4D-CT-based Ventilation Imaging for Adaptive Functional Guidance in Radiotherapy

Trial ID or NCT#

NCT01034514

Status

not recruiting iconNOT RECRUITING

Purpose

To develop and investigate a novel radiotherapy technique for preserving lung function based on a map of lung function.

Official Title

4D-CT-based Ventilation Imaging for Adaptive Functional Guidance in Radiotherapy

Eligibility Criteria

Ages Eligible for Study: Older than 18 Years
Sexes Eligible for Study: All
Accepts Healthy Volunteers: No
Inclusion Criteria:
  1. - Eligible disease(s)/stage(s) AJCC Stage I, II, III or IV lung cancer of any histology to be treated using radiotherapy will be eligible for this study. Note that we will carefully consider the inclusion of cases with turbulent flow or greater flow velocities (Cabahug et al., 1996; Crawford et al., 1990) and COPD cases (Magnant et al., 2006) due to the impaction of aerosol particles in central airways. - Allowable type and amount of prior therapy. Any types and amounts of prior therapy will be allowed for this study. - Age restriction and/or gender/ethnic restrictions - Patients must be greater than or equal to 18 years of age. - There are no gender or ethnic restrictions. - Life expectancy restrictions - None. - ECOG or Karnofsky Performance Status - Not employed. Note that patients will need to be sufficiently healthy to undergo audiovisual (AV) biofeedback to generate high quality 4D-CT images. - Requirements for organ and marrow function None. - Ability to understand and the willingness to sign a written informed consent document.
Exclusion Criteria:
  1. Children (less than 18 years of age), pregnant women, Stanford employees or students, or prisoners will be excluded from this study.
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Investigator(s)

Billy W Loo, Jr, MD PhD FASTRO FACR
Billy W Loo, Jr, MD PhD FASTRO FACR
Radiation oncologist, Thoracic specialist
Professor of Radiation Oncology (Radiation Therapy)
Heather Wakelee
Heather Wakelee
Medical oncologist, Thoracic specialist
Winston Chen and Phyllis Huang Professor
Joseph Shrager
Joseph Shrager
Thoracic surgeon, Surgical oncologist
Professor of Cardiothoracic Surgery
A. Dimitrios Colevas, MD
A. Dimitrios Colevas, MD
Medical oncologist, Head and neck specialist, Cutaneous oncology specialist
Professor of Medicine (Oncology) and, by courtesy, of Otolaryngology - Head & Neck Surgery (OHNS) and of Radiation Oncology (Radiation Therapy)

Contact us to find out if this trial is right for you.

Contact

Cancer Clinical Trials Office
650-498-7061

View on ClinicalTrials.gov