodium falciparum.
Bennett, J. M., Ward, K. E., Muir, R. K., Kabeche, S., Yoo, E., Yeo, T., … Bogyo, M. (2023). Covalent Macrocyclic Proteasome Inhibitors Mitigate Resistance in Plasmodium falciparum. ACS Infectious Diseases. -
Expansion of GTP cyclohydrolase I copy number in malaria parasites resistant to a pyrimidine biosynthesis inhibitor.
Liu, S., Ebel, E. R., Kim, J., Ene, N., Braukmann, T. W., Yeh, E., … Guler, J. L. (2023). Expansion of GTP cyclohydrolase I copy number in malaria parasites resistant to a pyrimidine biosynthesis inhibitor. BioRxiv : the Preprint Server for Biology. -
Mixed Alkyl/Aryl Phosphonates Identify Metabolic Serine Hydrolases as Antimalarial Targets.
Bennett, J. M., Narwal, S. K., Kabeche, S., Abegg, D., Hackett, F., Yeo, T., … Bogyo, M. (2024). Mixed Alkyl/Aryl Phosphonates Identify Metabolic Serine Hydrolases as Antimalarial Targets. BioRxiv : the Preprint Server for Biology.
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