Moyamoya Center

The Stanford Moyamoya Center offers a highly experienced group of professionals who see several new moyamoya patients each week, making Stanford the largest moyamoya referral center in the world. 

Moyamoya Center
875blakewilburdr-stanford
300 Pasteur Drive
Stanford, CA 94305
Phone: 650-723-5575 Getting Here
Maps & Directions
300 Pasteur Drive
Stanford, CA 94305
Phone: 650-723-5575 Getting Here
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Our Doctors

Care and Treatment of Moyamoya Disease

Outcomes

Our patients lead full and active lives after surgery. Our long term follow up allows us to see our moyamoya patients living full, healthy lives.

Clinical Article

Clinical Outcome after 450 Revascularization Procedures for Moyamoya Disease

Objective

Moyamoya disease (MMD) is a rare cerebrovascular disease mainly described in the Asian literature. To address a lack of data on clinical characteristics and long-term outcomes in the treatment of MMD in North America, the authors analyzed their experience at Stanford University Medical Center. They report on a consecutive series of patients treated for MMD and detail their demographics, clinical characteristics, and long-term surgical outcomes. Methods. Data obtained in consecutive series of 329 patients with MMD treated microsurgically by the senior author (G.K.S.) between 1991 and 2008 were analyzed. Demographic, clinical, and surgical data were prospectively gathered and neurological outcomes assessed in postoperative follow-up using the modified Rankin Scale. Association of demographic, clinical, and surgical data with postoperative outcome was assessed by chi-square, uni- and multivariate logistic regression, and Kaplan-Meier survival analyses.

Results

The authors treated a total of 233 adult patients undergoing 389 procedures (mean age 39.5 years) and 96 pediatric patients undergoing 168 procedures (mean age 10.1 years). Direct revascularization technique was used in 95.1% of adults and 76.2% of pediatric patients. In 264 patients undergoing 450 procedures (mean follow-up 4.9 years), the surgical morbidity rate was 3.5% and the mortality rate was 0.7% per treated hemisphere. The cumulative 5-year risk of perioperative or subsequent stroke or death was 5.5%. Of the 171 patients presenting with a transient ischemic attack, 91.8% were free of transient ischemic attacks at 1 year or later. Overall, there was a significant improvement in quality of life in the cohort as measured using the modified Rankin Scale (p < 0.0001).

Conclusions

Revascularization surgery in patients with MMD carries a low risk, is effective at preventing future ischemic events, and improves quality of life. Patients in whom symptomatic MMD is diagnosed should be offered revascularization surgery.

Clinical Trials

Clinical trials are research studies that evaluate a new medical approach, device, drug, or other treatment. As a Stanford Health Care patient, you have access to the latest, advanced clinical trials.

Open trials refer to studies currently accepting participants. Closed trials are not currently enrolling, but may open in the future.

For Patients

Call us at 650-723-5575 to make an appointment or send a fax to 650-723-1948.

For questions, send an email to DL-TheMoyamoyaCenter@stanfordmed.org.

International Patients
Phone: +1 650-723-8561
Email: IMS@stanfordmed.org

Call us to make an appointment

650-723-5575

For Health Care Professionals

PHYSICIAN HELPLINE

Phone: 1-866-742-4811 
Fax: 650-320-9443
Monday – Friday,  8:30 a.m. – 5 p.m.

TRANSFER CENTER

Phone: 1-800-800-1551,  24 hours - 7 days a week

Stanford Health Care (formerly Stanford Hospital & Clinics) provides comprehensive services to refer and track patients, as well as provides the latest information and news for physicians and office staff. For help with all referral needs and questions visit Referring Physicians.

HOW TO REFER

Call us at 650-723-5575 to refer a patient. Mail films for review to:

  • Gary Steinberg, MD, PhD
    Dept. of Neurosurgery
    300 Pasteur Drive, Room R-281
    Stanford, CA 94305-5327

Track your patients' progress and communicate with Stanford providers securely online.

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