Comparison of Transdermal and Oral Estrogens in Adolescent Girls With Ovarian Failure

Trial ID or NCT#

NCT01023178

Status

not recruiting iconNOT RECRUITING

Purpose

To directly compare the safety (by laboratory evaluation) and efficacy (feminization and growth) of three commonly used estrogen preparations in adolescent patients with ovarian failure, either due to congenital causes (Turner syndrome) or medical therapies. We hypothesize that transdermal estrogen will have equivalent efficacy and a more favorable safety profile in comparison with conventional oral estrogen replacement.

Official Title

Comparison of Transdermal and Oral Estrogens in Adolescents With Ovarian Failure

Eligibility Criteria

Ages Eligible for Study: 12 Years to 18 Years
Sexes Eligible for Study: Female
Accepts Healthy Volunteers: No
Inclusion Criteria:
  1. in whom initiation of estrogen therapy has been recommended due to ovarian failure - Outpatients - age >=12 years to 17.99 years old
Exclusion Criteria:
  1. - spontaneous menses - significant concurrent medical problem including: - Liver function tests (LFTs) 3 times normal - clotting disorder - ongoing cancer treatment

Investigator(s)

Darrell Wilson
Sejal Shah

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Contact

Sejal Shah
6507235791