Adult Growth Hormone Deficiency (AGHD)

AGHD is characterized by diminished growth hormone (GH) secretion by the pituitary gland. This can be have many causes, including the presence of a pituitary tumor, other growths/disorders in the pituitary or hypothalamic area, history of surgery or radiation therapy to the pituitary area or base of skull, or head trauma. In these situations, reduced GH secretion in children leads to short stature. In adults, the clinical syndrome includes:

  • Altered body composition (increased fat mass, decreased lean body mass)
  • Decreased muscle strength
  • Altered lipid profile
  • Decreased bone mineral density
  • Diminished quality of life, characterized by low energy level, increased emotional lability and irritability, and increased social isolation
  • Enhanced cardiovascular risk
  • In children: short stature

GH appears to be one of the first hormones to be lost in patients with pituitary tumors and nearly all patients with two or more other pituitary deficiencies also lack GH.

Clinical Trials

Clinical trials are research studies that evaluate a new medical approach, device, drug, or other treatment. As a Stanford Health Care patient, you have access to the latest, advanced clinical trials.

Open trials refer to studies currently accepting participants. Closed trials are not currently enrolling, but may open in the future.

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