PREVALENCE OF MEASLES ANTIBODIES IN ADULTS WITH HIV-INFECTION - POSSIBLE RISK-FACTORS OF MEASLES SERONEGATIVITY AIDS Kemper, C. A., Zolopa, A. R., Hamilton, J. R., Fenstersheib, M., Bhatia, G., Deresinski, S. C. 1992; 6 (11): 1321-1325


To determine the prevalence of measles (rubeola) immunity in a group of HIV-1-infected adults and to examine predictors of measles seronegativity in this population.County hospital outpatient clinic and public-health department early HIV intervention clinic.A total of 262 HIV-infected adults presenting to outpatient clinics between September 1990 and January 1991.Patients were screened for the presence of measles immunoglobulin G antibody, as measured by an enzyme-linked immunosorbent assay (ELISA). Pertinent clinical and immunologic information was recorded. Univariate and multivariate analyses were performed to identify possible risk factors for measles seronegativity.Measles seronegativity, as defined by a lack of detectable antibody (ELISA predicted index value < 1.0).Thirteen (5%) patients lacked serologic evidence of immunity. Risk factors for measles seronegativity included year of birth in 1957 or later, Caucasian (non-Hispanic) race and oral hairy leukoplakia. Factors associated with progressive HIV disease (other than hairy leukoplakia) were not associated with a lack of existing immunity.A high prevalence (95%) of measles antibody was found in this large group of HIV-infected adults. Young, white individuals born in 1957 or later were at the greatest risk for measles seronegativity, but declining immunity due to progressive HIV infection did not appear to be associated with a lack of antibody. Self-reported histories of measles infection or immunization were not reliable predictors of measles immunity.

View details for Web of Science ID A1992JY79600013

View details for PubMedID 1472336