Leaders in Cancer Genetics

Stanford's Cancer Genetics Program doctors and researchers have been instrumental in developing many of the leading technologies used to understand, diagnose, test and screen for hereditary cancer syndromes. This expertise allows our specialists to offer you personalized plans for managing your cancer risk.

Cancer Genetics Program
875blakewilburdr-stanford
875 Blake Wilbur Drive
Palo Alto, CA 94304
Phone: 650-498-6000 Getting Here
Maps & Directions
875 Blake Wilbur Drive
Palo Alto, CA 94304
Phone: 650-498-6000 Getting Here

Our Doctors

Care and Treatment of Hereditary Cancers

Features of Inherited Cancers

When a healthcare provider looks at a family's medical history to determine whether the cancer in a family is hereditary, he/she starts by asking the following questions:

  • How many persons in the family have cancer?
  • What type(s) of cancer are present in the family?
  • Is there someone who has more than one type of cancer?
  • What are the ages of onset of cancer?
  • What is the gender of the individuals with cancer?
  • Are the cancers unilateral (occurring on one side of the body) or bilateral (i.e., both kidneys)?
  • What type of environmental exposures or lifestyle factors do the persons with cancer have that might have influenced their risk of cancer (i.e., are they smokers)?
  • How are the persons with cancer related to one another?
  • Is there a vertical pattern of inheritance observed (parents with cancer who have children with cancer)?
  • What is the ancestry and ethnicity of the family?

All of this information is recorded in the form of a family tree, called a pedigree. The information is used to try to classify the family history into one of three categories described below. Often, additional information such as medical records or results of genetic testing may be gathered to aid in the classification process. Classifying the family history helps in determining whether relatives have an increased chance of developing specific types of cancer, how great the risk of cancer might be, and whether genetic testing might be helpful in further evaluating cancer risks in the family.

What is sporadic cancer?

The word sporadic means "to occur by chance." Families who have a single person with cancer at an older age are usually classified as "sporadic." In other words, there is not an inherited pattern of cancer present, and often only one or two individuals in the family have cancer at a typical age of onset. Relatives are usually not at increased risk of developing cancer.

Genetic testing is usually not beneficial in these families.

What is familial cancer?

When there are more cases of cancer in a family than chance alone would predict, but the features of hereditary cancer (described below) are not present, a family is said to have "familial cancer." In other words, in these cases, there is a cluster of cancers in the family, but no clear pattern of inheritance, and the cancers occur at the average age of onset. Familial cancers may be due to a combination of genes and shared lifestyle factors or environmental exposures (multifactorial inheritance).

On the other hand, some of these histories can represent a chance occurrence of sporadic cancers. A familial history may also arise due to a single gene mutation (hereditary cancer) that has reduced penetrance (a mutation associated with lower cancer risks and later onset of cancer). In general, with familial cancer, close relatives have a modestly increased risk of developing the cancer in question.

The chance that genetic testing will be beneficial in further assessing cancer risks is usually small.

What is inherited cancer?

These families have multiple family members with the same or related cancers. The cancers tend to occur at younger than average ages (usually <50 years). Also, there is often a history of persons who developed two or more separate cancers; i.e., colon cancer in a breast cancer survivor, bilateral cancers (bilateral breast cancer), or multifocal cancers (two or more cancers in the same organ such as two separate colon cancers).

Families with inherited cancer often have cancer in two or more generations with cancer displaying an autosomal dominant pattern of inheritance. In other words, when a parent has inherited predisposition to cancer, each child has a 50/50 (one in two) chance of inheriting the predisposition. Those in the family that inherit the predisposition have a high chance of developing the associated cancers. Those who do not inherit the predisposition are not at increased cancer risk.

Genetic testing can often be beneficial in determining who in the family has an increased cancer risk. In most cases, it is important to test a relative with cancer first, to see if a causative mutation can be identified, before testing relatives who have not had cancer. 

Clinical Trials

Clinical trials are research studies that evaluate a new medical approach, device, drug, or other treatment. As a Stanford Health Care patient, you have access to the latest, advanced clinical trials.

Open trials refer to studies currently accepting participants. Closed trials are not currently enrolling, but may open in the future.

Before beginning treatment, ask your doctor about any clinical trials you should consider. Learn more about clinical trials for cancer patients.

For Patients

PREPARE FOR YOUR APPOINTMENT

Review the New Patient Packet for information about:

  • What to expect on the day of your appointment
  • Maps, directions, parking, public transit options, and contact information
  • Other patient resources

Bring completed forms found in the New Patient Appointment Letter and Pre-Visit Questionnaire.

AFTER YOUR APPOINTMENT

See the BRCA Decision Tool which guides the management of cancer risks for BRCA1 and BRCA2 mutation carriers.

MEDICAL RELEASE

Please fax the Medical Record Release Form to your new patient coordinator. The medical release form is an authorization form for external facilities to release medical records to Stanford Health Care (formerly Stanford Hospital & Clinics). 

International Patients
Phone: +1 650-723-8561
Email: IMS@stanfordmed.org

Call us to make an appointment

650-498-6000

For Health Care Professionals

PHYSICIAN HELPLINE

Phone: 1-866-742-4811
Fax: 650-320-9443
Monday – Friday, 8:30 a.m. – 5 p.m.

Stanford Health Care (formerly Stanford Hospital & Clinics) provides comprehensive services to refer and track patients, as well as provides the latest information and news for physicians and office staff. For help with all referral needs and questions visit Referring Physicians.

HOW TO REFER

Fax a referral form with supporting documentation to 650-320-9443.

Please note, though this form is from Stanford Health Care (formerly Stanford Hospital & Clinics), it is also used for all Cancer Center referrals.

Track your patients' progress and communicate with Stanford providers securely online.

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